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Protein

Beta-synuclein

Gene

SNCB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • cuprous ion binding Source: CAFA
  • phospholipase inhibitor activity Source: ProtInc
  • transition metal ion binding Source: CAFA

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5660489. MTF1 activates gene expression.
SIGNORiQ16143.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-synuclein
Gene namesi
Name:SNCB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000074317.10.
HGNCiHGNC:11140. SNCB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6620.
MalaCardsiSNCB.
OpenTargetsiENSG00000074317.
Orphaneti1648. Dementia with Lewy body.
PharmGKBiPA35988.

Polymorphism and mutation databases

BioMutaiSNCB.
DMDMi2501105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840351 – 134Beta-synucleinAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118Phosphoserine; by BARK1, CK2 and GRK51 Publication1

Post-translational modificationi

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16143.
MaxQBiQ16143.
PaxDbiQ16143.
PeptideAtlasiQ16143.
PRIDEiQ16143.

PTM databases

iPTMnetiQ16143.
PhosphoSitePlusiQ16143.

Expressioni

Tissue specificityi

Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

Gene expression databases

BgeeiENSG00000074317.
CleanExiHS_SNCB.
ExpressionAtlasiQ16143. baseline and differential.
GenevisibleiQ16143. HS.

Organism-specific databases

HPAiCAB002681.
HPA035876.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MORN4Q8NDC44EBI-727106,EBI-10269566

Protein-protein interaction databases

BioGridi112504. 17 interactors.
IntActiQ16143. 4 interactors.
MINTiMINT-1407095.
STRINGi9606.ENSP00000308057.

Structurei

3D structure databases

DisProtiDP00555.
ProteinModelPortaliQ16143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZ8U. Eukaryota.
ENOG4111Y4R. LUCA.
GeneTreeiENSGT00390000016161.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ16143.
OMAiDPEGETY.
OrthoDBiEOG091G11PA.
PhylomeDBiQ16143.
TreeFamiTF332776.

Family and domain databases

InterProiView protein in InterPro
IPR001058. Synuclein.
IPR002461. Synuclein_beta.
PANTHERiPTHR13820. PTHR13820. 1 hit.
PTHR13820:SF13. PTHR13820:SF13. 1 hit.
PfamiView protein in Pfam
PF01387. Synuclein. 1 hit.
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

Q16143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ
60 70 80 90 100
GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ
110 120 130
EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
Length:134
Mass (Da):14,288
Last modified:November 1, 1996 - v1
Checksum:i5BCA9FCA615AC4EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69965 mRNA. Translation: AAB30860.1.
AF053136, AF053134, AF053135 Genomic DNA. Translation: AAC80286.1.
BT006627 mRNA. Translation: AAP35273.1.
CR457027 mRNA. Translation: CAG33308.1.
BC002902 mRNA. Translation: AAH02902.1.
CCDSiCCDS4406.1.
PIRiS44430.
RefSeqiNP_001001502.1. NM_001001502.2.
NP_003076.1. NM_003085.4.
XP_006714979.1. XM_006714916.2.
UniGeneiHs.90297.

Genome annotation databases

EnsembliENST00000310112; ENSP00000308057; ENSG00000074317.
ENST00000393693; ENSP00000377296; ENSG00000074317.
ENST00000506696; ENSP00000422223; ENSG00000074317.
ENST00000510387; ENSP00000424073; ENSG00000074317.
GeneIDi6620.
KEGGihsa:6620.
UCSCiuc003mep.4. human.

Similar proteinsi

Entry informationi

Entry nameiSYUB_HUMAN
AccessioniPrimary (citable) accession number: Q16143
Secondary accession number(s): Q6IAX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families