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Protein

Zinc finger protein 124

Gene

ZNF124

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri122 – 14423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 124
Alternative name(s):
Zinc finger protein HZF-16
Gene namesi
Name:ZNF124
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12907. ZNF124.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37496.

Polymorphism and mutation databases

BioMutaiZNF124.
DMDMi76803836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Zinc finger protein 124PRO_0000047410Add
BLAST

Proteomic databases

EPDiQ15973.
MaxQBiQ15973.
PRIDEiQ15973.

PTM databases

iPTMnetiQ15973.
PhosphoSiteiQ15973.

Expressioni

Gene expression databases

BgeeiQ15973.
CleanExiHS_ZNF124.
ExpressionAtlasiQ15973. baseline and differential.
GenevisibleiQ15973. HS.

Organism-specific databases

HPAiHPA031127.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-2555767,EBI-748961
FSD2A1L4K13EBI-2555767,EBI-5661036
GOLGA2Q083793EBI-2555767,EBI-618309
KRT31Q153233EBI-2555767,EBI-948001
KRT40Q6A1623EBI-2555767,EBI-10171697
KRTAP10-7P604093EBI-2555767,EBI-10172290
KRTAP10-8P604103EBI-2555767,EBI-10171774
KRTAP10-9P604113EBI-2555767,EBI-10172052
KRTAP4-2Q9BYR53EBI-2555767,EBI-10172511
KRTAP5-9P263713EBI-2555767,EBI-3958099
MDFIQ997503EBI-2555767,EBI-724076
MEOX2A4D1273EBI-2555767,EBI-10172134
SSX2IPQ9Y2D83EBI-2555767,EBI-2212028
SYCE1Q8N0S23EBI-2555767,EBI-6872807
TCF4P158843EBI-2555767,EBI-533224
TRAF1Q130773EBI-2555767,EBI-359224
TSGA10Q9BZW73EBI-2555767,EBI-744794

Protein-protein interaction databases

BioGridi113476. 21 interactions.
IntActiQ15973. 19 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ15973.
SMRiQ15973. Positions 6-68, 92-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 10694KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri122 – 14423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000119089.
HOVERGENiHBG018163.
InParanoidiQ15973.
KOiK09228.
OMAiEEPYPCK.
PhylomeDBiQ15973.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15973-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGHPGSWEM NSVAFEDVAV NFTQEEWALL DPSQKNLYRD VMQETFRNLA
60 70 80 90 100
SIGNKGEDQS IEDQYKNSSR NLRHIISHSG NNPYGCEECG KKPCTCKQCQ
110 120 130 140 150
KTSLSVTRVH RDTVMHTGNG HYGCTICEKV FNIPSSFQIH QRNHTGEKPY
160 170 180 190 200
ECMECGKALG FSRSLNRHKR IHTGEKRYEC KQCGKAFSRS SHLRDHERTH
210 220 230 240 250
TGEKPYECKH CGKAFRYSNC LHYHERTHTG EKPYVCMECG KAFSCLSSLQ
260 270 280 290 300
GHIKAHAGEE PYPCKQCGKA FRYASSLQKH EKTHIAQKPY VCNNCGKGFR
310 320 330 340 350
CSSSLRDHER THTGEKPYEC QKCGKAFSRA STLWKHKKTH TGEKPYKCKK

M
Length:351
Mass (Da):40,217
Last modified:September 27, 2005 - v2
Checksum:i9C6C2E4DC3B61FF2
GO
Isoform 2 (identifier: Q15973-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-134: Missing.

Show »
Length:289
Mass (Da):33,330
Checksum:i0E0E795F61327F89
GO
Isoform 3 (identifier: Q15973-1) [UniParc]FASTAAdd to basket

Also known as: HZF-16.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MSGHPGSWEM...DQYKNSSRNL → MNALCVKNSSYVHSSLH

Show »
Length:296
Mass (Da):33,853
Checksum:iC5223EEA038F34E0
GO
Isoform 4 (identifier: Q15973-2) [UniParc]FASTAAdd to basket

Also known as: HZF-16.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MSGHPGSWEM...DQYKNSSRNL → MNALCVKNSSYVHSSLH
     190-329: Missing.

Show »
Length:156
Mass (Da):17,830
Checksum:iD16975FCD62305F6
GO
Isoform 5 (identifier: Q15973-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-351: Missing.

Note: No experimental confirmation available.
Show »
Length:73
Mass (Da):8,411
Checksum:i99F7A7AF818D633E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7272MSGHP…SSRNL → MNALCVKNSSYVHSSLH in isoform 3 and isoform 4. 1 PublicationVSP_015691Add
BLAST
Alternative sequencei73 – 13462Missing in isoform 2. 2 PublicationsVSP_015692Add
BLAST
Alternative sequencei74 – 351278Missing in isoform 5. 1 PublicationVSP_046852Add
BLAST
Alternative sequencei190 – 329140Missing in isoform 4. 1 PublicationVSP_006895Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54641 mRNA. Translation: AAB25346.1.
S54641 mRNA. Translation: AAB25347.1.
AK054647 mRNA. Translation: BAG51405.1.
AL390728 Genomic DNA. Translation: CAI14564.1.
CH471148 Genomic DNA. Translation: EAW77169.1.
BC032514 mRNA. No translation available.
BC096349 mRNA. Translation: AAH96349.1.
BC096350 mRNA. Translation: AAH96350.1.
BC096351 mRNA. Translation: AAH96351.1.
BC099661 mRNA. Translation: AAH99661.1.
CCDSiCCDS31089.1. [Q15973-4]
CCDS58067.1. [Q15973-5]
CCDS73057.1. [Q15973-3]
PIRiA45447.
B45447.
RefSeqiNP_001230669.1. NM_001243740.2. [Q15973-5]
NP_001284497.1. NM_001297568.1. [Q15973-3]
NP_001284498.1. NM_001297569.1.
NP_003422.2. NM_003431.3. [Q15973-4]
UniGeneiHs.421238.
Hs.621705.
Hs.655205.
Hs.743338.

Genome annotation databases

EnsembliENST00000340684; ENSP00000340749; ENSG00000196418. [Q15973-4]
ENST00000472531; ENSP00000462445; ENSG00000196418. [Q15973-5]
ENST00000543802; ENSP00000440365; ENSG00000196418. [Q15973-3]
GeneIDi7678.
KEGGihsa:7678.
UCSCiuc001ici.4. human. [Q15973-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54641 mRNA. Translation: AAB25346.1.
S54641 mRNA. Translation: AAB25347.1.
AK054647 mRNA. Translation: BAG51405.1.
AL390728 Genomic DNA. Translation: CAI14564.1.
CH471148 Genomic DNA. Translation: EAW77169.1.
BC032514 mRNA. No translation available.
BC096349 mRNA. Translation: AAH96349.1.
BC096350 mRNA. Translation: AAH96350.1.
BC096351 mRNA. Translation: AAH96351.1.
BC099661 mRNA. Translation: AAH99661.1.
CCDSiCCDS31089.1. [Q15973-4]
CCDS58067.1. [Q15973-5]
CCDS73057.1. [Q15973-3]
PIRiA45447.
B45447.
RefSeqiNP_001230669.1. NM_001243740.2. [Q15973-5]
NP_001284497.1. NM_001297568.1. [Q15973-3]
NP_001284498.1. NM_001297569.1.
NP_003422.2. NM_003431.3. [Q15973-4]
UniGeneiHs.421238.
Hs.621705.
Hs.655205.
Hs.743338.

3D structure databases

ProteinModelPortaliQ15973.
SMRiQ15973. Positions 6-68, 92-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113476. 21 interactions.
IntActiQ15973. 19 interactions.

PTM databases

iPTMnetiQ15973.
PhosphoSiteiQ15973.

Polymorphism and mutation databases

BioMutaiZNF124.
DMDMi76803836.

Proteomic databases

EPDiQ15973.
MaxQBiQ15973.
PRIDEiQ15973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340684; ENSP00000340749; ENSG00000196418. [Q15973-4]
ENST00000472531; ENSP00000462445; ENSG00000196418. [Q15973-5]
ENST00000543802; ENSP00000440365; ENSG00000196418. [Q15973-3]
GeneIDi7678.
KEGGihsa:7678.
UCSCiuc001ici.4. human. [Q15973-3]

Organism-specific databases

CTDi7678.
GeneCardsiZNF124.
HGNCiHGNC:12907. ZNF124.
HPAiHPA031127.
MIMi194631. gene.
neXtProtiNX_Q15973.
PharmGKBiPA37496.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119089.
HOVERGENiHBG018163.
InParanoidiQ15973.
KOiK09228.
OMAiEEPYPCK.
PhylomeDBiQ15973.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF124. human.
GenomeRNAii7678.
PROiQ15973.
SOURCEiSearch...

Gene expression databases

BgeeiQ15973.
CleanExiHS_ZNF124.
ExpressionAtlasiQ15973. baseline and differential.
GenevisibleiQ15973. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines."
    Saleh M., Selleri L., Evans G.A.
    Am. J. Hum. Genet. 52:192-203(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
    Tissue: Retinoblastoma.

Entry informationi

Entry nameiZN124_HUMAN
AccessioniPrimary (citable) accession number: Q15973
Secondary accession number(s): B3KNP3
, J3KSE1, Q15974, Q4VAJ7, Q5T2V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2005
Last modified: June 8, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.