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Q15VK0

- SYL_PSEA6

UniProt

Q15VK0 - SYL_PSEA6

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei629 – 6291ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPATL342610:GHGT-1595-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Patl_1566
    OrganismiPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
    Taxonomic identifieri342610 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000001981: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 870870Leucine--tRNA ligasePRO_0000334793Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342610.Patl_1566.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15VK0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi626 – 6305"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15VK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKIYEPQK IEQEVQALWE TNQTFKATEQ EDKEKFYCLS MFPYPSGRLH    50
    MGHVRNYTIG DVVSRFQRMN GKNVLQPMGW DAFGLPAENA ALNNNTAPAK 100
    WTYQNIDYMK NQLKSLGFGY DWDREVATCK KDYYRWEQWF FTRLYEKGLV 150
    YKKNSTVNWD PVDHTVLANE QVIDGRGWRS GALVEQKEIP QWFIKITDYA 200
    EELLTDLEQL EDWPEQVRAM QKNWIGRSEG VDITFNLSEN AADISSFDVY 250
    TTRPDTLYGV TYVAVAAQHP LALHAAQTRP ELAEFIESCK NTKVAEAELA 300
    TMEKKGCDTG LFAIHPLTGE KVAVWVANFV LMGYGSGAVM SVPGHDQRDW 350
    EFAQKYGLPI KQVVEPSADE PQECDLTTAA YTDKGVLVNS AEFNGLAFQE 400
    AFDAIAAKLE ALGAGSKKVN YRLRDWGVSR QRYWGSPIPM LNLENGESVP 450
    VPSDQLPVEL PEDVQMNGVI SPIKADPDWA KTEYNGQPAL RETDTFDTFM 500
    ESSWYYARYC SAQNQDAMLD PTQANYWLPV DQYVGGIEHA ILHLLYSRFF 550
    HKLLRDEGLV NSDEPYKRLL CQGMVLADSF FREDESGKKE WFSPADVDTV 600
    KDEKGRITQA TLKADGKPVE HGGMTKMSKS KNNGIDPQHV IDLYGADTIR 650
    VFTMFAAPPE QTLEWVDSGV EGANRFIKRV WKLTQDHIDA LDGDTAPAID 700
    KTALTGDQKT LRRAVHRTIA KVTDDVGRRQ TFNTAVAAIM ELLNSLQRAP 750
    QSTDQDKAVL REAIESVVLL LNPIAPHMCH ILWHDLGHKN DIETAPWPAV 800
    DESALVEDEK LIIVQVNGKV RSKITVAADA SQEEVQALGL AQENVQQFVD 850
    GKTIRKVIYI AGKLLNIVAN 870
    Length:870
    Mass (Da):98,121
    Last modified:July 25, 2006 - v1
    Checksum:i6FB0DCCA8696AD1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000388 Genomic DNA. Translation: ABG40088.1.
    RefSeqiYP_661142.1. NC_008228.1.

    Genome annotation databases

    EnsemblBacteriaiABG40088; ABG40088; Patl_1566.
    GeneIDi4172558.
    KEGGipat:Patl_1566.
    PATRICi23048160. VBIPseAtl25434_1671.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000388 Genomic DNA. Translation: ABG40088.1 .
    RefSeqi YP_661142.1. NC_008228.1.

    3D structure databases

    ProteinModelPortali Q15VK0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342610.Patl_1566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG40088 ; ABG40088 ; Patl_1566 .
    GeneIDi 4172558.
    KEGGi pat:Patl_1566.
    PATRICi 23048160. VBIPseAtl25434_1671.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PATL342610:GHGT-1595-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: T6c / ATCC BAA-1087.

    Entry informationi

    Entry nameiSYL_PSEA6
    AccessioniPrimary (citable) accession number: Q15VK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3