Reviewed,
UniProtKB/Swiss-Prot Q16186 (ADRM1_HUMAN)
Last modified
November 25, 2008.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein ADRM1 Alternative name(s): Adhesion-regulating molecule 1 110 kDa cell membrane glycoprotein Gp110 Proteasome regulatory particle non-ATPase 13 Short name=hRpn13 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 407 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity. |
| Subunit structure | Interacts with PSMD1 and UCHL5. |
| Subcellular location | |
| Sequence similarities | Belongs to the ADRM1 family. |
| Caution | Although initially described as a cell membrane glycoprotein, ADRM1 is intracellular and non-glycosylated, and has probably no direct role in cell adhesion. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus Proteasome |
| PTM | Acetylation Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | RNA elongation from RNA polymerase II promoter Inferred from mutant phenotype. Source: UniProtKB proteasome assembly Ref.2Inferred from direct assay. Source: UniProtKB |
| Cellular component | cytosol Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Ref.1Traceable author statement. Source: ProtInc membrane fraction Ref.1Traceable author statement. Source: ProtInc nucleusInferred from electronic annotation. Source: InterPro proteasome complex Ref.2Inferred from direct assay. Source: UniProtKB |
| Molecular function | proteasome activator activity Ref.2 Inferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Chain | 2 – 407 | 406 | Protein ADRM1 | PRO_0000020631 | |||||
Regions | |||||||||
| Region | 2 – 132 | 131 | Interaction with PSMD1 | ||||||
| Region | 362 – 407 | 46 | Interaction with UCHL5 | ||||||
| Compositional bias | 135 – 202 | 68 | Gly-rich | ||||||
| Compositional bias | 193 – 257 | 65 | Ser-rich | ||||||
| Compositional bias | 203 – 213 | 11 | Poly-Ser | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylthreonine | ||||||
| Modified residue | 211 | 1 | Phosphoserine | ||||||
| Modified residue | 213 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 217 | 1 | Phosphothreonine | ||||||
| Modified residue | 220 | 1 | Phosphoserine | ||||||
| Modified residue | 405 | 1 | Phosphoserine | ||||||
Experimental info | |||||||||
| Sequence conflict | 142 | 1 | S → T in BAA11023. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferon." Shimada S., Ogawa M., Takahashi M., Schlom J., Greiner J.W. Cancer Res. 54:3831-3836(1994) [PubMed: 8033103] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes." Hamazaki J., Iemura S., Natsume T., Yashiroda H., Tanaka K., Murata S. EMBO J. 25:4524-4536(2006) [PubMed: 16990800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PSMD1 AND UCHL5, SUBCELLULAR LOCATION, MASS SPECTROMETRY. |
| [3] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Pancreas. |
| [5] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-405, MASS SPECTROMETRY. Tissue: Epithelium. |
| [6] | "hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37." Qiu X.-B., Ouyang S.-Y., Li C.-J., Miao S., Wang L., Goldberg A.L. EMBO J. 25:5742-5753(2006) [PubMed: 17139257] [Abstract] Cited for: FUNCTION, INTERACTION WITH UCHL5, SUBCELLULAR LOCATION, MASS SPECTROMETRY. |
| [7] | "Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor." Joergensen J.P., Lauridsen A.-M., Kristensen P., Dissing K., Johnsen A.H., Hendil K.B., Hartmann-Petersen R. J. Mol. Biol. 360:1043-1052(2006) [PubMed: 16815440] [Abstract] Cited for: FUNCTION, INTERACTION WITH 26S PROTEASOME, SUBCELLULAR LOCATION, MASS SPECTROMETRY. |
| [8] | "Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1." Yao T., Song L., Xu W., DeMartino G.N., Florens L., Swanson S.K., Washburn M.P., Conaway R.C., Conaway J.W., Cohen R.E. Nat. Cell Biol. 8:994-1002(2006) [PubMed: 16906146] [Abstract] Cited for: FUNCTION, INTERACTION WITH PSMD1 AND UCHL5, MASS SPECTROMETRY. |
| [9] | "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex." Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L. Biochemistry 46:3553-3565(2007) [PubMed: 17323924] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, MASS SPECTROMETRY. |
| [10] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211; THR-217; SER-220 AND SER-405, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D64154 mRNA. Translation: BAA11023.1. AL354836 Genomic DNA. Translation: CAC22308.1. BR000321 mRNA. Translation: FAA00246.1. BC010733 mRNA. Translation: AAH10733.1. BC017245 mRNA. Translation: AAH17245.1. | |
| PIR | I52703. |
| RefSeq | NP_008933.2. NP_783163.1. |
| UniGene | Hs.90107 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q16186. |
PTM databases | |
| PhosphoSite | Q16186. |
Genome annotation databases | |
| Ensembl | ENSG00000130706. Homo sapiens. [Contig view] |
| GeneID | 11047. |
| KEGG | hsa:11047. |
Organism-specific databases | |
| H-InvDB | HIX0015977. |
| HGNC | HGNC:15759. ADRM1. |
| MIM | 610650. gene. |
| PharmGKB | PA24599. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q16186. |
| HOVERGEN | Q16186. |
Gene expression databases | |
| CleanEx | HS_ADRM1. |
| GermOnline | ENSG00000130706. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006773. ARM_1. [Graphical view] |
| PANTHER | PTHR12225. ARM_1. 1 hit. |
| Pfam | PF04683. ARM_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 41984. |
| SOURCE | Search... |
Entry information
| Entry name | ADRM1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16186 Secondary accession number(s): A0PKB1, Q96FJ7, Q9H1P2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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