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Protein

Zyxin

Gene

ZYX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • cell-matrix adhesion Source: UniProtKB
  • integrin-mediated signaling pathway Source: UniProtKB
  • regulation of inflammatory response Source: Ensembl
  • signal transduction Source: ProtInc
  • stress fiber assembly Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ15942.

Names & Taxonomyi

Protein namesi
Recommended name:
Zyxin
Alternative name(s):
Zyxin-2
Gene namesi
Name:ZYX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13200. ZYX.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: MGI
  • cytoplasm Source: HPA
  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • nucleus Source: UniProtKB
  • plasma membrane Source: ProtInc
  • stress fiber Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi71 – 711F → A: Reduced interaction with ENAH and VASP. 1 Publication
Mutagenesisi93 – 931F → A: Reduced interaction with ENAH and VASP. 1 Publication
Mutagenesisi104 – 1041F → A: Greatly reduced interaction with ENAH and VASP; when associated with A-71 or with A-71 and A-93. 1 Publication
Mutagenesisi114 – 1141F → A: No targeting to focal adhesions and reduced actin-rich structures; when associated with A-71; A-93 and A-104. 1 Publication

Organism-specific databases

PharmGKBiPA37765.

Polymorphism and mutation databases

BioMutaiZYX.
DMDMi2497677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 572571ZyxinPRO_0000075913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources1 Publication
Modified residuei116 – 1161PhosphoserineCombined sources
Modified residuei142 – 1421PhosphoserineCombined sources
Modified residuei143 – 1431PhosphoserineBy similarity
Modified residuei169 – 1691PhosphoserineCombined sources
Modified residuei170 – 1701PhosphoserineCombined sources
Modified residuei179 – 1791PhosphothreonineCombined sources
Modified residuei259 – 2591PhosphoserineCombined sources
Modified residuei265 – 2651N6-acetyllysineBy similarity
Modified residuei267 – 2671PhosphoserineCombined sources
Modified residuei270 – 2701PhosphothreonineCombined sources
Modified residuei272 – 2721N6-acetyllysineBy similarity
Modified residuei274 – 2741PhosphothreonineCombined sources
Modified residuei279 – 2791N6-acetyllysineCombined sources
Modified residuei281 – 2811PhosphoserineCombined sources
Modified residuei288 – 2881PhosphoserineCombined sources
Modified residuei308 – 3081PhosphoserineCombined sources
Modified residuei344 – 3441PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ15942.
MaxQBiQ15942.
PaxDbiQ15942.
PeptideAtlasiQ15942.
PRIDEiQ15942.

2D gel databases

OGPiQ15942.

PTM databases

iPTMnetiQ15942.
PhosphoSiteiQ15942.
SwissPalmiQ15942.

Miscellaneous databases

PMAP-CutDBQ15942.

Expressioni

Gene expression databases

BgeeiENSG00000159840.
CleanExiHS_ZYX.
ExpressionAtlasiQ15942. baseline and differential.
GenevisibleiQ15942. HS.

Organism-specific databases

HPAiCAB009321.
CAB075747.
HPA004835.
HPA073497.

Interactioni

Subunit structurei

Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R9Y13EBI-444225,EBI-10175746
IMP3Q9NV313EBI-444225,EBI-747481
LASP1Q148475EBI-444225,EBI-742828
LATS1O9583510EBI-444225,EBI-444209
LIN7AO149103EBI-444225,EBI-2513988
OPRM1P353722EBI-444225,EBI-2624570
PDLIM5Q96HC43EBI-444225,EBI-751267
PHF21AQ96BD53EBI-444225,EBI-745085

Protein-protein interaction databases

BioGridi113569. 89 interactions.
IntActiQ15942. 58 interactions.
MINTiMINT-220515.
STRINGi9606.ENSP00000324422.

Structurei

3D structure databases

ProteinModelPortaliQ15942.
SMRiQ15942. Positions 383-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini384 – 44360LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini444 – 50360LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST
Domaini504 – 57067LIM zinc-binding 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 7714Pro-richAdd
BLAST
Compositional biasi94 – 10815Pro-richAdd
BLAST
Compositional biasi115 – 1217Pro-rich
Compositional biasi127 – 13711Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated
Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000220910.
HOVERGENiHBG093602.
InParanoidiQ15942.
KOiK06273.
OMAiPITERML.
OrthoDBiEOG091G085F.
PhylomeDBiQ15942.
TreeFamiTF320310.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15942-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPRPSPAI SVSVSAPAFY APQKKFGPVV APKPKVNPFR PGDSEPPPAP
60 70 80 90 100
GAQRAQMGRV GEIPPPPPED FPLPPPPLAG DGDDAEGALG GAFPPPPPPI
110 120 130 140 150
EESFPPAPLE EEIFPSPPPP PEEEGGPEAP IPPPPQPREK VSSIDLEIDS
160 170 180 190 200
LSSLLDDMTK NDPFKARVSS GYVPPPVATP FSSKSSTKPA AGGTAPLPPW
210 220 230 240 250
KSPSSSQPLP QVPAPAQSQT QFHVQPQPQP KPQVQLHVQS QTQPVSLANT
260 270 280 290 300
QPRGPPASSP APAPKFSPVT PKFTPVASKF SPGAPGGSGS QPNQKLGHPE
310 320 330 340 350
ALSAGTGSPQ PPSFTYAQQR EKPRVQEKQH PVPPPAQNQN QVRSPGAPGP
360 370 380 390 400
LTLKEVEELE QLTQQLMQDM EHPQRQNVAV NELCGRCHQP LARAQPAVRA
410 420 430 440 450
LGQLFHIACF TCHQCAQQLQ GQQFYSLEGA PYCEGCYTDT LEKCNTCGEP
460 470 480 490 500
ITDRMLRATG KAYHPHCFTC VVCARPLEGT SFIVDQANRP HCVPDYHKQY
510 520 530 540 550
APRCSVCSEP IMPEPGRDET VRVVALDKNF HMKCYKCEDC GKPLSIEADD
560 570
NGCFPLDGHV LCRKCHTARA QT
Length:572
Mass (Da):61,277
Last modified:November 1, 1997 - v1
Checksum:i2833B1EFA260B762
GO
Isoform 2 (identifier: Q15942-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):45,075
Checksum:i75942A4015025612
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti223 – 2231H → L.
Corresponds to variant rs11978404 [ dbSNP | Ensembl ].
VAR_034081

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 157157Missing in isoform 2. 1 PublicationVSP_057288Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94991 mRNA. Translation: CAA64447.1.
X95735 mRNA. Translation: CAA65050.1.
AK299005 mRNA. Translation: BAG61089.1.
AK316227 mRNA. Translation: BAH14598.1.
CR457431 mRNA. Translation: CAG33712.1.
AC092214 Genomic DNA. Translation: AAS07459.1.
CH236959 Genomic DNA. Translation: EAL23788.1.
CH471198 Genomic DNA. Translation: EAW51848.1.
BC008743 mRNA. Translation: AAH08743.1.
BC009360 mRNA. Translation: AAH09360.1.
BC010031 mRNA. Translation: AAH10031.1.
CCDSiCCDS5883.1. [Q15942-1]
PIRiG02845.
RefSeqiNP_001010972.1. NM_001010972.1. [Q15942-1]
NP_003452.1. NM_003461.4. [Q15942-1]
UniGeneiHs.490415.

Genome annotation databases

EnsembliENST00000322764; ENSP00000324422; ENSG00000159840. [Q15942-1]
ENST00000392910; ENSP00000376642; ENSG00000159840. [Q15942-2]
GeneIDi7791.
KEGGihsa:7791.
UCSCiuc003wcx.5. human. [Q15942-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94991 mRNA. Translation: CAA64447.1.
X95735 mRNA. Translation: CAA65050.1.
AK299005 mRNA. Translation: BAG61089.1.
AK316227 mRNA. Translation: BAH14598.1.
CR457431 mRNA. Translation: CAG33712.1.
AC092214 Genomic DNA. Translation: AAS07459.1.
CH236959 Genomic DNA. Translation: EAL23788.1.
CH471198 Genomic DNA. Translation: EAW51848.1.
BC008743 mRNA. Translation: AAH08743.1.
BC009360 mRNA. Translation: AAH09360.1.
BC010031 mRNA. Translation: AAH10031.1.
CCDSiCCDS5883.1. [Q15942-1]
PIRiG02845.
RefSeqiNP_001010972.1. NM_001010972.1. [Q15942-1]
NP_003452.1. NM_003461.4. [Q15942-1]
UniGeneiHs.490415.

3D structure databases

ProteinModelPortaliQ15942.
SMRiQ15942. Positions 383-545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113569. 89 interactions.
IntActiQ15942. 58 interactions.
MINTiMINT-220515.
STRINGi9606.ENSP00000324422.

PTM databases

iPTMnetiQ15942.
PhosphoSiteiQ15942.
SwissPalmiQ15942.

Polymorphism and mutation databases

BioMutaiZYX.
DMDMi2497677.

2D gel databases

OGPiQ15942.

Proteomic databases

EPDiQ15942.
MaxQBiQ15942.
PaxDbiQ15942.
PeptideAtlasiQ15942.
PRIDEiQ15942.

Protocols and materials databases

DNASUi7791.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322764; ENSP00000324422; ENSG00000159840. [Q15942-1]
ENST00000392910; ENSP00000376642; ENSG00000159840. [Q15942-2]
GeneIDi7791.
KEGGihsa:7791.
UCSCiuc003wcx.5. human. [Q15942-1]

Organism-specific databases

CTDi7791.
GeneCardsiZYX.
HGNCiHGNC:13200. ZYX.
HPAiCAB009321.
CAB075747.
HPA004835.
HPA073497.
MIMi602002. gene.
neXtProtiNX_Q15942.
PharmGKBiPA37765.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000220910.
HOVERGENiHBG093602.
InParanoidiQ15942.
KOiK06273.
OMAiPITERML.
OrthoDBiEOG091G085F.
PhylomeDBiQ15942.
TreeFamiTF320310.

Enzyme and pathway databases

SIGNORiQ15942.

Miscellaneous databases

ChiTaRSiZYX. human.
GeneWikiiZyxin.
GenomeRNAii7791.
PMAP-CutDBQ15942.
PROiQ15942.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159840.
CleanExiHS_ZYX.
ExpressionAtlasiQ15942. baseline and differential.
GenevisibleiQ15942. HS.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZYX_HUMAN
AccessioniPrimary (citable) accession number: Q15942
Secondary accession number(s): A4D2G6, B4DQX7, Q6I9S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.