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Protein

Heat shock protein beta-2

Gene

HSPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the kinase DMPK.1 Publication

GO - Molecular functioni

  1. enzyme activator activity Source: ProtInc

GO - Biological processi

  1. positive regulation of catalytic activity Source: GOC
  2. response to unfolded protein Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-2
Short name:
HspB2
Alternative name(s):
DMPK-binding protein
Short name:
MKBP
Gene namesi
Name:HSPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:5247. HSPB2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Localizes to nuclear foci.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: ProtInc
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Heat shock protein beta-2PRO_0000125933Add
BLAST

Proteomic databases

MaxQBiQ16082.
PaxDbiQ16082.
PRIDEiQ16082.

PTM databases

PhosphoSiteiQ16082.

Expressioni

Tissue specificityi

Expressed preferentially in skeletal muscle and heart but not in the lens.

Gene expression databases

BgeeiQ16082.
CleanExiHS_HSPB2.
ExpressionAtlasiQ16082. baseline.
GenevestigatoriQ16082.

Organism-specific databases

HPAiHPA038889.
HPA038890.

Interactioni

Subunit structurei

Interacts with DMPK; may enhance its kinase activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSPB8Q9UJY13EBI-739395,EBI-739074

Protein-protein interaction databases

BioGridi109548. 22 interactions.
IntActiQ16082. 2 interactions.
MINTiMINT-1616978.
STRINGi9606.ENSP00000302476.

Structurei

3D structure databases

ProteinModelPortaliQ16082.
SMRiQ16082. Positions 16-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG245877.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiQ16082.
KOiK09543.
OMAiPATTEYE.
OrthoDBiEOG7WHHBK.
PhylomeDBiQ16082.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR
60 70 80 90 100
PRAAPAGEGS RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS
110 120 130 140 150
ARHPQRLDRH GFVSREFCRT YVLPADVDPW RVRAALSHDG ILNLEAPRGG
160 170 180
RHLDTEVNEV YISLLPAPPD PEEEEEAAIV EP
Length:182
Mass (Da):20,233
Last modified:November 1, 1998 - v2
Checksum:i7586DCE8FBD19F6D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111G → S.1 Publication
Corresponds to variant rs4252589 [ dbSNP | Ensembl ].
VAR_016316

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75898 Genomic DNA. Translation: AAB82757.1.
D89617 mRNA. Translation: BAA24004.1.
CR457408 mRNA. Translation: CAG33689.1.
AY208910 Genomic DNA. Translation: AAO18081.1.
BC109393 mRNA. Translation: AAI09394.1.
S67070 mRNA. Translation: AAB28816.1.
CCDSiCCDS8352.1.
RefSeqiNP_001532.1. NM_001541.3.
UniGeneiHs.709660.

Genome annotation databases

EnsembliENST00000304298; ENSP00000302476; ENSG00000170276.
GeneIDi3316.
KEGGihsa:3316.
UCSCiuc001pmg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75898 Genomic DNA. Translation: AAB82757.1.
D89617 mRNA. Translation: BAA24004.1.
CR457408 mRNA. Translation: CAG33689.1.
AY208910 Genomic DNA. Translation: AAO18081.1.
BC109393 mRNA. Translation: AAI09394.1.
S67070 mRNA. Translation: AAB28816.1.
CCDSiCCDS8352.1.
RefSeqiNP_001532.1. NM_001541.3.
UniGeneiHs.709660.

3D structure databases

ProteinModelPortaliQ16082.
SMRiQ16082. Positions 16-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109548. 22 interactions.
IntActiQ16082. 2 interactions.
MINTiMINT-1616978.
STRINGi9606.ENSP00000302476.

PTM databases

PhosphoSiteiQ16082.

Proteomic databases

MaxQBiQ16082.
PaxDbiQ16082.
PRIDEiQ16082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304298; ENSP00000302476; ENSG00000170276.
GeneIDi3316.
KEGGihsa:3316.
UCSCiuc001pmg.2. human.

Organism-specific databases

CTDi3316.
GeneCardsiGC11P111782.
GC11P111785.
HGNCiHGNC:5247. HSPB2.
HPAiHPA038889.
HPA038890.
MIMi602179. gene.
neXtProtiNX_Q16082.
PharmGKBiPA29512.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG245877.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiQ16082.
KOiK09543.
OMAiPATTEYE.
OrthoDBiEOG7WHHBK.
PhylomeDBiQ16082.

Miscellaneous databases

GeneWikiiHSPB2.
GenomeRNAii3316.
NextBioi13152.
PROiQ16082.
SOURCEiSearch...

Gene expression databases

BgeeiQ16082.
CleanExiHS_HSPB2.
ExpressionAtlasiQ16082. baseline.
GenevestigatoriQ16082.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner."
    Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y.
    Genomics 45:386-394(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase."
    Suzuki A., Sugiyama Y., Hayashi Y., Nyu-i N., Yoshida M., Nonaka I., Ishiura S., Arahata K., Ohno S.
    J. Cell Biol. 140:1113-1124(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DMPK.
    Tissue: Muscle.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. NIEHS SNPs program
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-111.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics."
    Elisei R., Weightman D., Kendall-Taylor P., Vassart G., Ludgate M.
    J. Endocrinol. Invest. 16:533-540(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-182.
  7. "HSPB7 is a SC35 speckle resident small heat shock protein."
    Vos M.J., Kanon B., Kampinga H.H.
    Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHSPB2_HUMAN
AccessioniPrimary (citable) accession number: Q16082
Secondary accession number(s): Q6I9U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.