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Q16099

- GRIK4_HUMAN

UniProt

Q16099 - GRIK4_HUMAN

Protein

Glutamate receptor ionotropic, kainate 4

Gene

GRIK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

    GO - Molecular functioni

    1. extracellular-glutamate-gated ion channel activity Source: RefGenome
    2. kainate selective glutamate receptor activity Source: RefGenome

    GO - Biological processi

    1. glutamate receptor signaling pathway Source: ProtInc
    2. ionotropic glutamate receptor signaling pathway Source: RefGenome
    3. ion transmembrane transport Source: RefGenome
    4. response to corticosteroid Source: Ensembl
    5. synaptic transmission Source: Reactome
    6. synaptic transmission, glutamatergic Source: RefGenome
    7. transport Source: ProtInc

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_21346. Activation of Ca-permeable Kainate Receptor.

    Protein family/group databases

    TCDBi1.A.10.1.9. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate receptor ionotropic, kainate 4
    Short name:
    GluK4
    Alternative name(s):
    Excitatory amino acid receptor 1
    Short name:
    EAA1
    Glutamate receptor KA-1
    Short name:
    KA1
    Gene namesi
    Name:GRIK4
    Synonyms:GRIK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:4582. GRIK4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dendrite Source: RefGenome
    3. integral component of plasma membrane Source: ProtInc
    4. kainate selective glutamate receptor complex Source: RefGenome
    5. nucleus Source: Ensembl
    6. perikaryon Source: Ensembl
    7. plasma membrane Source: Reactome
    8. postsynaptic membrane Source: RefGenome
    9. presynaptic membrane Source: RefGenome
    10. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28976.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 956936Glutamate receptor ionotropic, kainate 4PRO_0000011549Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi479 – 4791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ16099.
    PRIDEiQ16099.

    PTM databases

    PhosphoSiteiQ16099.

    Expressioni

    Gene expression databases

    BgeeiQ16099.
    CleanExiHS_GRIK4.
    GenevestigatoriQ16099.

    Interactioni

    Subunit structurei

    Forms a heteromeric channel with GRIK1 or GRIK3.

    Protein-protein interaction databases

    BioGridi109157. 2 interactions.
    STRINGi9606.ENSP00000278723.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16099.
    SMRiQ16099. Positions 24-829.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 545525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini567 – 62357CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini645 – 804160ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini826 – 956131CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei546 – 56621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei624 – 64421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei805 – 82521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi862 – 8654Poly-Arg

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG316680.
    HOGENOMiHOG000234371.
    HOVERGENiHBG051839.
    InParanoidiQ16099.
    KOiK05204.
    OMAiCTHIRVC.
    OrthoDBiEOG71G9W6.
    PhylomeDBiQ16099.
    TreeFamiTF334668.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10613. Lig_chan-Glu_bd. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q16099-1 [UniParc]FASTAAdd to Basket

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    MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN    50
    RINRAPERLG KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS 100
    PASSSIISNI CGEKEVPHFK VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV 150
    AGILNFFNCT TACLICAKAE CLLNLEKLLR QFLISKDTLS VRMLDDTRDP 200
    TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY YTYIFTNLEF 250
    SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG 300
    PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY 350
    LRMVELEGLT GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM 400
    DSHLYASNIS DTLFNTTLVV TTILENPYLM LKGNHQEMEG NDRYEGFCVD 450
    MLKELAEILR FNYKIRLVGD GVYGVPEANG TWTGMVGELI ARKADLAVAG 500
    LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL DPFSPGVWLF 550
    MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 600
    VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD 650
    VPIESVDDLA DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS 700
    VFVKSTEEGI ARVLNSNYAF LLESTMNEYY RQRNCNLTQI GGLLDTKGYG 750
    IGMPVGSVFR DEFDLAILQL QENNRLEILK RKWWEGGKCP KEEDHRAKGL 800
    GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS VCQEMVTELR 850
    SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ 900
    LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT 950
    NSSEPE 956
    Length:956
    Mass (Da):107,246
    Last modified:October 14, 2008 - v2
    Checksum:iB7CBEA402A79397A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti255 – 2551M → T in AAB29311. (PubMed:8263508)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti528 – 5281V → I.1 Publication
    Corresponds to variant rs35599906 [ dbSNP | Ensembl ].
    VAR_046998
    Natural varianti824 – 8241M → T.
    Corresponds to variant rs9988907 [ dbSNP | Ensembl ].
    VAR_046999

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67803 mRNA. Translation: AAB29311.1.
    AK292726 mRNA. Translation: BAF85415.1.
    CH471065 Genomic DNA. Translation: EAW67512.1.
    CCDSiCCDS8433.1.
    PIRiJH0826.
    RefSeqiNP_001269399.1. NM_001282470.1.
    NP_055434.2. NM_014619.3.
    UniGeneiHs.538738.
    Hs.568901.

    Genome annotation databases

    EnsembliENST00000438375; ENSP00000404063; ENSG00000149403.
    ENST00000527524; ENSP00000435648; ENSG00000149403.
    GeneIDi2900.
    KEGGihsa:2900.
    UCSCiuc001pxn.2. human.

    Polymorphism databases

    DMDMi209572625.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67803 mRNA. Translation: AAB29311.1 .
    AK292726 mRNA. Translation: BAF85415.1 .
    CH471065 Genomic DNA. Translation: EAW67512.1 .
    CCDSi CCDS8433.1.
    PIRi JH0826.
    RefSeqi NP_001269399.1. NM_001282470.1.
    NP_055434.2. NM_014619.3.
    UniGenei Hs.538738.
    Hs.568901.

    3D structure databases

    ProteinModelPortali Q16099.
    SMRi Q16099. Positions 24-829.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109157. 2 interactions.
    STRINGi 9606.ENSP00000278723.

    Chemistry

    BindingDBi Q16099.
    ChEMBLi CHEMBL2109241.
    DrugBanki DB00142. L-Glutamic Acid.
    GuidetoPHARMACOLOGYi 453.

    Protein family/group databases

    TCDBi 1.A.10.1.9. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

    PTM databases

    PhosphoSitei Q16099.

    Polymorphism databases

    DMDMi 209572625.

    Proteomic databases

    PaxDbi Q16099.
    PRIDEi Q16099.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000438375 ; ENSP00000404063 ; ENSG00000149403 .
    ENST00000527524 ; ENSP00000435648 ; ENSG00000149403 .
    GeneIDi 2900.
    KEGGi hsa:2900.
    UCSCi uc001pxn.2. human.

    Organism-specific databases

    CTDi 2900.
    GeneCardsi GC11P120388.
    H-InvDB HIX0036043.
    HGNCi HGNC:4582. GRIK4.
    MIMi 600282. gene.
    neXtProti NX_Q16099.
    PharmGKBi PA28976.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG316680.
    HOGENOMi HOG000234371.
    HOVERGENi HBG051839.
    InParanoidi Q16099.
    KOi K05204.
    OMAi CTHIRVC.
    OrthoDBi EOG71G9W6.
    PhylomeDBi Q16099.
    TreeFami TF334668.

    Enzyme and pathway databases

    Reactomei REACT_21346. Activation of Ca-permeable Kainate Receptor.

    Miscellaneous databases

    GenomeRNAii 2900.
    NextBioi 11479.
    PROi Q16099.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q16099.
    CleanExi HS_GRIK4.
    Genevestigatori Q16099.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10613. Lig_chan-Glu_bd. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit."
      Kamboj R.K., Schoepp D.D., Nutt S., Shekter L., Korczak B., True R.A., Rampersad V., Zimmerman D.M., Wosnick M.A.
      J. Neurochem. 62:1-9(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-528.
      Tissue: Hippocampus.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGRIK4_HUMAN
    AccessioniPrimary (citable) accession number: Q16099
    Secondary accession number(s): A8K9L1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3