Reviewed, UniProtKB/Swiss-Prot Q16181 (SEPT7_HUMAN)

Names and origin

Protein names

Recommended name:
    Septin-7
Alternative name(s):
    CDC10 protein homolog

Gene names

Name:	SEPT7
Synonyms:	CDC10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in cytokinesis Potential.
Subunit structure	May assemble into a multicomponent structure.
Sequence similarities	Belongs to the septin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: InterPro cytokinesis Ref.1 Traceable author statement. Source: ProtInc protein heterooligomerization Inferred from direct assay. Source: UniProtKB
Cellular component	nucleus Inferred from direct assay. Source: UniProtKB septin complex Inferred from electronic annotation. Source: InterPro stress fiber Inferred from direct assay. Source: UniProtKB
Molecular function	GTP binding Ref.1 Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: UniProtKB structural molecule activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q16181-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q16181-2)

The sequence of this isoform differs from the canonical sequence as follows:
     21-21: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Septin-7		PRO_0000173528
Regions
	Nucleotide binding	57 – 64	8	GTP Potential
	Coiled coil	332 – 437	106	Potential
Amino acid modifications
	Modified residue	30	1	Phosphotyrosine
	Modified residue	228	1	Phosphothreonine By similarity
	Modified residue	319	1	Phosphotyrosine
	Modified residue	334	1	Phosphoserine
	Modified residue	423	1	Phosphoserine
	Modified residue	424	1	Phosphoserine
	Modified residue	426	1	Phosphothreonine
Natural variations
	Alternative sequence	21	1	Missing in isoform 2.		VSP_022202
Experimental info
	Sequence conflict	271	1	V → I in AAB31337. Ref.1
	Sequence conflict	289	1	L → K in AAB31337. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 10, 2005. Version 2. Checksum: 946A08C54B7124FF	FASTA	437	50,680
	10 20 30 40 50 60 MSVSARSAAA EERSVNSSTM VAQQKNLEGY VGFANLPNQV YRKSVKRGFE FTLMVVGESG 70 80 90 100 110 120 LGKSTLINSL FLTDLYSPEY PGPSHRIKKT VQVEQSKVLI KEGGVQLLLT IVDTPGFGDA 130 140 150 160 170 180 VDNSNCWQPV IDYIDSKFED YLNAESRVNR RQMPDNRVQC CLYFIAPSGH GLKPLDIEFM 190 200 210 220 230 240 KRLHEKVNII PLIAKADTLT PEECQQFKKQ IMKEIQEHKI KIYEFPETDD EEENKLVKKI 250 260 270 280 290 300 KDRLPLAVVG SNTIIEVNGK RVRGRQYPWG VAEVENGEHC DFTILRNMLI RTHMQDLKDV 310 320 330 340 350 360 TNNVHYENYR SRKLAAVTYN GVDNNKNKGQ LTKSPLAQME EERREHVAKM KKMEMEMEQV 370 380 390 400 410 420 FEMKVKEKVQ KLKDSEAELQ RRHEQMKKNL EAQHKELEEK RRQFEDEKAN WEAQQRILEQ 430 QNSSRTLEKN KKKGKIF
	Isoform 2 [UniParc]. Checksum: 803345D98374253B		436	50,581
	10 20 30 40 50 60 MSVSARSAAA EERSVNSSTM AQQKNLEGYV GFANLPNQVY RKSVKRGFEF TLMVVGESGL 70 80 90 100 110 120 GKSTLINSLF LTDLYSPEYP GPSHRIKKTV QVEQSKVLIK EGGVQLLLTI VDTPGFGDAV 130 140 150 160 170 180 DNSNCWQPVI DYIDSKFEDY LNAESRVNRR QMPDNRVQCC LYFIAPSGHG LKPLDIEFMK 190 200 210 220 230 240 RLHEKVNIIP LIAKADTLTP EECQQFKKQI MKEIQEHKIK IYEFPETDDE EENKLVKKIK 250 260 270 280 290 300 DRLPLAVVGS NTIIEVNGKR VRGRQYPWGV AEVENGEHCD FTILRNMLIR THMQDLKDVT 310 320 330 340 350 360 NNVHYENYRS RKLAAVTYNG VDNNKNKGQL TKSPLAQMEE ERREHVAKMK KMEMEMEQVF 370 380 390 400 410 420 EMKVKEKVQK LKDSEAELQR RHEQMKKNLE AQHKELEEKR RQFEDEKANW EAQQRILEQQ 430 NSSRTLEKNK KKGKIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae." Nakatsuru S., Sudo K., Nakamura Y. Biochem. Biophys. Res. Commun. 202:82-87(1994) [PubMed: 8037772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-437 (ISOFORM 1). Tissue: Fetal lung.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-437 (ISOFORMS 1 AND 2). Tissue: Brain and Uterus.
[3]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-319, MASS SPECTROMETRY.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, MASS SPECTROMETRY.
[6]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND THR-426, MASS SPECTROMETRY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-424 AND THR-426, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

S72008 mRNA. Translation: AAB31337.1. Different initiation.
BC067264 mRNA. Translation: AAH67264.2. Different initiation.
BC093640 mRNA. Translation: AAH93640.2. Different initiation.
BC093642 mRNA. Translation: AAH93642.2. Different initiation.

PIR

JC2352.

RefSeq

NP_001779.3.

UniGene

Hs.191346

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2QAG	X-ray	4.00	C	20-437	[»]

ModBase

Search...

PTM databases

PhosphoSite

Q16181.

2-D gel databases

OGP

Q16181.

Genome annotation databases

Ensembl

ENSG00000122545. Homo sapiens. [Contig view]

GeneID

989.

Organism-specific databases

HGNC

HGNC:1717. SEPT7.

MIM

603151. gene.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q16181.

HOVERGEN

Q16181.

Gene expression databases

ArrayExpress

Q16181.

CleanEx

HS_SEPT7.

GermOnline

ENSG00000122545. Homo sapiens.

Family and domain databases

InterPro

IPR000038. Cell_Div_GTP_bd.
IPR016491. Septin.
IPR008115. Septin7.
[Graphical view]

PANTHER

PTHR18884. Cell_Div_GTP_bd. 1 hit.

Pfam

PF00735. Septin. 1 hit.
[Graphical view]

PIRSF

PIRSF006698. Septin. 1 hit.

PRINTS

PR01742. SEPTIN7.

ProDom

PD002565. GTP_Cell_Div. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Other Resources

LinkHub

Q16181.

NextBio

4150.

SOURCE

Search...

Entry information

Entry name

SEPT7_HUMAN

Accession

Primary (citable) accession number: Q16181
Secondary accession number(s): Q52M76, Q6NX50

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 10, 2005
Last modified:	November 25, 2008
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)