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Q15VK0 (SYL_PSEA6) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Patl_1566
OrganismPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) [Complete proteome] [HAMAP]
Taxonomic identifier342610 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

Protein attributes

Sequence length870 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 870870Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334793

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif626 – 6305"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6291ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q15VK0 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 6FB0DCCA8696AD1F

FASTA87098,121
        10         20         30         40         50         60 
MAEKIYEPQK IEQEVQALWE TNQTFKATEQ EDKEKFYCLS MFPYPSGRLH MGHVRNYTIG 

        70         80         90        100        110        120 
DVVSRFQRMN GKNVLQPMGW DAFGLPAENA ALNNNTAPAK WTYQNIDYMK NQLKSLGFGY 

       130        140        150        160        170        180 
DWDREVATCK KDYYRWEQWF FTRLYEKGLV YKKNSTVNWD PVDHTVLANE QVIDGRGWRS 

       190        200        210        220        230        240 
GALVEQKEIP QWFIKITDYA EELLTDLEQL EDWPEQVRAM QKNWIGRSEG VDITFNLSEN 

       250        260        270        280        290        300 
AADISSFDVY TTRPDTLYGV TYVAVAAQHP LALHAAQTRP ELAEFIESCK NTKVAEAELA 

       310        320        330        340        350        360 
TMEKKGCDTG LFAIHPLTGE KVAVWVANFV LMGYGSGAVM SVPGHDQRDW EFAQKYGLPI 

       370        380        390        400        410        420 
KQVVEPSADE PQECDLTTAA YTDKGVLVNS AEFNGLAFQE AFDAIAAKLE ALGAGSKKVN 

       430        440        450        460        470        480 
YRLRDWGVSR QRYWGSPIPM LNLENGESVP VPSDQLPVEL PEDVQMNGVI SPIKADPDWA 

       490        500        510        520        530        540 
KTEYNGQPAL RETDTFDTFM ESSWYYARYC SAQNQDAMLD PTQANYWLPV DQYVGGIEHA 

       550        560        570        580        590        600 
ILHLLYSRFF HKLLRDEGLV NSDEPYKRLL CQGMVLADSF FREDESGKKE WFSPADVDTV 

       610        620        630        640        650        660 
KDEKGRITQA TLKADGKPVE HGGMTKMSKS KNNGIDPQHV IDLYGADTIR VFTMFAAPPE 

       670        680        690        700        710        720 
QTLEWVDSGV EGANRFIKRV WKLTQDHIDA LDGDTAPAID KTALTGDQKT LRRAVHRTIA 

       730        740        750        760        770        780 
KVTDDVGRRQ TFNTAVAAIM ELLNSLQRAP QSTDQDKAVL REAIESVVLL LNPIAPHMCH 

       790        800        810        820        830        840 
ILWHDLGHKN DIETAPWPAV DESALVEDEK LIIVQVNGKV RSKITVAADA SQEEVQALGL 

       850        860        870 
AQENVQQFVD GKTIRKVIYI AGKLLNIVAN 

« Hide

References

[1]"Complete sequence of Pseudoalteromonas atlantica T6c."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T6c / ATCC BAA-1087.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000388 Genomic DNA. Translation: ABG40088.1.
RefSeqYP_661142.1. NC_008228.1.

3D structure databases

ProteinModelPortalQ15VK0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342610.Patl_1566.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG40088; ABG40088; Patl_1566.
GeneID4172558.
KEGGpat:Patl_1566.
PATRIC23048160. VBIPseAtl25434_1671.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycPATL342610:GHGT-1595-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PSEA6
AccessionPrimary (citable) accession number: Q15VK0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries