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Q16082

- HSPB2_HUMAN

UniProt

Q16082 - HSPB2_HUMAN

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Protein

Heat shock protein beta-2

Gene
HSPB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate the kinase DMPK.1 Publication

GO - Molecular functioni

  1. enzyme activator activity Source: ProtInc
  2. protein binding Source: IntAct

GO - Biological processi

  1. positive regulation of catalytic activity Source: GOC
  2. response to unfolded protein Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-2
Short name:
HspB2
Alternative name(s):
DMPK-binding protein
Short name:
MKBP
Gene namesi
Name:HSPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:5247. HSPB2.

Subcellular locationi

Cytoplasm. Nucleus
Note: Localizes to nuclear foci.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: ProtInc
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Heat shock protein beta-2PRO_0000125933Add
BLAST

Proteomic databases

MaxQBiQ16082.
PaxDbiQ16082.
PRIDEiQ16082.

PTM databases

PhosphoSiteiQ16082.

Expressioni

Tissue specificityi

Expressed preferentially in skeletal muscle and heart but not in the lens.

Gene expression databases

BgeeiQ16082.
CleanExiHS_HSPB2.
GenevestigatoriQ16082.

Organism-specific databases

HPAiHPA038889.
HPA038890.

Interactioni

Subunit structurei

Interacts with DMPK; may enhance its kinase activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSPB8Q9UJY13EBI-739395,EBI-739074

Protein-protein interaction databases

BioGridi109548. 21 interactions.
IntActiQ16082. 2 interactions.
MINTiMINT-1616978.
STRINGi9606.ENSP00000302476.

Structurei

3D structure databases

ProteinModelPortaliQ16082.
SMRiQ16082. Positions 16-148.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG245877.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiQ16082.
KOiK09543.
OMAiPATTEYE.
OrthoDBiEOG7WHHBK.
PhylomeDBiQ16082.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16082-1 [UniParc]FASTAAdd to Basket

« Hide

MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR    50
PRAAPAGEGS RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS 100
ARHPQRLDRH GFVSREFCRT YVLPADVDPW RVRAALSHDG ILNLEAPRGG 150
RHLDTEVNEV YISLLPAPPD PEEEEEAAIV EP 182
Length:182
Mass (Da):20,233
Last modified:November 1, 1998 - v2
Checksum:i7586DCE8FBD19F6D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111G → S.1 Publication
Corresponds to variant rs4252589 [ dbSNP | Ensembl ].
VAR_016316

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U75898 Genomic DNA. Translation: AAB82757.1.
D89617 mRNA. Translation: BAA24004.1.
CR457408 mRNA. Translation: CAG33689.1.
AY208910 Genomic DNA. Translation: AAO18081.1.
BC109393 mRNA. Translation: AAI09394.1.
S67070 mRNA. Translation: AAB28816.1.
CCDSiCCDS8352.1.
RefSeqiNP_001532.1. NM_001541.3.
UniGeneiHs.709660.

Genome annotation databases

GeneIDi3316.
KEGGihsa:3316.
UCSCiuc001pmg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U75898 Genomic DNA. Translation: AAB82757.1 .
D89617 mRNA. Translation: BAA24004.1 .
CR457408 mRNA. Translation: CAG33689.1 .
AY208910 Genomic DNA. Translation: AAO18081.1 .
BC109393 mRNA. Translation: AAI09394.1 .
S67070 mRNA. Translation: AAB28816.1 .
CCDSi CCDS8352.1.
RefSeqi NP_001532.1. NM_001541.3.
UniGenei Hs.709660.

3D structure databases

ProteinModelPortali Q16082.
SMRi Q16082. Positions 16-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109548. 21 interactions.
IntActi Q16082. 2 interactions.
MINTi MINT-1616978.
STRINGi 9606.ENSP00000302476.

PTM databases

PhosphoSitei Q16082.

Proteomic databases

MaxQBi Q16082.
PaxDbi Q16082.
PRIDEi Q16082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3316.
KEGGi hsa:3316.
UCSCi uc001pmg.2. human.

Organism-specific databases

CTDi 3316.
GeneCardsi GC11P111782.
GC11P111785.
HGNCi HGNC:5247. HSPB2.
HPAi HPA038889.
HPA038890.
MIMi 602179. gene.
neXtProti NX_Q16082.
PharmGKBi PA29512.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245877.
HOGENOMi HOG000233954.
HOVERGENi HBG054766.
InParanoidi Q16082.
KOi K09543.
OMAi PATTEYE.
OrthoDBi EOG7WHHBK.
PhylomeDBi Q16082.

Miscellaneous databases

GeneWikii HSPB2.
GenomeRNAii 3316.
NextBioi 13152.
PROi Q16082.
SOURCEi Search...

Gene expression databases

Bgeei Q16082.
CleanExi HS_HSPB2.
Genevestigatori Q16082.

Family and domain databases

Gene3Di 2.60.40.790. 1 hit.
InterProi IPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR008978. HSP20-like_chaperone.
[Graphical view ]
Pfami PF00011. HSP20. 1 hit.
[Graphical view ]
PIRSFi PIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSi PR00299. ACRYSTALLIN.
SUPFAMi SSF49764. SSF49764. 1 hit.
PROSITEi PS01031. HSP20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner."
    Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y.
    Genomics 45:386-394(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase."
    Suzuki A., Sugiyama Y., Hayashi Y., Nyu-i N., Yoshida M., Nonaka I., Ishiura S., Arahata K., Ohno S.
    J. Cell Biol. 140:1113-1124(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DMPK.
    Tissue: Muscle.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. NIEHS SNPs program
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-111.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics."
    Elisei R., Weightman D., Kendall-Taylor P., Vassart G., Ludgate M.
    J. Endocrinol. Invest. 16:533-540(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-182.
  7. "HSPB7 is a SC35 speckle resident small heat shock protein."
    Vos M.J., Kanon B., Kampinga H.H.
    Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHSPB2_HUMAN
AccessioniPrimary (citable) accession number: Q16082
Secondary accession number(s): Q6I9U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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