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Protein

Heat shock protein beta-2

Gene

HSPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the kinase DMPK.1 Publication

GO - Molecular functioni

  • enzyme activator activity Source: ProtInc

GO - Biological processi

  • response to unfolded protein Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-2
Short name:
HspB2
Alternative name(s):
DMPK-binding protein
Short name:
MKBP
Gene namesi
Name:HSPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:5247. HSPB2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: ProtInc
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3316.
OpenTargetsiENSG00000170276.
ENSG00000254445.
PharmGKBiPA29512.

Polymorphism and mutation databases

BioMutaiHSPB2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259331 – 182Heat shock protein beta-2Add BLAST182

Proteomic databases

EPDiQ16082.
MaxQBiQ16082.
PaxDbiQ16082.
PeptideAtlasiQ16082.
PRIDEiQ16082.

PTM databases

iPTMnetiQ16082.
PhosphoSitePlusiQ16082.

Expressioni

Tissue specificityi

Expressed preferentially in skeletal muscle and heart but not in the lens.

Gene expression databases

BgeeiENSG00000170276.
CleanExiHS_HSPB2.
GenevisibleiQ16082. HS.

Organism-specific databases

HPAiHPA038889.
HPA038890.

Interactioni

Subunit structurei

Interacts with DMPK; may enhance its kinase activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSPB8Q9UJY13EBI-739395,EBI-739074

Protein-protein interaction databases

BioGridi109548. 98 interactors.
IntActiQ16082. 3 interactors.
MINTiMINT-1616978.
STRINGi9606.ENSP00000457706.

Structurei

3D structure databases

ProteinModelPortaliQ16082.
SMRiQ16082.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiQ16082.
KOiK09543.
OMAiANPSKIY.
OrthoDBiEOG091G0USC.
PhylomeDBiQ16082.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR
60 70 80 90 100
PRAAPAGEGS RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS
110 120 130 140 150
ARHPQRLDRH GFVSREFCRT YVLPADVDPW RVRAALSHDG ILNLEAPRGG
160 170 180
RHLDTEVNEV YISLLPAPPD PEEEEEAAIV EP
Length:182
Mass (Da):20,233
Last modified:November 1, 1998 - v2
Checksum:i7586DCE8FBD19F6D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016316111G → S.1 PublicationCorresponds to variant rs4252589dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75898 Genomic DNA. Translation: AAB82757.1.
D89617 mRNA. Translation: BAA24004.1.
CR457408 mRNA. Translation: CAG33689.1.
AY208910 Genomic DNA. Translation: AAO18081.1.
BC109393 mRNA. Translation: AAI09394.1.
S67070 mRNA. Translation: AAB28816.1.
CCDSiCCDS8352.1.
RefSeqiNP_001532.1. NM_001541.3.
UniGeneiHs.709660.

Genome annotation databases

EnsembliENST00000304298; ENSP00000302476; ENSG00000170276.
GeneIDi3316.
KEGGihsa:3316.
UCSCiuc001pmg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75898 Genomic DNA. Translation: AAB82757.1.
D89617 mRNA. Translation: BAA24004.1.
CR457408 mRNA. Translation: CAG33689.1.
AY208910 Genomic DNA. Translation: AAO18081.1.
BC109393 mRNA. Translation: AAI09394.1.
S67070 mRNA. Translation: AAB28816.1.
CCDSiCCDS8352.1.
RefSeqiNP_001532.1. NM_001541.3.
UniGeneiHs.709660.

3D structure databases

ProteinModelPortaliQ16082.
SMRiQ16082.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109548. 98 interactors.
IntActiQ16082. 3 interactors.
MINTiMINT-1616978.
STRINGi9606.ENSP00000457706.

PTM databases

iPTMnetiQ16082.
PhosphoSitePlusiQ16082.

Polymorphism and mutation databases

BioMutaiHSPB2.

Proteomic databases

EPDiQ16082.
MaxQBiQ16082.
PaxDbiQ16082.
PeptideAtlasiQ16082.
PRIDEiQ16082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304298; ENSP00000302476; ENSG00000170276.
GeneIDi3316.
KEGGihsa:3316.
UCSCiuc001pmg.3. human.

Organism-specific databases

CTDi3316.
DisGeNETi3316.
GeneCardsiHSPB2.
HGNCiHGNC:5247. HSPB2.
HPAiHPA038889.
HPA038890.
MIMi602179. gene.
neXtProtiNX_Q16082.
OpenTargetsiENSG00000170276.
ENSG00000254445.
PharmGKBiPA29512.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiQ16082.
KOiK09543.
OMAiANPSKIY.
OrthoDBiEOG091G0USC.
PhylomeDBiQ16082.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170276-MONOMER.

Miscellaneous databases

GeneWikiiHSPB2.
GenomeRNAii3316.
PROiQ16082.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170276.
CleanExiHS_HSPB2.
GenevisibleiQ16082. HS.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB2_HUMAN
AccessioniPrimary (citable) accession number: Q16082
Secondary accession number(s): Q6I9U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.