Q16288 (NTRK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NT-3 growth factor receptor
EC=2.7.10.1

Alternative name(s):
GP145-TrkC
Short name=Trk-C
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase

Gene names

Name:	NTRK3
Synonyms:	TRKC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	839 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
Post-translational modification	Ligand-mediated auto-phosphorylation.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPK activity Inferred from direct assay PubMed 23027130. Source: BHF-UCL activation of Ras GTPase activity Inferred from direct assay PubMed 23027130. Source: BHF-UCL activation of protein kinase B activity Inferred from direct assay PubMed 23027130. Source: BHF-UCL cellular response to retinoic acid Inferred from electronic annotation. Source: Compara cochlea development Inferred from electronic annotation. Source: Compara mechanoreceptor differentiation Inferred from electronic annotation. Source: Compara modulation by virus of host transcription Inferred from electronic annotation. Source: Compara negative regulation of astrocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of cell death Inferred from electronic annotation. Source: Compara negative regulation of protein phosphorylation Inferred from direct assay PubMed 23027130. Source: BHF-UCL neuron fate specification Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara positive regulation of actin cytoskeleton reorganization Inferred from direct assay PubMed 23027130. Source: BHF-UCL positive regulation of axon extension involved in regeneration Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from direct assay PubMed 23027130. Source: BHF-UCL positive regulation of cell proliferation Inferred from direct assay PubMed 23027130. Source: BHF-UCL positive regulation of gene expression Inferred from direct assay PubMed 23027130. Source: BHF-UCL positive regulation of peptidyl-serine phosphorylation Inferred from direct assay PubMed 23027130. Source: BHF-UCL positive regulation of positive chemotaxis Inferred from direct assay PubMed 23027130. Source: BHF-UCL protein autophosphorylation Inferred from electronic annotation. Source: Compara response to axon injury Inferred from electronic annotation. Source: Compara response to corticosterone stimulus Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara transmembrane receptor protein tyrosine kinase signaling pathway Inferred from direct assay PubMed 23027130. Source: BHF-UCL
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW neurotrophin binding Traceable author statement Ref.1. Source: ProtInc neurotrophin receptor activity Inferred from direct assay PubMed 23027130. Source: BHF-UCL transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform A (identifier: Q16288-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q16288-2)

The sequence of this isoform differs from the canonical sequence as follows:
     529-612: YVQHIKRRDI...FYGVCGDGDP → WVFSNIDNHG...VYFSKGRHGF
     613-839: Missing.

Isoform C (identifier: Q16288-3)

The sequence of this isoform differs from the canonical sequence as follows:
     712-725: Missing.

Isoform D (identifier: Q16288-4)

The sequence of this isoform differs from the canonical sequence as follows:
     402-410: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 31

31

Chain

32 – 839

808

NT-3 growth factor receptor

PRO_0000016731

Regions

Topological domain

32 – 429

398

Extracellular Potential

Transmembrane

430 – 453

24

Helical; Potential

Topological domain

454 – 839

386

Cytoplasmic Potential

Repeat

104 – 125

22

LRR 1

Repeat

128 – 149

22

LRR 2

Domain

160 – 209

50

LRRCT

Domain

210 – 300

91

Ig-like C2-type 1

Domain

309 – 382

74

Ig-like C2-type 2

Domain

538 – 839

302

Protein kinase

Nucleotide binding

544 – 552

9

ATP By similarity

Sites

Active site

679

1

Proton acceptor By similarity

Binding site

572

1

ATP By similarity

Site

516

1

Interaction with SHC1 By similarity

Site

834

1

Interaction with PLC-gamma-1 By similarity

Amino acid modifications

Modified residue

516

1

Phosphotyrosine; by autocatalysis By similarity

Modified residue

705

1

Phosphotyrosine; by autocatalysis By similarity

Modified residue

709

1

Phosphotyrosine; by autocatalysis By similarity

Modified residue

710

1

Phosphotyrosine; by autocatalysis By similarity

Glycosylation

72

1

N-linked (GlcNAc...) Potential

Glycosylation

79

1

N-linked (GlcNAc...) Potential

Glycosylation

133

1

N-linked (GlcNAc...) Potential

Glycosylation

163

1

N-linked (GlcNAc...) Potential

Glycosylation

203

1

N-linked (GlcNAc...) Potential

Glycosylation

218

1

N-linked (GlcNAc...) Potential

Glycosylation

232

1

N-linked (GlcNAc...) Potential

Glycosylation

259

1

N-linked (GlcNAc...) Potential

Glycosylation

267

1

N-linked (GlcNAc...) Potential

Glycosylation

272

1

N-linked (GlcNAc...) Potential

Glycosylation

294

1

N-linked (GlcNAc...) Potential

Glycosylation

375

1

N-linked (GlcNAc...) Potential

Glycosylation

388

1

N-linked (GlcNAc...) Potential

Disulfide bond

320 ↔ 362

Ref.4

Natural variations

Alternative sequence

402 – 410

9

Missing in isoform D.

VSP_002924

Alternative sequence

529 – 612

84

YVQHI…GDGDP → WVFSNIDNHGILNLKDNRDH LVPSTHYIYEEPEVQSGEVS YPRSHGFREIMLNPISLPGH SKPLNHGIYVEDVNVYFSKG RHGF in isoform B.

VSP_002925

Alternative sequence

613 – 839

227

Missing in isoform B.

VSP_002926

Alternative sequence

712 – 725

14

Missing in isoform C.

VSP_002927

Natural variant

149

1

T → R in a gastric adenocarcinoma sample; somatic mutation. Ref.5

VAR_041471

Natural variant

306

1

R → C. Ref.5
Corresponds to variant rs56386352 [ dbSNP | Ensembl ].

VAR_041472

Natural variant

307

1

V → L in a lung adenocarcinoma sample; somatic mutation. Ref.5

VAR_041473

Natural variant

336

1

L → Q in a lung adenocarcinoma sample; somatic mutation. Ref.5

VAR_041474

Natural variant

664

1

A → S in a lung carcinoma sample; somatic mutation. Ref.6

VAR_046521

Natural variant

677

1

H → Y in a lung adenocarcinoma sample; somatic mutation. Ref.5 Ref.6

VAR_041475

Natural variant

678

1

R → Q. Ref.5
Corresponds to variant rs55890138 [ dbSNP | Ensembl ].

VAR_041476

Natural variant

735

1

R → F in a lung large cell carcinoma sample; somatic mutation; requires 2 nucleotide substitutions.

VAR_046770

Natural variant

736

1

W → C in a lung carcinoma sample; somatic mutation. Ref.6

VAR_046522

Natural variant

745

1

R → P in a lung carcinoma sample; somatic mutation. Ref.6

VAR_046523

Natural variant

766

1

Y → F in a lung carcinoma sample; somatic mutation. Ref.6

VAR_046524

Natural variant

768

1

K → R. Ref.5
Corresponds to variant rs55770052 [ dbSNP | Ensembl ].

VAR_046771

Natural variant

781

1

E → K. Ref.5
Corresponds to variant rs56393451 [ dbSNP | Ensembl ].

VAR_046772

Experimental info

Sequence conflict

70

1

S → N in AAB33111. Ref.2

Sequence conflict

70

1

S → N in AAB33112. Ref.2

Sequence conflict

635

1

D → N in AAA75374. Ref.1

Secondary structure

1

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839

Helix Strand Turn

Details...

Beta strand

318 – 326

9

Beta strand

332 – 337

6

Beta strand

345 – 354

10

Beta strand

356 – 367

12

Helix

370 – 372

3

Beta strand

374 – 382

9

Beta strand

385 – 393

9

Helix

535 – 537

3

Beta strand

538 – 543

6

Beta strand

552 – 559

8

Beta strand

562 – 573

12

Helix

579 – 594

16

Beta strand

603 – 612

10

Beta strand

614 – 618

5

Helix

625 – 631

7

Helix

653 – 672

20

Helix

682 – 684

3

Beta strand

685 – 687

3

Helix

689 – 691

3

Beta strand

693 – 695

3

Helix

706 – 708

3

Helix

734 – 736

3

Helix

739 – 744

6

Helix

749 – 763

15

Turn

764 – 766

3

Turn

770 – 773

4

Helix

776 – 785

10

Helix

797 – 806

10

Helix

811 – 813

3

Helix

817 – 829

13

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified March 6, 2007. Version 2. Checksum: 7FE8846830083C08	FASTA	839	94,428
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILF DEVSPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF VMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 550 560 570 580 590 600 KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 610 620 630 640 650 660 VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 670 680 690 700 710 720 SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY RLFNPSGNDF 730 740 750 760 770 780 CIWCEVGGHT MLPIRWMPPE SIMYRKFTTE SDVWSFGVIL WEIFTYGKQP WFQLSNTEVI 790 800 810 820 830 ECITQGRVLE RPRVCPKEVY DVMLGCWQRE PQQRLNIKEI YKILHALGKA TPIYLDILG
	Isoform B [UniParc]. Checksum: F2E84DC71B8E4DB3	FASTA	612	68,452
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILF DEVSPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF VMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTWV FSNIDNHGIL 550 560 570 580 590 600 NLKDNRDHLV PSTHYIYEEP EVQSGEVSYP RSHGFREIML NPISLPGHSK PLNHGIYVED 610 VNVYFSKGRH GF
	Isoform C [UniParc]. Checksum: 7ADBE1AF6DB280BF	FASTA	825	92,801
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILF DEVSPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF VMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 550 560 570 580 590 600 KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 610 620 630 640 650 660 VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 670 680 690 700 710 720 SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY RVGGHTMLPI 730 740 750 760 770 780 RWMPPESIMY RKFTTESDVW SFGVILWEIF TYGKQPWFQL SNTEVIECIT QGRVLERPRV 790 800 810 820 CPKEVYDVML GCWQREPQQR LNIKEIYKIL HALGKATPIY LDILG
	Isoform D [UniParc]. Checksum: 4409D52CA249C0FE	FASTA	830	93,361
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PDEVSPTPPI TVTHKPEEDT 430 440 450 460 470 480 FGVSIAVGLA AFACVLLVVL FVMINKYGRR SKFGMKGPVA VISGEEDSAS PLHHINHGIT 490 500 510 520 530 540 TPSSLDAGPD TVVIGMTRIP VIENPQYFRQ GHNCHKPDTY VQHIKRRDIV LKRELGEGAF 550 560 570 580 590 600 GKVFLAECYN LSPTKDKMLV AVKALKDPTL AARKDFQREA ELLTNLQHEH IVKFYGVCGD 610 620 630 640 650 660 GDPLIMVFEY MKHGDLNKFL RAHGPDAMIL VDGQPRQAKG ELGLSQMLHI ASQIASGMVY 670 680 690 700 710 720 LASQHFVHRD LATRNCLVGA NLLVKIGDFG MSRDVYSTDY YRLFNPSGND FCIWCEVGGH 730 740 750 760 770 780 TMLPIRWMPP ESIMYRKFTT ESDVWSFGVI LWEIFTYGKQ PWFQLSNTEV IECITQGRVL 790 800 810 820 830 ERPRVCPKEV YDVMLGCWQR EPQQRLNIKE IYKILHALGK ATPIYLDILG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant." McGregor L.M., Baylin S.B., Griffin C.A., Hawkins A.L., Nelkin B.D. Genomics 22:267-272(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND C). Tissue: Fetal brain.
[2]	"Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins." Shelton D.L., Sutherland J., Gripp J., Camerato T., Armanini M.P., Phillips H.S., Carroll K., Spencer S.D., Levinson A.D. J. Neurosci. 15:477-491(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D), PARTIAL PROTEIN SEQUENCE. Tissue: Brain.
[3]	"Genomic characterization of the human trkC gene." Ichaso N., Rodriguez R.E., Martin-Zanca D., Gonzalez-Sarmiento R. Oncogene 17:1871-1875(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC." Ultsch M.H., Wiesmann C., Simmons L.C., Henrich J., Yang M., Reilly D., Bass S.H., de Vos A.M. J. Mol. Biol. 290:149-159(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 297-401, DISULFIDE BOND.
[5]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-149; CYS-306; LEU-307; GLN-336; TYR-677; GLN-678; ARG-768 AND LYS-781.
[6]	"Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung." Marchetti A., Felicioni L., Pelosi G., Del Grammastro M., Fumagalli C., Sciarrotta M., Malatesta S., Chella A., Barassi F., Mucilli F., Camplese P., D'Antuono T., Sacco R., Buttitta F. Hum. Mutat. 29:609-616(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS SER-664; TYR-677; CYS-736; PRO-745 AND PHE-766.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U05012 mRNA. Translation: AAA75374.1.
S76475 mRNA. Translation: AAB33111.1.
S76476 mRNA. Translation: AAB33112.1.
AJ224521 , AJ224522, AJ224523, AJ224524, AJ224525, AJ224526, AJ224527, AJ224528, AJ224529, AJ224530, AJ224531, AJ224532, AJ224533, AJ224534, AJ224535 Genomic DNA. Translation: CAA12029.1.

IPI

IPI00000824.
IPI00185466.
IPI00289961.
IPI00376986.

PIR

A55178.
I73632.
I73633.

RefSeq

NP_001012338.1. NM_001012338.2.
NP_002521.2. NM_002530.3.

UniGene

Hs.410969.
Hs.706364.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WWC	X-ray	1.90	A	297-422	[»]
3V5Q	X-ray	2.20	A/B	530-832	[»]

ProteinModelPortal

Q16288.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5723N.

IntAct

Q16288. 2 interactions.

MINT

MINT-188514.

STRING

9606.ENSP00000354207.

PTM databases

PhosphoSite

Q16288.

Polymorphism databases

DMDM

134035335.

Proteomic databases

PaxDb

Q16288.

PRIDE

Q16288.

Protocols and materials databases

DNASU

4916.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000317501; ENSP00000318328; ENSG00000140538.
ENST00000355254; ENSP00000347397; ENSG00000140538.
ENST00000360948; ENSP00000354207; ENSG00000140538.
ENST00000394480; ENSP00000377990; ENSG00000140538.
ENST00000540489; ENSP00000444673; ENSG00000140538.

GeneID

4916.

KEGG

hsa:4916.

UCSC

uc002bme.2. human.
uc002bmf.2. human.

Organism-specific databases

CTD

4916.

GeneCards

GC15M088402.

HGNC

HGNC:8033. NTRK3.

HPA

CAB009233.

MIM

191316. gene.

neXtProt

NX_Q16288.

Orphanet

2030. Fibrosarcoma.

PharmGKB

PA31819.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0515.

HOGENOM

HOG000264255.

HOVERGEN

HBG056735.

InParanoid

Q16288.

KO

K05101.

OMA

NFVSIYE.

PhylomeDB

Q16288.

Enzyme and pathway databases

BRENDA

2.7.10.1. 2681.

Pathway_Interaction_DB

trkrpathway. Neurotrophic factor-mediated Trk receptor signaling.

Gene expression databases

ArrayExpress

Q16288.

Bgee

Q16288.

CleanEx

HS_NTRK3.

Genevestigator

Q16288.

GermOnline

ENSG00000140538. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020446. Tyr_kin_neurotrophic_rcpt_3.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]

Pfam

PF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF01462. LRRNT. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]

PRINTS

PR01939. NTKRECEPTOR.
PR01942. NTKRECEPTOR3.
PR00109. TYRKINASE.

SMART

SM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]

SUPFAM

SSF56112. Kinase_like. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q16288.

ChEMBL

CHEMBL5608.

ChiTaRS

NTRK3. human.

EvolutionaryTrace

Q16288.

GenomeRNAi

4916.

NextBio

18927.

SOURCE

Search...

Entry information

Entry name

NTRK3_HUMAN

Accession

Primary (citable) accession number: Q16288
Secondary accession number(s): O75682, Q12827, Q16289

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 153 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.