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Q160C2

- FTHS_ROSDO

UniProt

Q160C2 - FTHS_ROSDO

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, RD1_4235
Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-3990-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:RD1_4235
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000300536Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi375451.RD1_4235.

Structurei

3D structure databases

ProteinModelPortaliQ160C2.
SMRiQ160C2. Positions 6-556.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q160C2-1 [UniParc]FASTAAdd to Basket

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MAYKSDIEIA REAKKRPIQE IGEKIGIGSD DLLPYGHDKA KVSQSFINSV    50
QDKPNGRLVL VTAINPTPAG EGKTTTTVGL GDGLNHIGKN AMICIREASL 100
GPNFGMKGGA AGGGYAQVVP MEDMNLHFTG DFHAITSAHS LLSAMIDNHI 150
YWGNEAEIDV RRVQWRRVVD MNDRALRQIT ASLGGVANGF PREAGFDITV 200
ASEVMAILCL AKDLKDLEKR LGDMIVAYRR DRSPVFCRDI KAQGAMTVLL 250
KDAMQPNLVQ TLENNPAFVH GGPFANIAHG CNSVIATTTA LKLADYVVTE 300
AGFGADLGAE KFMNIKCRKA GIAPSVVVCV ATVRAMKMNG GVAKADLGAE 350
NVDAVKKGCP NLGRHIENLK SFGVPVIVAI NHFVTDTDAE VEAIKSYVSE 400
HGAEAVLSRH WELGSEGSAD LARKVVEVAE KDSANFAPIY PDDMPLAEKV 450
QTIAKRIYRA DEALMDKKVR DQLKLWEEQG YGHLPVCMAK TQYSFSTDPN 500
LRGAPTGHSV PVREVRLSAG AGFVVVVCGE IMTMPGLPRV PSAENIHLNE 550
DGQIEGLF 558
Length:558
Mass (Da):60,126
Last modified:July 25, 2006 - v1
Checksum:i3706CFA79DC30643
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG33671.1.
RefSeqiWP_011570281.1. NC_008209.1.
YP_684357.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG33671; ABG33671; RD1_4235.
GeneIDi4195553.
KEGGirde:RD1_4235.
PATRICi23366389. VBIRosDen86677_4059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000362 Genomic DNA. Translation: ABG33671.1 .
RefSeqi WP_011570281.1. NC_008209.1.
YP_684357.1. NC_008209.1.

3D structure databases

ProteinModelPortali Q160C2.
SMRi Q160C2. Positions 6-556.
ModBasei Search...

Protein-protein interaction databases

STRINGi 375451.RD1_4235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG33671 ; ABG33671 ; RD1_4235 .
GeneIDi 4195553.
KEGGi rde:RD1_4235.
PATRICi 23366389. VBIRosDen86677_4059.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RDEN375451:GJIZ-3990-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114.

Entry informationi

Entry nameiFTHS_ROSDO
AccessioniPrimary (citable) accession number: Q160C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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