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Protein

Zyxin

Gene

ZYX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).By similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • cell-matrix adhesion Source: UniProtKB
  • integrin-mediated signaling pathway Source: UniProtKB
  • regulation of inflammatory response Source: Ensembl
  • signal transduction Source: ProtInc
  • stress fiber assembly Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processCell adhesion, Host-virus interaction
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ15942.

Names & Taxonomyi

Protein namesi
Recommended name:
Zyxin
Alternative name(s):
Zyxin-2
Gene namesi
Name:ZYX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000159840.15.
HGNCiHGNC:13200. ZYX.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi71F → A: Reduced interaction with ENAH and VASP. 1 Publication1
Mutagenesisi93F → A: Reduced interaction with ENAH and VASP. 1 Publication1
Mutagenesisi104F → A: Greatly reduced interaction with ENAH and VASP; when associated with A-71 or with A-71 and A-93. 1 Publication1
Mutagenesisi114F → A: No targeting to focal adhesions and reduced actin-rich structures; when associated with A-71; A-93 and A-104. 1 Publication1

Organism-specific databases

DisGeNETi7791.
OpenTargetsiENSG00000159840.
PharmGKBiPA37765.

Polymorphism and mutation databases

BioMutaiZYX.
DMDMi2497677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000759132 – 572ZyxinAdd BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei116PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei143PhosphoserineBy similarity1
Modified residuei169PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei179PhosphothreonineCombined sources1
Modified residuei253Asymmetric dimethylarginineBy similarity1
Modified residuei259PhosphoserineCombined sources1
Modified residuei265N6-acetyllysineBy similarity1
Modified residuei267PhosphoserineCombined sources1
Modified residuei270PhosphothreonineCombined sources1
Modified residuei272N6-acetyllysineBy similarity1
Modified residuei274PhosphothreonineCombined sources1
Modified residuei279N6-acetyllysineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ15942.
MaxQBiQ15942.
PaxDbiQ15942.
PeptideAtlasiQ15942.
PRIDEiQ15942.

2D gel databases

OGPiQ15942.

PTM databases

iPTMnetiQ15942.
PhosphoSitePlusiQ15942.
SwissPalmiQ15942.

Miscellaneous databases

PMAP-CutDBiQ15942.

Expressioni

Gene expression databases

BgeeiENSG00000159840.
CleanExiHS_ZYX.
ExpressionAtlasiQ15942. baseline and differential.
GenevisibleiQ15942. HS.

Organism-specific databases

HPAiCAB009321.
CAB075747.
HPA004835.
HPA073497.

Interactioni

Subunit structurei

Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Interacts with SYNPO2.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113569. 109 interactors.
IntActiQ15942. 66 interactors.
MINTiMINT-220515.
STRINGi9606.ENSP00000324422.

Structurei

3D structure databases

ProteinModelPortaliQ15942.
SMRiQ15942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini384 – 443LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini444 – 503LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini504 – 570LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 77Pro-richAdd BLAST14
Compositional biasi94 – 108Pro-richAdd BLAST15
Compositional biasi115 – 121Pro-rich7
Compositional biasi127 – 137Pro-richAdd BLAST11

Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000220910.
HOVERGENiHBG093602.
InParanoidiQ15942.
KOiK06273.
OMAiEADENGC.
OrthoDBiEOG091G085F.
PhylomeDBiQ15942.
TreeFamiTF320310.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 3 hits.
SMARTiView protein in SMART
SM00132. LIM. 3 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15942-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPRPSPAI SVSVSAPAFY APQKKFGPVV APKPKVNPFR PGDSEPPPAP
60 70 80 90 100
GAQRAQMGRV GEIPPPPPED FPLPPPPLAG DGDDAEGALG GAFPPPPPPI
110 120 130 140 150
EESFPPAPLE EEIFPSPPPP PEEEGGPEAP IPPPPQPREK VSSIDLEIDS
160 170 180 190 200
LSSLLDDMTK NDPFKARVSS GYVPPPVATP FSSKSSTKPA AGGTAPLPPW
210 220 230 240 250
KSPSSSQPLP QVPAPAQSQT QFHVQPQPQP KPQVQLHVQS QTQPVSLANT
260 270 280 290 300
QPRGPPASSP APAPKFSPVT PKFTPVASKF SPGAPGGSGS QPNQKLGHPE
310 320 330 340 350
ALSAGTGSPQ PPSFTYAQQR EKPRVQEKQH PVPPPAQNQN QVRSPGAPGP
360 370 380 390 400
LTLKEVEELE QLTQQLMQDM EHPQRQNVAV NELCGRCHQP LARAQPAVRA
410 420 430 440 450
LGQLFHIACF TCHQCAQQLQ GQQFYSLEGA PYCEGCYTDT LEKCNTCGEP
460 470 480 490 500
ITDRMLRATG KAYHPHCFTC VVCARPLEGT SFIVDQANRP HCVPDYHKQY
510 520 530 540 550
APRCSVCSEP IMPEPGRDET VRVVALDKNF HMKCYKCEDC GKPLSIEADD
560 570
NGCFPLDGHV LCRKCHTARA QT
Length:572
Mass (Da):61,277
Last modified:November 1, 1997 - v1
Checksum:i2833B1EFA260B762
GO
Isoform 2 (identifier: Q15942-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):45,075
Checksum:i75942A4015025612
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034081223H → L. Corresponds to variant dbSNP:rs11978404Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0572881 – 157Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94991 mRNA. Translation: CAA64447.1.
X95735 mRNA. Translation: CAA65050.1.
AK299005 mRNA. Translation: BAG61089.1.
AK316227 mRNA. Translation: BAH14598.1.
CR457431 mRNA. Translation: CAG33712.1.
AC092214 Genomic DNA. Translation: AAS07459.1.
CH236959 Genomic DNA. Translation: EAL23788.1.
CH471198 Genomic DNA. Translation: EAW51848.1.
BC008743 mRNA. Translation: AAH08743.1.
BC009360 mRNA. Translation: AAH09360.1.
BC010031 mRNA. Translation: AAH10031.1.
CCDSiCCDS5883.1. [Q15942-1]
PIRiG02845.
RefSeqiNP_001010972.1. NM_001010972.1. [Q15942-1]
NP_003452.1. NM_003461.4. [Q15942-1]
UniGeneiHs.490415.

Genome annotation databases

EnsembliENST00000322764; ENSP00000324422; ENSG00000159840. [Q15942-1]
ENST00000392910; ENSP00000376642; ENSG00000159840. [Q15942-2]
GeneIDi7791.
KEGGihsa:7791.
UCSCiuc003wcx.5. human. [Q15942-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZYX_HUMAN
AccessioniPrimary (citable) accession number: Q15942
Secondary accession number(s): A4D2G6, B4DQX7, Q6I9S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families