Reviewed,
UniProtKB/Swiss-Prot Q16181 (SEPT7_HUMAN)
Last modified
June 16, 2009.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Septin-7 Alternative name(s): CDC10 protein homolog | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 437 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Ref.7 |
| Subunit structure | Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7. Ref.7 Ref.10 |
| Subcellular location | Cytoplasm. Kinetochore. Spindle. Note: Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Ref.7 |
| Sequence similarities | Belongs to the septin family. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q16181-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q16181-2) The sequence of this isoform differs from the canonical sequence as follows: 21-21: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 437 | 437 | Septin-7 | PRO_0000173528 | |||||
Regions | |||||||||
| Nucleotide binding | 57 – 64 | 8 | GTP | ||||||
| Nucleotide binding | 197 – 203 | 7 | GTP By similarity | ||||||
| Coiled coil | 332 – 437 | 106 | Potential | ||||||
Sites | |||||||||
| Binding site | 250 | 1 | GTP; via amide nitrogen and carbonyl oxygen | ||||||
| Binding site | 267 | 1 | GTP | ||||||
Amino acid modifications | |||||||||
| Modified residue | 30 | 1 | Phosphotyrosine Ref.5 | ||||||
| Modified residue | 228 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 319 | 1 | Phosphotyrosine Ref.3 | ||||||
| Modified residue | 334 | 1 | Phosphoserine Ref.4 Ref.8 | ||||||
| Modified residue | 423 | 1 | Phosphoserine Ref.6 | ||||||
| Modified residue | 424 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 426 | 1 | Phosphothreonine Ref.8 Ref.6 | ||||||
Natural variations | |||||||||
| Alternative sequence | 21 | 1 | Missing in isoform 2. | VSP_022202 | |||||
Experimental info | |||||||||
| Sequence conflict | 271 | 1 | V → I in AAB31337. Ref.1 | ||||||
| Sequence conflict | 289 | 1 | L → K in AAB31337. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae." Nakatsuru S., Sudo K., Nakamura Y. Biochem. Biophys. Res. Commun. 202:82-87(1994) [PubMed: 8037772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-437 (ISOFORM 1). Tissue: Fetal lung. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-437 (ISOFORMS 1 AND 2). Tissue: Brain and Uterus. |
| [3] | "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-319, MASS SPECTROMETRY. |
| [4] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, MASS SPECTROMETRY. Tissue: Epithelium. |
| [5] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, MASS SPECTROMETRY. |
| [6] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND THR-426, MASS SPECTROMETRY. |
| [7] | "Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization." Zhu M., Wang F., Yan F., Yao P.Y., Du J., Gao X., Wang X., Wu Q., Ward T., Li J., Kioko S., Hu R., Xie W., Ding X., Yao X. J. Biol. Chem. 283:18916-18925(2008) [PubMed: 18460473] [Abstract] Cited for: INTERACTION WITH CENPE, SUBCELLULAR LOCATION, FUNCTION. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-424 AND THR-426, MASS SPECTROMETRY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [10] | "Structural insight into filament formation by mammalian septins." Sirajuddin M., Farkasovsky M., Hauer F., Kuehlmann D., Macara I.G., Weyand M., Stark H., Wittinghofer A. Nature 449:311-315(2007) [PubMed: 17637674] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 20-437 IN COMPLEX WITH GDP, SUBUNIT. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S72008 mRNA. Translation: AAB31337.1. Different initiation. BC067264 mRNA. Translation: AAH67264.2. Different initiation. BC093640 mRNA. Translation: AAH93640.2. Different initiation. BC093642 mRNA. Translation: AAH93642.2. Different initiation. | |||||||||||||
| IPI | IPI00033025. IPI00816201. | ||||||||||||
| PIR | JC2352. | ||||||||||||
| RefSeq | NP_001779.3. | ||||||||||||
| UniGene | Hs.191346 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q16181. 1 interaction. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q16181. | ||||||||||||
2-D gel databases | |||||||||||||
| OGP | Q16181. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q16181. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000122545. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 989. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC07P035807. | ||||||||||||
| HGNC | HGNC:1717. SEPT7. | ||||||||||||
| MIM | 603151. gene. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | Q16181. | ||||||||||||
| HOVERGEN | Q16181. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q16181. | ||||||||||||
| Bgee | Q16181. | ||||||||||||
| CleanEx | HS_SEPT7. | ||||||||||||
| GermOnline | ENSG00000122545. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR000038. Cell_Div_GTP_bd. IPR016491. Septin. IPR008115. Septin7. [Graphical view] | ||||||||||||
| PANTHER | PTHR18884. Cell_Div_GTP_bd. 1 hit. | ||||||||||||
| Pfam | PF00735. Septin. 1 hit. [Graphical view] | ||||||||||||
| PIRSF | PIRSF006698. Septin. 1 hit. | ||||||||||||
| PRINTS | PR01742. SEPTIN7. | ||||||||||||
| ProDom | PD002565. GTP_Cell_Div. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 4150. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | SEPT7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16181 Secondary accession number(s): Q52M76, Q6NX50 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


