Reviewed,
UniProtKB/Swiss-Prot Q16082 (HSPB2_HUMAN)
Last modified
December 15, 2009.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Heat shock protein beta-2 Short name=HspB2 Alternative name(s): DMPK-binding protein Short name=MKBP | ||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 182 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | Associates specifically with myotonic dystrophy protein kinase (DMPK). |
| Tissue specificity | Expressed preferentially in skeletal muscle and heart but not in the lens. |
| Sequence similarities | Belongs to the small heat shock protein (HSP20) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Stress response |
| Coding sequence diversity | Polymorphism |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | response to heat Inferred from electronic annotation. Source: InterPro response to unfolded protein Ref.1Non-traceable author statement. Source: ProtInc |
| Cellular component | cytosol Ref.2 Traceable author statement. Source: ProtInc |
| Molecular function | enzyme activator activity Ref.2 Traceable author statement. Source: ProtInc protein binding Ref.2Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner." Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y. Genomics 45:386-394(1997) [PubMed: 9344664] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase." Suzuki A., Sugiyama Y., Hayashi Y., Nyu-i N., Yoshida M., Nonaka I., Ishiura S., Arahata K., Ohno S. J. Cell Biol. 140:1113-1124(1998) [PubMed: 9490724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Muscle. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | NIEHS SNPs program Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-111. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics." Elisei R., Weightman D., Kendall-Taylor P., Vassart G., Ludgate M. J. Endocrinol. Invest. 16:533-540(1993) [PubMed: 8227983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-182. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U75898 Genomic DNA. Translation: AAB82757.1. D89617 mRNA. Translation: BAA24004.1. CR457408 mRNA. Translation: CAG33689.1. AY208910 Genomic DNA. Translation: AAO18081.1. BC109393 mRNA. Translation: AAI09394.1. S67070 mRNA. Translation: AAB28816.1. | |
| IPI | IPI00032195. |
| RefSeq | NP_001532.1. |
| UniGene | Hs.709660 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q16082. 1 interaction. |
| STRING | Q16082. |
Proteomic databases | |
| PRIDE | Q16082. |
Genome annotation databases | |
| Ensembl | ENST00000304298; ENSP00000302476; ENSG00000170276; Homo sapiens. [Genome view] |
| GeneID | 3316. |
| KEGG | hsa:3316. |
| UCSC | uc001pmg.1. human. |
Organism-specific databases | |
| CTD | 3316. |
| GeneCards | GC11P111288. |
| H-InvDB | HIX0035830. |
| HGNC | HGNC:5247. HSPB2. |
| MIM | 602179. gene. |
| PharmGKB | PA29512. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG748242. |
| HOVERGEN | Q16082. |
| InParanoid | Q16082. |
| OMA | PADVDPW. |
| OrthoDB | EOG98D3DT. |
Gene expression databases | |
| Bgee | Q16082. |
| CleanEx | HS_HSPB2. |
| Genevestigator | Q16082. |
| GermOnline | ENSG00000170276. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001436. Alpha-crystallin/HSP. IPR002068. Hsp20. IPR008978. HSP20-like_chaperone. [Graphical view] |
| Pfam | PF00011. HSP20. 1 hit. [Graphical view] |
| PRINTS | PR00299. ACRYSTALLIN. |
| PROSITE | PS01031. HSP20. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 13152. |
| SOURCE | Search... |
Entry information
| Entry name | HSPB2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16082 Secondary accession number(s): Q6I9U7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


