Reviewed, UniProtKB/Swiss-Prot Q15ZU4 (TDH_PSEA6)

Names and origin

Protein names

Recommended name:
    L-threonine 3-dehydrogenase
    EC=1.1.1.103

Gene names

Name:	tdh
Ordered Locus Names:	Patl_0062

Organism

Pseudoalteromonas atlantica (strain T6c / BAA-1087) [Complete proteome] [HAMAP]

Taxonomic identifier

342610 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. HAMAP MF_00627
Cofactor	Binds 2 zinc ions per subunit By similarity. HAMAP MF_00627
Pathway	Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. HAMAP MF_00627
Subunit structure	Homotetramer By similarity. HAMAP MF_00627
Subcellular location	Cytoplasm By similarity HAMAP MF_00627.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW threonine catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-threonine 3-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	L-threonine 3-dehydrogenase HAMAP MF_00627		PRO_1000051645
Sites
	Metal binding	38	1	Zinc 1; catalytic By similarity
	Metal binding	63	1	Zinc 1; catalytic By similarity
	Metal binding	93	1	Zinc 2 By similarity
	Metal binding	96	1	Zinc 2 By similarity
	Metal binding	99	1	Zinc 2 By similarity
	Metal binding	107	1	Zinc 2 By similarity
	Metal binding	148	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q15ZU4-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 0AE752FAB098478A	FASTA	340	36,988
	10 20 30 40 50 60 MKSLAKLKSE KGIWLHDSEM PTVGHNDILI KIRKTAICGT DMHIYNWDEW SQNTIPVPMV 70 80 90 100 110 120 VGHEYVGEVV EIGEEVRGFA IGDRVSGEGH ITCGHCRNCR AGRRHLCRNT SGVGVNRAGA 130 140 150 160 170 180 FAEYLSIPAF NAFKIPDNIS DDLAAIFDPF GNAVHTALSF DLVGEDVLIT GAGPIGIMAA 190 200 210 220 230 240 AVAQHVGARH VVITDVNEYR LDLARKMGAS RAVNVAKESL KDVMNDLGMS EGFDVGLEMS 250 260 270 280 290 300 GVPAAFRDML DKMNHGGKVA MLGIPSGDVA VDWNKVIFKG LVIKGIYGRE MFETWYKMAS 310 320 330 340 LIQGGLNLAP IITHQFNIDE FQQGFDTMGS GQSGKVILNW

References

[1]

"Complete sequence of Pseudoalteromonas atlantica T6c." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000388 Genomic DNA. Translation: ABG38594.1.
RefSeq	YP_659648.1.
3D structure databases
SMR	Q15ZU4. Positions 1-340.
ModBase	Search...
Protein-protein interaction databases
STRING	Q15ZU4.
Genome annotation databases
GeneID	4171896.
GenomeReviews	Gene locus Patl_0062 in contig CP000388_GR.
KEGG	pat:Patl_0062.
NMPDR	fig|342610.3.peg.372.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1063.
HOGENOM	HBG753318.
OMA	MVDAPKP.
PhylomeDB	Q15ZU4.
Enzyme and pathway databases
BioCyc	PATL342610:PATL_0062-MONOMER.
Family and domain databases
HAMAP	MF_00627. Thr_dehydrog. [Tree]
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR004627. L-Threonine_3-DHase. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00692. tdh. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TDH_PSEA6

Accession

Primary (citable) accession number: Q15ZU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 25, 2006
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)