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Protein

NT-3 growth factor receptor

Gene

NTRK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei572ATPPROSITE-ProRule annotation1
Active sitei679Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi544 – 552ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • GPI-linked ephrin receptor activity Source: Ensembl
  • neurotrophin binding Source: ProtInc
  • neurotrophin receptor activity Source: BHF-UCL
  • p53 binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS06735-MONOMER.
BRENDAi2.7.10.1. 2681.
SignaLinkiQ16288.
SIGNORiQ16288.

Names & Taxonomyi

Protein namesi
Recommended name:
NT-3 growth factor receptor (EC:2.7.10.1)
Alternative name(s):
GP145-TrkC
Short name:
Trk-C
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase
Gene namesi
Name:NTRK3
Synonyms:TRKC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:8033. NTRK3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 429ExtracellularSequence analysisAdd BLAST398
Transmembranei430 – 453HelicalSequence analysisAdd BLAST24
Topological domaini454 – 839CytoplasmicSequence analysisAdd BLAST386

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi572K → N: Loss of autophosphorylation and loss of NTRK3 signaling. 1 Publication1

Organism-specific databases

DisGeNETi4916.
MalaCardsiNTRK3.
OpenTargetsiENSG00000140538.
Orphaneti2665. Congenital mesoblastic nephroma.
2030. Fibrosarcoma.
PharmGKBiPA31819.

Chemistry databases

ChEMBLiCHEMBL5608.
GuidetoPHARMACOLOGYi1819.

Polymorphism and mutation databases

BioMutaiNTRK3.
DMDMi134035335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Add BLAST31
ChainiPRO_000001673132 – 839NT-3 growth factor receptorAdd BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Glycosylationi133N-linked (GlcNAc...)Sequence analysis1
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Glycosylationi294N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi320 ↔ 362PROSITE-ProRule annotation1 Publication
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1
Modified residuei493PhosphoserineBy similarity1
Modified residuei516Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei705Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei709Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei710Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Ligand-mediated auto-phosphorylation.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ16288.
PeptideAtlasiQ16288.
PRIDEiQ16288.

PTM databases

iPTMnetiQ16288.
PhosphoSitePlusiQ16288.

Expressioni

Tissue specificityi

Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

Gene expression databases

BgeeiENSG00000140538.
CleanExiHS_NTRK3.
ExpressionAtlasiQ16288. baseline and differential.
GenevisibleiQ16288. HS.

Organism-specific databases

HPAiCAB009233.
HPA027484.
HPA048065.

Interactioni

Subunit structurei

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei516Interaction with SHC1By similarity1
Sitei834Interaction with PLC-gamma-1By similarity1

Binary interactionsi

WithEntry#Exp.IntActNotes
SORT1Q995232EBI-3936704,EBI-1057058

GO - Molecular functioni

  • neurotrophin binding Source: ProtInc
  • p53 binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi110971. 39 interactors.
DIPiDIP-5723N.
IntActiQ16288. 5 interactors.
MINTiMINT-188514.
STRINGi9606.ENSP00000354207.

Chemistry databases

BindingDBiQ16288.

Structurei

Secondary structure

1839
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi318 – 326Combined sources9
Beta strandi332 – 337Combined sources6
Beta strandi345 – 354Combined sources10
Beta strandi356 – 367Combined sources12
Helixi370 – 372Combined sources3
Beta strandi374 – 382Combined sources9
Beta strandi385 – 393Combined sources9
Helixi535 – 537Combined sources3
Beta strandi538 – 546Combined sources9
Beta strandi548 – 559Combined sources12
Beta strandi562 – 576Combined sources15
Helixi579 – 594Combined sources16
Beta strandi603 – 607Combined sources5
Beta strandi610 – 612Combined sources3
Beta strandi614 – 618Combined sources5
Helixi625 – 631Combined sources7
Helixi653 – 672Combined sources20
Helixi682 – 684Combined sources3
Beta strandi685 – 687Combined sources3
Helixi689 – 691Combined sources3
Beta strandi693 – 695Combined sources3
Helixi706 – 708Combined sources3
Helixi734 – 736Combined sources3
Helixi739 – 744Combined sources6
Helixi749 – 764Combined sources16
Turni770 – 773Combined sources4
Helixi776 – 784Combined sources9
Helixi797 – 806Combined sources10
Helixi811 – 813Combined sources3
Helixi817 – 830Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WWCX-ray1.90A297-422[»]
3V5QX-ray2.20A/B530-832[»]
4YMJX-ray2.00A/B530-839[»]
ProteinModelPortaliQ16288.
SMRiQ16288.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 125LRR 1Add BLAST22
Repeati128 – 149LRR 2Add BLAST22
Domaini160 – 209LRRCTAdd BLAST50
Domaini210 – 300Ig-like C2-type 1Add BLAST91
Domaini309 – 382Ig-like C2-type 2Add BLAST74
Domaini538 – 839Protein kinasePROSITE-ProRule annotationAdd BLAST302

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 2 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000264255.
HOVERGENiHBG056735.
InParanoidiQ16288.
KOiK05101.
PhylomeDBiQ16288.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR000372. LRRNT.
IPR031635. NTRK_C2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020446. Tyr_kin_neurotrophic_rcpt_3.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF16920. TPKR_C2. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01942. NTKRECEPTOR3.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q16288-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD
60 70 80 90 100
GNLFPLLEGQ DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME
110 120 130 140 150
LYTGLQKLTI KNSGLRSIQP RAFAKNPHLR YINLSSNRLT TLSWQLFQTL
160 170 180 190 200
SLRELQLEQN FFNCSCDIRW MQLWQEQGEA KLNSQNLYCI NADGSQLPLF
210 220 230 240 250
RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD VDWIVTGLQS
260 270 280 290 300
INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT
310 320 330 340 350
VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV
360 370 380 390 400
EYYQEGEISE GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF
410 420 430 440 450
PESTDNFILF DEVSPTPPIT VTHKPEEDTF GVSIAVGLAA FACVLLVVLF
460 470 480 490 500
VMINKYGRRS KFGMKGPVAV ISGEEDSASP LHHINHGITT PSSLDAGPDT
510 520 530 540 550
VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL KRELGEGAFG
560 570 580 590 600
KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI
610 620 630 640 650
VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE
660 670 680 690 700
LGLSQMLHIA SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM
710 720 730 740 750
SRDVYSTDYY RLFNPSGNDF CIWCEVGGHT MLPIRWMPPE SIMYRKFTTE
760 770 780 790 800
SDVWSFGVIL WEIFTYGKQP WFQLSNTEVI ECITQGRVLE RPRVCPKEVY
810 820 830
DVMLGCWQRE PQQRLNIKEI YKILHALGKA TPIYLDILG
Length:839
Mass (Da):94,428
Last modified:March 6, 2007 - v2
Checksum:i7FE8846830083C08
GO
Isoform 2 (identifier: Q16288-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     529-612: YVQHIKRRDI...FYGVCGDGDP → WVFSNIDNHG...VYFSKGRHGF
     613-839: Missing.

Show »
Length:612
Mass (Da):68,452
Checksum:iF2E84DC71B8E4DB3
GO
Isoform 3 (identifier: Q16288-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     712-725: Missing.

Show »
Length:825
Mass (Da):92,801
Checksum:i7ADBE1AF6DB280BF
GO
Isoform 4 (identifier: Q16288-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     402-410: ESTDNFILF → V

Show »
Length:831
Mass (Da):93,460
Checksum:i4823FA200F88433F
GO
Isoform 5 (identifier: Q16288-5) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     402-410: ESTDNFILF → V
     712-725: Missing.

Note: No experimental confirmation.
Show »
Length:817
Mass (Da):91,833
Checksum:i674CC49828F86789
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65S → G in BAH12511 (PubMed:14702039).Curated1
Sequence conflicti70S → N in AAB33111 (PubMed:7823156).Curated1
Sequence conflicti70S → N in AAB33112 (PubMed:7823156).Curated1
Sequence conflicti635D → N in AAA75374 (PubMed:7806211).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07460121V → F Rare polymorphism. 1 PublicationCorresponds to variant rs200822610dbSNPEnsembl.1
Natural variantiVAR_07460271I → V Found in patients with CHD; unknown pathological significance. 1 PublicationCorresponds to variant rs200923715dbSNPEnsembl.1
Natural variantiVAR_07460393T → M Probable disease-associated mutation found in patients with CHD; associated with CHD susceptibility; significantly reduced autophosphorylation; decreased NTRK3 signaling associated with decreased apoptosis in absence of NTF3. 1 PublicationCorresponds to variant rs147992979dbSNPEnsembl.1
Natural variantiVAR_041471149T → R in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs368222977dbSNPEnsembl.1
Natural variantiVAR_074604163N → I Found in patients with CHD; unknown pathological significance; no change in autophosphorylation; no effect on NTRK3 signaling. 1 PublicationCorresponds to variant rs547862658dbSNPEnsembl.1
Natural variantiVAR_041472306R → C.1 PublicationCorresponds to variant rs56386352dbSNPEnsembl.1
Natural variantiVAR_041473307V → L in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041474336L → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_074605533I → F Probable disease-associated mutation found in patients with CHD; associated with CHD susceptibility; no change in autophosphorylation; changed NTRK3 signaling with decreased apoptosis in absence of NTF3. 1 Publication1
Natural variantiVAR_046521664A → S in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041475677H → Y in a lung adenocarcinoma sample; somatic mutation. 2 Publications1
Natural variantiVAR_041476678R → Q.1 PublicationCorresponds to variant rs55890138dbSNPEnsembl.1
Natural variantiVAR_046770735R → F in a lung large cell carcinoma sample; somatic mutation; requires 2 nucleotide substitutions. 1
Natural variantiVAR_046522736W → C in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046523745R → P in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046524766Y → F in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046771768K → R.1 PublicationCorresponds to variant rs55770052dbSNPEnsembl.1
Natural variantiVAR_046772781E → K.1 PublicationCorresponds to variant rs56393451dbSNPEnsembl.1
Natural variantiVAR_074606817I → M Probable disease-associated mutation found in patients with CHD; associated with CHD susceptibility; no change in autophosphorylation; changed NTRK3 signaling with decreased apoptosis in absence of NTF3. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002924402 – 410ESTDNFILF → V in isoform 4 and isoform 5. 1 Publication9
Alternative sequenceiVSP_002925529 – 612YVQHI…GDGDP → WVFSNIDNHGILNLKDNRDH LVPSTHYIYEEPEVQSGEVS YPRSHGFREIMLNPISLPGH SKPLNHGIYVEDVNVYFSKG RHGF in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_002926613 – 839Missing in isoform 2. 1 PublicationAdd BLAST227
Alternative sequenceiVSP_002927712 – 725Missing in isoform 3 and isoform 5. 3 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05012 mRNA. Translation: AAA75374.1.
S76475 mRNA. Translation: AAB33111.1.
S76476 mRNA. Translation: AAB33112.1.
AJ224521
, AJ224522, AJ224523, AJ224524, AJ224525, AJ224526, AJ224527, AJ224528, AJ224529, AJ224530, AJ224531, AJ224532, AJ224533, AJ224534, AJ224535 Genomic DNA. Translation: CAA12029.1.
AK297160 mRNA. Translation: BAH12511.1.
AC009711 Genomic DNA. No translation available.
AC011966 Genomic DNA. No translation available.
AC021677 Genomic DNA. No translation available.
CCDSiCCDS10340.1. [Q16288-3]
CCDS32322.1. [Q16288-1]
CCDS32323.1. [Q16288-2]
CCDS58399.1. [Q16288-5]
PIRiA55178.
I73632.
I73633.
RefSeqiNP_001012338.1. NM_001012338.2. [Q16288-1]
NP_001307063.1. NM_001320134.1.
NP_001307064.1. NM_001320135.1.
NP_002521.2. NM_002530.3.
XP_016877742.1. XM_017022253.1. [Q16288-1]
UniGeneiHs.185701.
Hs.410969.
Hs.706364.

Genome annotation databases

EnsembliENST00000317501; ENSP00000318328; ENSG00000140538. [Q16288-2]
ENST00000355254; ENSP00000347397; ENSG00000140538. [Q16288-5]
ENST00000357724; ENSP00000350356; ENSG00000140538. [Q16288-4]
ENST00000360948; ENSP00000354207; ENSG00000140538. [Q16288-1]
ENST00000394480; ENSP00000377990; ENSG00000140538. [Q16288-3]
ENST00000540489; ENSP00000444673; ENSG00000140538. [Q16288-2]
ENST00000557856; ENSP00000453959; ENSG00000140538. [Q16288-5]
ENST00000629765; ENSP00000485864; ENSG00000140538. [Q16288-1]
GeneIDi4916.
KEGGihsa:4916.
UCSCiuc059mwc.1. human. [Q16288-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05012 mRNA. Translation: AAA75374.1.
S76475 mRNA. Translation: AAB33111.1.
S76476 mRNA. Translation: AAB33112.1.
AJ224521
, AJ224522, AJ224523, AJ224524, AJ224525, AJ224526, AJ224527, AJ224528, AJ224529, AJ224530, AJ224531, AJ224532, AJ224533, AJ224534, AJ224535 Genomic DNA. Translation: CAA12029.1.
AK297160 mRNA. Translation: BAH12511.1.
AC009711 Genomic DNA. No translation available.
AC011966 Genomic DNA. No translation available.
AC021677 Genomic DNA. No translation available.
CCDSiCCDS10340.1. [Q16288-3]
CCDS32322.1. [Q16288-1]
CCDS32323.1. [Q16288-2]
CCDS58399.1. [Q16288-5]
PIRiA55178.
I73632.
I73633.
RefSeqiNP_001012338.1. NM_001012338.2. [Q16288-1]
NP_001307063.1. NM_001320134.1.
NP_001307064.1. NM_001320135.1.
NP_002521.2. NM_002530.3.
XP_016877742.1. XM_017022253.1. [Q16288-1]
UniGeneiHs.185701.
Hs.410969.
Hs.706364.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WWCX-ray1.90A297-422[»]
3V5QX-ray2.20A/B530-832[»]
4YMJX-ray2.00A/B530-839[»]
ProteinModelPortaliQ16288.
SMRiQ16288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110971. 39 interactors.
DIPiDIP-5723N.
IntActiQ16288. 5 interactors.
MINTiMINT-188514.
STRINGi9606.ENSP00000354207.

Chemistry databases

BindingDBiQ16288.
ChEMBLiCHEMBL5608.
GuidetoPHARMACOLOGYi1819.

PTM databases

iPTMnetiQ16288.
PhosphoSitePlusiQ16288.

Polymorphism and mutation databases

BioMutaiNTRK3.
DMDMi134035335.

Proteomic databases

PaxDbiQ16288.
PeptideAtlasiQ16288.
PRIDEiQ16288.

Protocols and materials databases

DNASUi4916.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317501; ENSP00000318328; ENSG00000140538. [Q16288-2]
ENST00000355254; ENSP00000347397; ENSG00000140538. [Q16288-5]
ENST00000357724; ENSP00000350356; ENSG00000140538. [Q16288-4]
ENST00000360948; ENSP00000354207; ENSG00000140538. [Q16288-1]
ENST00000394480; ENSP00000377990; ENSG00000140538. [Q16288-3]
ENST00000540489; ENSP00000444673; ENSG00000140538. [Q16288-2]
ENST00000557856; ENSP00000453959; ENSG00000140538. [Q16288-5]
ENST00000629765; ENSP00000485864; ENSG00000140538. [Q16288-1]
GeneIDi4916.
KEGGihsa:4916.
UCSCiuc059mwc.1. human. [Q16288-1]

Organism-specific databases

CTDi4916.
DisGeNETi4916.
GeneCardsiNTRK3.
HGNCiHGNC:8033. NTRK3.
HPAiCAB009233.
HPA027484.
HPA048065.
MalaCardsiNTRK3.
MIMi191316. gene.
neXtProtiNX_Q16288.
OpenTargetsiENSG00000140538.
Orphaneti2665. Congenital mesoblastic nephroma.
2030. Fibrosarcoma.
PharmGKBiPA31819.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000264255.
HOVERGENiHBG056735.
InParanoidiQ16288.
KOiK05101.
PhylomeDBiQ16288.
TreeFamiTF106465.

Enzyme and pathway databases

BioCyciZFISH:HS06735-MONOMER.
BRENDAi2.7.10.1. 2681.
SignaLinkiQ16288.
SIGNORiQ16288.

Miscellaneous databases

ChiTaRSiNTRK3. human.
EvolutionaryTraceiQ16288.
GeneWikiiTrkC_receptor.
GenomeRNAii4916.
PROiQ16288.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140538.
CleanExiHS_NTRK3.
ExpressionAtlasiQ16288. baseline and differential.
GenevisibleiQ16288. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR000372. LRRNT.
IPR031635. NTRK_C2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020446. Tyr_kin_neurotrophic_rcpt_3.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF16920. TPKR_C2. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01942. NTKRECEPTOR3.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTRK3_HUMAN
AccessioniPrimary (citable) accession number: Q16288
Secondary accession number(s): B7Z4C5
, E9PG56, H0YND1, O75682, Q12827, Q16289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: November 2, 2016
This is version 189 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.