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Protein

Beta-synuclein

Gene

SNCB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. phospholipase inhibitor activity Source: ProtInc

GO - Biological processi

  1. dopamine metabolic process Source: Ensembl
  2. negative regulation of catalytic activity Source: GOC
  3. negative regulation of neuron apoptotic process Source: Ensembl
  4. synapse organization Source: Ensembl
  5. synaptic transmission Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-synuclein
Gene namesi
Name:SNCB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:11140. SNCB.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. Golgi apparatus Source: HPA
  3. growth cone Source: Ensembl
  4. inclusion body Source: ParkinsonsUK-UCL
  5. mitochondrion Source: Ensembl
  6. neuronal cell body Source: Ensembl
  7. nucleoplasm Source: HPA
  8. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

Orphaneti1648. Dementia with Lewy body.
PharmGKBiPA35988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Beta-synucleinPRO_0000184035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181Phosphoserine; by BARK1, CK2 and GRK51 Publication

Post-translational modificationi

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ16143.
PRIDEiQ16143.

PTM databases

PhosphoSiteiQ16143.

Expressioni

Tissue specificityi

Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

Gene expression databases

BgeeiQ16143.
CleanExiHS_SNCB.
ExpressionAtlasiQ16143. baseline and differential.
GenevestigatoriQ16143.

Organism-specific databases

HPAiCAB002681.
HPA035876.

Interactioni

Protein-protein interaction databases

BioGridi112504. 16 interactions.
IntActiQ16143. 2 interactions.
MINTiMINT-1407095.
STRINGi9606.ENSP00000308057.

Structurei

3D structure databases

DisProtiDP00555.
ProteinModelPortaliQ16143.
SMRiQ16143. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 30111Add
BLAST
Repeati31 – 41112Add
BLAST
Repeati42 – 56153; approximateAdd
BLAST
Repeati57 – 67114Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 67484 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add
BLAST

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG39253.
GeneTreeiENSGT00390000016161.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ16143.
OMAiDSPQEEY.
OrthoDBiEOG7034KG.
PhylomeDBiQ16143.
TreeFamiTF332776.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002461. Synuclein_beta.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

Q16143-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ
60 70 80 90 100
GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ
110 120 130
EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
Length:134
Mass (Da):14,288
Last modified:November 1, 1996 - v1
Checksum:i5BCA9FCA615AC4EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69965 mRNA. Translation: AAB30860.1.
AF053136, AF053134, AF053135 Genomic DNA. Translation: AAC80286.1.
BT006627 mRNA. Translation: AAP35273.1.
CR457027 mRNA. Translation: CAG33308.1.
BC002902 mRNA. Translation: AAH02902.1.
CCDSiCCDS4406.1.
PIRiS44430.
RefSeqiNP_001001502.1. NM_001001502.1.
NP_003076.1. NM_003085.3.
XP_006714979.1. XM_006714916.1.
UniGeneiHs.90297.

Genome annotation databases

EnsembliENST00000310112; ENSP00000308057; ENSG00000074317.
ENST00000393693; ENSP00000377296; ENSG00000074317.
ENST00000506696; ENSP00000422223; ENSG00000074317.
ENST00000510387; ENSP00000424073; ENSG00000074317.
GeneIDi6620.
KEGGihsa:6620.
UCSCiuc003mep.3. human.

Polymorphism databases

DMDMi2501105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69965 mRNA. Translation: AAB30860.1.
AF053136, AF053134, AF053135 Genomic DNA. Translation: AAC80286.1.
BT006627 mRNA. Translation: AAP35273.1.
CR457027 mRNA. Translation: CAG33308.1.
BC002902 mRNA. Translation: AAH02902.1.
CCDSiCCDS4406.1.
PIRiS44430.
RefSeqiNP_001001502.1. NM_001001502.1.
NP_003076.1. NM_003085.3.
XP_006714979.1. XM_006714916.1.
UniGeneiHs.90297.

3D structure databases

DisProtiDP00555.
ProteinModelPortaliQ16143.
SMRiQ16143. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112504. 16 interactions.
IntActiQ16143. 2 interactions.
MINTiMINT-1407095.
STRINGi9606.ENSP00000308057.

PTM databases

PhosphoSiteiQ16143.

Polymorphism databases

DMDMi2501105.

Proteomic databases

PaxDbiQ16143.
PRIDEiQ16143.

Protocols and materials databases

DNASUi6620.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310112; ENSP00000308057; ENSG00000074317.
ENST00000393693; ENSP00000377296; ENSG00000074317.
ENST00000506696; ENSP00000422223; ENSG00000074317.
ENST00000510387; ENSP00000424073; ENSG00000074317.
GeneIDi6620.
KEGGihsa:6620.
UCSCiuc003mep.3. human.

Organism-specific databases

CTDi6620.
GeneCardsiGC05M176047.
HGNCiHGNC:11140. SNCB.
HPAiCAB002681.
HPA035876.
MIMi602569. gene.
neXtProtiNX_Q16143.
Orphaneti1648. Dementia with Lewy body.
PharmGKBiPA35988.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39253.
GeneTreeiENSGT00390000016161.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ16143.
OMAiDSPQEEY.
OrthoDBiEOG7034KG.
PhylomeDBiQ16143.
TreeFamiTF332776.

Miscellaneous databases

ChiTaRSiSNCB. human.
GeneWikiiBeta-synuclein.
GenomeRNAii6620.
NextBioi25779.
PROiQ16143.
SOURCEiSearch...

Gene expression databases

BgeeiQ16143.
CleanExiHS_SNCB.
ExpressionAtlasiQ16143. baseline and differential.
GenevestigatoriQ16143.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002461. Synuclein_beta.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two distinct synucleins from human brain."
    Jakes R., Spillantini M.G., Goedert M.
    FEBS Lett. 345:27-32(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Brain.
  2. "Genomic organization and expression of the human beta-synuclein gene (SNCB)."
    Lavedan C., Leroy E., Torres R., Dehejia A., Dutra A., Buchholtz S., Nussbaum R.L., Polymeropoulos M.H.
    Genomics 54:173-175(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 46-85, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  7. "Synucleins are a novel class of substrates for G protein-coupled receptor kinases."
    Pronin A.N., Morris A.J., Surguchov A., Benovic J.L.
    J. Biol. Chem. 275:26515-26522(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.

Entry informationi

Entry nameiSYUB_HUMAN
AccessioniPrimary (citable) accession number: Q16143
Secondary accession number(s): Q6IAX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.