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Q15Z55 (GCH4_PSEA6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Patl_0301
OrganismPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) [Complete proteome] [HAMAP]
Taxonomic identifier342610 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289505

Sites

Site1551May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q15Z55 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 853227950BC4DA35

FASTA30633,502
        10         20         30         40         50         60 
MGMTLPDITS SENVASAAPL KWVGMEGITV PIQVPMSGEV PAYVNAKTDV YVSLDKSDAK 

        70         80         90        100        110        120 
GIHMSRLFLK LNDILGTELL SSTSLTALLN ELILSQQGLS QGAKVNLDFA LTLRKKALLS 

       130        140        150        160        170        180 
NEFGYQSYPI GISTQLVKGV ARTVLSLTIA YSSTCPCSSA LAQQALSDAI SQRFDDEMIS 

       190        200        210        220        230        240 
KSELTQWITS KTGAVATPHS QRSYAYIKLT LDGDALPNLP ELITLLETTI GTPVQTAVKR 

       250        260        270        280        290        300 
QDEQAFAKLN AENLMFCEDA ARRLKRALER KENVLDYWFK VEHQESLHAH NAVAIDFKDN 


ADEDTM 

« Hide

References

[1]"Complete sequence of Pseudoalteromonas atlantica T6c."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T6c / ATCC BAA-1087.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000388 Genomic DNA. Translation: ABG38833.1.
RefSeqYP_659887.1. NC_008228.1.

3D structure databases

ProteinModelPortalQ15Z55.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342610.Patl_0301.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG38833; ABG38833; Patl_0301.
GeneID4172895.
KEGGpat:Patl_0301.
PATRIC23045410. VBIPseAtl25434_0316.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMAAGRTTIQ.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycPATL342610:GHGT-307-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_PSEA6
AccessionPrimary (citable) accession number: Q15Z55
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways