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Q15N09

- BIOH_PSEA6

UniProt

Q15N09 - BIOH_PSEA6

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Protein
Pimeloyl-[acyl-carrier protein] methyl ester esterase
Gene
bioH, Patl_4230
Organism
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters By similarity.UniRule annotation

Catalytic activityi

Pimeloyl-[acyl-carrier protein] methyl ester + H2O = pimeloyl-[acyl-carrier protein] + methanol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 221Substrate; via amide nitrogen and carbonyl oxygen By similarity
Active sitei84 – 841Nucleophile By similarity
Active sitei209 – 2091 By similarity
Active sitei238 – 2381 By similarity
Binding sitei238 – 2381Substrate By similarity

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. biotin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Biotin biosynthesis

Enzyme and pathway databases

BioCyciPATL342610:GHGT-4312-MONOMER.
UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
Pimeloyl-[acyl-carrier protein] methyl ester esterase (EC:3.1.1.85)
Alternative name(s):
Biotin synthesis protein BioH
Carboxylesterase BioH
Gene namesi
Name:bioH
Ordered Locus Names:Patl_4230
OrganismiPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Taxonomic identifieri342610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000001981: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Pimeloyl-[acyl-carrier protein] methyl ester esteraseUniRule annotation
PRO_1000085809Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi342610.Patl_4230.

Structurei

3D structure databases

ProteinModelPortaliQ15N09.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 852Substrate binding By similarity
Regioni145 – 1495Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028062.
KOiK02170.
OMAiFDKAAHA.
OrthoDBiEOG6FJNH9.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01260. Carboxylester.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR010076. BioH.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01738. bioH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15N09-1 [UniParc]FASTAAdd to Basket

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MHTTLKTRTV GSGPNFVLLH GWGVNSGVWQ PIAKQLEQHF SVTYVDLPGF    50
GENNQIMPKP YDLKNLAECV ANVLPENSVL AGWSLGGLVA QHVALLEPTN 100
VKQLILIATS PKFQKGNDWA GIDPNILQAF SQQLVKNLSK TIERFLAIQA 150
MGSDSAKTDI RKIKNSIEAS PQADIAALTA GLDILEHVDL RDQIAALKMP 200
IHWMLGRLDS LVPVKLQGYV QRSLAKNHSV TIFPHASHAP FISHTEDFLI 250
DLMENTLR 258
Length:258
Mass (Da):28,421
Last modified:July 25, 2006 - v1
Checksum:iCCBFA701ECAA6DEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000388 Genomic DNA. Translation: ABG42729.1.
RefSeqiYP_663783.1. NC_008228.1.

Genome annotation databases

EnsemblBacteriaiABG42729; ABG42729; Patl_4230.
GeneIDi4176020.
KEGGipat:Patl_4230.
PATRICi23053920. VBIPseAtl25434_4500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000388 Genomic DNA. Translation: ABG42729.1 .
RefSeqi YP_663783.1. NC_008228.1.

3D structure databases

ProteinModelPortali Q15N09.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342610.Patl_4230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG42729 ; ABG42729 ; Patl_4230 .
GeneIDi 4176020.
KEGGi pat:Patl_4230.
PATRICi 23053920. VBIPseAtl25434_4500.

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000028062.
KOi K02170.
OMAi FDKAAHA.
OrthoDBi EOG6FJNH9.

Enzyme and pathway databases

UniPathwayi UPA00078 .
BioCyci PATL342610:GHGT-4312-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
HAMAPi MF_01260. Carboxylester.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR010076. BioH.
[Graphical view ]
PRINTSi PR00111. ABHYDROLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
TIGRFAMsi TIGR01738. bioH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T6c / ATCC BAA-1087.

Entry informationi

Entry nameiBIOH_PSEA6
AccessioniPrimary (citable) accession number: Q15N09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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