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Q15N19

- GPPA_PSEA6

UniProt

Q15N19 - GPPA_PSEA6

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Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, Patl_4220
Organism
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: InterPro
  3. phosphoric diester hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPATL342610:GHGT-4301-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:Patl_4220
OrganismiPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Taxonomic identifieri342610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000001981: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
PRO_0000314496Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342610.Patl_4220.

Structurei

3D structure databases

ProteinModelPortaliQ15N19.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
InterProiIPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15N19-1 [UniParc]FASTAAdd to Basket

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MITSTRLPQN HPEELYAAVD LGSNSFHLVI VRVVAGSVQI IGKVKQKVRL    50
AAGLDDNMML DNESLERGWR CLETFAERLQ DIPRDNIRVV ATATLRLAKN 100
ADVFTVKAQQ ILDHTLSVIS GEEEARQIYL GVAYTSANQG NSLVIDIGGA 150
STEIIIGNDM TPIHLVSLNM GCVTFKERHF AGDVLSEENF AAAIDAAKAM 200
VDAVADKFVC FDWQQCLGAS GTPQAITEIL VAQGISDAIR LDYLYNLRQQ 250
CIDCSTLDNL IIDGLDESRR IIFPSGLAIL IALFESLSIR DMQISGGALR 300
EGLIYGMLEN MQQNDRRMQT IHQHMQHFHI DSEQAERVTE VALTLFKQLS 350
EQTDVDGIDG EAMLVAAAML HETGLHIEYK LHHKHGAYIL GHVPMVGYTN 400
LQRDGIKTLV LNHRQQISPE VFDQNHSETR GIMRSLVRVL RLACILSIRR 450
KDNLLPQFCL EVEENDWRLV FPEGWLKAHP LIDAELANEK WQQHKMGWHL 500
TCE 503
Length:503
Mass (Da):56,404
Last modified:July 25, 2006 - v1
Checksum:iFCDB2F501A792378
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000388 Genomic DNA. Translation: ABG42719.1.
RefSeqiWP_011576907.1. NC_008228.1.
YP_663773.1. NC_008228.1.

Genome annotation databases

EnsemblBacteriaiABG42719; ABG42719; Patl_4220.
GeneIDi4176009.
KEGGipat:Patl_4220.
PATRICi23053898. VBIPseAtl25434_4490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000388 Genomic DNA. Translation: ABG42719.1 .
RefSeqi WP_011576907.1. NC_008228.1.
YP_663773.1. NC_008228.1.

3D structure databases

ProteinModelPortali Q15N19.
ModBasei Search...

Protein-protein interaction databases

STRINGi 342610.Patl_4220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG42719 ; ABG42719 ; Patl_4220 .
GeneIDi 4176009.
KEGGi pat:Patl_4220.
PATRICi 23053898. VBIPseAtl25434_4490.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci PATL342610:GHGT-4301-MONOMER.

Family and domain databases

Gene3Di 1.10.3210.10. 1 hit.
InterProi IPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T6c / ATCC BAA-1087.

Entry informationi

Entry nameiGPPA_PSEA6
AccessioniPrimary (citable) accession number: Q15N19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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