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Protein

Zinc finger protein 124

Gene

ZNF124

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri122 – 144C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 124
Alternative name(s):
Zinc finger protein HZF-16
Gene namesi
Name:ZNF124
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000196418.12
HGNCiHGNC:12907 ZNF124
MIMi194631 gene
neXtProtiNX_Q15973

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196418
PharmGKBiPA37496

Polymorphism and mutation databases

BioMutaiZNF124
DMDMi76803836

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474101 – 351Zinc finger protein 124Add BLAST351

Proteomic databases

EPDiQ15973
PeptideAtlasiQ15973
PRIDEiQ15973

PTM databases

iPTMnetiQ15973
PhosphoSitePlusiQ15973

Expressioni

Gene expression databases

BgeeiENSG00000196418
CleanExiHS_ZNF124
ExpressionAtlasiQ15973 baseline and differential
GenevisibleiQ15973 HS

Organism-specific databases

HPAiHPA031127

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11347622 interactors.
IntActiQ15973 45 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ15973
SMRiQ15973
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 106KRABPROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri122 – 144C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00910000144154
HOVERGENiHBG018163
InParanoidiQ15973
KOiK09228
OMAiEEPYPCK
OrthoDBiEOG091G02KC
PhylomeDBiQ15973
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15973-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGHPGSWEM NSVAFEDVAV NFTQEEWALL DPSQKNLYRD VMQETFRNLA
60 70 80 90 100
SIGNKGEDQS IEDQYKNSSR NLRHIISHSG NNPYGCEECG KKPCTCKQCQ
110 120 130 140 150
KTSLSVTRVH RDTVMHTGNG HYGCTICEKV FNIPSSFQIH QRNHTGEKPY
160 170 180 190 200
ECMECGKALG FSRSLNRHKR IHTGEKRYEC KQCGKAFSRS SHLRDHERTH
210 220 230 240 250
TGEKPYECKH CGKAFRYSNC LHYHERTHTG EKPYVCMECG KAFSCLSSLQ
260 270 280 290 300
GHIKAHAGEE PYPCKQCGKA FRYASSLQKH EKTHIAQKPY VCNNCGKGFR
310 320 330 340 350
CSSSLRDHER THTGEKPYEC QKCGKAFSRA STLWKHKKTH TGEKPYKCKK

M
Length:351
Mass (Da):40,217
Last modified:September 27, 2005 - v2
Checksum:i9C6C2E4DC3B61FF2
GO
Isoform 2 (identifier: Q15973-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-134: Missing.

Show »
Length:289
Mass (Da):33,330
Checksum:i0E0E795F61327F89
GO
Isoform 3 (identifier: Q15973-1) [UniParc]FASTAAdd to basket
Also known as: HZF-16.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MSGHPGSWEM...DQYKNSSRNL → MNALCVKNSSYVHSSLH

Show »
Length:296
Mass (Da):33,853
Checksum:iC5223EEA038F34E0
GO
Isoform 4 (identifier: Q15973-2) [UniParc]FASTAAdd to basket
Also known as: HZF-16.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MSGHPGSWEM...DQYKNSSRNL → MNALCVKNSSYVHSSLH
     190-329: Missing.

Show »
Length:156
Mass (Da):17,830
Checksum:iD16975FCD62305F6
GO
Isoform 5 (identifier: Q15973-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-351: Missing.

Note: No experimental confirmation available.
Show »
Length:73
Mass (Da):8,411
Checksum:i99F7A7AF818D633E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156911 – 72MSGHP…SSRNL → MNALCVKNSSYVHSSLH in isoform 3 and isoform 4. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_01569273 – 134Missing in isoform 2. 2 PublicationsAdd BLAST62
Alternative sequenceiVSP_04685274 – 351Missing in isoform 5. 1 PublicationAdd BLAST278
Alternative sequenceiVSP_006895190 – 329Missing in isoform 4. 1 PublicationAdd BLAST140

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54641 mRNA Translation: AAB25346.1
S54641 mRNA Translation: AAB25347.1
AK054647 mRNA Translation: BAG51405.1
AL390728 Genomic DNA No translation available.
CH471148 Genomic DNA Translation: EAW77169.1
BC032514 mRNA No translation available.
BC096349 mRNA Translation: AAH96349.1
BC096350 mRNA Translation: AAH96350.1
BC096351 mRNA Translation: AAH96351.1
BC099661 mRNA Translation: AAH99661.1
CCDSiCCDS31089.1 [Q15973-4]
CCDS58067.1 [Q15973-5]
CCDS73057.1 [Q15973-3]
PIRiA45447
B45447
RefSeqiNP_001230669.1, NM_001243740.2 [Q15973-5]
NP_001284497.1, NM_001297568.1 [Q15973-3]
NP_001284498.1, NM_001297569.1
NP_003422.2, NM_003431.3 [Q15973-4]
UniGeneiHs.421238
Hs.621705
Hs.655205
Hs.743338

Genome annotation databases

EnsembliENST00000340684; ENSP00000340749; ENSG00000196418 [Q15973-4]
ENST00000472531; ENSP00000462445; ENSG00000196418 [Q15973-5]
ENST00000543802; ENSP00000440365; ENSG00000196418 [Q15973-3]
GeneIDi7678
KEGGihsa:7678
UCSCiuc001ici.4 human [Q15973-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN124_HUMAN
AccessioniPrimary (citable) accession number: Q15973
Secondary accession number(s): B3KNP3
, J3KSE1, Q15974, Q4VAJ7, Q5T2V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2005
Last modified: March 28, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome