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Q15SZ6 (PUR7_PSEA6) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:Patl_2476
OrganismPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) [Complete proteome] [HAMAP]
Taxonomic identifier342610 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_1000117839

Sequences

Sequence LengthMass (Da)Tools
Q15SZ6 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 1A9F1EC874582611

FASTA36741,590
        10         20         30         40         50         60 
MSFADKVLAV NDNLPIRTDL PVHSGKVRSV YWLTEQDSRR LIEEHNYPVP KDTPLAIMLI 

        70         80         90        100        110        120 
SDRISAFDCI WRGEEGMQGV PGKGAALNAI SNHWFGLFKE QGLADSHILD IPHPLVWIVQ 

       130        140        150        160        170        180 
KARPIMIEAI CRQYITGSMW RAYEKGEREF CGIRLEEGLS RDSKLANILI TPSTKGVLKG 

       190        200        210        220        230        240 
IEGVPEADDV NVSRSDIAQH YAAFNFNSAD DIALYEKLLT EGFGVISHAL NKIDQIFVDT 

       250        260        270        280        290        300 
KFEFGYVKDV DGNDKLIYMD EVGTPDSSRI WDAKQYDQGN IVENSKEGFR QLLLNYFPDP 

       310        320        330        340        350        360 
DILLNKERMD EREALARNNA LPVQVLMDIS KTYTQIAEKI TGQKIVLSDN PKEEVISVLR 


DRYQLID

« Hide

References

[1]"Complete sequence of Pseudoalteromonas atlantica T6c."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T6c / ATCC BAA-1087.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000388 Genomic DNA. Translation: ABG40992.1.
RefSeqYP_662046.1. NC_008228.1.

3D structure databases

ProteinModelPortalQ15SZ6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ15SZ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4174230.
GenomeReviewsGene locus Patl_2476 in contig CP000388_GR.
KEGGpat:Patl_2476.
NMPDRfig|342610.3.peg.4196.
PATRIC23050140. VBIPseAtl25434_2648.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0152.
HOGENOMHBG555040.
OMASSRIWDG.
PhylomeDBQ15SZ6.
ProtClustDBPRK13960.

Enzyme and pathway databases

BioCycPATL342610:PATL_2476-MONOMER.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR014106. PurC_vibrio.
IPR001636. SAICAR_synth.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KOK01923.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR02735. PurC_vibrio. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. False negative.
PS01058. SAICAR_SYNTHETASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_PSEA6
AccessionPrimary (citable) accession number: Q15SZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 25, 2006
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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