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Q16280

- CNGA2_HUMAN

UniProt

Q16280 - CNGA2_HUMAN

Protein

Cyclic nucleotide-gated olfactory channel

Gene

CNGA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei521 – 5211cAMPBy similarity
    Binding sitei536 – 5361cAMPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi454 – 577124cAMPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB-KW
    2. cGMP binding Source: RefGenome
    3. intracellular cGMP activated cation channel activity Source: RefGenome
    4. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. phototransduction, visible light Source: RefGenome
    2. potassium ion transmembrane transport Source: RefGenome
    3. regulation of membrane potential Source: RefGenome
    4. sensory perception of smell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel

    Keywords - Biological processi

    Ion transport, Olfaction, Sensory transduction, Transport

    Keywords - Ligandi

    Calmodulin-binding, cAMP, cAMP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic nucleotide-gated olfactory channel
    Alternative name(s):
    Cyclic nucleotide-gated cation channel 2
    Cyclic nucleotide-gated channel alpha-2
    Short name:
    CNG channel alpha-2
    Short name:
    CNG-2
    Short name:
    CNG2
    Gene namesi
    Name:CNGA2
    Synonyms:CNCA, CNCA1, CNCG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:2149. CNGA2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26659.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 664664Cyclic nucleotide-gated olfactory channelPRO_0000219312Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ16280.
    PRIDEiQ16280.

    PTM databases

    PhosphoSiteiQ16280.

    Expressioni

    Gene expression databases

    CleanExiHS_CNGA2.
    GenevestigatoriQ16280.

    Organism-specific databases

    HPAiHPA015065.

    Interactioni

    Subunit structurei

    Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000328478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16280.
    SMRiQ16280. Positions 59-85, 323-571, 597-640.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 138138CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 17112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini193 – 22432CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 27429ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 35055CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini372 – 45382ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini475 – 662188CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei139 – 15921Helical; Name=H1Sequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221Helical; Name=H2Sequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521Helical; Name=H3Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521Helical; Name=H4Sequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121Helical; Name=H5Sequence AnalysisAdd
    BLAST
    Transmembranei454 – 47421Helical; Name=H6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili597 – 64044By similarityAdd
    BLAST

    Domaini

    The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.By similarity

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300025.
    HOGENOMiHOG000007898.
    HOVERGENiHBG000281.
    InParanoidiQ16280.
    KOiK04949.
    OMAiYLSDGMN.
    OrthoDBiEOG771268.
    PhylomeDBiQ16280.
    TreeFamiTF319048.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16280-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEKTNGVKS SPANNHNHHA PPAIKANGKD DHRTSSRPHS AADDDTSSEL    50
    QRLADVDAPQ QGRSGFRRIV RLVGIIREWA NKNFREEEPR PDSFLERFRG 100
    PELQTVTTQE GDGKGDKDGE DKGTKKKFEL FVLDPAGDWY YCWLFVIAMP 150
    VLYNWCLLVA RACFSDLQKG YYLVWLVLDY VSDVVYIADL FIRLRTGFLE 200
    QGLLVKDTKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVDI HSPEVRFNRL 250
    LHFARMFEFF DRTETRTNYP NIFRISNLVL YILVIIHWNA CIYYAISKSI 300
    GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY 350
    LFVIFDFLIG VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK 400
    VSKGMEAKVI RWFDYLWTNK KTVDEREILK NLPAKLRAEI AINVHLSTLK 450
    KVRIFHDCEA GLLVELVLKL RPQVFSPGDY ICRKGDIGKE MYIIKEGKLA 500
    VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI RSLGYSDLFC 550
    LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA TSMEVDVQEK 600
    LGQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLETKM KQNNEDDYLS 650
    DGMNSPELAA ADEP 664
    Length:664
    Mass (Da):76,048
    Last modified:December 12, 2006 - v2
    Checksum:iE8FB934468429CE5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971R → H in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036603
    Natural varianti118 – 1181D → H.
    Corresponds to variant rs6627455 [ dbSNP | Ensembl ].
    VAR_048748
    Natural varianti139 – 1391W → L.
    Corresponds to variant rs35350051 [ dbSNP | Ensembl ].
    VAR_061107
    Natural varianti399 – 3991R → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036604
    Natural varianti663 – 6631E → K.
    Corresponds to variant rs714147 [ dbSNP | Ensembl ].
    VAR_048749

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126302 mRNA. Translation: AAI26303.1.
    BC126304 mRNA. Translation: AAI26305.1.
    S76067 Genomic DNA. Translation: AAD14207.1.
    CCDSiCCDS14701.1.
    PIRiI78559.
    RefSeqiNP_005131.1. NM_005140.1.
    UniGeneiHs.447360.

    Genome annotation databases

    EnsembliENST00000329903; ENSP00000328478; ENSG00000183862.
    GeneIDi1260.
    KEGGihsa:1260.
    UCSCiuc004fey.1. human.

    Polymorphism databases

    DMDMi119370323.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126302 mRNA. Translation: AAI26303.1 .
    BC126304 mRNA. Translation: AAI26305.1 .
    S76067 Genomic DNA. Translation: AAD14207.1 .
    CCDSi CCDS14701.1.
    PIRi I78559.
    RefSeqi NP_005131.1. NM_005140.1.
    UniGenei Hs.447360.

    3D structure databases

    ProteinModelPortali Q16280.
    SMRi Q16280. Positions 59-85, 323-571, 597-640.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000328478.

    Chemistry

    ChEMBLi CHEMBL1628471.

    PTM databases

    PhosphoSitei Q16280.

    Polymorphism databases

    DMDMi 119370323.

    Proteomic databases

    PaxDbi Q16280.
    PRIDEi Q16280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329903 ; ENSP00000328478 ; ENSG00000183862 .
    GeneIDi 1260.
    KEGGi hsa:1260.
    UCSCi uc004fey.1. human.

    Organism-specific databases

    CTDi 1260.
    GeneCardsi GC0XP150904.
    HGNCi HGNC:2149. CNGA2.
    HPAi HPA015065.
    MIMi 300338. gene.
    neXtProti NX_Q16280.
    PharmGKBi PA26659.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300025.
    HOGENOMi HOG000007898.
    HOVERGENi HBG000281.
    InParanoidi Q16280.
    KOi K04949.
    OMAi YLSDGMN.
    OrthoDBi EOG771268.
    PhylomeDBi Q16280.
    TreeFami TF319048.

    Miscellaneous databases

    GeneWikii Cyclic_nucleotide-gated_channel_alpha_2.
    GenomeRNAii 1260.
    NextBioi 5097.
    PROi Q16280.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_CNGA2.
    Genevestigatori Q16280.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells."
      Distler M., Biel M., Flockerzi V., Hofmann F.
      Neuropharmacology 33:1275-1282(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-552.
    3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-97 AND GLN-399.

    Entry informationi

    Entry nameiCNGA2_HUMAN
    AccessioniPrimary (citable) accession number: Q16280
    Secondary accession number(s): A0AVD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3