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Q16270

- IBP7_HUMAN

UniProt

Q16270 - IBP7_HUMAN

Protein

Insulin-like growth factor-binding protein 7

Gene

IGFBP7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. cellular response to hormone stimulus Source: Ensembl
    3. embryo implantation Source: Ensembl
    4. inner ear development Source: Ensembl
    5. negative regulation of cell proliferation Source: ProtInc
    6. regulation of cell growth Source: InterPro
    7. regulation of steroid biosynthetic process Source: Ensembl
    8. response to cortisol Source: Ensembl
    9. response to heat Source: Ensembl
    10. response to retinoic acid Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Growth factor binding

    Enzyme and pathway databases

    ReactomeiREACT_169168. Senescence-Associated Secretory Phenotype (SASP).

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 7
    Short name:
    IBP-7
    Short name:
    IGF-binding protein 7
    Short name:
    IGFBP-7
    Alternative name(s):
    IGFBP-rP1
    MAC25 protein
    PGI2-stimulating factor
    Prostacyclin-stimulating factor
    Tumor-derived adhesion factor
    Short name:
    TAF
    Gene namesi
    Name:IGFBP7
    Synonyms:MAC25, PSF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:5476. IGFBP7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: BHF-UCL
    3. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi614224. phenotype.
    Orphaneti284247. Familial retinal arterial macroaneurysm.
    PharmGKBiPA29709.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26263 PublicationsAdd
    BLAST
    Chaini27 – 282256Insulin-like growth factor-binding protein 7PRO_0000014392Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi171 – 1711N-linked (GlcNAc...)1 Publication
    Disulfide bondi181 ↔ 248PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ16270.
    PaxDbiQ16270.
    PeptideAtlasiQ16270.
    PRIDEiQ16270.

    PTM databases

    PhosphoSiteiQ16270.

    Expressioni

    Gene expression databases

    BgeeiQ16270.
    CleanExiHS_IGFBP7.
    GenevestigatoriQ16270.

    Organism-specific databases

    HPAiCAB020668.
    HPA002196.

    Interactioni

    Subunit structurei

    May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.

    Protein-protein interaction databases

    BioGridi109711. 10 interactions.
    IntActiQ16270. 9 interactions.
    MINTiMINT-7006618.
    STRINGi9606.ENSP00000295666.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16270.
    SMRiQ16270. Positions 35-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 10679IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini105 – 15854Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini160 – 264105Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG40288.
    HOGENOMiHOG000261684.
    HOVERGENiHBG031621.
    InParanoidiQ16270.
    OMAiACGCCPV.
    OrthoDBiEOG7BW0M2.
    PhylomeDBiQ16270.
    TreeFamiTF331645.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR000867. IGFBP-like.
    IPR011390. IGFBP_rP_mac25.
    IPR002350. Kazal_dom.
    [Graphical view]
    PANTHERiPTHR14186. PTHR14186. 1 hit.
    PfamiPF07679. I-set. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
    SMARTiSM00121. IB. 1 hit.
    SM00409. IG. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16270-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL    50
    GETRDACGCC PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA 100
    AAGGPGVSGV CVCKSRYPVC GSDGTTYPSG CQLRAASQRA ESRGEKAITQ 150
    VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS CEVIGIPTPV LIWNKVKRGH 200
    YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK EDAGEYECHA 250
    SNSQGQASAS AKITVVDALH EIPVKKGEGA EL 282
    Length:282
    Mass (Da):29,130
    Last modified:November 1, 1996 - v1
    Checksum:i75F96EBC3B444D37
    GO
    Isoform 2 (identifier: Q16270-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         278-282: EGAEL → TQ

    Show »
    Length:279
    Mass (Da):28,860
    Checksum:i3281F44D371F721E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41P → A in AAA16187. (PubMed:7694637)Curated
    Sequence conflicti13 – 131A → P in AAA16187. (PubMed:7694637)Curated
    Sequence conflicti69 – 691E → G in BAH14453. (PubMed:14702039)Curated
    Sequence conflicti273 – 28210PVKKGEGAEL → ASEKR in AAA16187. (PubMed:7694637)Curated

    RNA editingi

    Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111L → F.2 Publications
    Corresponds to variant rs11573021 [ dbSNP | Ensembl ].
    VAR_018959
    Natural varianti78 – 781R → G in RNA edited version.
    VAR_063638
    Natural varianti95 – 951K → R in RNA edited version.
    VAR_063639

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei278 – 2825EGAEL → TQ in isoform 2. 1 PublicationVSP_045297

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19182 mRNA. Translation: AAA16187.1.
    S75725 mRNA. Translation: AAB32370.1.
    AY518539 Genomic DNA. Translation: AAR89912.1.
    BT006654 mRNA. Translation: AAP35300.1.
    AK303915 mRNA. Translation: BAG64844.1.
    AK316082 mRNA. Translation: BAH14453.1.
    AC069307 Genomic DNA. No translation available.
    AC111197 Genomic DNA. No translation available.
    BC017201 mRNA. Translation: AAH17201.1.
    BC066339 mRNA. Translation: AAH66339.1.
    CCDSiCCDS3512.1. [Q16270-1]
    CCDS58900.1. [Q16270-2]
    PIRiI52825.
    PC2030.
    S50031.
    RefSeqiNP_001240764.1. NM_001253835.1. [Q16270-2]
    NP_001544.1. NM_001553.2. [Q16270-1]
    UniGeneiHs.479808.
    Hs.691061.

    Genome annotation databases

    EnsembliENST00000295666; ENSP00000295666; ENSG00000163453. [Q16270-1]
    GeneIDi3490.
    KEGGihsa:3490.
    UCSCiuc003hcn.3. human. [Q16270-1]
    uc011cag.2. human.

    Polymorphism databases

    DMDMi23396609.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism, RNA editing

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19182 mRNA. Translation: AAA16187.1 .
    S75725 mRNA. Translation: AAB32370.1 .
    AY518539 Genomic DNA. Translation: AAR89912.1 .
    BT006654 mRNA. Translation: AAP35300.1 .
    AK303915 mRNA. Translation: BAG64844.1 .
    AK316082 mRNA. Translation: BAH14453.1 .
    AC069307 Genomic DNA. No translation available.
    AC111197 Genomic DNA. No translation available.
    BC017201 mRNA. Translation: AAH17201.1 .
    BC066339 mRNA. Translation: AAH66339.1 .
    CCDSi CCDS3512.1. [Q16270-1 ]
    CCDS58900.1. [Q16270-2 ]
    PIRi I52825.
    PC2030.
    S50031.
    RefSeqi NP_001240764.1. NM_001253835.1. [Q16270-2 ]
    NP_001544.1. NM_001553.2. [Q16270-1 ]
    UniGenei Hs.479808.
    Hs.691061.

    3D structure databases

    ProteinModelPortali Q16270.
    SMRi Q16270. Positions 35-266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109711. 10 interactions.
    IntActi Q16270. 9 interactions.
    MINTi MINT-7006618.
    STRINGi 9606.ENSP00000295666.

    Chemistry

    DrugBanki DB00047. Insulin Glargine recombinant.
    DB00046. Insulin Lyspro recombinant.
    DB00030. Insulin recombinant.
    DB00071. Insulin, porcine.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q16270.

    Polymorphism databases

    DMDMi 23396609.

    Proteomic databases

    MaxQBi Q16270.
    PaxDbi Q16270.
    PeptideAtlasi Q16270.
    PRIDEi Q16270.

    Protocols and materials databases

    DNASUi 3490.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295666 ; ENSP00000295666 ; ENSG00000163453 . [Q16270-1 ]
    GeneIDi 3490.
    KEGGi hsa:3490.
    UCSCi uc003hcn.3. human. [Q16270-1 ]
    uc011cag.2. human.

    Organism-specific databases

    CTDi 3490.
    GeneCardsi GC04M057897.
    HGNCi HGNC:5476. IGFBP7.
    HPAi CAB020668.
    HPA002196.
    MIMi 602867. gene.
    614224. phenotype.
    neXtProti NX_Q16270.
    Orphaneti 284247. Familial retinal arterial macroaneurysm.
    PharmGKBi PA29709.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40288.
    HOGENOMi HOG000261684.
    HOVERGENi HBG031621.
    InParanoidi Q16270.
    OMAi ACGCCPV.
    OrthoDBi EOG7BW0M2.
    PhylomeDBi Q16270.
    TreeFami TF331645.

    Enzyme and pathway databases

    Reactomei REACT_169168. Senescence-Associated Secretory Phenotype (SASP).

    Miscellaneous databases

    ChiTaRSi IGFBP7. human.
    GeneWikii IGFBP7.
    GenomeRNAii 3490.
    NextBioi 13726.
    PROi Q16270.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q16270.
    CleanExi HS_IGFBP7.
    Genevestigatori Q16270.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR000867. IGFBP-like.
    IPR011390. IGFBP_rP_mac25.
    IPR002350. Kazal_dom.
    [Graphical view ]
    PANTHERi PTHR14186. PTHR14186. 1 hit.
    Pfami PF07679. I-set. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018239. IGFBP_rP_mac25. 1 hit.
    SMARTi SM00121. IB. 1 hit.
    SM00409. IG. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of genes differentially expressed in meningiomas."
      Murphy M., Pykett M.J., Harnish P., Zang K.D., George D.L.
      Cell Growth Differ. 4:715-722(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-11, RNA EDITING OF POSITION 95.
      Tissue: Leptomeninges.
    2. "Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells."
      Yamauchi T., Umeda F., Masakado M., Isaji M., Mizushima S., Nawata H.
      Biochem. J. 303:591-598(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. NIEHS SNPs program
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-11.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thalamus and Trachea.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis and Uterus.
    8. "Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells."
      Akaogi K., Okabe Y., Funahashi K., Yoshitake Y., Nishikawa K., Yasumitsu H., Umeda M., Miyazaki K.
      Biochem. Biophys. Res. Commun. 198:1046-1053(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-46, FUNCTION.
      Tissue: Urinary bladder carcinoma.
    9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-41.
    10. "Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II."
      Oh Y., Nagalla S.R., Yamanaka Y., Kim H.-S., Wilson E., Rosenfeld R.G.
      J. Biol. Chem. 271:30322-30325(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-36, FUNCTION, GLYCOSYLATION.
    11. "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells."
      Wilson E.M., Oh Y., Hwa V., Rosenfeld R.G.
      J. Clin. Endocrinol. Metab. 86:4504-4511(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INTERACTION WITH CHMP3.
    12. "Screening of human SNP database identifies recoding sites of A-to-I RNA editing."
      Gommans W.M., Tatalias N.E., Sie C.P., Dupuis D., Vendetti N., Smith L., Kaushal R., Maas S.
      RNA 14:2074-2085(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA EDITING OF POSITIONS 78 AND 95.
    13. "Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms."
      Abu-Safieh L., Abboud E.B., Alkuraya H., Shamseldin H., Al-Enzi S., Al-Abdi L., Hashem M., Colak D., Jarallah A., Ahmad H., Bobis S., Nemer G., Bitar F., Alkuraya F.S.
      Am. J. Hum. Genet. 89:313-319(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN RAMSVPS.

    Entry informationi

    Entry nameiIBP7_HUMAN
    AccessioniPrimary (citable) accession number: Q16270
    Secondary accession number(s): B4E1N2
    , B7Z9W7, Q07822, Q53YE6, Q9UCA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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