ID   HSPB2_HUMAN             Reviewed;         182 AA.
AC   Q16082; Q6I9U7;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 2.
DT   24-JAN-2024, entry version 185.
DE   RecName: Full=Heat shock protein beta-2;
DE            Short=HspB2;
DE   AltName: Full=DMPK-binding protein;
DE            Short=MKBP;
GN   Name=HSPB2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9344664; DOI=10.1006/geno.1997.4956;
RA   Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y.;
RT   "Identification and characterization of the gene encoding a new member of
RT   the alpha-crystallin/small hsp family, closely linked to the alphaB-
RT   crystallin gene in a head-to-head manner.";
RL   Genomics 45:386-394(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH DMPK.
RC   TISSUE=Muscle;
RX   PubMed=9490724; DOI=10.1083/jcb.140.5.1113;
RA   Suzuki A., Sugiyama Y., Hayashi Y., Nyu-i N., Yoshida M., Nonaka I.,
RA   Ishiura S., Arahata K., Ohno S.;
RT   "MKBP, a novel member of the small heat shock protein family, binds and
RT   activates the myotonic dystrophy protein kinase.";
RL   J. Cell Biol. 140:1113-1124(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-111.
RG   NIEHS SNPs program;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 88-182.
RX   PubMed=8227983; DOI=10.1007/bf03348900;
RA   Elisei R., Weightman D., Kendall-Taylor P., Vassart G., Ludgate M.;
RT   "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of
RT   molecular genetics.";
RL   J. Endocrinol. Invest. 16:533-540(1993).
RN   [7]
RP   SUBCELLULAR LOCATION.
RX   PubMed=19464326; DOI=10.1016/j.bbamcr.2009.05.005;
RA   Vos M.J., Kanon B., Kampinga H.H.;
RT   "HSPB7 is a SC35 speckle resident small heat shock protein.";
RL   Biochim. Biophys. Acta 1793:1343-1353(2009).
CC   -!- FUNCTION: May regulate the kinase DMPK. {ECO:0000269|PubMed:9490724}.
CC   -!- SUBUNIT: Interacts with DMPK; may enhance its kinase activity.
CC       {ECO:0000269|PubMed:9490724}.
CC   -!- INTERACTION:
CC       Q16082; Q9NQ94: A1CF; NbExp=3; IntAct=EBI-739395, EBI-2809489;
CC       Q16082; P05067: APP; NbExp=3; IntAct=EBI-739395, EBI-77613;
CC       Q16082; O95817: BAG3; NbExp=3; IntAct=EBI-739395, EBI-747185;
CC       Q16082; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-739395, EBI-745073;
CC       Q16082; Q6AI39: BICRAL; NbExp=3; IntAct=EBI-739395, EBI-1012434;
CC       Q16082; Q96LK0: CEP19; NbExp=6; IntAct=EBI-739395, EBI-741885;
CC       Q16082; P02511: CRYAB; NbExp=3; IntAct=EBI-739395, EBI-739060;
CC       Q16082; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-739395, EBI-744099;
CC       Q16082; P17482: HOXB9; NbExp=3; IntAct=EBI-739395, EBI-745290;
CC       Q16082; Q9UJY1: HSPB8; NbExp=3; IntAct=EBI-739395, EBI-739074;
CC       Q16082; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-739395, EBI-2556193;
CC       Q16082; P25800: LMO1; NbExp=3; IntAct=EBI-739395, EBI-8639312;
CC       Q16082; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-739395, EBI-11742507;
CC       Q16082; Q8IVT2: MISP; NbExp=3; IntAct=EBI-739395, EBI-2555085;
CC       Q16082; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-739395, EBI-11022007;
CC       Q16082; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-739395, EBI-1389308;
CC       Q16082; P0CG20: PRR35; NbExp=3; IntAct=EBI-739395, EBI-11986293;
CC       Q16082; O75679: RFPL3; NbExp=4; IntAct=EBI-739395, EBI-10188956;
CC       Q16082; Q96RF0: SNX18; NbExp=3; IntAct=EBI-739395, EBI-298169;
CC       Q16082; O43711: TLX3; NbExp=3; IntAct=EBI-739395, EBI-3939165;
CC       Q16082; Q14119: VEZF1; NbExp=3; IntAct=EBI-739395, EBI-11980193;
CC       Q16082; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-739395, EBI-12040603;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus
CC       {ECO:0000269|PubMed:19464326}. Note=Localizes to nuclear foci.
CC   -!- TISSUE SPECIFICITY: Expressed preferentially in skeletal muscle and
CC       heart but not in the lens.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/hspb2/";
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DR   EMBL; U75898; AAB82757.1; -; Genomic_DNA.
DR   EMBL; D89617; BAA24004.1; -; mRNA.
DR   EMBL; CR457408; CAG33689.1; -; mRNA.
DR   EMBL; AY208910; AAO18081.1; -; Genomic_DNA.
DR   EMBL; BC109393; AAI09394.1; -; mRNA.
DR   EMBL; S67070; AAB28816.1; -; mRNA.
DR   CCDS; CCDS8352.1; -.
DR   RefSeq; NP_001532.1; NM_001541.3.
DR   PDB; 6F2R; X-ray; 3.90 A; A/C/D/E/F/G/I/J/K=1-182.
DR   PDBsum; 6F2R; -.
DR   AlphaFoldDB; Q16082; -.
DR   SMR; Q16082; -.
DR   BioGRID; 109548; 136.
DR   IntAct; Q16082; 175.
DR   MINT; Q16082; -.
DR   STRING; 9606.ENSP00000302476; -.
DR   iPTMnet; Q16082; -.
DR   PhosphoSitePlus; Q16082; -.
DR   BioMuta; HSPB2; -.
DR   MassIVE; Q16082; -.
DR   MaxQB; Q16082; -.
DR   PaxDb; 9606-ENSP00000302476; -.
DR   PeptideAtlas; Q16082; -.
DR   ProteomicsDB; 60830; -.
DR   Antibodypedia; 32089; 574 antibodies from 31 providers.
DR   DNASU; 3316; -.
DR   Ensembl; ENST00000304298.4; ENSP00000302476.3; ENSG00000170276.6.
DR   GeneID; 3316; -.
DR   KEGG; hsa:3316; -.
DR   MANE-Select; ENST00000304298.4; ENSP00000302476.3; NM_001541.4; NP_001532.1.
DR   UCSC; uc001pmg.3; human.
DR   AGR; HGNC:5247; -.
DR   CTD; 3316; -.
DR   DisGeNET; 3316; -.
DR   GeneCards; HSPB2; -.
DR   HGNC; HGNC:5247; HSPB2.
DR   HPA; ENSG00000170276; Group enriched (heart muscle, skeletal muscle, tongue).
DR   MIM; 602179; gene.
DR   neXtProt; NX_Q16082; -.
DR   OpenTargets; ENSG00000170276; -.
DR   PharmGKB; PA29512; -.
DR   VEuPathDB; HostDB:ENSG00000170276; -.
DR   eggNOG; KOG3591; Eukaryota.
DR   GeneTree; ENSGT00940000161288; -.
DR   HOGENOM; CLU_095001_1_0_1; -.
DR   InParanoid; Q16082; -.
DR   OMA; MSTEYEF; -.
DR   OrthoDB; 2953415at2759; -.
DR   PhylomeDB; Q16082; -.
DR   PathwayCommons; Q16082; -.
DR   SignaLink; Q16082; -.
DR   BioGRID-ORCS; 3316; 9 hits in 1126 CRISPR screens.
DR   GeneWiki; HSPB2; -.
DR   GenomeRNAi; 3316; -.
DR   Pharos; Q16082; Tbio.
DR   PRO; PR:Q16082; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q16082; Protein.
DR   Bgee; ENSG00000170276; Expressed in right atrium auricular region and 94 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005829; C:cytosol; TAS:ProtInc.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0008047; F:enzyme activator activity; TAS:ProtInc.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   GO; GO:0009408; P:response to heat; IBA:GO_Central.
DR   GO; GO:0006986; P:response to unfolded protein; NAS:ProtInc.
DR   GO; GO:0007525; P:somatic muscle development; IEA:Ensembl.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR003090; Alpha-crystallin_N.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   PANTHER; PTHR45640:SF27; HEAT SHOCK PROTEIN BETA-2; 1.
DR   PANTHER; PTHR45640; HEAT SHOCK PROTEIN HSP-12.2-RELATED; 1.
DR   Pfam; PF00525; Crystallin; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR   PROSITE; PS01031; SHSP; 1.
DR   Genevisible; Q16082; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Nucleus; Reference proteome; Stress response.
FT   CHAIN           1..182
FT                   /note="Heat shock protein beta-2"
FT                   /id="PRO_0000125933"
FT   DOMAIN          55..163
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   VARIANT         111
FT                   /note="G -> S (in dbSNP:rs4252589)"
FT                   /evidence="ECO:0000269|Ref.4"
FT                   /id="VAR_016316"
SQ   SEQUENCE   182 AA;  20233 MW;  7586DCE8FBD19F6D CRC64;
     MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAAPAGEGS
     RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT
     YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEAAIV
     EP
//