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Protein

Xylose isomerase

Gene

xylA

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991UniRule annotation
Active sitei102 – 1021UniRule annotation
Metal bindingi230 – 2301Magnesium 1UniRule annotation
Metal bindingi266 – 2661Magnesium 1UniRule annotation
Metal bindingi266 – 2661Magnesium 2UniRule annotation
Metal bindingi269 – 2691Magnesium 2UniRule annotation
Metal bindingi294 – 2941Magnesium 1UniRule annotation
Metal bindingi305 – 3051Magnesium 2UniRule annotation
Metal bindingi307 – 3071Magnesium 2UniRule annotation
Metal bindingi337 – 3371Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-3493-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:RD1_3705
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Xylose isomerasePRO_1000026454Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi375451.RD1_3705.

Structurei

3D structure databases

ProteinModelPortaliQ162B6.
SMRiQ162B6. Positions 2-433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q162B6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDFFKDIPA IRYEGPDTEN EFAFRHYNPD EVVMGKTLKD HLRFACAYWH
60 70 80 90 100
SFAWPGGDPF GGQTFERPWF GDTMELAKLK ADVAFDMFER LGVPYFCFHD
110 120 130 140 150
ADVRPEGDTF AESTKNLEEI TDYFAEKMDA TGVKLLWGTA NLFSHRRFMA
160 170 180 190 200
GAATNPDPEV FAYSAATIKS CMDATRKLGG ENYVLWGGRE GYETLLNTDM
210 220 230 240 250
ARERAQAGRM LQMVVDYKHK TGFAGTILIE PKPQEPTKHQ YDYDVATVYG
260 270 280 290 300
FLKDFGLEGE VKVNIEQGHA ILAGHSFEHE LALARALGIF GSIDMNRNDY
310 320 330 340 350
QSGWDTDQFP NNVPEMALAY YEVLRAGGFD TGGTNFDAKL RRQSLDPADL
360 370 380 390 400
ILAHVGGMDA CAAGLKAAAA MLEDGKLEAA REARYAGWSE GLGQKLLTSD
410 420 430
LAEISDLVIA KGINPQPRSG RQERLENLVN KYL
Length:433
Mass (Da):48,309
Last modified:July 25, 2006 - v1
Checksum:i6E9465CDEF79142E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA. Translation: ABG33177.1.
RefSeqiWP_011569788.1. NC_008209.1.
YP_683863.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG33177; ABG33177; RD1_3705.
GeneIDi4196123.
KEGGirde:RD1_3705.
PATRICi23365361. VBIRosDen86677_3546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA. Translation: ABG33177.1.
RefSeqiWP_011569788.1. NC_008209.1.
YP_683863.1. NC_008209.1.

3D structure databases

ProteinModelPortaliQ162B6.
SMRiQ162B6. Positions 2-433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi375451.RD1_3705.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG33177; ABG33177; RD1_3705.
GeneIDi4196123.
KEGGirde:RD1_3705.
PATRICi23365361. VBIRosDen86677_3546.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-3493-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114.

Entry informationi

Entry nameiXYLA_ROSDO
AccessioniPrimary (citable) accession number: Q162B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.