PML protein - Homo sapiens (Human)

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Unreviewed, UniProtKB/TrEMBL Q15959 (Q15959_HUMAN)

Last modified June 16, 2009. Version 57. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
PML protein EMBL AAB19601.2

Gene names

Name:

PML EMBL AAB19601.2

Organism

Homo sapiens (Human) EMBL AAB19601.2

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	641 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 RING-type zinc finger. Spearmint SPM000315

Ontologies

Keywords
Domain	Zinc-finger RuleBase RU000353V2
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Biological process	DNA repair Non-traceable author statement. Source: UniProtKB induction of apoptosis Inferred from mutant phenotype. Source: UniProtKB response to ionizing radiation Inferred from direct assay. Source: UniProtKB
Cellular component	cytoplasm Inferred from direct assay. Source: UniProtKB
Molecular function	nucleic acid binding Ref.1 Non-traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: UniProtKB transcription repressor activity Inferred from direct assay. Source: UniProtKB zinc ion binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MDM2	Q00987	1	EBI-779712,EBI-389668
ZBTB16	Q05516	2	EBI-779712,EBI-711925

Sequences

Sequence

Length

Mass (Da)

Tools

Q15959-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8262393E2B00CBC7
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641

70,368

        10         20         30         40         50         60 
MEPAPARSPR PQQDPARPQE PTMPPPETPS EGRQPSPSPS PTERAPASEE EFQFLRCQQC 

        70         80         90        100        110        120 
QAEAKCPKLL PCLHTLCSGC LEASGMQCPI CQAPWPLGAD TPALDNVFFE SLQRRLSVYR 

       130        140        150        160        170        180 
QIVDAQAVCT RCKESADFWC FECEQLLCAK CFEAHQWFLK HEARPLAELR NQSVREFLDG 

       190        200        210        220        230        240 
TRKTNNIFCS NPNHRTPTLT SIYCRGCSKP LCCSCALLDS SHSELKCDIS AEIQQRQEEL 

       250        260        270        280        290        300 
DAMTQALQEQ DSAFGAVHAQ MHAAVGQLGR ARAETEELIR ERVRQVVAHV RAQERELLEA 

       310        320        330        340        350        360 
VDARYQRDYE EMASRLGRLD AVLQRIRTGS ALVQRMKCYA SDQEVLDMHG FLRQALCRLR 

       370        380        390        400        410        420 
QEEPQSLQAA VRTDGFDEFK VRLQDLSSCI TQGKDAAVSK KASPEAASTP RDPIDVDLPE 

       430        440        450        460        470        480 
EAERVKAQVQ ALGLAEAQPM AVVQSVPGAH PVPVYAFSIK GPSYGEDVSN TTTAQKRKCS 

       490        500        510        520        530        540 
QTQCPRKVIK MESEEGKEAR LARSSPEQPR PSTSKAVSPP HLDGPPSPRS PVIGSEVFLP 

       550        560        570        580        590        600 
NSNHVASGAG EAEERVVVIS SSEDSDAENS VSSSPQSEVL YWKVHGAHGD RRATVLASPL 

       610        620        630        640 
LASPLLASPL LASPVSAEST RSLQPALWHI PPPSLASPPA R

References

[1]	"The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR." de The H., Lavau C., Marchio A., Chomienne C., Degos L., Dejean A. Cell 66:675-684(1991) [PubMed: 1652369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
	S50913 mRNA. Translation: AAB19601.2.
IPI	IPI00744329.
PIR	A40045.
UniGene	Hs.526464
3D structure databases
HSSP	HSSP built from PDB template 1BOR based on UniProtKB P29590.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15959. 3 interactions.
Proteomic databases
PRIDE	Q15959.
Phylogenomic databases
HOVERGEN	Q15959.
Family and domain databases
InterPro	IPR000315. Znf_B-box. IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00643. zf-B_box. 2 hits. PF00097. zf-C3HC4. 1 hit. [Graphical view]
SMART	SM00336. BBOX. 1 hit. SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS50119. ZF_BBOX. 2 hits. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q15959_HUMAN

Accession

Primary (citable) accession number: Q15959

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequences · References · Cross-references · Entry information