Q16082 (HSPB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock protein beta-2
Short name=HspB2

Alternative name(s):
DMPK-binding protein
Short name=MKBP

Gene names

Name:

HSPB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May regulate the kinase DMPK. Ref.2
Subunit structure	Interacts with DMPK; may enhance its kinase activity. Ref.2
Subcellular location	Cytoplasm. Nucleus. Note: Localizes to nuclear foci. Ref.7
Tissue specificity	Expressed preferentially in skeletal muscle and heart but not in the lens.
Sequence similarities	Belongs to the small heat shock protein (HSP20) family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to heat Inferred from electronic annotation. Source: Compara response to unfolded protein Non-traceable author statement Ref.1. Source: ProtInc somatic muscle development Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Traceable author statement Ref.2. Source: ProtInc nucleus Inferred from direct assay Ref.7. Source: UniProtKB
Molecular_function	enzyme activator activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSPB8	Q9UJY1	3	EBI-739395,EBI-739074

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Heat shock protein beta-2		PRO_0000125933
Natural variations
	Natural variant	111	1	G → S. Ref.4 Corresponds to variant rs4252589 [ dbSNP | Ensembl ].		VAR_016316

Sequences

	Sequence		Length	Mass (Da)
	Q16082 [UniParc]. Last modified November 1, 1998. Version 2. Checksum: 7586DCE8FBD19F6D	FASTA	182	20,233
	10 20 30 40 50 60 MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAAPAGEGS 70 80 90 100 110 120 RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT 130 140 150 160 170 180 YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEAAIV EP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner." Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y. Genomics 45:386-394(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase." Suzuki A., Sugiyama Y., Hayashi Y., Nyu-i N., Yoshida M., Nonaka I., Ishiura S., Arahata K., Ohno S. J. Cell Biol. 140:1113-1124(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DMPK. Tissue: Muscle.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	NIEHS SNPs program Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-111.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics." Elisei R., Weightman D., Kendall-Taylor P., Vassart G., Ludgate M. J. Endocrinol. Invest. 16:533-540(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-182.
[7]	"HSPB7 is a SC35 speckle resident small heat shock protein." Vos M.J., Kanon B., Kampinga H.H. Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	U75898 Genomic DNA. Translation: AAB82757.1. D89617 mRNA. Translation: BAA24004.1. CR457408 mRNA. Translation: CAG33689.1. AY208910 Genomic DNA. Translation: AAO18081.1. BC109393 mRNA. Translation: AAI09394.1. S67070 mRNA. Translation: AAB28816.1.
IPI	IPI00032195.
RefSeq	NP_001532.1. NM_001541.3.
UniGene	Hs.709660.
3D structure databases
ProteinModelPortal	Q16082.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q16082. 1 interaction.
STRING	9606.ENSP00000302476.
PTM databases
PhosphoSite	Q16082.
Polymorphism databases
DMDM	6016268.
Proteomic databases
PaxDb	Q16082.
PRIDE	Q16082.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3316.
KEGG	hsa:3316.
UCSC	uc001pmg.2. human.
Organism-specific databases
CTD	3316.
GeneCards	GC11P111782.
HGNC	HGNC:5247. HSPB2.
HPA	HPA038889. HPA038890.
MIM	602179. gene.
neXtProt	NX_Q16082.
PharmGKB	PA29512.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG245877.
HOGENOM	HOG000233954.
HOVERGEN	HBG054766.
InParanoid	Q16082.
KO	K09543.
OMA	PATTEYE.
OrthoDB	EOG4CRM1B.
PhylomeDB	Q16082.
Gene expression databases
ArrayExpress	Q16082.
Bgee	Q16082.
CleanEx	HS_HSPB2.
Genevestigator	Q16082.
GermOnline	ENSG00000170276. Homo sapiens.
Family and domain databases
InterPro	IPR002068. a-crystallin/Hsp20_dom. IPR001436. Alpha-crystallin/HSP. IPR008978. HSP20-like_chaperone. [Graphical view]
Pfam	PF00011. HSP20. 1 hit. [Graphical view]
PIRSF	PIRSF036514. Sm_HSP_B1. 1 hit.
PRINTS	PR00299. ACRYSTALLIN.
SUPFAM	SSF49764. HSP20_chap. 1 hit.
PROSITE	PS01031. HSP20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3316.
NextBio	13152.
SOURCE	Search...

Entry information

Entry name

HSPB2_HUMAN

Accession

Primary (citable) accession number: Q16082
Secondary accession number(s): Q6I9U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.