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Protein

Glutamate receptor ionotropic, kainate 4

Gene

GRIK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • glutamate receptor signaling pathway Source: ProtInc

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-451308 Activation of Ca-permeable Kainate Receptor

Protein family/group databases

TCDBi1.A.10.1.9 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 4
Short name:
GluK4
Alternative name(s):
Excitatory amino acid receptor 1
Short name:
EAA1
Glutamate receptor KA-1
Short name:
KA1
Gene namesi
Name:GRIK4
Synonyms:GRIK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149403.11
HGNCiHGNC:4582 GRIK4
MIMi600282 gene
neXtProtiNX_Q16099

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 545ExtracellularSequence analysisAdd BLAST525
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 623CytoplasmicSequence analysisAdd BLAST57
Transmembranei624 – 644HelicalSequence analysisAdd BLAST21
Topological domaini645 – 804ExtracellularSequence analysisAdd BLAST160
Transmembranei805 – 825HelicalSequence analysisAdd BLAST21
Topological domaini826 – 956CytoplasmicSequence analysisAdd BLAST131

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2900
OpenTargetsiENSG00000149403
PharmGKBiPA28976

Chemistry databases

ChEMBLiCHEMBL2109241
DrugBankiDB00142 L-Glutamic Acid

Polymorphism and mutation databases

BioMutaiGRIK4
DMDMi209572625

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001154921 – 956Glutamate receptor ionotropic, kainate 4Add BLAST936

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ16099
PeptideAtlasiQ16099
PRIDEiQ16099

PTM databases

iPTMnetiQ16099
PhosphoSitePlusiQ16099

Expressioni

Gene expression databases

BgeeiENSG00000149403
CleanExiHS_GRIK4
GenevisibleiQ16099 HS

Interactioni

Subunit structurei

Forms a heteromeric channel with GRIK1 or GRIK3.

Protein-protein interaction databases

BioGridi109157, 3 interactors
STRINGi9606.ENSP00000404063

Chemistry databases

BindingDBiQ16099

Structurei

3D structure databases

ProteinModelPortaliQ16099
SMRiQ16099
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi862 – 865Poly-Arg4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDI6 Eukaryota
ENOG4110PNJ LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000234371
HOVERGENiHBG051839
InParanoidiQ16099
KOiK05204
OMAiMVACSPH
OrthoDBiEOG091G02LN
PhylomeDBiQ16099
TreeFamiTF334668

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN
60 70 80 90 100
RINRAPERLG KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS
110 120 130 140 150
PASSSIISNI CGEKEVPHFK VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV
160 170 180 190 200
AGILNFFNCT TACLICAKAE CLLNLEKLLR QFLISKDTLS VRMLDDTRDP
210 220 230 240 250
TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY YTYIFTNLEF
260 270 280 290 300
SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG
310 320 330 340 350
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY
360 370 380 390 400
LRMVELEGLT GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM
410 420 430 440 450
DSHLYASNIS DTLFNTTLVV TTILENPYLM LKGNHQEMEG NDRYEGFCVD
460 470 480 490 500
MLKELAEILR FNYKIRLVGD GVYGVPEANG TWTGMVGELI ARKADLAVAG
510 520 530 540 550
LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL DPFSPGVWLF
560 570 580 590 600
MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP
610 620 630 640 650
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD
660 670 680 690 700
VPIESVDDLA DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS
710 720 730 740 750
VFVKSTEEGI ARVLNSNYAF LLESTMNEYY RQRNCNLTQI GGLLDTKGYG
760 770 780 790 800
IGMPVGSVFR DEFDLAILQL QENNRLEILK RKWWEGGKCP KEEDHRAKGL
810 820 830 840 850
GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS VCQEMVTELR
860 870 880 890 900
SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ
910 920 930 940 950
LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT

NSSEPE
Length:956
Mass (Da):107,246
Last modified:October 14, 2008 - v2
Checksum:iB7CBEA402A79397A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255M → T in AAB29311 (PubMed:8263508).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046998528V → I1 PublicationCorresponds to variant dbSNP:rs2230298Ensembl.1
Natural variantiVAR_046999824M → T. Corresponds to variant dbSNP:rs9988907Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67803 mRNA Translation: AAB29311.1
AK292726 mRNA Translation: BAF85415.1
CH471065 Genomic DNA Translation: EAW67512.1
CCDSiCCDS8433.1
PIRiJH0826
RefSeqiNP_001269399.1, NM_001282470.2
NP_055434.2, NM_014619.4
UniGeneiHs.538738
Hs.568901

Genome annotation databases

EnsembliENST00000438375; ENSP00000404063; ENSG00000149403
ENST00000527524; ENSP00000435648; ENSG00000149403
ENST00000638419; ENSP00000492086; ENSG00000149403
GeneIDi2900
KEGGihsa:2900
UCSCiuc001pxn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGRIK4_HUMAN
AccessioniPrimary (citable) accession number: Q16099
Secondary accession number(s): A8K9L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: May 23, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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