Q16280 (CNGA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclic nucleotide-gated olfactory channel

Alternative name(s):
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2
Short name=CNG channel alpha-2
Short name=CNG-2
Short name=CNG2

Gene names

Name:	CNGA2
Synonyms:	CNCA, CNCA1, CNCG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	664 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Subunit structure	Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	The C-terminal coiled-coil domain mediates trimerization of CNGA subunits By similarity.
Sequence similarities	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. [View classification] Contains 1 cyclic nucleotide-binding domain.

Ontologies

Keywords
Biological process	Ion transport Olfaction Sensory transduction Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Ligand	Calmodulin-binding Nucleotide-binding cAMP cAMP-binding
Molecular function	Ion channel Ligand-gated ion channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Non-traceable author statement. Source: UniProtKB
Cellular_component	intracellular cyclic nucleotide activated cation channel complex Non-traceable author statement. Source: UniProtKB
Molecular_function	cAMP binding Inferred from electronic annotation. Source: UniProtKB-KW intracellular cAMP activated cation channel activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 664	664	Cyclic nucleotide-gated olfactory channel		PRO_0000219312
Regions
	Topological domain	1 – 138	138	Cytoplasmic Potential
	Transmembrane	139 – 159	21	Helical; Name=H1; Potential
	Topological domain	160 – 171	12	Extracellular Potential
	Transmembrane	172 – 192	21	Helical; Name=H2; Potential
	Topological domain	193 – 224	32	Cytoplasmic Potential
	Transmembrane	225 – 245	21	Helical; Name=H3; Potential
	Topological domain	246 – 274	29	Extracellular Potential
	Transmembrane	275 – 295	21	Helical; Name=H4; Potential
	Topological domain	296 – 350	55	Cytoplasmic Potential
	Transmembrane	351 – 371	21	Helical; Name=H5; Potential
	Topological domain	372 – 453	82	Extracellular Potential
	Transmembrane	454 – 474	21	Helical; Name=H6; Potential
	Topological domain	475 – 662	188	Cytoplasmic Potential
	Nucleotide binding	454 – 577	124	cAMP By similarity
	Coiled coil	597 – 640	44	By similarity
Sites
	Binding site	521	1	cAMP By similarity
	Binding site	536	1	cAMP By similarity
Amino acid modifications
	Glycosylation	379	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	97	1	R → H in a breast cancer sample; somatic mutation. Ref.3		VAR_036603
	Natural variant	118	1	D → H. Corresponds to variant rs6627455 [ dbSNP | Ensembl ].		VAR_048748
	Natural variant	139	1	W → L. Corresponds to variant rs35350051 [ dbSNP | Ensembl ].		VAR_061107
	Natural variant	399	1	R → Q in a breast cancer sample; somatic mutation. Ref.3		VAR_036604
	Natural variant	663	1	E → K. Corresponds to variant rs714147 [ dbSNP | Ensembl ].		VAR_048749

Sequences

	Sequence		Length	Mass (Da)
	Q16280 [UniParc]. Last modified December 12, 2006. Version 2. Checksum: E8FB934468429CE5	FASTA	664	76,048
	10 20 30 40 50 60 MTEKTNGVKS SPANNHNHHA PPAIKANGKD DHRTSSRPHS AADDDTSSEL QRLADVDAPQ 70 80 90 100 110 120 QGRSGFRRIV RLVGIIREWA NKNFREEEPR PDSFLERFRG PELQTVTTQE GDGKGDKDGE 130 140 150 160 170 180 DKGTKKKFEL FVLDPAGDWY YCWLFVIAMP VLYNWCLLVA RACFSDLQKG YYLVWLVLDY 190 200 210 220 230 240 VSDVVYIADL FIRLRTGFLE QGLLVKDTKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVDI 250 260 270 280 290 300 HSPEVRFNRL LHFARMFEFF DRTETRTNYP NIFRISNLVL YILVIIHWNA CIYYAISKSI 310 320 330 340 350 360 GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY LFVIFDFLIG 370 380 390 400 410 420 VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK VSKGMEAKVI RWFDYLWTNK 430 440 450 460 470 480 KTVDEREILK NLPAKLRAEI AINVHLSTLK KVRIFHDCEA GLLVELVLKL RPQVFSPGDY 490 500 510 520 530 540 ICRKGDIGKE MYIIKEGKLA VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI 550 560 570 580 590 600 RSLGYSDLFC LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA TSMEVDVQEK 610 620 630 640 650 660 LGQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLETKM KQNNEDDYLS DGMNSPELAA ADEP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells." Distler M., Biel M., Flockerzi V., Hofmann F. Neuropharmacology 33:1275-1282(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-552.
[3]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-97 AND GLN-399.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC126302 mRNA. Translation: AAI26303.1. BC126304 mRNA. Translation: AAI26305.1. S76067 Genomic DNA. Translation: AAD14207.1.
IPI	IPI00399234.
PIR	I78559.
RefSeq	NP_005131.1. NM_005140.1.
UniGene	Hs.447360.
3D structure databases
ProteinModelPortal	Q16280.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000328478.
PTM databases
PhosphoSite	Q16280.
Polymorphism databases
DMDM	119370323.
Proteomic databases
PaxDb	Q16280.
PRIDE	Q16280.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329903; ENSP00000328478; ENSG00000183862.
GeneID	1260.
KEGG	hsa:1260.
UCSC	uc004fey.1. human.
Organism-specific databases
CTD	1260.
GeneCards	GC0XP150904.
HGNC	HGNC:2149. CNGA2.
HPA	HPA015065.
MIM	300338. gene.
neXtProt	NX_Q16280.
PharmGKB	PA26659.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG300025.
HOGENOM	HOG000007898.
HOVERGEN	HBG000281.
InParanoid	Q16280.
KO	K04949.
OMA	HYMHFRK.
OrthoDB	EOG4N5VWD.
PhylomeDB	Q16280.
Gene expression databases
CleanEx	HS_CNGA2.
Genevestigator	Q16280.
Family and domain databases
Gene3D	2.60.120.10. 1 hit.
InterPro	IPR018490. cNMP-bd-like. IPR018488. cNMP-bd_CS. IPR000595. cNMP-bd_dom. IPR005821. Ion_trans_dom. IPR014710. RmlC-like_jellyroll. [Graphical view]
Pfam	PF00027. cNMP_binding. 1 hit. PF00520. Ion_trans. 1 hit. [Graphical view]
SMART	SM00100. cNMP. 1 hit. [Graphical view]
SUPFAM	SSF51206. cNMP_binding. 1 hit.
PROSITE	PS00888. CNMP_BINDING_1. 1 hit. PS00889. CNMP_BINDING_2. 1 hit. PS50042. CNMP_BINDING_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1628471.
GenomeRNAi	1260.
NextBio	5097.
SOURCE	Search...

Entry information

Entry name

CNGA2_HUMAN

Accession

Primary (citable) accession number: Q16280
Secondary accession number(s): A0AVD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.