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Q16099

- GRIK4_HUMAN

UniProt

Q16099 - GRIK4_HUMAN

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Protein
Glutamate receptor ionotropic, kainate 4
Gene
GRIK4, GRIK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

GO - Molecular functioni

  1. extracellular-glutamate-gated ion channel activity Source: RefGenome
  2. kainate selective glutamate receptor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. glutamate receptor signaling pathway Source: ProtInc
  2. ion transmembrane transport Source: RefGenome
  3. ionotropic glutamate receptor signaling pathway Source: RefGenome
  4. response to corticosteroid Source: Ensembl
  5. synaptic transmission Source: Reactome
  6. synaptic transmission, glutamatergic Source: RefGenome
  7. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_21346. Activation of Ca-permeable Kainate Receptor.

Protein family/group databases

TCDBi1.A.10.1.9. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 4
Short name:
GluK4
Alternative name(s):
Excitatory amino acid receptor 1
Short name:
EAA1
Glutamate receptor KA-1
Short name:
KA1
Gene namesi
Name:GRIK4
Synonyms:GRIK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:4582. GRIK4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 545525Extracellular Reviewed prediction
Add
BLAST
Transmembranei546 – 56621Helical; Reviewed prediction
Add
BLAST
Topological domaini567 – 62357Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei624 – 64421Helical; Reviewed prediction
Add
BLAST
Topological domaini645 – 804160Extracellular Reviewed prediction
Add
BLAST
Transmembranei805 – 82521Helical; Reviewed prediction
Add
BLAST
Topological domaini826 – 956131Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. integral component of plasma membrane Source: ProtInc
  4. kainate selective glutamate receptor complex Source: RefGenome
  5. nucleus Source: Ensembl
  6. perikaryon Source: Ensembl
  7. plasma membrane Source: Reactome
  8. postsynaptic membrane Source: RefGenome
  9. presynaptic membrane Source: RefGenome
  10. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 956936Glutamate receptor ionotropic, kainate 4
PRO_0000011549Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi286 – 2861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi323 – 3231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi408 – 4081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi415 – 4151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi479 – 4791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ16099.
PRIDEiQ16099.

PTM databases

PhosphoSiteiQ16099.

Expressioni

Gene expression databases

BgeeiQ16099.
CleanExiHS_GRIK4.
GenevestigatoriQ16099.

Interactioni

Subunit structurei

Forms a heteromeric channel with GRIK1 or GRIK3.

Protein-protein interaction databases

BioGridi109157. 2 interactions.
STRINGi9606.ENSP00000278723.

Structurei

3D structure databases

ProteinModelPortaliQ16099.
SMRiQ16099. Positions 24-829.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi862 – 8654Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG316680.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ16099.
KOiK05204.
OMAiCTHIRVC.
OrthoDBiEOG71G9W6.
PhylomeDBiQ16099.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16099-1 [UniParc]FASTAAdd to Basket

« Hide

MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN    50
RINRAPERLG KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS 100
PASSSIISNI CGEKEVPHFK VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV 150
AGILNFFNCT TACLICAKAE CLLNLEKLLR QFLISKDTLS VRMLDDTRDP 200
TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY YTYIFTNLEF 250
SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG 300
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY 350
LRMVELEGLT GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM 400
DSHLYASNIS DTLFNTTLVV TTILENPYLM LKGNHQEMEG NDRYEGFCVD 450
MLKELAEILR FNYKIRLVGD GVYGVPEANG TWTGMVGELI ARKADLAVAG 500
LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL DPFSPGVWLF 550
MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 600
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD 650
VPIESVDDLA DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS 700
VFVKSTEEGI ARVLNSNYAF LLESTMNEYY RQRNCNLTQI GGLLDTKGYG 750
IGMPVGSVFR DEFDLAILQL QENNRLEILK RKWWEGGKCP KEEDHRAKGL 800
GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS VCQEMVTELR 850
SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ 900
LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT 950
NSSEPE 956
Length:956
Mass (Da):107,246
Last modified:October 14, 2008 - v2
Checksum:iB7CBEA402A79397A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti528 – 5281V → I.1 Publication
Corresponds to variant rs35599906 [ dbSNP | Ensembl ].
VAR_046998
Natural varianti824 – 8241M → T.
Corresponds to variant rs9988907 [ dbSNP | Ensembl ].
VAR_046999

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551M → T in AAB29311. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67803 mRNA. Translation: AAB29311.1.
AK292726 mRNA. Translation: BAF85415.1.
CH471065 Genomic DNA. Translation: EAW67512.1.
CCDSiCCDS8433.1.
PIRiJH0826.
RefSeqiNP_001269399.1. NM_001282470.1.
NP_055434.2. NM_014619.3.
UniGeneiHs.538738.
Hs.568901.

Genome annotation databases

EnsembliENST00000438375; ENSP00000404063; ENSG00000149403.
ENST00000527524; ENSP00000435648; ENSG00000149403.
GeneIDi2900.
KEGGihsa:2900.
UCSCiuc001pxn.2. human.

Polymorphism databases

DMDMi209572625.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67803 mRNA. Translation: AAB29311.1 .
AK292726 mRNA. Translation: BAF85415.1 .
CH471065 Genomic DNA. Translation: EAW67512.1 .
CCDSi CCDS8433.1.
PIRi JH0826.
RefSeqi NP_001269399.1. NM_001282470.1.
NP_055434.2. NM_014619.3.
UniGenei Hs.538738.
Hs.568901.

3D structure databases

ProteinModelPortali Q16099.
SMRi Q16099. Positions 24-829.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109157. 2 interactions.
STRINGi 9606.ENSP00000278723.

Chemistry

BindingDBi Q16099.
ChEMBLi CHEMBL2109241.
DrugBanki DB00142. L-Glutamic Acid.
GuidetoPHARMACOLOGYi 453.

Protein family/group databases

TCDBi 1.A.10.1.9. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

PTM databases

PhosphoSitei Q16099.

Polymorphism databases

DMDMi 209572625.

Proteomic databases

PaxDbi Q16099.
PRIDEi Q16099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000438375 ; ENSP00000404063 ; ENSG00000149403 .
ENST00000527524 ; ENSP00000435648 ; ENSG00000149403 .
GeneIDi 2900.
KEGGi hsa:2900.
UCSCi uc001pxn.2. human.

Organism-specific databases

CTDi 2900.
GeneCardsi GC11P120388.
H-InvDB HIX0036043.
HGNCi HGNC:4582. GRIK4.
MIMi 600282. gene.
neXtProti NX_Q16099.
PharmGKBi PA28976.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG316680.
HOGENOMi HOG000234371.
HOVERGENi HBG051839.
InParanoidi Q16099.
KOi K05204.
OMAi CTHIRVC.
OrthoDBi EOG71G9W6.
PhylomeDBi Q16099.
TreeFami TF334668.

Enzyme and pathway databases

Reactomei REACT_21346. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

GenomeRNAii 2900.
NextBioi 11479.
PROi Q16099.
SOURCEi Search...

Gene expression databases

Bgeei Q16099.
CleanExi HS_GRIK4.
Genevestigatori Q16099.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit."
    Kamboj R.K., Schoepp D.D., Nutt S., Shekter L., Korczak B., True R.A., Rampersad V., Zimmerman D.M., Wosnick M.A.
    J. Neurochem. 62:1-9(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-528.
    Tissue: Hippocampus.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGRIK4_HUMAN
AccessioniPrimary (citable) accession number: Q16099
Secondary accession number(s): A8K9L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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