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Q16082

- HSPB2_HUMAN

UniProt

Q16082 - HSPB2_HUMAN

Protein

Heat shock protein beta-2

Gene

HSPB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May regulate the kinase DMPK.1 Publication

    GO - Molecular functioni

    1. enzyme activator activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. positive regulation of catalytic activity Source: GOC
    2. response to unfolded protein Source: ProtInc

    Keywords - Biological processi

    Stress response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock protein beta-2
    Short name:
    HspB2
    Alternative name(s):
    DMPK-binding protein
    Short name:
    MKBP
    Gene namesi
    Name:HSPB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:5247. HSPB2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Localizes to nuclear foci.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: ProtInc
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29512.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Heat shock protein beta-2PRO_0000125933Add
    BLAST

    Proteomic databases

    MaxQBiQ16082.
    PaxDbiQ16082.
    PRIDEiQ16082.

    PTM databases

    PhosphoSiteiQ16082.

    Expressioni

    Tissue specificityi

    Expressed preferentially in skeletal muscle and heart but not in the lens.

    Gene expression databases

    BgeeiQ16082.
    CleanExiHS_HSPB2.
    GenevestigatoriQ16082.

    Organism-specific databases

    HPAiHPA038889.
    HPA038890.

    Interactioni

    Subunit structurei

    Interacts with DMPK; may enhance its kinase activity.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSPB8Q9UJY13EBI-739395,EBI-739074

    Protein-protein interaction databases

    BioGridi109548. 22 interactions.
    IntActiQ16082. 2 interactions.
    MINTiMINT-1616978.
    STRINGi9606.ENSP00000302476.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16082.
    SMRiQ16082. Positions 16-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG245877.
    HOGENOMiHOG000233954.
    HOVERGENiHBG054766.
    InParanoidiQ16082.
    KOiK09543.
    OMAiPATTEYE.
    OrthoDBiEOG7WHHBK.
    PhylomeDBiQ16082.

    Family and domain databases

    Gene3Di2.60.40.790. 1 hit.
    InterProiIPR002068. a-crystallin/Hsp20_dom.
    IPR001436. Alpha-crystallin/HSP.
    IPR008978. HSP20-like_chaperone.
    [Graphical view]
    PfamiPF00011. HSP20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
    PRINTSiPR00299. ACRYSTALLIN.
    SUPFAMiSSF49764. SSF49764. 1 hit.
    PROSITEiPS01031. HSP20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16082-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR    50
    PRAAPAGEGS RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS 100
    ARHPQRLDRH GFVSREFCRT YVLPADVDPW RVRAALSHDG ILNLEAPRGG 150
    RHLDTEVNEV YISLLPAPPD PEEEEEAAIV EP 182
    Length:182
    Mass (Da):20,233
    Last modified:November 1, 1998 - v2
    Checksum:i7586DCE8FBD19F6D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti111 – 1111G → S.1 Publication
    Corresponds to variant rs4252589 [ dbSNP | Ensembl ].
    VAR_016316

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75898 Genomic DNA. Translation: AAB82757.1.
    D89617 mRNA. Translation: BAA24004.1.
    CR457408 mRNA. Translation: CAG33689.1.
    AY208910 Genomic DNA. Translation: AAO18081.1.
    BC109393 mRNA. Translation: AAI09394.1.
    S67070 mRNA. Translation: AAB28816.1.
    CCDSiCCDS8352.1.
    RefSeqiNP_001532.1. NM_001541.3.
    UniGeneiHs.709660.

    Genome annotation databases

    EnsembliENST00000304298; ENSP00000302476; ENSG00000170276.
    GeneIDi3316.
    KEGGihsa:3316.
    UCSCiuc001pmg.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75898 Genomic DNA. Translation: AAB82757.1 .
    D89617 mRNA. Translation: BAA24004.1 .
    CR457408 mRNA. Translation: CAG33689.1 .
    AY208910 Genomic DNA. Translation: AAO18081.1 .
    BC109393 mRNA. Translation: AAI09394.1 .
    S67070 mRNA. Translation: AAB28816.1 .
    CCDSi CCDS8352.1.
    RefSeqi NP_001532.1. NM_001541.3.
    UniGenei Hs.709660.

    3D structure databases

    ProteinModelPortali Q16082.
    SMRi Q16082. Positions 16-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109548. 22 interactions.
    IntActi Q16082. 2 interactions.
    MINTi MINT-1616978.
    STRINGi 9606.ENSP00000302476.

    PTM databases

    PhosphoSitei Q16082.

    Proteomic databases

    MaxQBi Q16082.
    PaxDbi Q16082.
    PRIDEi Q16082.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304298 ; ENSP00000302476 ; ENSG00000170276 .
    GeneIDi 3316.
    KEGGi hsa:3316.
    UCSCi uc001pmg.2. human.

    Organism-specific databases

    CTDi 3316.
    GeneCardsi GC11P111782.
    GC11P111785.
    HGNCi HGNC:5247. HSPB2.
    HPAi HPA038889.
    HPA038890.
    MIMi 602179. gene.
    neXtProti NX_Q16082.
    PharmGKBi PA29512.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245877.
    HOGENOMi HOG000233954.
    HOVERGENi HBG054766.
    InParanoidi Q16082.
    KOi K09543.
    OMAi PATTEYE.
    OrthoDBi EOG7WHHBK.
    PhylomeDBi Q16082.

    Miscellaneous databases

    GeneWikii HSPB2.
    GenomeRNAii 3316.
    NextBioi 13152.
    PROi Q16082.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q16082.
    CleanExi HS_HSPB2.
    Genevestigatori Q16082.

    Family and domain databases

    Gene3Di 2.60.40.790. 1 hit.
    InterProi IPR002068. a-crystallin/Hsp20_dom.
    IPR001436. Alpha-crystallin/HSP.
    IPR008978. HSP20-like_chaperone.
    [Graphical view ]
    Pfami PF00011. HSP20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036514. Sm_HSP_B1. 1 hit.
    PRINTSi PR00299. ACRYSTALLIN.
    SUPFAMi SSF49764. SSF49764. 1 hit.
    PROSITEi PS01031. HSP20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner."
      Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y.
      Genomics 45:386-394(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase."
      Suzuki A., Sugiyama Y., Hayashi Y., Nyu-i N., Yoshida M., Nonaka I., Ishiura S., Arahata K., Ohno S.
      J. Cell Biol. 140:1113-1124(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DMPK.
      Tissue: Muscle.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. NIEHS SNPs program
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-111.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics."
      Elisei R., Weightman D., Kendall-Taylor P., Vassart G., Ludgate M.
      J. Endocrinol. Invest. 16:533-540(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-182.
    7. "HSPB7 is a SC35 speckle resident small heat shock protein."
      Vos M.J., Kanon B., Kampinga H.H.
      Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiHSPB2_HUMAN
    AccessioniPrimary (citable) accession number: Q16082
    Secondary accession number(s): Q6I9U7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3