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Q16134

- ETFD_HUMAN

UniProt

Q16134 - ETFD_HUMAN

Protein

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Gene

ETFDH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Accepts electrons from ETF and reduces ubiquinone.

    Catalytic activityi

    Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.

    Cofactori

    Binds 1 4Fe-4S cluster.
    FAD.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei305 – 3051Ubiquinone; via carbonyl oxygenBy similarity
    Binding sitei306 – 3061Ubiquinone; via amide nitrogenBy similarity
    Metal bindingi561 – 5611Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi586 – 5861Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi589 – 5891Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi592 – 5921Iron-sulfur (4Fe-4S)Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 8515FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB
    2. electron carrier activity Source: UniProtKB
    3. electron-transferring-flavoprotein dehydrogenase activity Source: UniProtKB
    4. flavin adenine dinucleotide binding Source: UniProtKB
    5. metal ion binding Source: UniProtKB-KW
    6. oxidoreductase activity Source: UniProtKB
    7. oxidoreductase activity, oxidizing metal ions with flavin as acceptor Source: UniProtKB
    8. quinone binding Source: UniProtKB
    9. ubiquinone binding Source: UniProtKB

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. electron transport chain Source: UniProtKB
    3. fatty acid beta-oxidation using acyl-CoA dehydrogenase Source: BHF-UCL
    4. respiratory electron transport chain Source: Reactome
    5. response to oxidative stress Source: UniProtKB
    6. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Ubiquinone

    Enzyme and pathway databases

    BioCyciMetaCyc:HS10326-MONOMER.
    BRENDAi1.5.5.1. 2681.
    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (EC:1.5.5.1)
    Short name:
    ETF-QO
    Short name:
    ETF-ubiquinone oxidoreductase
    Alternative name(s):
    Electron-transferring-flavoprotein dehydrogenase
    Short name:
    ETF dehydrogenase
    Gene namesi
    Name:ETFDH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:3483. ETFDH.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial matrix Source: Reactome
    3. mitochondrial membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Involvement in diseasei

    Glutaric aciduria 2C (GA2C) [MIM:231680]: An autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Glutaricaciduria

    Organism-specific databases

    MIMi231680. phenotype.
    Orphaneti394532. Multiple acyl-CoA dehydrogenation deficiency, mild type.
    394529. Multiple acyl-CoA dehydrogenation deficiency, severe neonatal type.
    PharmGKBiPA27899.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
    BLAST
    Chaini34 – 617584Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialPRO_0000008661Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei96 – 961N6-acetyllysineBy similarity
    Modified residuei132 – 1321N6-acetyllysineBy similarity
    Modified residuei223 – 2231N6-acetyllysineBy similarity
    Modified residuei357 – 3571N6-acetyllysineBy similarity
    Modified residuei551 – 5511PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ16134.
    PaxDbiQ16134.
    PRIDEiQ16134.

    PTM databases

    PhosphoSiteiQ16134.

    Expressioni

    Gene expression databases

    ArrayExpressiQ16134.
    BgeeiQ16134.
    CleanExiHS_ETFDH.
    GenevestigatoriQ16134.

    Organism-specific databases

    HPAiHPA041978.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi108411. 3 interactions.
    IntActiQ16134. 1 interaction.
    STRINGi9606.ENSP00000303552.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16134.
    SMRiQ16134. Positions 39-617.
    ModBaseiSearch...
    MobiDBiSearch...

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei109 – 13022By similarityAdd
    BLAST
    Intramembranei428 – 44720By similarityAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini577 – 606304Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETF-QO/FixC family.Curated
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0644.
    HOGENOMiHOG000259450.
    HOVERGENiHBG005615.
    InParanoidiQ16134.
    KOiK00311.
    OMAiEKDIRVC.
    OrthoDBiEOG7WX07W.
    PhylomeDBiQ16134.
    TreeFamiTF105687.

    Family and domain databases

    InterProiIPR017896. 4Fe4S_Fe-S-bd.
    IPR007859. ETFD_OxRdtase.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    [Graphical view]
    PfamiPF05187. ETF_QO. 1 hit.
    [Graphical view]
    PRINTSiPR00469. PNDRDTASEII.
    PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16134-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLVPLAKLSC LAYQCFHALK IKKNYLPLCA TRWSSTSTVP RITTHYTIYP    50
    RDKDKRWEGV NMERFAEEAD VVIVGAGPAG LSAAVRLKQL AVAHEKDIRV 100
    CLVEKAAQIG AHTLSGACLD PGAFKELFPD WKEKGAPLNT PVTEDRFGIL 150
    TEKYRIPVPI LPGLPMNNHG NYIVRLGHLV SWMGEQAEAL GVEVYPGYAA 200
    AEVLFHDDGS VKGIATNDVG IQKDGAPKAT FERGLELHAK VTIFAEGCHG 250
    HLAKQLYKKF DLRANCEPQT YGIGLKELWV IDEKNWKPGR VDHTVGWPLD 300
    RHTYGGSFLY HLNEGEPLVA LGLVVGLDYQ NPYLSPFREF QRWKHHPSIR 350
    PTLEGGKRIA YGARALNEGG FQSIPKLTFP GGLLIGCSPG FMNVPKIKGT 400
    HTAMKSGILA AESIFNQLTS ENLQSKTIGL HVTEYEDNLK NSWVWKELYS 450
    VRNIRPSCHG VLGVYGGMIY TGIFYWILRG MEPWTLKHKG SDFERLKPAK 500
    DCTPIEYPKP DGQISFDLLS SVALSGTNHE HDQPAHLTLR DDSIPVNRNL 550
    SIYDGPEQRF CPAGVYEFVP VEQGDGFRLQ INAQNCVHCK TCDIKDPSQN 600
    INWVVPEGGG GPAYNGM 617
    Length:617
    Mass (Da):68,495
    Last modified:March 23, 2010 - v2
    Checksum:i099EBA36C59AF3D6
    GO
    Isoform 2 (identifier: Q16134-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-58: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:570
    Mass (Da):62,825
    Checksum:i9F62F0271FA24BB0
    GO

    Sequence cautioni

    The sequence CAD98030.1 differs from that shown. Reason: Aberrant splicing.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091I → V in CAD98030. (PubMed:17974005)Curated
    Sequence conflicti456 – 4561P → S in BAG65581. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311T → I.3 Publications
    Corresponds to variant rs11559290 [ dbSNP | Ensembl ].
    VAR_062966
    Natural varianti94 – 941H → R.
    Corresponds to variant rs1140065 [ dbSNP | Ensembl ].
    VAR_055711
    Natural varianti565 – 5651V → L in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036134

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei12 – 5847Missing in isoform 2. 1 PublicationVSP_055158Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69232 mRNA. Translation: AAC60628.1.
    AK304838 mRNA. Translation: BAG65581.1.
    BX538129 mRNA. Translation: CAD98030.1. Sequence problems.
    AC107219 Genomic DNA. No translation available.
    BC011890 mRNA. Translation: AAH11890.1.
    CCDSiCCDS3800.1. [Q16134-1]
    CCDS64090.1. [Q16134-3]
    PIRiS41115.
    RefSeqiNP_001268666.1. NM_001281737.1.
    NP_004444.2. NM_004453.3.
    UniGeneiHs.155729.

    Genome annotation databases

    EnsembliENST00000307738; ENSP00000303552; ENSG00000171503. [Q16134-3]
    ENST00000511912; ENSP00000426638; ENSG00000171503. [Q16134-1]
    GeneIDi2110.
    KEGGihsa:2110.
    UCSCiuc003iqb.3. human. [Q16134-1]

    Polymorphism databases

    DMDMi292495008.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69232 mRNA. Translation: AAC60628.1 .
    AK304838 mRNA. Translation: BAG65581.1 .
    BX538129 mRNA. Translation: CAD98030.1 . Sequence problems.
    AC107219 Genomic DNA. No translation available.
    BC011890 mRNA. Translation: AAH11890.1 .
    CCDSi CCDS3800.1. [Q16134-1 ]
    CCDS64090.1. [Q16134-3 ]
    PIRi S41115.
    RefSeqi NP_001268666.1. NM_001281737.1.
    NP_004444.2. NM_004453.3.
    UniGenei Hs.155729.

    3D structure databases

    ProteinModelPortali Q16134.
    SMRi Q16134. Positions 39-617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108411. 3 interactions.
    IntActi Q16134. 1 interaction.
    STRINGi 9606.ENSP00000303552.

    PTM databases

    PhosphoSitei Q16134.

    Polymorphism databases

    DMDMi 292495008.

    Proteomic databases

    MaxQBi Q16134.
    PaxDbi Q16134.
    PRIDEi Q16134.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307738 ; ENSP00000303552 ; ENSG00000171503 . [Q16134-3 ]
    ENST00000511912 ; ENSP00000426638 ; ENSG00000171503 . [Q16134-1 ]
    GeneIDi 2110.
    KEGGi hsa:2110.
    UCSCi uc003iqb.3. human. [Q16134-1 ]

    Organism-specific databases

    CTDi 2110.
    GeneCardsi GC04P159593.
    H-InvDB HIX0200647.
    HGNCi HGNC:3483. ETFDH.
    HPAi HPA041978.
    MIMi 231675. gene.
    231680. phenotype.
    neXtProti NX_Q16134.
    Orphaneti 394532. Multiple acyl-CoA dehydrogenation deficiency, mild type.
    394529. Multiple acyl-CoA dehydrogenation deficiency, severe neonatal type.
    PharmGKBi PA27899.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0644.
    HOGENOMi HOG000259450.
    HOVERGENi HBG005615.
    InParanoidi Q16134.
    KOi K00311.
    OMAi EKDIRVC.
    OrthoDBi EOG7WX07W.
    PhylomeDBi Q16134.
    TreeFami TF105687.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS10326-MONOMER.
    BRENDAi 1.5.5.1. 2681.
    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi ETFDH. human.
    GeneWikii ETFDH.
    GenomeRNAii 2110.
    NextBioi 35477610.
    PROi Q16134.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16134.
    Bgeei Q16134.
    CleanExi HS_ETFDH.
    Genevestigatori Q16134.

    Family and domain databases

    InterProi IPR017896. 4Fe4S_Fe-S-bd.
    IPR007859. ETFD_OxRdtase.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    [Graphical view ]
    Pfami PF05187. ETF_QO. 1 hit.
    [Graphical view ]
    PRINTSi PR00469. PNDRDTASEII.
    PROSITEi PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a cDNA encoding human electron transfer flavoprotein-ubiquinone oxidoreductase."
      Goodman S.I., Axtell K.M., Bindoff L.A., Beard S.E., Gill R.E., Frerman F.E.
      Eur. J. Biochem. 219:277-286(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-31.
      Tissue: Fetal liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-31.
      Tissue: Small intestine.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-31.
      Tissue: Lung.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-565.

    Entry informationi

    Entry nameiETFD_HUMAN
    AccessioniPrimary (citable) accession number: Q16134
    Secondary accession number(s): B4E3R9, J3KND9, Q7Z347
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3