Q16099 (GRIK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate receptor ionotropic, kainate 4
Short name=GluK4

Alternative name(s):
Excitatory amino acid receptor 1
Short name=EAA1
Glutamate receptor KA-1
Short name=KA1

Gene names

Name:	GRIK4
Synonyms:	GRIK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	956 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Subunit structure	Forms a heteromeric channel with GRIK1 or GRIK3.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc kainate selective glutamate receptor complex Inferred from electronic annotation. Source: Compara postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell presynaptic membrane Inferred from electronic annotation. Source: Compara
Molecular_function	extracellular-glutamate-gated ion channel activity Inferred from electronic annotation. Source: InterPro kainate selective glutamate receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 956	936	Glutamate receptor ionotropic, kainate 4		PRO_0000011549
Regions
	Topological domain	21 – 545	525	Extracellular Potential
	Transmembrane	546 – 566	21	Helical; Potential
	Topological domain	567 – 623	57	Cytoplasmic Potential
	Transmembrane	624 – 644	21	Helical; Potential
	Topological domain	645 – 804	160	Extracellular Potential
	Transmembrane	805 – 825	21	Helical; Potential
	Topological domain	826 – 956	131	Cytoplasmic Potential
	Compositional bias	862 – 865	4	Poly-Arg
Amino acid modifications
	Glycosylation	158	1	N-linked (GlcNAc...) Potential
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Glycosylation	272	1	N-linked (GlcNAc...) Potential
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Glycosylation	323	1	N-linked (GlcNAc...) Potential
	Glycosylation	408	1	N-linked (GlcNAc...) Potential
	Glycosylation	415	1	N-linked (GlcNAc...) Potential
	Glycosylation	479	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	528	1	V → I. Ref.1 Corresponds to variant rs35599906 [ dbSNP | Ensembl ].		VAR_046998
	Natural variant	824	1	M → T. Corresponds to variant rs9988907 [ dbSNP | Ensembl ].		VAR_046999
Experimental info
	Sequence conflict	255	1	M → T in AAB29311. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q16099 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: B7CBEA402A79397A	FASTA	956	107,246
	10 20 30 40 50 60 MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN RINRAPERLG 70 80 90 100 110 120 KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS PASSSIISNI CGEKEVPHFK 130 140 150 160 170 180 VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV AGILNFFNCT TACLICAKAE CLLNLEKLLR 190 200 210 220 230 240 QFLISKDTLS VRMLDDTRDP TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY 250 260 270 280 290 300 YTYIFTNLEF SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG 310 320 330 340 350 360 PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY LRMVELEGLT 370 380 390 400 410 420 GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM DSHLYASNIS DTLFNTTLVV 430 440 450 460 470 480 TTILENPYLM LKGNHQEMEG NDRYEGFCVD MLKELAEILR FNYKIRLVGD GVYGVPEANG 490 500 510 520 530 540 TWTGMVGELI ARKADLAVAG LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL 550 560 570 580 590 600 DPFSPGVWLF MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 610 620 630 640 650 660 VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD VPIESVDDLA 670 680 690 700 710 720 DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS VFVKSTEEGI ARVLNSNYAF 730 740 750 760 770 780 LLESTMNEYY RQRNCNLTQI GGLLDTKGYG IGMPVGSVFR DEFDLAILQL QENNRLEILK 790 800 810 820 830 840 RKWWEGGKCP KEEDHRAKGL GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS 850 860 870 880 890 900 VCQEMVTELR SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ 910 920 930 940 950 LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT NSSEPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit." Kamboj R.K., Schoepp D.D., Nutt S., Shekter L., Korczak B., True R.A., Rampersad V., Zimmerman D.M., Wosnick M.A. J. Neurochem. 62:1-9(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-528. Tissue: Hippocampus.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S67803 mRNA. Translation: AAB29311.1. AK292726 mRNA. Translation: BAF85415.1. CH471065 Genomic DNA. Translation: EAW67512.1.
IPI	IPI00292269.
PIR	JH0826.
RefSeq	NP_055434.2. NM_014619.2.
UniGene	Hs.568901.
3D structure databases
ProteinModelPortal	Q16099.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000278723.
Protein family/group databases
TCDB	1.A.10.1.9. glutamate-gated ion channel (GIC) family of neurotransmitter receptors.
PTM databases
PhosphoSite	Q16099.
Polymorphism databases
DMDM	209572625.
Proteomic databases
PaxDb	Q16099.
PRIDE	Q16099.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000438375; ENSP00000404063; ENSG00000149403. ENST00000527524; ENSP00000435648; ENSG00000149403.
GeneID	2900.
KEGG	hsa:2900.
UCSC	uc001pxn.2. human.
Organism-specific databases
CTD	2900.
GeneCards	GC11P120480.
H-InvDB	HIX0036043.
HGNC	HGNC:4582. GRIK4.
MIM	600282. gene.
neXtProt	NX_Q16099.
PharmGKB	PA28976.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316680.
HOGENOM	HOG000234371.
HOVERGEN	HBG051839.
InParanoid	Q16099.
KO	K05204.
OMA	NRAPERL.
PhylomeDB	Q16099.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q16099.
CleanEx	HS_GRIK4.
Genevestigator	Q16099.
GermOnline	ENSG00000149403. Homo sapiens.
Family and domain databases
InterPro	IPR001828. ANF_lig-bd_rcpt. IPR019594. Glu_rcpt_Glu/Gly-bd. IPR001320. Iontro_glu_rcpt. IPR001508. NMDA_rcpt. [Graphical view]
Pfam	PF01094. ANF_receptor. 1 hit. PF00060. Lig_chan. 1 hit. PF10613. Lig_chan-Glu_bd. 1 hit. [Graphical view]
PRINTS	PR00177. NMDARECEPTOR.
SMART	SM00918. Lig_chan-Glu_bd. 1 hit. SM00079. PBPe. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q16099.
ChEMBL	CHEMBL2829.
DrugBank	DB00142. L-Glutamic Acid.
GenomeRNAi	2900.
NextBio	11479.
SOURCE	Search...

Entry information

Entry name

GRIK4_HUMAN

Accession

Primary (citable) accession number: Q16099
Secondary accession number(s): A8K9L1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 14, 2008
Last modified:	May 1, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.