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Q16288

- NTRK3_HUMAN

UniProt

Q16288 - NTRK3_HUMAN

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Protein

NT-3 growth factor receptor

Gene

NTRK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei516 – 5161Interaction with SHC1By similarity
Binding sitei572 – 5721ATPPROSITE-ProRule annotation
Active sitei679 – 6791Proton acceptorPROSITE-ProRule annotation
Sitei834 – 8341Interaction with PLC-gamma-1By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi544 – 5529ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. neurotrophin binding Source: ProtInc
  3. neurotrophin receptor activity Source: BHF-UCL
  4. p53 binding Source: BHF-UCL
  5. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. activation of MAPK activity Source: BHF-UCL
  2. activation of protein kinase B activity Source: BHF-UCL
  3. activation of Ras GTPase activity Source: BHF-UCL
  4. cellular response to retinoic acid Source: Ensembl
  5. circadian rhythm Source: Ensembl
  6. cochlea development Source: Ensembl
  7. lens fiber cell differentiation Source: Ensembl
  8. mechanoreceptor differentiation Source: Ensembl
  9. modulation by virus of host transcription Source: Ensembl
  10. negative regulation of astrocyte differentiation Source: Ensembl
  11. negative regulation of cell death Source: Ensembl
  12. negative regulation of protein phosphorylation Source: BHF-UCL
  13. neuron fate specification Source: Ensembl
  14. neuron migration Source: Ensembl
  15. neurotrophin signaling pathway Source: GOC
  16. positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
  17. positive regulation of axon extension involved in regeneration Source: Ensembl
  18. positive regulation of cell migration Source: BHF-UCL
  19. positive regulation of cell proliferation Source: BHF-UCL
  20. positive regulation of gene expression Source: BHF-UCL
  21. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  22. positive regulation of positive chemotaxis Source: BHF-UCL
  23. protein autophosphorylation Source: Ensembl
  24. response to axon injury Source: Ensembl
  25. response to corticosterone Source: Ensembl
  26. response to ethanol Source: Ensembl
  27. transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 2681.
SignaLinkiQ16288.

Names & Taxonomyi

Protein namesi
Recommended name:
NT-3 growth factor receptor (EC:2.7.10.1)
Alternative name(s):
GP145-TrkC
Short name:
Trk-C
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase
Gene namesi
Name:NTRK3
Synonyms:TRKC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:8033. NTRK3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti2665. Congenital mesoblastic nephroma.
2030. Fibrosarcoma.
PharmGKBiPA31819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Add
BLAST
Chaini32 – 839808NT-3 growth factor receptorPRO_0000016731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi320 ↔ 3621 PublicationPROSITE-ProRule annotation
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
Modified residuei516 – 5161Phosphotyrosine; by autocatalysisBy similarity
Modified residuei705 – 7051Phosphotyrosine; by autocatalysisBy similarity
Modified residuei709 – 7091Phosphotyrosine; by autocatalysisBy similarity
Modified residuei710 – 7101Phosphotyrosine; by autocatalysisBy similarity

Post-translational modificationi

Ligand-mediated auto-phosphorylation.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ16288.
PaxDbiQ16288.
PRIDEiQ16288.

PTM databases

PhosphoSiteiQ16288.

Expressioni

Tissue specificityi

Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

Gene expression databases

BgeeiQ16288.
CleanExiHS_NTRK3.
ExpressionAtlasiQ16288. baseline and differential.
GenevestigatoriQ16288.

Organism-specific databases

HPAiCAB009233.

Interactioni

Subunit structurei

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity).By similarity

Protein-protein interaction databases

BioGridi110971. 10 interactions.
DIPiDIP-5723N.
IntActiQ16288. 4 interactions.
MINTiMINT-188514.
STRINGi9606.ENSP00000354207.

Structurei

Secondary structure

1
839
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi318 – 3269
Beta strandi332 – 3376
Beta strandi345 – 35410
Beta strandi356 – 36712
Helixi370 – 3723
Beta strandi374 – 3829
Beta strandi385 – 3939
Helixi535 – 5373
Beta strandi538 – 5436
Beta strandi552 – 5598
Beta strandi562 – 57312
Helixi579 – 59416
Beta strandi603 – 61210
Beta strandi614 – 6185
Helixi625 – 6317
Helixi653 – 67220
Helixi682 – 6843
Beta strandi685 – 6873
Helixi689 – 6913
Beta strandi693 – 6953
Helixi706 – 7083
Helixi734 – 7363
Helixi739 – 7446
Helixi749 – 76315
Turni764 – 7663
Turni770 – 7734
Helixi776 – 78510
Helixi797 – 80610
Helixi811 – 8133
Helixi817 – 82913

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WWCX-ray1.90A297-422[»]
3V5QX-ray2.20A/B530-832[»]
ProteinModelPortaliQ16288.
SMRiQ16288. Positions 28-401, 529-832.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16288.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 429398ExtracellularSequence AnalysisAdd
BLAST
Topological domaini454 – 839386CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei430 – 45324HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati104 – 12522LRR 1Add
BLAST
Repeati128 – 14922LRR 2Add
BLAST
Domaini160 – 20950LRRCTAdd
BLAST
Domaini210 – 30091Ig-like C2-type 1Add
BLAST
Domaini309 – 38274Ig-like C2-type 2Add
BLAST
Domaini538 – 839302Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 2 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000264255.
HOVERGENiHBG056735.
InParanoidiQ16288.
KOiK05101.
OMAiNFVSIYE.
OrthoDBiEOG7GTT32.
PhylomeDBiQ16288.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020446. Tyr_kin_neurotrophic_rcpt_3.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01942. NTKRECEPTOR3.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q16288-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD
60 70 80 90 100
GNLFPLLEGQ DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME
110 120 130 140 150
LYTGLQKLTI KNSGLRSIQP RAFAKNPHLR YINLSSNRLT TLSWQLFQTL
160 170 180 190 200
SLRELQLEQN FFNCSCDIRW MQLWQEQGEA KLNSQNLYCI NADGSQLPLF
210 220 230 240 250
RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD VDWIVTGLQS
260 270 280 290 300
INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT
310 320 330 340 350
VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV
360 370 380 390 400
EYYQEGEISE GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF
410 420 430 440 450
PESTDNFILF DEVSPTPPIT VTHKPEEDTF GVSIAVGLAA FACVLLVVLF
460 470 480 490 500
VMINKYGRRS KFGMKGPVAV ISGEEDSASP LHHINHGITT PSSLDAGPDT
510 520 530 540 550
VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL KRELGEGAFG
560 570 580 590 600
KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI
610 620 630 640 650
VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE
660 670 680 690 700
LGLSQMLHIA SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM
710 720 730 740 750
SRDVYSTDYY RLFNPSGNDF CIWCEVGGHT MLPIRWMPPE SIMYRKFTTE
760 770 780 790 800
SDVWSFGVIL WEIFTYGKQP WFQLSNTEVI ECITQGRVLE RPRVCPKEVY
810 820 830
DVMLGCWQRE PQQRLNIKEI YKILHALGKA TPIYLDILG
Length:839
Mass (Da):94,428
Last modified:March 6, 2007 - v2
Checksum:i7FE8846830083C08
GO
Isoform 2 (identifier: Q16288-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     529-612: YVQHIKRRDI...FYGVCGDGDP → WVFSNIDNHG...VYFSKGRHGF
     613-839: Missing.

Show »
Length:612
Mass (Da):68,452
Checksum:iF2E84DC71B8E4DB3
GO
Isoform 3 (identifier: Q16288-3) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     712-725: Missing.

Show »
Length:825
Mass (Da):92,801
Checksum:i7ADBE1AF6DB280BF
GO
Isoform 4 (identifier: Q16288-4) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     402-410: ESTDNFILF → V

Show »
Length:831
Mass (Da):93,460
Checksum:i4823FA200F88433F
GO
Isoform 5 (identifier: Q16288-5) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     402-410: ESTDNFILF → V
     712-725: Missing.

Note: No experimental confirmation.

Show »
Length:817
Mass (Da):91,833
Checksum:i674CC49828F86789
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651S → G in BAH12511. (PubMed:14702039)Curated
Sequence conflicti70 – 701S → N in AAB33111. (PubMed:7823156)Curated
Sequence conflicti70 – 701S → N in AAB33112. (PubMed:7823156)Curated
Sequence conflicti635 – 6351D → N in AAA75374. (PubMed:7806211)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491T → R in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041471
Natural varianti306 – 3061R → C.1 Publication
Corresponds to variant rs56386352 [ dbSNP | Ensembl ].
VAR_041472
Natural varianti307 – 3071V → L in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041473
Natural varianti336 – 3361L → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041474
Natural varianti664 – 6641A → S in a lung carcinoma sample; somatic mutation. 1 Publication
VAR_046521
Natural varianti677 – 6771H → Y in a lung adenocarcinoma sample; somatic mutation. 2 Publications
VAR_041475
Natural varianti678 – 6781R → Q.1 Publication
Corresponds to variant rs55890138 [ dbSNP | Ensembl ].
VAR_041476
Natural varianti735 – 7351R → F in a lung large cell carcinoma sample; somatic mutation; requires 2 nucleotide substitutions.
VAR_046770
Natural varianti736 – 7361W → C in a lung carcinoma sample; somatic mutation. 1 Publication
VAR_046522
Natural varianti745 – 7451R → P in a lung carcinoma sample; somatic mutation. 1 Publication
VAR_046523
Natural varianti766 – 7661Y → F in a lung carcinoma sample; somatic mutation. 1 Publication
VAR_046524
Natural varianti768 – 7681K → R.1 Publication
Corresponds to variant rs55770052 [ dbSNP | Ensembl ].
VAR_046771
Natural varianti781 – 7811E → K.1 Publication
Corresponds to variant rs56393451 [ dbSNP | Ensembl ].
VAR_046772

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei402 – 4109ESTDNFILF → V in isoform 4 and isoform 5. 1 PublicationVSP_002924
Alternative sequencei529 – 61284YVQHI…GDGDP → WVFSNIDNHGILNLKDNRDH LVPSTHYIYEEPEVQSGEVS YPRSHGFREIMLNPISLPGH SKPLNHGIYVEDVNVYFSKG RHGF in isoform 2. 1 PublicationVSP_002925Add
BLAST
Alternative sequencei613 – 839227Missing in isoform 2. 1 PublicationVSP_002926Add
BLAST
Alternative sequencei712 – 72514Missing in isoform 3 and isoform 5. 3 PublicationsVSP_002927Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05012 mRNA. Translation: AAA75374.1.
S76475 mRNA. Translation: AAB33111.1.
S76476 mRNA. Translation: AAB33112.1.
AJ224521
, AJ224522, AJ224523, AJ224524, AJ224525, AJ224526, AJ224527, AJ224528, AJ224529, AJ224530, AJ224531, AJ224532, AJ224533, AJ224534, AJ224535 Genomic DNA. Translation: CAA12029.1.
AK297160 mRNA. Translation: BAH12511.1.
AC009711 Genomic DNA. No translation available.
AC011966 Genomic DNA. No translation available.
AC021677 Genomic DNA. No translation available.
CCDSiCCDS10340.1. [Q16288-3]
CCDS32322.1. [Q16288-1]
CCDS32323.1. [Q16288-2]
CCDS58399.1. [Q16288-5]
PIRiA55178.
I73632.
I73633.
RefSeqiNP_001012338.1. NM_001012338.2. [Q16288-1]
NP_002521.2. NM_002530.3.
UniGeneiHs.410969.
Hs.706364.

Genome annotation databases

EnsembliENST00000317501; ENSP00000318328; ENSG00000140538. [Q16288-2]
ENST00000355254; ENSP00000347397; ENSG00000140538. [Q16288-5]
ENST00000357724; ENSP00000350356; ENSG00000140538. [Q16288-4]
ENST00000360948; ENSP00000354207; ENSG00000140538. [Q16288-1]
ENST00000394480; ENSP00000377990; ENSG00000140538. [Q16288-3]
ENST00000540489; ENSP00000444673; ENSG00000140538. [Q16288-2]
ENST00000557856; ENSP00000453959; ENSG00000140538. [Q16288-5]
GeneIDi4916.
KEGGihsa:4916.
UCSCiuc002bme.2. human. [Q16288-1]
uc002bmf.2. human. [Q16288-3]

Polymorphism databases

DMDMi134035335.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05012 mRNA. Translation: AAA75374.1 .
S76475 mRNA. Translation: AAB33111.1 .
S76476 mRNA. Translation: AAB33112.1 .
AJ224521
, AJ224522 , AJ224523 , AJ224524 , AJ224525 , AJ224526 , AJ224527 , AJ224528 , AJ224529 , AJ224530 , AJ224531 , AJ224532 , AJ224533 , AJ224534 , AJ224535 Genomic DNA. Translation: CAA12029.1 .
AK297160 mRNA. Translation: BAH12511.1 .
AC009711 Genomic DNA. No translation available.
AC011966 Genomic DNA. No translation available.
AC021677 Genomic DNA. No translation available.
CCDSi CCDS10340.1. [Q16288-3 ]
CCDS32322.1. [Q16288-1 ]
CCDS32323.1. [Q16288-2 ]
CCDS58399.1. [Q16288-5 ]
PIRi A55178.
I73632.
I73633.
RefSeqi NP_001012338.1. NM_001012338.2. [Q16288-1 ]
NP_002521.2. NM_002530.3.
UniGenei Hs.410969.
Hs.706364.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WWC X-ray 1.90 A 297-422 [» ]
3V5Q X-ray 2.20 A/B 530-832 [» ]
ProteinModelPortali Q16288.
SMRi Q16288. Positions 28-401, 529-832.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110971. 10 interactions.
DIPi DIP-5723N.
IntActi Q16288. 4 interactions.
MINTi MINT-188514.
STRINGi 9606.ENSP00000354207.

Chemistry

BindingDBi Q16288.
ChEMBLi CHEMBL5608.
GuidetoPHARMACOLOGYi 1819.

PTM databases

PhosphoSitei Q16288.

Polymorphism databases

DMDMi 134035335.

Proteomic databases

MaxQBi Q16288.
PaxDbi Q16288.
PRIDEi Q16288.

Protocols and materials databases

DNASUi 4916.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317501 ; ENSP00000318328 ; ENSG00000140538 . [Q16288-2 ]
ENST00000355254 ; ENSP00000347397 ; ENSG00000140538 . [Q16288-5 ]
ENST00000357724 ; ENSP00000350356 ; ENSG00000140538 . [Q16288-4 ]
ENST00000360948 ; ENSP00000354207 ; ENSG00000140538 . [Q16288-1 ]
ENST00000394480 ; ENSP00000377990 ; ENSG00000140538 . [Q16288-3 ]
ENST00000540489 ; ENSP00000444673 ; ENSG00000140538 . [Q16288-2 ]
ENST00000557856 ; ENSP00000453959 ; ENSG00000140538 . [Q16288-5 ]
GeneIDi 4916.
KEGGi hsa:4916.
UCSCi uc002bme.2. human. [Q16288-1 ]
uc002bmf.2. human. [Q16288-3 ]

Organism-specific databases

CTDi 4916.
GeneCardsi GC15M088418.
HGNCi HGNC:8033. NTRK3.
HPAi CAB009233.
MIMi 191316. gene.
neXtProti NX_Q16288.
Orphaneti 2665. Congenital mesoblastic nephroma.
2030. Fibrosarcoma.
PharmGKBi PA31819.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118818.
HOGENOMi HOG000264255.
HOVERGENi HBG056735.
InParanoidi Q16288.
KOi K05101.
OMAi NFVSIYE.
OrthoDBi EOG7GTT32.
PhylomeDBi Q16288.
TreeFami TF106465.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 2681.
SignaLinki Q16288.

Miscellaneous databases

ChiTaRSi NTRK3. human.
EvolutionaryTracei Q16288.
GeneWikii TrkC_receptor.
GenomeRNAii 4916.
NextBioi 18927.
PROi Q16288.
SOURCEi Search...

Gene expression databases

Bgeei Q16288.
CleanExi HS_NTRK3.
ExpressionAtlasi Q16288. baseline and differential.
Genevestigatori Q16288.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020446. Tyr_kin_neurotrophic_rcpt_3.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view ]
Pfami PF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR01939. NTKRECEPTOR.
PR01942. NTKRECEPTOR3.
PR00109. TYRKINASE.
SMARTi SM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant."
    McGregor L.M., Baylin S.B., Griffin C.A., Hawkins A.L., Nelkin B.D.
    Genomics 22:267-272(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Tissue: Fetal brain.
  2. "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins."
    Shelton D.L., Sutherland J., Gripp J., Camerato T., Armanini M.P., Phillips H.S., Carroll K., Spencer S.D., Levinson A.D.
    J. Neurosci. 15:477-491(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), PARTIAL PROTEIN SEQUENCE.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC."
    Ultsch M.H., Wiesmann C., Simmons L.C., Henrich J., Yang M., Reilly D., Bass S.H., de Vos A.M.
    J. Mol. Biol. 290:149-159(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 297-401, DISULFIDE BOND.
  7. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-149; CYS-306; LEU-307; GLN-336; TYR-677; GLN-678; ARG-768 AND LYS-781.
  8. "Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung."
    Marchetti A., Felicioni L., Pelosi G., Del Grammastro M., Fumagalli C., Sciarrotta M., Malatesta S., Chella A., Barassi F., Mucilli F., Camplese P., D'Antuono T., Sacco R., Buttitta F.
    Hum. Mutat. 29:609-616(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SER-664; TYR-677; CYS-736; PRO-745 AND PHE-766.

Entry informationi

Entry nameiNTRK3_HUMAN
AccessioniPrimary (citable) accession number: Q16288
Secondary accession number(s): B7Z4C5
, E9PG56, H0YND1, O75682, Q12827, Q16289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3