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Protein

Zinc finger protein 79

Gene

ZNF79

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 215C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31092-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 79
Alternative name(s):
ZNFpT7
Gene namesi
Name:ZNF79
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:13153. ZNF79.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7633.
OpenTargetsiENSG00000196152.
PharmGKBiPA37727.

Polymorphism and mutation databases

BioMutaiZNF79.
DMDMi85681870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473881 – 498Zinc finger protein 79Add BLAST498

Proteomic databases

MaxQBiQ15937.
PaxDbiQ15937.
PeptideAtlasiQ15937.
PRIDEiQ15937.

PTM databases

iPTMnetiQ15937.
PhosphoSitePlusiQ15937.

Expressioni

Gene expression databases

BgeeiENSG00000196152.
CleanExiHS_ZNF79.
ExpressionAtlasiQ15937. baseline and differential.
GenevisibleiQ15937. HS.

Organism-specific databases

HPAiHPA028977.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-10237274,EBI-724076
TRIM27P143733EBI-10237274,EBI-719493

Protein-protein interaction databases

BioGridi113451. 3 interactors.
IntActiQ15937. 5 interactors.
STRINGi9606.ENSP00000362446.

Structurei

3D structure databases

ProteinModelPortaliQ15937.
SMRiQ15937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 109KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 215C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133693.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15937.
KOiK09228.
OMAiQPGMNSQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ15937.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEEGVLPSP GPALPQEENT GEEGMAAGLL TAGPRGSTFF SSVTVAFAQE
60 70 80 90 100
RWRCLVSTPR DRFKEGIPGK SRSLVLLGLP VSQPGMNSQL EQREGAWMLE
110 120 130 140 150
GEDLRSPSPG WKIISGSPPE QALSEASFQD PCVEMPPGDS DHGTSDLEKS
160 170 180 190 200
FNLRPVLSPQ QRVPVEARPR KCETHTESFK NSEILKPHRA KPYACNECGK
210 220 230 240 250
AFSYCSSLSQ HQKSHTGEKP YECSECGKAF SQSSSLIQHQ RIHTGEKPYK
260 270 280 290 300
CSECGRAFSQ NANLTKHQRT HTGEKPYRCS ECEKAFSDCS ALVQHQRIHT
310 320 330 340 350
GEKPYECSDC GKAFRHSANL TNHQRTHTGE KPYKCSECGK AFSYCAAFIQ
360 370 380 390 400
HQRIHTGEKP YRCAACGKAF SQSANLTNHQ RTHTGEKPYK CSECGKAFSQ
410 420 430 440 450
STNLIIHQKT HTGEKPYKCN ECGKFFSESS ALIRHHIIHT GEKPYECNEC
460 470 480 490
GKAFNQSSSL SQHQRIHTGV KPYECSECGK AFRCSSAFVR HQRLHAGE
Length:498
Mass (Da):55,350
Last modified:January 10, 2006 - v2
Checksum:i6E4A9F5AE680BF0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345C → G in CAA46339 (PubMed:8478004).Curated1
Sequence conflicti375 – 377Missing in CAA46339 (PubMed:8478004).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02484131T → I.2 PublicationsCorresponds to variant rs13292096dbSNPEnsembl.1
Natural variantiVAR_02484251R → G.2 PublicationsCorresponds to variant rs4504745dbSNPEnsembl.1
Natural variantiVAR_059896401S → N.Corresponds to variant rs3210752dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054606 mRNA. Translation: BAB70771.1.
AL445222 Genomic DNA. Translation: CAH72928.1.
BC062309 mRNA. Translation: AAH62309.1.
X65232 mRNA. Translation: CAA46339.1.
CCDSiCCDS6871.1.
PIRiI39315.
RefSeqiNP_009066.2. NM_007135.2.
UniGeneiHs.522399.

Genome annotation databases

EnsembliENST00000342483; ENSP00000362446; ENSG00000196152.
GeneIDi7633.
KEGGihsa:7633.
UCSCiuc004bqw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054606 mRNA. Translation: BAB70771.1.
AL445222 Genomic DNA. Translation: CAH72928.1.
BC062309 mRNA. Translation: AAH62309.1.
X65232 mRNA. Translation: CAA46339.1.
CCDSiCCDS6871.1.
PIRiI39315.
RefSeqiNP_009066.2. NM_007135.2.
UniGeneiHs.522399.

3D structure databases

ProteinModelPortaliQ15937.
SMRiQ15937.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113451. 3 interactors.
IntActiQ15937. 5 interactors.
STRINGi9606.ENSP00000362446.

PTM databases

iPTMnetiQ15937.
PhosphoSitePlusiQ15937.

Polymorphism and mutation databases

BioMutaiZNF79.
DMDMi85681870.

Proteomic databases

MaxQBiQ15937.
PaxDbiQ15937.
PeptideAtlasiQ15937.
PRIDEiQ15937.

Protocols and materials databases

DNASUi7633.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342483; ENSP00000362446; ENSG00000196152.
GeneIDi7633.
KEGGihsa:7633.
UCSCiuc004bqw.5. human.

Organism-specific databases

CTDi7633.
DisGeNETi7633.
GeneCardsiZNF79.
HGNCiHGNC:13153. ZNF79.
HPAiHPA028977.
MIMi194552. gene.
neXtProtiNX_Q15937.
OpenTargetsiENSG00000196152.
PharmGKBiPA37727.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133693.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15937.
KOiK09228.
OMAiQPGMNSQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ15937.
TreeFamiTF337055.

Enzyme and pathway databases

BioCyciZFISH:G66-31092-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF79. human.
GeneWikiiZNF79.
GenomeRNAii7633.
PROiQ15937.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196152.
CleanExiHS_ZNF79.
ExpressionAtlasiQ15937. baseline and differential.
GenevisibleiQ15937. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF79_HUMAN
AccessioniPrimary (citable) accession number: Q15937
Secondary accession number(s): Q5VVW1, Q96NV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.