Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q16143

- SYUB_HUMAN

UniProt

Q16143 - SYUB_HUMAN

Protein

Beta-synuclein

Gene

SNCB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. phospholipase inhibitor activity Source: ProtInc

    GO - Biological processi

    1. dopamine metabolic process Source: Ensembl
    2. negative regulation of catalytic activity Source: GOC
    3. negative regulation of neuron apoptotic process Source: Ensembl
    4. synapse organization Source: Ensembl
    5. synaptic transmission Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-synuclein
    Gene namesi
    Name:SNCB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:11140. SNCB.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. Golgi apparatus Source: HPA
    3. growth cone Source: Ensembl
    4. mitochondrion Source: Ensembl
    5. neuronal cell body Source: Ensembl
    6. nucleus Source: HPA
    7. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti1648. Dementia with Lewy body.
    PharmGKBiPA35988.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 134134Beta-synucleinPRO_0000184035Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei118 – 1181Phosphoserine; by BARK1, CK2 and GRK51 Publication

    Post-translational modificationi

    Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ16143.
    PRIDEiQ16143.

    PTM databases

    PhosphoSiteiQ16143.

    Expressioni

    Tissue specificityi

    Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

    Gene expression databases

    ArrayExpressiQ16143.
    BgeeiQ16143.
    CleanExiHS_SNCB.
    GenevestigatoriQ16143.

    Organism-specific databases

    HPAiCAB002681.
    HPA035876.

    Interactioni

    Protein-protein interaction databases

    BioGridi112504. 12 interactions.
    IntActiQ16143. 2 interactions.
    MINTiMINT-1407095.
    STRINGi9606.ENSP00000308057.

    Structurei

    3D structure databases

    DisProtiDP00555.
    ProteinModelPortaliQ16143.
    SMRiQ16143. Positions 1-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati20 – 30111Add
    BLAST
    Repeati31 – 41112Add
    BLAST
    Repeati42 – 56153; approximateAdd
    BLAST
    Repeati57 – 67114Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 67484 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add
    BLAST

    Sequence similaritiesi

    Belongs to the synuclein family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG39253.
    HOGENOMiHOG000008691.
    HOVERGENiHBG000481.
    InParanoidiQ16143.
    OMAiVEPMVEP.
    OrthoDBiEOG7034KG.
    PhylomeDBiQ16143.
    TreeFamiTF332776.

    Family and domain databases

    Gene3Di1.10.287.700. 1 hit.
    InterProiIPR001058. Synuclein.
    IPR002461. Synuclein_beta.
    [Graphical view]
    PANTHERiPTHR13820. PTHR13820. 1 hit.
    PfamiPF01387. Synuclein. 1 hit.
    [Graphical view]
    PRINTSiPR01213. BSYNUCLEIN.
    PR01211. SYNUCLEIN.

    Sequencei

    Sequence statusi: Complete.

    Q16143-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ    50
    GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ 100
    EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA 134
    Length:134
    Mass (Da):14,288
    Last modified:November 1, 1996 - v1
    Checksum:i5BCA9FCA615AC4EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69965 mRNA. Translation: AAB30860.1.
    AF053136, AF053134, AF053135 Genomic DNA. Translation: AAC80286.1.
    BT006627 mRNA. Translation: AAP35273.1.
    CR457027 mRNA. Translation: CAG33308.1.
    BC002902 mRNA. Translation: AAH02902.1.
    CCDSiCCDS4406.1.
    PIRiS44430.
    RefSeqiNP_001001502.1. NM_001001502.1.
    NP_003076.1. NM_003085.3.
    XP_006714979.1. XM_006714916.1.
    UniGeneiHs.90297.

    Genome annotation databases

    EnsembliENST00000310112; ENSP00000308057; ENSG00000074317.
    ENST00000393693; ENSP00000377296; ENSG00000074317.
    ENST00000506696; ENSP00000422223; ENSG00000074317.
    ENST00000510387; ENSP00000424073; ENSG00000074317.
    GeneIDi6620.
    KEGGihsa:6620.
    UCSCiuc003mep.3. human.

    Polymorphism databases

    DMDMi2501105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69965 mRNA. Translation: AAB30860.1 .
    AF053136 , AF053134 , AF053135 Genomic DNA. Translation: AAC80286.1 .
    BT006627 mRNA. Translation: AAP35273.1 .
    CR457027 mRNA. Translation: CAG33308.1 .
    BC002902 mRNA. Translation: AAH02902.1 .
    CCDSi CCDS4406.1.
    PIRi S44430.
    RefSeqi NP_001001502.1. NM_001001502.1.
    NP_003076.1. NM_003085.3.
    XP_006714979.1. XM_006714916.1.
    UniGenei Hs.90297.

    3D structure databases

    DisProti DP00555.
    ProteinModelPortali Q16143.
    SMRi Q16143. Positions 1-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112504. 12 interactions.
    IntActi Q16143. 2 interactions.
    MINTi MINT-1407095.
    STRINGi 9606.ENSP00000308057.

    PTM databases

    PhosphoSitei Q16143.

    Polymorphism databases

    DMDMi 2501105.

    Proteomic databases

    PaxDbi Q16143.
    PRIDEi Q16143.

    Protocols and materials databases

    DNASUi 6620.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310112 ; ENSP00000308057 ; ENSG00000074317 .
    ENST00000393693 ; ENSP00000377296 ; ENSG00000074317 .
    ENST00000506696 ; ENSP00000422223 ; ENSG00000074317 .
    ENST00000510387 ; ENSP00000424073 ; ENSG00000074317 .
    GeneIDi 6620.
    KEGGi hsa:6620.
    UCSCi uc003mep.3. human.

    Organism-specific databases

    CTDi 6620.
    GeneCardsi GC05M176047.
    HGNCi HGNC:11140. SNCB.
    HPAi CAB002681.
    HPA035876.
    MIMi 602569. gene.
    neXtProti NX_Q16143.
    Orphaneti 1648. Dementia with Lewy body.
    PharmGKBi PA35988.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39253.
    HOGENOMi HOG000008691.
    HOVERGENi HBG000481.
    InParanoidi Q16143.
    OMAi VEPMVEP.
    OrthoDBi EOG7034KG.
    PhylomeDBi Q16143.
    TreeFami TF332776.

    Miscellaneous databases

    ChiTaRSi SNCB. human.
    GeneWikii Beta-synuclein.
    GenomeRNAii 6620.
    NextBioi 25779.
    PROi Q16143.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16143.
    Bgeei Q16143.
    CleanExi HS_SNCB.
    Genevestigatori Q16143.

    Family and domain databases

    Gene3Di 1.10.287.700. 1 hit.
    InterProi IPR001058. Synuclein.
    IPR002461. Synuclein_beta.
    [Graphical view ]
    PANTHERi PTHR13820. PTHR13820. 1 hit.
    Pfami PF01387. Synuclein. 1 hit.
    [Graphical view ]
    PRINTSi PR01213. BSYNUCLEIN.
    PR01211. SYNUCLEIN.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two distinct synucleins from human brain."
      Jakes R., Spillantini M.G., Goedert M.
      FEBS Lett. 345:27-32(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Brain.
    2. "Genomic organization and expression of the human beta-synuclein gene (SNCB)."
      Lavedan C., Leroy E., Torres R., Dehejia A., Dutra A., Buchholtz S., Nussbaum R.L., Polymeropoulos M.H.
      Genomics 54:173-175(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. Lubec G., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 46-85, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Fetal brain cortex.
    7. "Synucleins are a novel class of substrates for G protein-coupled receptor kinases."
      Pronin A.N., Morris A.J., Surguchov A., Benovic J.L.
      J. Biol. Chem. 275:26515-26522(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.

    Entry informationi

    Entry nameiSYUB_HUMAN
    AccessioniPrimary (citable) accession number: Q16143
    Secondary accession number(s): Q6IAX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3