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Protein

Cyclic nucleotide-gated olfactory channel

Gene

CNGA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei521 – 5211cAMPBy similarity
Binding sitei536 – 5361cAMPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi454 – 577124cAMPBy similarityAdd
BLAST

GO - Molecular functioni

  1. cAMP binding Source: UniProtKB-KW
  2. cGMP binding Source: GO_Central
  3. intracellular cGMP activated cation channel activity Source: GO_Central
  4. voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

  1. organelle organization Source: Reactome
  2. phototransduction, visible light Source: GO_Central
  3. potassium ion transmembrane transport Source: GO_Central
  4. regulation of membrane potential Source: GO_Central
  5. sensory perception of smell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Olfaction, Sensory transduction, Transport

Keywords - Ligandi

Calmodulin-binding, cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated olfactory channel
Alternative name(s):
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2
Short name:
CNG channel alpha-2
Short name:
CNG-2
Short name:
CNG2
Gene namesi
Name:CNGA2
Synonyms:CNCA, CNCA1, CNCG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:2149. CNGA2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 138138CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=H1Sequence AnalysisAdd
BLAST
Topological domaini160 – 17112ExtracellularSequence AnalysisAdd
BLAST
Transmembranei172 – 19221Helical; Name=H2Sequence AnalysisAdd
BLAST
Topological domaini193 – 22432CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei225 – 24521Helical; Name=H3Sequence AnalysisAdd
BLAST
Topological domaini246 – 27429ExtracellularSequence AnalysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=H4Sequence AnalysisAdd
BLAST
Topological domaini296 – 35055CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei351 – 37121Helical; Name=H5Sequence AnalysisAdd
BLAST
Topological domaini372 – 45382ExtracellularSequence AnalysisAdd
BLAST
Transmembranei454 – 47421Helical; Name=H6Sequence AnalysisAdd
BLAST
Topological domaini475 – 662188CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. ciliary membrane Source: Reactome
  2. Golgi-associated vesicle membrane Source: Reactome
  3. Golgi membrane Source: Reactome
  4. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Cyclic nucleotide-gated olfactory channelPRO_0000219312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ16280.
PRIDEiQ16280.

PTM databases

PhosphoSiteiQ16280.

Expressioni

Gene expression databases

CleanExiHS_CNGA2.
GenevestigatoriQ16280.

Organism-specific databases

HPAiHPA015065.

Interactioni

Subunit structurei

Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000328478.

Structurei

3D structure databases

ProteinModelPortaliQ16280.
SMRiQ16280. Positions 59-85, 323-571, 597-640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili597 – 64044By similarityAdd
BLAST

Domaini

The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300025.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ16280.
KOiK04949.
OMAiDLVYFAV.
OrthoDBiEOG771268.
PhylomeDBiQ16280.
TreeFamiTF319048.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEKTNGVKS SPANNHNHHA PPAIKANGKD DHRTSSRPHS AADDDTSSEL
60 70 80 90 100
QRLADVDAPQ QGRSGFRRIV RLVGIIREWA NKNFREEEPR PDSFLERFRG
110 120 130 140 150
PELQTVTTQE GDGKGDKDGE DKGTKKKFEL FVLDPAGDWY YCWLFVIAMP
160 170 180 190 200
VLYNWCLLVA RACFSDLQKG YYLVWLVLDY VSDVVYIADL FIRLRTGFLE
210 220 230 240 250
QGLLVKDTKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVDI HSPEVRFNRL
260 270 280 290 300
LHFARMFEFF DRTETRTNYP NIFRISNLVL YILVIIHWNA CIYYAISKSI
310 320 330 340 350
GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY
360 370 380 390 400
LFVIFDFLIG VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK
410 420 430 440 450
VSKGMEAKVI RWFDYLWTNK KTVDEREILK NLPAKLRAEI AINVHLSTLK
460 470 480 490 500
KVRIFHDCEA GLLVELVLKL RPQVFSPGDY ICRKGDIGKE MYIIKEGKLA
510 520 530 540 550
VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI RSLGYSDLFC
560 570 580 590 600
LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA TSMEVDVQEK
610 620 630 640 650
LGQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLETKM KQNNEDDYLS
660
DGMNSPELAA ADEP
Length:664
Mass (Da):76,048
Last modified:December 12, 2006 - v2
Checksum:iE8FB934468429CE5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971R → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_036603
Natural varianti118 – 1181D → H.
Corresponds to variant rs6627455 [ dbSNP | Ensembl ].
VAR_048748
Natural varianti139 – 1391W → L.
Corresponds to variant rs35350051 [ dbSNP | Ensembl ].
VAR_061107
Natural varianti399 – 3991R → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_036604
Natural varianti663 – 6631E → K.
Corresponds to variant rs714147 [ dbSNP | Ensembl ].
VAR_048749

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126302 mRNA. Translation: AAI26303.1.
BC126304 mRNA. Translation: AAI26305.1.
S76067 Genomic DNA. Translation: AAD14207.1.
CCDSiCCDS14701.1.
PIRiI78559.
RefSeqiNP_005131.1. NM_005140.1.
UniGeneiHs.447360.

Genome annotation databases

EnsembliENST00000329903; ENSP00000328478; ENSG00000183862.
GeneIDi1260.
KEGGihsa:1260.
UCSCiuc004fey.1. human.

Polymorphism databases

DMDMi119370323.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126302 mRNA. Translation: AAI26303.1.
BC126304 mRNA. Translation: AAI26305.1.
S76067 Genomic DNA. Translation: AAD14207.1.
CCDSiCCDS14701.1.
PIRiI78559.
RefSeqiNP_005131.1. NM_005140.1.
UniGeneiHs.447360.

3D structure databases

ProteinModelPortaliQ16280.
SMRiQ16280. Positions 59-85, 323-571, 597-640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328478.

Chemistry

ChEMBLiCHEMBL1628471.

PTM databases

PhosphoSiteiQ16280.

Polymorphism databases

DMDMi119370323.

Proteomic databases

PaxDbiQ16280.
PRIDEiQ16280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329903; ENSP00000328478; ENSG00000183862.
GeneIDi1260.
KEGGihsa:1260.
UCSCiuc004fey.1. human.

Organism-specific databases

CTDi1260.
GeneCardsiGC0XP150904.
HGNCiHGNC:2149. CNGA2.
HPAiHPA015065.
MIMi300338. gene.
neXtProtiNX_Q16280.
PharmGKBiPA26659.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG300025.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ16280.
KOiK04949.
OMAiDLVYFAV.
OrthoDBiEOG771268.
PhylomeDBiQ16280.
TreeFamiTF319048.

Miscellaneous databases

GeneWikiiCyclic_nucleotide-gated_channel_alpha_2.
GenomeRNAii1260.
NextBioi5097.
PROiQ16280.
SOURCEiSearch...

Gene expression databases

CleanExiHS_CNGA2.
GenevestigatoriQ16280.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells."
    Distler M., Biel M., Flockerzi V., Hofmann F.
    Neuropharmacology 33:1275-1282(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-552.
  3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-97 AND GLN-399.

Entry informationi

Entry nameiCNGA2_HUMAN
AccessioniPrimary (citable) accession number: Q16280
Secondary accession number(s): A0AVD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 12, 2006
Last modified: March 4, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.