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Q15MY4 (ILVC_PSEA6) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:Patl_4255
OrganismPseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) [Complete proteome] [HAMAP]
Taxonomic identifier342610 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000124322

Sites

Active site1321 Potential

Sequences

Sequence LengthMass (Da)Tools
Q15MY4 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: A3E5CCD2AD8394B3

FASTA49453,902
        10         20         30         40         50         60 
MANYFNTLSL RQQLDQIGRC RFMQRSEFSE GCDFLKGKKI VIVGCGAQGL NQGLNMRDSG 

        70         80         90        100        110        120 
LDVAYALRQA AIDEKRDSFQ RASGNGFTVG TYKELIPSAD LVYNLTPDKQ HSSVVEAIMP 

       130        140        150        160        170        180 
LMKEGASLGY SHGFNIVEEG QQIRSDITVV MCAPKCPGTE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPQQQGWDI AKALASATGG DRAGVLESSF VAEVKSDLMG EQTILCGMQQ AAAVLGYEKM 

       250        260        270        280        290        300 
VADGIDPAYA GALIQFGLEA ITEALKIGGV TNMMDRLSNP AKIKAFDLSE QLKDMLKPLF 

       310        320        330        340        350        360 
GKHQDDIISG EFSRTMMEDW ANGDANLLKW REETGQTGFE NAPEYNGKID EQEFFDNGVF 

       370        380        390        400        410        420 
IVAMIKAGVE LAFDVMVEAG ILPESAYYES LHETPLISNT IARKRLYEMN VVISDTAEYG 

       430        440        450        460        470        480 
NYLFANAAIP LLADKLMPSI GTELIGKPFA AASNSVDNKT LVAVNKAIRE HGVESVGDTL 

       490 
RGYMTDMKAI VEAV

« Hide

References

[1]"Complete sequence of Pseudoalteromonas atlantica T6c."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T6c / ATCC BAA-1087.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000388 Genomic DNA. Translation: ABG42754.1.
RefSeqYP_663808.1. NC_008228.1.

3D structure databases

ProteinModelPortalQ15MY4.
SMRQ15MY4. Positions 3-490.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ15MY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4176045.
GenomeReviewsGene locus Patl_4255 in contig CP000388_GR.
KEGGpat:Patl_4255.
NMPDRfig|342610.3.peg.1033.
PATRIC23053974. VBIPseAtl25434_4527.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG297205.
OMAEKHMDDI.
PhylomeDBQ15MY4.
ProtClustDBPRK05225.

Enzyme and pathway databases

BioCycPATL342610:PATL_4255-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_PSEA6
AccessionPrimary (citable) accession number: Q15MY4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 25, 2006
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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