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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei629ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPATL342610:G1G6R-1617-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Patl_1566
OrganismiPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Taxonomic identifieri342610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
Proteomesi
  • UP000001981 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347931 – 870Leucine--tRNA ligaseAdd BLAST870

Proteomic databases

PRIDEiQ15VK0

Interactioni

Protein-protein interaction databases

STRINGi342610.Patl_1566

Structurei

3D structure databases

ProteinModelPortaliQ15VK0
SMRiQ15VK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi626 – 630"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q15VK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKIYEPQK IEQEVQALWE TNQTFKATEQ EDKEKFYCLS MFPYPSGRLH
60 70 80 90 100
MGHVRNYTIG DVVSRFQRMN GKNVLQPMGW DAFGLPAENA ALNNNTAPAK
110 120 130 140 150
WTYQNIDYMK NQLKSLGFGY DWDREVATCK KDYYRWEQWF FTRLYEKGLV
160 170 180 190 200
YKKNSTVNWD PVDHTVLANE QVIDGRGWRS GALVEQKEIP QWFIKITDYA
210 220 230 240 250
EELLTDLEQL EDWPEQVRAM QKNWIGRSEG VDITFNLSEN AADISSFDVY
260 270 280 290 300
TTRPDTLYGV TYVAVAAQHP LALHAAQTRP ELAEFIESCK NTKVAEAELA
310 320 330 340 350
TMEKKGCDTG LFAIHPLTGE KVAVWVANFV LMGYGSGAVM SVPGHDQRDW
360 370 380 390 400
EFAQKYGLPI KQVVEPSADE PQECDLTTAA YTDKGVLVNS AEFNGLAFQE
410 420 430 440 450
AFDAIAAKLE ALGAGSKKVN YRLRDWGVSR QRYWGSPIPM LNLENGESVP
460 470 480 490 500
VPSDQLPVEL PEDVQMNGVI SPIKADPDWA KTEYNGQPAL RETDTFDTFM
510 520 530 540 550
ESSWYYARYC SAQNQDAMLD PTQANYWLPV DQYVGGIEHA ILHLLYSRFF
560 570 580 590 600
HKLLRDEGLV NSDEPYKRLL CQGMVLADSF FREDESGKKE WFSPADVDTV
610 620 630 640 650
KDEKGRITQA TLKADGKPVE HGGMTKMSKS KNNGIDPQHV IDLYGADTIR
660 670 680 690 700
VFTMFAAPPE QTLEWVDSGV EGANRFIKRV WKLTQDHIDA LDGDTAPAID
710 720 730 740 750
KTALTGDQKT LRRAVHRTIA KVTDDVGRRQ TFNTAVAAIM ELLNSLQRAP
760 770 780 790 800
QSTDQDKAVL REAIESVVLL LNPIAPHMCH ILWHDLGHKN DIETAPWPAV
810 820 830 840 850
DESALVEDEK LIIVQVNGKV RSKITVAADA SQEEVQALGL AQENVQQFVD
860 870
GKTIRKVIYI AGKLLNIVAN
Length:870
Mass (Da):98,121
Last modified:July 25, 2006 - v1
Checksum:i6FB0DCCA8696AD1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000388 Genomic DNA Translation: ABG40088.1
RefSeqiWP_011574402.1, NC_008228.1

Genome annotation databases

EnsemblBacteriaiABG40088; ABG40088; Patl_1566
KEGGipat:Patl_1566

Similar proteinsi

Entry informationi

Entry nameiSYL_PSEA6
AccessioniPrimary (citable) accession number: Q15VK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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