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Q15UE5 (KATG_PSEA6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Catalase-peroxidase
Short name=CP
EC=1.11.1.21
Alternative name(s):
Peroxidase/catalase
Gene names
Name:katG
Ordered Locus Names:Patl_1975
OrganismPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) [Complete proteome] [HAMAP]
Taxonomic identifier342610 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas ›

Protein attributes

Sequence length753 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP-Rule MF_01961

Catalytic activity

Donor + H2O2 = oxidized donor + 2 H2O. HAMAP-Rule MF_01961

2 H2O2 = O2 + 2 H2O. HAMAP-Rule MF_01961

Cofactor

Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.

Subunit structure

Homodimer or homotetramer By similarity.

Post-translational modification

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP-Rule MF_01961

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Ontologies

Keywords
   Biological processHydrogen peroxide
   DomainSignal
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncatalase activity

Inferred from electronic annotation. Source: HAMAP

heme binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3939 Potential
Chain40 – 753714Catalase-peroxidase HAMAP-Rule MF_01961
PRO_5000125426

Sites

Active site1191Proton acceptor By similarity
Metal binding2821Iron (heme axial ligand) By similarity
Site1151Transition state stabilizer By similarity

Amino acid modifications

Cross-link118 ↔ 241Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-267) By similarity
Cross-link241 ↔ 267Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-118) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q15UE5 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 0BDFBA0FF39D79EB

FASTA75383,419
        10         20         30         40         50         60 
MLPRVNKRSN CIAKKTSNRL ISAVSLAIAS LCISQSALAD GMPKTNTFWW PEQLNLQPLR 

        70         80         90        100        110        120 
QNDAKSNPLG GDFNYADAFK TLNLANVKSD IKALLTSSQD WWPADYGHYG PFFVRMAWHS 

       130        140        150        160        170        180 
TGTYRMSDGR GGGAGGQQRF EPLNSWPDNV SLDKARRLLW PIKQKYGRSL SWADLMVLTG 

       190        200        210        220        230        240 
NVAMESMGFT IYGFAGGRED DFEPDLVYWG PEKKWLGGNE RYSGERKLEE PLAAVQMGLI 

       250        260        270        280        290        300 
YVNPEGPNGN HDPISAAADI RDVFARMAMN DEETVALIAG GHTFGKAHGA HKPDECLDPA 

       310        320        330        340        350        360 
PAGATIEEQG LGWKNKCGKG NAEDTITSGL EGAWSVSPTQ WTMQYLDNLF GFEWVETQSP 

       370        380        390        400        410        420 
AGATQWIPKD NAGANLVPDA HVKSKRHAPI MFTTDLALKE DPQYRKIAER FHANPKEFEL 

       430        440        450        460        470        480 
AFSKAWFKLT HRDMGPRARY VGDESPTDDF LWQDPIPSVD YSLIDKRDIQ HLKTKLLDGD 

       490        500        510        520        530        540 
VTPAQLVKTA WAAAASFRAT DMRGGVNGAR IQLAPQKNWE VNNPDELNTV LMFLNKVKKD 

       550        560        570        580        590        600 
FNDGQSGNKQ VSLADLIVLG GAAAIEHAAS KNDFDVEVPF IPGRSDATQA QTEVESFAVL 

       610        620        630        640        650        660 
EPKADGFRNY YAQGNTLSPV EMLVDKANTL DLSVPEMSVL VAGLRVMNIN ADGSDRGVLT 

       670        680        690        700        710        720 
DNPGTLNNDF FVNLLDMSTR WEKAKDQQDL YLGIDRKSNK QRWSASSVDL IFGSNSELRA 

       730        740        750 
VAEVYASDDA HQQFVDDFVN AWTKVMTLDR FDL

« Hide

References

[1]"Complete sequence of Pseudoalteromonas atlantica T6c."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T6c / ATCC BAA-1087.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000388 Genomic DNA. Translation: ABG40493.1.
RefSeqYP_661547.1. NC_008228.1.

3D structure databases

ProteinModelPortalQ15UE5.
SMRQ15UE5. Positions 45-753.
ModBaseSearch...

Protein-protein interaction databases

STRING342610.Patl_1975.

Protein family/group databases

PeroxiBase2647. PatCP01.

Proteomic databases

PRIDEQ15UE5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG40493; ABG40493; Patl_1975.
GeneID4172110.
KEGGpat:Patl_1975.
PATRIC23049052. VBIPseAtl25434_2114.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0376.
HOGENOMHOG000218110.
KOK03782.
OMAWKNKCGK.
ProtClustDBPRK15061.

Enzyme and pathway databases

BioCycPATL342610:GHGT-2059-MONOMER.

Family and domain databases

HAMAPMF_01961. Catal-peroxid.
InterProIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMSSF48113. Peroxidase_super. 2 hits.
TIGRFAMsTIGR00198. cat_per_HPI. 1 hit.
PROSITEPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. False negative.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKATG_PSEA6
AccessionPrimary (citable) accession number: Q15UE5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 25, 2006
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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