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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities (By similarity).By similarity

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPATL342610:GHGT-4301-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:Patl_4220
OrganismiPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Taxonomic identifieri342610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000001981: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000314496Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342610.Patl_4220.

Structurei

3D structure databases

ProteinModelPortaliQ15N19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.Curated

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiFKRAPQH.
OrthoDBiEOG6M6JN6.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
InterProiIPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15N19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITSTRLPQN HPEELYAAVD LGSNSFHLVI VRVVAGSVQI IGKVKQKVRL
60 70 80 90 100
AAGLDDNMML DNESLERGWR CLETFAERLQ DIPRDNIRVV ATATLRLAKN
110 120 130 140 150
ADVFTVKAQQ ILDHTLSVIS GEEEARQIYL GVAYTSANQG NSLVIDIGGA
160 170 180 190 200
STEIIIGNDM TPIHLVSLNM GCVTFKERHF AGDVLSEENF AAAIDAAKAM
210 220 230 240 250
VDAVADKFVC FDWQQCLGAS GTPQAITEIL VAQGISDAIR LDYLYNLRQQ
260 270 280 290 300
CIDCSTLDNL IIDGLDESRR IIFPSGLAIL IALFESLSIR DMQISGGALR
310 320 330 340 350
EGLIYGMLEN MQQNDRRMQT IHQHMQHFHI DSEQAERVTE VALTLFKQLS
360 370 380 390 400
EQTDVDGIDG EAMLVAAAML HETGLHIEYK LHHKHGAYIL GHVPMVGYTN
410 420 430 440 450
LQRDGIKTLV LNHRQQISPE VFDQNHSETR GIMRSLVRVL RLACILSIRR
460 470 480 490 500
KDNLLPQFCL EVEENDWRLV FPEGWLKAHP LIDAELANEK WQQHKMGWHL

TCE
Length:503
Mass (Da):56,404
Last modified:July 25, 2006 - v1
Checksum:iFCDB2F501A792378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000388 Genomic DNA. Translation: ABG42719.1.
RefSeqiWP_011576907.1. NC_008228.1.
YP_663773.1. NC_008228.1.

Genome annotation databases

EnsemblBacteriaiABG42719; ABG42719; Patl_4220.
GeneIDi4176009.
KEGGipat:Patl_4220.
PATRICi23053898. VBIPseAtl25434_4490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000388 Genomic DNA. Translation: ABG42719.1.
RefSeqiWP_011576907.1. NC_008228.1.
YP_663773.1. NC_008228.1.

3D structure databases

ProteinModelPortaliQ15N19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342610.Patl_4220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG42719; ABG42719; Patl_4220.
GeneIDi4176009.
KEGGipat:Patl_4220.
PATRICi23053898. VBIPseAtl25434_4490.

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiFKRAPQH.
OrthoDBiEOG6M6JN6.

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.
BioCyciPATL342610:GHGT-4301-MONOMER.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
InterProiIPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T6c / ATCC BAA-1087.

Entry informationi

Entry nameiGPPA_PSEA6
AccessioniPrimary (citable) accession number: Q15N19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.