Reviewed, UniProtKB/Swiss-Prot Q16082 (HSPB2_HUMAN)

Names and origin

Protein names

Recommended name:
    Heat shock protein beta-2
      Short name=HspB2
Alternative name(s):
    DMPK-binding protein
      Short name=MKBP

Gene names

Name:

HSPB2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Associates specifically with myotonic dystrophy protein kinase (DMPK).
Tissue specificity	Expressed preferentially in skeletal muscle and heart but not in the lens.
Sequence similarities	Belongs to the small heat shock protein (HSP20) family.

Ontologies

Keywords
Biological process	Stress response
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	response to heat Inferred from electronic annotation. Source: InterPro response to unfolded protein Ref.1 Non-traceable author statement. Source: ProtInc
Cellular component	cytosol Ref.2 Traceable author statement. Source: ProtInc
Molecular function	enzyme activator activity Ref.2 Traceable author statement. Source: ProtInc protein binding Ref.2 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSPB8	Q9UJY1	2	EBI-739395,EBI-739074

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Heat shock protein beta-2		PRO_0000125933
Natural variations
	Natural variant	111	1	G → S: dbSNP rs4252589. Ref.4		VAR_016316

Sequences

	Sequence		Length	Mass (Da)
	Q16082-1 [UniParc]. Last modified November 1, 1998. Version 2. Checksum: 7586DCE8FBD19F6D	FASTA	182	20,233
	10 20 30 40 50 60 MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAAPAGEGS 70 80 90 100 110 120 RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT 130 140 150 160 170 180 YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEAAIV EP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner." Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y. Genomics 45:386-394(1997) [PubMed: 9344664] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase." Suzuki A., Sugiyama Y., Hayashi Y., Nyu-i N., Yoshida M., Nonaka I., Ishiura S., Arahata K., Ohno S. J. Cell Biol. 140:1113-1124(1998) [PubMed: 9490724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Muscle.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	NIEHS SNPs program Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-111.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics." Elisei R., Weightman D., Kendall-Taylor P., Vassart G., Ludgate M. J. Endocrinol. Invest. 16:533-540(1993) [PubMed: 8227983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-182.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	U75898 Genomic DNA. Translation: AAB82757.1. D89617 mRNA. Translation: BAA24004.1. CR457408 mRNA. Translation: CAG33689.1. AY208910 Genomic DNA. Translation: AAO18081.1. BC109393 mRNA. Translation: AAI09394.1. S67070 mRNA. Translation: AAB28816.1.
IPI	IPI00032195.
RefSeq	NP_001532.1.
UniGene	Hs.709660
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q16082. 1 interaction.
STRING	Q16082.
Proteomic databases
PRIDE	Q16082.
Genome annotation databases
Ensembl	ENST00000304298; ENSP00000302476; ENSG00000170276; Homo sapiens. [Genome view]
GeneID	3316.
KEGG	hsa:3316.
UCSC	uc001pmg.1. human.
Organism-specific databases
CTD	3316.
GeneCards	GC11P111288.
H-InvDB	HIX0035830.
HGNC	HGNC:5247. HSPB2.
MIM	602179. gene.
PharmGKB	PA29512.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG748242.
HOVERGEN	Q16082.
InParanoid	Q16082.
OMA	PADVDPW.
OrthoDB	EOG98D3DT.
Gene expression databases
Bgee	Q16082.
CleanEx	HS_HSPB2.
Genevestigator	Q16082.
GermOnline	ENSG00000170276. Homo sapiens.
Family and domain databases
InterPro	IPR001436. Alpha-crystallin/HSP. IPR002068. Hsp20. IPR008978. HSP20-like_chaperone. [Graphical view]
Pfam	PF00011. HSP20. 1 hit. [Graphical view]
PRINTS	PR00299. ACRYSTALLIN.
PROSITE	PS01031. HSP20. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	13152.
SOURCE	Search...

Entry information

Entry name

HSPB2_HUMAN

Accession

Primary (citable) accession number: Q16082
Secondary accession number(s): Q6I9U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	December 15, 2009
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.