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Q16280

- CNGA2_HUMAN

UniProt

Q16280 - CNGA2_HUMAN

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Protein
Cyclic nucleotide-gated olfactory channel
Gene
CNGA2, CNCA, CNCA1, CNCG2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei521 – 5211cAMP By similarity
Binding sitei536 – 5361cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi454 – 577124cAMP By similarity
Add
BLAST

GO - Molecular functioni

  1. cAMP binding Source: UniProtKB-KW
  2. cGMP binding Source: RefGenome
  3. intracellular cGMP activated cation channel activity Source: RefGenome
  4. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. phototransduction, visible light Source: RefGenome
  2. potassium ion transmembrane transport Source: RefGenome
  3. regulation of membrane potential Source: RefGenome
  4. sensory perception of smell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Olfaction, Sensory transduction, Transport

Keywords - Ligandi

Calmodulin-binding, cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated olfactory channel
Alternative name(s):
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2
Short name:
CNG channel alpha-2
Short name:
CNG-2
Short name:
CNG2
Gene namesi
Name:CNGA2
Synonyms:CNCA, CNCA1, CNCG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:2149. CNGA2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 138138Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei139 – 15921Helical; Name=H1; Reviewed prediction
Add
BLAST
Topological domaini160 – 17112Extracellular Reviewed prediction
Add
BLAST
Transmembranei172 – 19221Helical; Name=H2; Reviewed prediction
Add
BLAST
Topological domaini193 – 22432Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Name=H3; Reviewed prediction
Add
BLAST
Topological domaini246 – 27429Extracellular Reviewed prediction
Add
BLAST
Transmembranei275 – 29521Helical; Name=H4; Reviewed prediction
Add
BLAST
Topological domaini296 – 35055Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei351 – 37121Helical; Name=H5; Reviewed prediction
Add
BLAST
Topological domaini372 – 45382Extracellular Reviewed prediction
Add
BLAST
Transmembranei454 – 47421Helical; Name=H6; Reviewed prediction
Add
BLAST
Topological domaini475 – 662188Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Cyclic nucleotide-gated olfactory channel
PRO_0000219312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi379 – 3791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ16280.
PRIDEiQ16280.

PTM databases

PhosphoSiteiQ16280.

Expressioni

Gene expression databases

CleanExiHS_CNGA2.
GenevestigatoriQ16280.

Organism-specific databases

HPAiHPA015065.

Interactioni

Subunit structurei

Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000328478.

Structurei

3D structure databases

ProteinModelPortaliQ16280.
SMRiQ16280. Positions 59-85, 323-571, 597-640.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili597 – 64044 By similarity
Add
BLAST

Domaini

The C-terminal coiled-coil domain mediates trimerization of CNGA subunits By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300025.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ16280.
KOiK04949.
OMAiYLSDGMN.
OrthoDBiEOG771268.
PhylomeDBiQ16280.
TreeFamiTF319048.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16280-1 [UniParc]FASTAAdd to Basket

« Hide

MTEKTNGVKS SPANNHNHHA PPAIKANGKD DHRTSSRPHS AADDDTSSEL    50
QRLADVDAPQ QGRSGFRRIV RLVGIIREWA NKNFREEEPR PDSFLERFRG 100
PELQTVTTQE GDGKGDKDGE DKGTKKKFEL FVLDPAGDWY YCWLFVIAMP 150
VLYNWCLLVA RACFSDLQKG YYLVWLVLDY VSDVVYIADL FIRLRTGFLE 200
QGLLVKDTKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVDI HSPEVRFNRL 250
LHFARMFEFF DRTETRTNYP NIFRISNLVL YILVIIHWNA CIYYAISKSI 300
GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY 350
LFVIFDFLIG VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK 400
VSKGMEAKVI RWFDYLWTNK KTVDEREILK NLPAKLRAEI AINVHLSTLK 450
KVRIFHDCEA GLLVELVLKL RPQVFSPGDY ICRKGDIGKE MYIIKEGKLA 500
VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI RSLGYSDLFC 550
LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA TSMEVDVQEK 600
LGQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLETKM KQNNEDDYLS 650
DGMNSPELAA ADEP 664
Length:664
Mass (Da):76,048
Last modified:December 12, 2006 - v2
Checksum:iE8FB934468429CE5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971R → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_036603
Natural varianti118 – 1181D → H.
Corresponds to variant rs6627455 [ dbSNP | Ensembl ].
VAR_048748
Natural varianti139 – 1391W → L.
Corresponds to variant rs35350051 [ dbSNP | Ensembl ].
VAR_061107
Natural varianti399 – 3991R → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_036604
Natural varianti663 – 6631E → K.
Corresponds to variant rs714147 [ dbSNP | Ensembl ].
VAR_048749

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126302 mRNA. Translation: AAI26303.1.
BC126304 mRNA. Translation: AAI26305.1.
S76067 Genomic DNA. Translation: AAD14207.1.
CCDSiCCDS14701.1.
PIRiI78559.
RefSeqiNP_005131.1. NM_005140.1.
UniGeneiHs.447360.

Genome annotation databases

EnsembliENST00000329903; ENSP00000328478; ENSG00000183862.
GeneIDi1260.
KEGGihsa:1260.
UCSCiuc004fey.1. human.

Polymorphism databases

DMDMi119370323.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126302 mRNA. Translation: AAI26303.1 .
BC126304 mRNA. Translation: AAI26305.1 .
S76067 Genomic DNA. Translation: AAD14207.1 .
CCDSi CCDS14701.1.
PIRi I78559.
RefSeqi NP_005131.1. NM_005140.1.
UniGenei Hs.447360.

3D structure databases

ProteinModelPortali Q16280.
SMRi Q16280. Positions 59-85, 323-571, 597-640.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000328478.

Chemistry

ChEMBLi CHEMBL1628471.

PTM databases

PhosphoSitei Q16280.

Polymorphism databases

DMDMi 119370323.

Proteomic databases

PaxDbi Q16280.
PRIDEi Q16280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329903 ; ENSP00000328478 ; ENSG00000183862 .
GeneIDi 1260.
KEGGi hsa:1260.
UCSCi uc004fey.1. human.

Organism-specific databases

CTDi 1260.
GeneCardsi GC0XP150904.
HGNCi HGNC:2149. CNGA2.
HPAi HPA015065.
MIMi 300338. gene.
neXtProti NX_Q16280.
PharmGKBi PA26659.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300025.
HOGENOMi HOG000007898.
HOVERGENi HBG000281.
InParanoidi Q16280.
KOi K04949.
OMAi YLSDGMN.
OrthoDBi EOG771268.
PhylomeDBi Q16280.
TreeFami TF319048.

Miscellaneous databases

GeneWikii Cyclic_nucleotide-gated_channel_alpha_2.
GenomeRNAii 1260.
NextBioi 5097.
PROi Q16280.
SOURCEi Search...

Gene expression databases

CleanExi HS_CNGA2.
Genevestigatori Q16280.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells."
    Distler M., Biel M., Flockerzi V., Hofmann F.
    Neuropharmacology 33:1275-1282(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-552.
  3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-97 AND GLN-399.

Entry informationi

Entry nameiCNGA2_HUMAN
AccessioniPrimary (citable) accession number: Q16280
Secondary accession number(s): A0AVD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 12, 2006
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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