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Q16099 (GRIK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate receptor ionotropic, kainate 4

Short name=GluK4
Alternative name(s):
Excitatory amino acid receptor 1
Short name=EAA1
Glutamate receptor KA-1
Short name=KA1
Gene names
Name:GRIK4
Synonyms:GRIK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length956 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Subunit structure

Forms a heteromeric channel with GRIK1 or GRIK3.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionIon channel
Ligand-gated ion channel
Receptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamate receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

ion transmembrane transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

ionotropic glutamate receptor signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to corticosteroid

Inferred from electronic annotation. Source: Ensembl

synaptic transmission

Traceable author statement. Source: Reactome

synaptic transmission, glutamatergic

Inferred from Biological aspect of Ancestor. Source: RefGenome

transport

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

dendrite

Inferred from Biological aspect of Ancestor. Source: RefGenome

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

kainate selective glutamate receptor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

nucleus

Inferred from electronic annotation. Source: Ensembl

perikaryon

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

postsynaptic membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

presynaptic membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

terminal bouton

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionextracellular-glutamate-gated ion channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

kainate selective glutamate receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 956936Glutamate receptor ionotropic, kainate 4
PRO_0000011549

Regions

Topological domain21 – 545525Extracellular Potential
Transmembrane546 – 56621Helical; Potential
Topological domain567 – 62357Cytoplasmic Potential
Transmembrane624 – 64421Helical; Potential
Topological domain645 – 804160Extracellular Potential
Transmembrane805 – 82521Helical; Potential
Topological domain826 – 956131Cytoplasmic Potential
Compositional bias862 – 8654Poly-Arg

Amino acid modifications

Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2721N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Glycosylation4081N-linked (GlcNAc...) Potential
Glycosylation4151N-linked (GlcNAc...) Potential
Glycosylation4791N-linked (GlcNAc...) Potential

Natural variations

Natural variant5281V → I. Ref.1
Corresponds to variant rs35599906 [ dbSNP | Ensembl ].
VAR_046998
Natural variant8241M → T.
Corresponds to variant rs9988907 [ dbSNP | Ensembl ].
VAR_046999

Experimental info

Sequence conflict2551M → T in AAB29311. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q16099 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: B7CBEA402A79397A

FASTA956107,246
        10         20         30         40         50         60 
MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN RINRAPERLG 

        70         80         90        100        110        120 
KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS PASSSIISNI CGEKEVPHFK 

       130        140        150        160        170        180 
VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV AGILNFFNCT TACLICAKAE CLLNLEKLLR 

       190        200        210        220        230        240 
QFLISKDTLS VRMLDDTRDP TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY 

       250        260        270        280        290        300 
YTYIFTNLEF SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG 

       310        320        330        340        350        360 
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY LRMVELEGLT 

       370        380        390        400        410        420 
GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM DSHLYASNIS DTLFNTTLVV 

       430        440        450        460        470        480 
TTILENPYLM LKGNHQEMEG NDRYEGFCVD MLKELAEILR FNYKIRLVGD GVYGVPEANG 

       490        500        510        520        530        540 
TWTGMVGELI ARKADLAVAG LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL 

       550        560        570        580        590        600 
DPFSPGVWLF MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 

       610        620        630        640        650        660 
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD VPIESVDDLA 

       670        680        690        700        710        720 
DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS VFVKSTEEGI ARVLNSNYAF 

       730        740        750        760        770        780 
LLESTMNEYY RQRNCNLTQI GGLLDTKGYG IGMPVGSVFR DEFDLAILQL QENNRLEILK 

       790        800        810        820        830        840 
RKWWEGGKCP KEEDHRAKGL GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS 

       850        860        870        880        890        900 
VCQEMVTELR SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ 

       910        920        930        940        950 
LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT NSSEPE 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit."
Kamboj R.K., Schoepp D.D., Nutt S., Shekter L., Korczak B., True R.A., Rampersad V., Zimmerman D.M., Wosnick M.A.
J. Neurochem. 62:1-9(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-528.
Tissue: Hippocampus.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S67803 mRNA. Translation: AAB29311.1.
AK292726 mRNA. Translation: BAF85415.1.
CH471065 Genomic DNA. Translation: EAW67512.1.
PIRJH0826.
RefSeqNP_001269399.1. NM_001282470.1.
NP_055434.2. NM_014619.3.
UniGeneHs.538738.
Hs.568901.

3D structure databases

ProteinModelPortalQ16099.
SMRQ16099. Positions 24-829.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109157. 2 interactions.
STRING9606.ENSP00000278723.

Chemistry

BindingDBQ16099.
ChEMBLCHEMBL2109241.
DrugBankDB00142. L-Glutamic Acid.
GuidetoPHARMACOLOGY453.

Protein family/group databases

TCDB1.A.10.1.9. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

PTM databases

PhosphoSiteQ16099.

Polymorphism databases

DMDM209572625.

Proteomic databases

PaxDbQ16099.
PRIDEQ16099.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000438375; ENSP00000404063; ENSG00000149403.
ENST00000527524; ENSP00000435648; ENSG00000149403.
GeneID2900.
KEGGhsa:2900.
UCSCuc001pxn.2. human.

Organism-specific databases

CTD2900.
GeneCardsGC11P120388.
H-InvDBHIX0036043.
HGNCHGNC:4582. GRIK4.
MIM600282. gene.
neXtProtNX_Q16099.
PharmGKBPA28976.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316680.
HOGENOMHOG000234371.
HOVERGENHBG051839.
InParanoidQ16099.
KOK05204.
OMAMVACSPH.
OrthoDBEOG71G9W6.
PhylomeDBQ16099.
TreeFamTF334668.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ16099.
CleanExHS_GRIK4.
GenevestigatorQ16099.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSPR00177. NMDARECEPTOR.
SMARTSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMSSF53822. SSF53822. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi2900.
NextBio11479.
PROQ16099.
SOURCESearch...

Entry information

Entry nameGRIK4_HUMAN
AccessionPrimary (citable) accession number: Q16099
Secondary accession number(s): A8K9L1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM