Q15TS5 (ASTE_PSEA6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinylglutamate desuccinylase
EC=3.5.1.96

Gene names

Name:	astE
Ordered Locus Names:	Patl_2195

Organism

Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) [Complete proteome] [HAMAP]

Taxonomic identifier

342610 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transforms N(2)-succinylglutamate into succinate and glutamate. HAMAP MF_00767
Catalytic activity	N-succinyl-L-glutamate + H2O = succinate + L-glutamate. HAMAP MF_00767
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00767
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 5/5. HAMAP MF_00767
Sequence similarities	Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: InterPro
Molecular function	hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro succinylglutamate desuccinylase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Succinylglutamate desuccinylase HAMAP MF_00767		PRO_0000262079
Sites
	Active site	233	1	Potential
	Metal binding	71	1	Zinc By similarity
	Metal binding	74	1	Zinc By similarity
	Metal binding	169	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q15TS5 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 9B68EB60E9BA6BC4	FASTA	350	39,246
	10 20 30 40 50 60 MQTVNTHKLI SHLQQQGQFL TLSRCSGELV QNPISFTLYE HTQVSIISPG IISFSPKIKS 70 80 90 100 110 120 DKAIVLSSGI HGNETAPIEI CDQYVIDILT GKIRVAHRIL FIFGNLPAMD RATRFVDENL 130 140 150 160 170 180 NRLFSHAHAS ESVDQNSYEC ARAKEIEEAV AEFYGSGHGE ESRYHYDLHT AIRPSKNEKF 190 200 210 220 230 240 AVYPFLHGEK HDKEQISFLL ACGIDTFLLS GSPTTTFSYY SSRQFGAHAF TVELGKVQAF 250 260 270 280 290 300 GQNDMSRFTQ VNDTLKRFIS GQPLNLKSFN DQDVLIYQVN QVINKHAEDF ELDFSDDLPN 310 320 330 340 350 FSDFPKGTLL AHETGNEYRA EFDGEAVVFP NANVAIGQRA ILTVIPTTLD

References

[1]

"Complete sequence of Pseudoalteromonas atlantica T6c." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: T6c / ATCC BAA-1087.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000388 Genomic DNA. Translation: ABG40713.1.
RefSeq	YP_661767.1. NC_008228.1.
3D structure databases
ProteinModelPortal	Q15TS5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q15TS5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4172347.
GenomeReviews	Gene locus Patl_2195 in contig CP000388_GR.
KEGG	pat:Patl_2195.
NMPDR	fig|342610.3.peg.3166.
PATRIC	23049516. VBIPseAtl25434_2346.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2988.
HOGENOM	HBG298271.
OMA	RWRWLGH.
PhylomeDB	Q15TS5.
ProtClustDB	PRK05324.
Enzyme and pathway databases
BioCyc	PATL342610:PATL_2195-MONOMER.
Family and domain databases
HAMAP	MF_00767. Arg_catab_AstE. [Tree]
InterPro	IPR007036. Aste_AspA. IPR016681. SuccinylGlu_desuccinylase. [Graphical view]
KO	K05526.
Pfam	PF04952. AstE_AspA. 1 hit. [Graphical view]
PIRSF	PIRSF017020. AstE. 1 hit.
TIGRFAMs	TIGR03242. Arg_catab_astE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ASTE_PSEA6

Accession

Primary (citable) accession number: Q15TS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program