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Q160C2

- FTHS_ROSDO

UniProt

Q160C2 - FTHS_ROSDO

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRDEN375451:GJIZ-3990-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:RD1_4235
    OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
    Taxonomic identifieri375451 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
    ProteomesiUP000007029: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_0000300536Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi375451.RD1_4235.

    Structurei

    3D structure databases

    ProteinModelPortaliQ160C2.
    SMRiQ160C2. Positions 6-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q160C2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYKSDIEIA REAKKRPIQE IGEKIGIGSD DLLPYGHDKA KVSQSFINSV    50
    QDKPNGRLVL VTAINPTPAG EGKTTTTVGL GDGLNHIGKN AMICIREASL 100
    GPNFGMKGGA AGGGYAQVVP MEDMNLHFTG DFHAITSAHS LLSAMIDNHI 150
    YWGNEAEIDV RRVQWRRVVD MNDRALRQIT ASLGGVANGF PREAGFDITV 200
    ASEVMAILCL AKDLKDLEKR LGDMIVAYRR DRSPVFCRDI KAQGAMTVLL 250
    KDAMQPNLVQ TLENNPAFVH GGPFANIAHG CNSVIATTTA LKLADYVVTE 300
    AGFGADLGAE KFMNIKCRKA GIAPSVVVCV ATVRAMKMNG GVAKADLGAE 350
    NVDAVKKGCP NLGRHIENLK SFGVPVIVAI NHFVTDTDAE VEAIKSYVSE 400
    HGAEAVLSRH WELGSEGSAD LARKVVEVAE KDSANFAPIY PDDMPLAEKV 450
    QTIAKRIYRA DEALMDKKVR DQLKLWEEQG YGHLPVCMAK TQYSFSTDPN 500
    LRGAPTGHSV PVREVRLSAG AGFVVVVCGE IMTMPGLPRV PSAENIHLNE 550
    DGQIEGLF 558
    Length:558
    Mass (Da):60,126
    Last modified:July 25, 2006 - v1
    Checksum:i3706CFA79DC30643
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG33671.1.
    RefSeqiWP_011570281.1. NC_008209.1.
    YP_684357.1. NC_008209.1.

    Genome annotation databases

    EnsemblBacteriaiABG33671; ABG33671; RD1_4235.
    GeneIDi4195553.
    KEGGirde:RD1_4235.
    PATRICi23366389. VBIRosDen86677_4059.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG33671.1 .
    RefSeqi WP_011570281.1. NC_008209.1.
    YP_684357.1. NC_008209.1.

    3D structure databases

    ProteinModelPortali Q160C2.
    SMRi Q160C2. Positions 6-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 375451.RD1_4235.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG33671 ; ABG33671 ; RD1_4235 .
    GeneIDi 4195553.
    KEGGi rde:RD1_4235.
    PATRICi 23366389. VBIRosDen86677_4059.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RDEN375451:GJIZ-3990-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33942 / OCh 114.

    Entry informationi

    Entry nameiFTHS_ROSDO
    AccessioniPrimary (citable) accession number: Q160C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3