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Q15N19 (GPPA_PSEA6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:Patl_4220
OrganismPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) [Complete proteome] [HAMAP]
Taxonomic identifier342610 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
PRO_0000314496

Sequences

Sequence LengthMass (Da)Tools
Q15N19 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: FCDB2F501A792378

FASTA50356,404
        10         20         30         40         50         60 
MITSTRLPQN HPEELYAAVD LGSNSFHLVI VRVVAGSVQI IGKVKQKVRL AAGLDDNMML 

        70         80         90        100        110        120 
DNESLERGWR CLETFAERLQ DIPRDNIRVV ATATLRLAKN ADVFTVKAQQ ILDHTLSVIS 

       130        140        150        160        170        180 
GEEEARQIYL GVAYTSANQG NSLVIDIGGA STEIIIGNDM TPIHLVSLNM GCVTFKERHF 

       190        200        210        220        230        240 
AGDVLSEENF AAAIDAAKAM VDAVADKFVC FDWQQCLGAS GTPQAITEIL VAQGISDAIR 

       250        260        270        280        290        300 
LDYLYNLRQQ CIDCSTLDNL IIDGLDESRR IIFPSGLAIL IALFESLSIR DMQISGGALR 

       310        320        330        340        350        360 
EGLIYGMLEN MQQNDRRMQT IHQHMQHFHI DSEQAERVTE VALTLFKQLS EQTDVDGIDG 

       370        380        390        400        410        420 
EAMLVAAAML HETGLHIEYK LHHKHGAYIL GHVPMVGYTN LQRDGIKTLV LNHRQQISPE 

       430        440        450        460        470        480 
VFDQNHSETR GIMRSLVRVL RLACILSIRR KDNLLPQFCL EVEENDWRLV FPEGWLKAHP 

       490        500 
LIDAELANEK WQQHKMGWHL TCE 

« Hide

References

[1]"Complete sequence of Pseudoalteromonas atlantica T6c."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T6c / ATCC BAA-1087.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000388 Genomic DNA. Translation: ABG42719.1.
RefSeqYP_663773.1. NC_008228.1.

3D structure databases

ProteinModelPortalQ15N19.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342610.Patl_4220.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG42719; ABG42719; Patl_4220.
GeneID4176009.
KEGGpat:Patl_4220.
PATRIC23053898. VBIPseAtl25434_4490.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBCLSK2315963.

Enzyme and pathway databases

BioCycPATL342610:GHGT-4301-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

Gene3D1.10.3210.10. 1 hit.
InterProIPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_PSEA6
AccessionPrimary (citable) accession number: Q15N19
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways