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Q16270

- IBP7_HUMAN

UniProt

Q16270 - IBP7_HUMAN

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Protein
Insulin-like growth factor-binding protein 7
Gene
IGFBP7, MAC25, PSF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. cellular response to hormone stimulus Source: Ensembl
  3. embryo implantation Source: Ensembl
  4. inner ear development Source: Ensembl
  5. negative regulation of cell proliferation Source: ProtInc
  6. regulation of cell growth Source: InterPro
  7. regulation of steroid biosynthetic process Source: Ensembl
  8. response to cortisol Source: Ensembl
  9. response to heat Source: Ensembl
  10. response to retinoic acid Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiREACT_169168. Senescence-Associated Secretory Phenotype (SASP).

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 7
Short name:
IBP-7
Short name:
IGF-binding protein 7
Short name:
IGFBP-7
Alternative name(s):
IGFBP-rP1
MAC25 protein
PGI2-stimulating factor
Prostacyclin-stimulating factor
Tumor-derived adhesion factor
Short name:
TAF
Gene namesi
Name:IGFBP7
Synonyms:MAC25, PSF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:5476. IGFBP7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: BHF-UCL
  3. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi614224. phenotype.
Orphaneti284247. Familial retinal arterial macroaneurysm.
PharmGKBiPA29709.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26263 Publications
Add
BLAST
Chaini27 – 282256Insulin-like growth factor-binding protein 7
PRO_0000014392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi171 – 1711N-linked (GlcNAc...) Inferred
Disulfide bondi181 ↔ 248 By similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ16270.
PaxDbiQ16270.
PeptideAtlasiQ16270.
PRIDEiQ16270.

PTM databases

PhosphoSiteiQ16270.

Expressioni

Gene expression databases

BgeeiQ16270.
CleanExiHS_IGFBP7.
GenevestigatoriQ16270.

Organism-specific databases

HPAiCAB020668.
HPA002196.

Interactioni

Subunit structurei

May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.

Protein-protein interaction databases

BioGridi109711. 10 interactions.
IntActiQ16270. 9 interactions.
MINTiMINT-7006618.
STRINGi9606.ENSP00000295666.

Structurei

3D structure databases

ProteinModelPortaliQ16270.
SMRiQ16270. Positions 35-266.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10679IGFBP N-terminal
Add
BLAST
Domaini105 – 15854Kazal-like
Add
BLAST
Domaini160 – 264105Ig-like C2-type
Add
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG40288.
HOGENOMiHOG000261684.
HOVERGENiHBG031621.
InParanoidiQ16270.
OMAiACGCCPV.
OrthoDBiEOG7BW0M2.
PhylomeDBiQ16270.
TreeFamiTF331645.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view]
PANTHERiPTHR14186. PTHR14186. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTiSM00121. IB. 1 hit.
SM00409. IG. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q16270-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL    50
GETRDACGCC PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA 100
AAGGPGVSGV CVCKSRYPVC GSDGTTYPSG CQLRAASQRA ESRGEKAITQ 150
VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS CEVIGIPTPV LIWNKVKRGH 200
YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK EDAGEYECHA 250
SNSQGQASAS AKITVVDALH EIPVKKGEGA EL 282
Length:282
Mass (Da):29,130
Last modified:November 1, 1996 - v1
Checksum:i75F96EBC3B444D37
GO
Isoform 2 (identifier: Q16270-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-282: EGAEL → TQ

Show »
Length:279
Mass (Da):28,860
Checksum:i3281F44D371F721E
GO

RNA editingi

Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%.2 Publications

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111L → F.2 Publications
Corresponds to variant rs11573021 [ dbSNP | Ensembl ].
VAR_018959
Natural varianti78 – 781R → G in RNA edited version.
VAR_063638
Natural varianti95 – 951K → R in RNA edited version.
VAR_063639

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei278 – 2825EGAEL → TQ in isoform 2.
VSP_045297

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → A in AAA16187. 1 Publication
Sequence conflicti13 – 131A → P in AAA16187. 1 Publication
Sequence conflicti69 – 691E → G in BAH14453. 1 Publication
Sequence conflicti273 – 28210PVKKGEGAEL → ASEKR in AAA16187. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19182 mRNA. Translation: AAA16187.1.
S75725 mRNA. Translation: AAB32370.1.
AY518539 Genomic DNA. Translation: AAR89912.1.
BT006654 mRNA. Translation: AAP35300.1.
AK303915 mRNA. Translation: BAG64844.1.
AK316082 mRNA. Translation: BAH14453.1.
AC069307 Genomic DNA. No translation available.
AC111197 Genomic DNA. No translation available.
BC017201 mRNA. Translation: AAH17201.1.
BC066339 mRNA. Translation: AAH66339.1.
CCDSiCCDS3512.1. [Q16270-1]
CCDS58900.1. [Q16270-2]
PIRiI52825.
PC2030.
S50031.
RefSeqiNP_001240764.1. NM_001253835.1. [Q16270-2]
NP_001544.1. NM_001553.2. [Q16270-1]
UniGeneiHs.479808.
Hs.691061.

Genome annotation databases

EnsembliENST00000295666; ENSP00000295666; ENSG00000163453. [Q16270-1]
ENST00000537922; ENSP00000444146; ENSG00000163453. [Q16270-2]
GeneIDi3490.
KEGGihsa:3490.
UCSCiuc003hcn.3. human. [Q16270-1]
uc011cag.2. human.

Polymorphism databases

DMDMi23396609.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19182 mRNA. Translation: AAA16187.1 .
S75725 mRNA. Translation: AAB32370.1 .
AY518539 Genomic DNA. Translation: AAR89912.1 .
BT006654 mRNA. Translation: AAP35300.1 .
AK303915 mRNA. Translation: BAG64844.1 .
AK316082 mRNA. Translation: BAH14453.1 .
AC069307 Genomic DNA. No translation available.
AC111197 Genomic DNA. No translation available.
BC017201 mRNA. Translation: AAH17201.1 .
BC066339 mRNA. Translation: AAH66339.1 .
CCDSi CCDS3512.1. [Q16270-1 ]
CCDS58900.1. [Q16270-2 ]
PIRi I52825.
PC2030.
S50031.
RefSeqi NP_001240764.1. NM_001253835.1. [Q16270-2 ]
NP_001544.1. NM_001553.2. [Q16270-1 ]
UniGenei Hs.479808.
Hs.691061.

3D structure databases

ProteinModelPortali Q16270.
SMRi Q16270. Positions 35-266.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109711. 10 interactions.
IntActi Q16270. 9 interactions.
MINTi MINT-7006618.
STRINGi 9606.ENSP00000295666.

Chemistry

DrugBanki DB00047. Insulin Glargine recombinant.
DB00046. Insulin Lyspro recombinant.
DB00030. Insulin recombinant.
DB00071. Insulin, porcine.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q16270.

Polymorphism databases

DMDMi 23396609.

Proteomic databases

MaxQBi Q16270.
PaxDbi Q16270.
PeptideAtlasi Q16270.
PRIDEi Q16270.

Protocols and materials databases

DNASUi 3490.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295666 ; ENSP00000295666 ; ENSG00000163453 . [Q16270-1 ]
ENST00000537922 ; ENSP00000444146 ; ENSG00000163453 . [Q16270-2 ]
GeneIDi 3490.
KEGGi hsa:3490.
UCSCi uc003hcn.3. human. [Q16270-1 ]
uc011cag.2. human.

Organism-specific databases

CTDi 3490.
GeneCardsi GC04M057897.
HGNCi HGNC:5476. IGFBP7.
HPAi CAB020668.
HPA002196.
MIMi 602867. gene.
614224. phenotype.
neXtProti NX_Q16270.
Orphaneti 284247. Familial retinal arterial macroaneurysm.
PharmGKBi PA29709.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40288.
HOGENOMi HOG000261684.
HOVERGENi HBG031621.
InParanoidi Q16270.
OMAi ACGCCPV.
OrthoDBi EOG7BW0M2.
PhylomeDBi Q16270.
TreeFami TF331645.

Enzyme and pathway databases

Reactomei REACT_169168. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

ChiTaRSi IGFBP7. human.
GeneWikii IGFBP7.
GenomeRNAii 3490.
NextBioi 13726.
PROi Q16270.
SOURCEi Search...

Gene expression databases

Bgeei Q16270.
CleanExi HS_IGFBP7.
Genevestigatori Q16270.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view ]
PANTHERi PTHR14186. PTHR14186. 1 hit.
Pfami PF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTi SM00121. IB. 1 hit.
SM00409. IG. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of genes differentially expressed in meningiomas."
    Murphy M., Pykett M.J., Harnish P., Zang K.D., George D.L.
    Cell Growth Differ. 4:715-722(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-11, RNA EDITING OF POSITION 95.
    Tissue: Leptomeninges.
  2. "Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells."
    Yamauchi T., Umeda F., Masakado M., Isaji M., Mizushima S., Nawata H.
    Biochem. J. 303:591-598(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. NIEHS SNPs program
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-11.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus and Trachea.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis and Uterus.
  8. "Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells."
    Akaogi K., Okabe Y., Funahashi K., Yoshitake Y., Nishikawa K., Yasumitsu H., Umeda M., Miyazaki K.
    Biochem. Biophys. Res. Commun. 198:1046-1053(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-46, FUNCTION.
    Tissue: Urinary bladder carcinoma.
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-41.
  10. "Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II."
    Oh Y., Nagalla S.R., Yamanaka Y., Kim H.-S., Wilson E., Rosenfeld R.G.
    J. Biol. Chem. 271:30322-30325(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-36, FUNCTION, GLYCOSYLATION.
  11. "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells."
    Wilson E.M., Oh Y., Hwa V., Rosenfeld R.G.
    J. Clin. Endocrinol. Metab. 86:4504-4511(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INTERACTION WITH CHMP3.
  12. "Screening of human SNP database identifies recoding sites of A-to-I RNA editing."
    Gommans W.M., Tatalias N.E., Sie C.P., Dupuis D., Vendetti N., Smith L., Kaushal R., Maas S.
    RNA 14:2074-2085(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING OF POSITIONS 78 AND 95.
  13. "Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms."
    Abu-Safieh L., Abboud E.B., Alkuraya H., Shamseldin H., Al-Enzi S., Al-Abdi L., Hashem M., Colak D., Jarallah A., Ahmad H., Bobis S., Nemer G., Bitar F., Alkuraya F.S.
    Am. J. Hum. Genet. 89:313-319(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RAMSVPS.

Entry informationi

Entry nameiIBP7_HUMAN
AccessioniPrimary (citable) accession number: Q16270
Secondary accession number(s): B4E1N2
, B7Z9W7, Q07822, Q53YE6, Q9UCA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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