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Q16082 (HSPB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock protein beta-2

Short name=HspB2
Alternative name(s):
DMPK-binding protein
Short name=MKBP
Gene names
Name:HSPB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate the kinase DMPK. Ref.2

Subunit structure

Interacts with DMPK; may enhance its kinase activity. Ref.2

Subcellular location

Cytoplasm. Nucleus. Note: Localizes to nuclear foci. Ref.7

Tissue specificity

Expressed preferentially in skeletal muscle and heart but not in the lens.

Sequence similarities

Belongs to the small heat shock protein (HSP20) family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpositive regulation of catalytic activity

Traceable author statement Ref.2. Source: GOC

response to unfolded protein

Non-traceable author statement Ref.1. Source: ProtInc

   Cellular_componentcytoplasm

Inferred from direct assay Ref.7. Source: UniProtKB

cytosol

Traceable author statement Ref.2. Source: ProtInc

nucleus

Inferred from direct assay Ref.7. Source: UniProtKB

   Molecular_functionenzyme activator activity

Traceable author statement Ref.2. Source: ProtInc

protein binding

Inferred from physical interaction PubMed 14594798. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HSPB8Q9UJY13EBI-739395,EBI-739074

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Heat shock protein beta-2
PRO_0000125933

Natural variations

Natural variant1111G → S. Ref.4
Corresponds to variant rs4252589 [ dbSNP | Ensembl ].
VAR_016316

Sequences

Sequence LengthMass (Da)Tools
Q16082 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: 7586DCE8FBD19F6D

FASTA18220,233
        10         20         30         40         50         60 
MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAAPAGEGS 

        70         80         90        100        110        120 
RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT 

       130        140        150        160        170        180 
YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEAAIV 


EP 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner."
Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y.
Genomics 45:386-394(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase."
Suzuki A., Sugiyama Y., Hayashi Y., Nyu-i N., Yoshida M., Nonaka I., Ishiura S., Arahata K., Ohno S.
J. Cell Biol. 140:1113-1124(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DMPK.
Tissue: Muscle.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]NIEHS SNPs program
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-111.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics."
Elisei R., Weightman D., Kendall-Taylor P., Vassart G., Ludgate M.
J. Endocrinol. Invest. 16:533-540(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-182.
[7]"HSPB7 is a SC35 speckle resident small heat shock protein."
Vos M.J., Kanon B., Kampinga H.H.
Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U75898 Genomic DNA. Translation: AAB82757.1.
D89617 mRNA. Translation: BAA24004.1.
CR457408 mRNA. Translation: CAG33689.1.
AY208910 Genomic DNA. Translation: AAO18081.1.
BC109393 mRNA. Translation: AAI09394.1.
S67070 mRNA. Translation: AAB28816.1.
CCDSCCDS8352.1.
RefSeqNP_001532.1. NM_001541.3.
UniGeneHs.709660.

3D structure databases

ProteinModelPortalQ16082.
SMRQ16082. Positions 16-148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109548. 21 interactions.
IntActQ16082. 2 interactions.
MINTMINT-1616978.
STRING9606.ENSP00000302476.

PTM databases

PhosphoSiteQ16082.

Proteomic databases

MaxQBQ16082.
PaxDbQ16082.
PRIDEQ16082.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3316.
KEGGhsa:3316.
UCSCuc001pmg.2. human.

Organism-specific databases

CTD3316.
GeneCardsGC11P111782.
GC11P111785.
HGNCHGNC:5247. HSPB2.
HPAHPA038889.
HPA038890.
MIM602179. gene.
neXtProtNX_Q16082.
PharmGKBPA29512.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245877.
HOGENOMHOG000233954.
HOVERGENHBG054766.
InParanoidQ16082.
KOK09543.
OMAPATTEYE.
OrthoDBEOG7WHHBK.
PhylomeDBQ16082.

Gene expression databases

BgeeQ16082.
CleanExHS_HSPB2.
GenevestigatorQ16082.

Family and domain databases

Gene3D2.60.40.790. 1 hit.
InterProIPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamPF00011. HSP20. 1 hit.
[Graphical view]
PIRSFPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSPR00299. ACRYSTALLIN.
SUPFAMSSF49764. SSF49764. 1 hit.
PROSITEPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHSPB2.
GenomeRNAi3316.
NextBio13152.
PROQ16082.
SOURCESearch...

Entry information

Entry nameHSPB2_HUMAN
AccessionPrimary (citable) accession number: Q16082
Secondary accession number(s): Q6I9U7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM