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Q15N19

- GPPA_PSEA6

UniProt

Q15N19 - GPPA_PSEA6

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.By similarity

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: InterPro
    3. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPATL342610:GHGT-4301-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolase
    pppGpp-5'-phosphohydrolase
    Gene namesi
    Name:gppA
    Ordered Locus Names:Patl_4220
    OrganismiPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
    Taxonomic identifieri342610 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000001981: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000314496Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342610.Patl_4220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15N19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    Gene3Di1.10.3210.10. 1 hit.
    InterProiIPR006674. HD_domain.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15N19-1 [UniParc]FASTAAdd to Basket

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    MITSTRLPQN HPEELYAAVD LGSNSFHLVI VRVVAGSVQI IGKVKQKVRL    50
    AAGLDDNMML DNESLERGWR CLETFAERLQ DIPRDNIRVV ATATLRLAKN 100
    ADVFTVKAQQ ILDHTLSVIS GEEEARQIYL GVAYTSANQG NSLVIDIGGA 150
    STEIIIGNDM TPIHLVSLNM GCVTFKERHF AGDVLSEENF AAAIDAAKAM 200
    VDAVADKFVC FDWQQCLGAS GTPQAITEIL VAQGISDAIR LDYLYNLRQQ 250
    CIDCSTLDNL IIDGLDESRR IIFPSGLAIL IALFESLSIR DMQISGGALR 300
    EGLIYGMLEN MQQNDRRMQT IHQHMQHFHI DSEQAERVTE VALTLFKQLS 350
    EQTDVDGIDG EAMLVAAAML HETGLHIEYK LHHKHGAYIL GHVPMVGYTN 400
    LQRDGIKTLV LNHRQQISPE VFDQNHSETR GIMRSLVRVL RLACILSIRR 450
    KDNLLPQFCL EVEENDWRLV FPEGWLKAHP LIDAELANEK WQQHKMGWHL 500
    TCE 503
    Length:503
    Mass (Da):56,404
    Last modified:July 25, 2006 - v1
    Checksum:iFCDB2F501A792378
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000388 Genomic DNA. Translation: ABG42719.1.
    RefSeqiWP_011576907.1. NC_008228.1.
    YP_663773.1. NC_008228.1.

    Genome annotation databases

    EnsemblBacteriaiABG42719; ABG42719; Patl_4220.
    GeneIDi4176009.
    KEGGipat:Patl_4220.
    PATRICi23053898. VBIPseAtl25434_4490.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000388 Genomic DNA. Translation: ABG42719.1 .
    RefSeqi WP_011576907.1. NC_008228.1.
    YP_663773.1. NC_008228.1.

    3D structure databases

    ProteinModelPortali Q15N19.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342610.Patl_4220.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG42719 ; ABG42719 ; Patl_4220 .
    GeneIDi 4176009.
    KEGGi pat:Patl_4220.
    PATRICi 23053898. VBIPseAtl25434_4490.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci PATL342610:GHGT-4301-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3210.10. 1 hit.
    InterProi IPR006674. HD_domain.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: T6c / ATCC BAA-1087.

    Entry informationi

    Entry nameiGPPA_PSEA6
    AccessioniPrimary (citable) accession number: Q15N19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3