Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q16143 (SYUB_HUMAN)

Last modified January 19, 2010. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Beta-synuclein
Gene names
Name: SNCB
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length134 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

Post-translational modification

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. Ref.7

Involvement in disease

Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.

Sequence similarities

Belongs to the synuclein family.

Hide | Top

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Molecular functionphospholipase inhibitor activity Ref.2

Traceable author statement. Source: ProtInc

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 134134Beta-synuclein
PRO_0000184035

Regions

Repeat20 – 30111
Repeat31 – 41112
Repeat42 – 56153; approximate
Repeat57 – 67114
Region20 – 67484 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)

Amino acid modifications

Modified residue1181Phosphoserine; by BARK1, CK2 and GRK5

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q16143-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5BCA9FCA615AC4EF

FASTA13414,288
        10         20         30         40         50         60 
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK 

        70         80         90        100        110        120 
EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE 

       130 
DPPQEEYQEY EPEA

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Identification of two distinct synucleins from human brain."
Jakes R., Spillantini M.G., Goedert M.
FEBS Lett. 345:27-32(1994) [PubMed: 8194594] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Brain.
[2]"Genomic organization and expression of the human beta-synuclein gene (SNCB)."
Lavedan C., Leroy E., Torres R., Dehejia A., Dutra A., Buchholtz S., Nussbaum R.L., Polymeropoulos M.H.
Genomics 54:173-175(1998) [PubMed: 9806846] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]Lubec G., Chen W.-Q., Sun Y.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 46-85, MASS SPECTROMETRY.
Tissue: Fetal brain cortex.
[7]"Synucleins are a novel class of substrates for G protein-coupled receptor kinases."
Pronin A.N., Morris A.J., Surguchov A., Benovic J.L.
J. Biol. Chem. 275:26515-26522(2000) [PubMed: 10852916] [Abstract]
Cited for: PHOSPHORYLATION.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S69965 mRNA. Translation: AAB30860.1.
AF053136, AF053134, AF053135 Genomic DNA. Translation: AAC80286.1.
BT006627 mRNA. Translation: AAP35273.1.
CR457027 mRNA. Translation: CAG33308.1.
BC002902 mRNA. Translation: AAH02902.1.
IPIIPI00032904.
PIRS44430.
RefSeqNP_001001502.1.
NP_003076.1.
UniGeneHs.90297

3D structure databases

SMRQ16143. Positions 1-134.
ModBaseSearch...

Protein-protein interaction databases

IntActQ16143. 1 interaction.
STRINGQ16143.

PTM databases

PhosphoSiteQ16143.

Proteomic databases

PRIDEQ16143.

Genome annotation databases

EnsemblENST00000310112; ENSP00000308057; ENSG00000074317; Homo sapiens. [Genome view]
ENST00000393693; ENSP00000377296; ENSG00000074317; Homo sapiens. [Genome view]
GeneID6620.
KEGGhsa:6620.
UCSCuc003mep.1. human.

Organism-specific databases

CTD6620.
GeneCardsGC05M175979.
H-InvDBHIX0005445.
HGNCHGNC:11140. SNCB.
HPACAB002681.
MIM602569. gene.
Orphanet1648. Lewy body dementia.
PharmGKBPA35988.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20519.
HOGENOMHBG715579.
HOVERGENQ16143.
InParanoidQ16143.
OMAKEEFPAD.
OrthoDBEOG9ZPHF6.
PhylomeDBQ16143.

Gene expression databases

ArrayExpressQ16143.
BgeeQ16143.
CleanExHS_SNCB.
GenevestigatorQ16143.
GermOnlineENSG00000074317. Homo sapiens.

Family and domain databases

InterProIPR001058. Synuclein.
IPR002461. Synuclein_beta.
[Graphical view]
Gene3DG3DSA:1.10.287.700. Synuclein. 1 hit.
PANTHERPTHR13820. Synuclein. 1 hit.
PTHR13820:SF4. Synuclein_beta. 1 hit.
PfamPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetSearch...

Other Resources

NextBio25779.
SOURCESearch...

Hide | Top

Entry information

Entry nameSYUB_HUMAN
AccessionPrimary (citable) accession number: Q16143
Secondary accession number(s): Q6IAX7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 19, 2010
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents