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Protein

Zinc finger protein 79

Gene

ZNF79

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri193 – 21523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 79
Alternative name(s):
ZNFpT7
Gene namesi
Name:ZNF79
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:13153. ZNF79.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37727.

Polymorphism and mutation databases

BioMutaiZNF79.
DMDMi85681870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Zinc finger protein 79PRO_0000047388Add
BLAST

Proteomic databases

MaxQBiQ15937.
PaxDbiQ15937.
PeptideAtlasiQ15937.
PRIDEiQ15937.

PTM databases

iPTMnetiQ15937.
PhosphoSiteiQ15937.

Expressioni

Gene expression databases

BgeeiQ15937.
CleanExiHS_ZNF79.
ExpressionAtlasiQ15937. baseline and differential.
GenevisibleiQ15937. HS.

Organism-specific databases

HPAiHPA028977.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-10237274,EBI-724076
TRIM27P143733EBI-10237274,EBI-719493

Protein-protein interaction databases

BioGridi113451. 3 interactions.
IntActiQ15937. 2 interactions.
STRINGi9606.ENSP00000362446.

Structurei

3D structure databases

ProteinModelPortaliQ15937.
SMRiQ15937. Positions 149-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 10972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri193 – 21523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15937.
OMAiQPGMNSQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ15937.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEEGVLPSP GPALPQEENT GEEGMAAGLL TAGPRGSTFF SSVTVAFAQE
60 70 80 90 100
RWRCLVSTPR DRFKEGIPGK SRSLVLLGLP VSQPGMNSQL EQREGAWMLE
110 120 130 140 150
GEDLRSPSPG WKIISGSPPE QALSEASFQD PCVEMPPGDS DHGTSDLEKS
160 170 180 190 200
FNLRPVLSPQ QRVPVEARPR KCETHTESFK NSEILKPHRA KPYACNECGK
210 220 230 240 250
AFSYCSSLSQ HQKSHTGEKP YECSECGKAF SQSSSLIQHQ RIHTGEKPYK
260 270 280 290 300
CSECGRAFSQ NANLTKHQRT HTGEKPYRCS ECEKAFSDCS ALVQHQRIHT
310 320 330 340 350
GEKPYECSDC GKAFRHSANL TNHQRTHTGE KPYKCSECGK AFSYCAAFIQ
360 370 380 390 400
HQRIHTGEKP YRCAACGKAF SQSANLTNHQ RTHTGEKPYK CSECGKAFSQ
410 420 430 440 450
STNLIIHQKT HTGEKPYKCN ECGKFFSESS ALIRHHIIHT GEKPYECNEC
460 470 480 490
GKAFNQSSSL SQHQRIHTGV KPYECSECGK AFRCSSAFVR HQRLHAGE
Length:498
Mass (Da):55,350
Last modified:January 10, 2006 - v2
Checksum:i6E4A9F5AE680BF0C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti345 – 3451C → G in CAA46339 (PubMed:8478004).Curated
Sequence conflicti375 – 3773Missing in CAA46339 (PubMed:8478004).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311T → I.2 Publications
Corresponds to variant rs13292096 [ dbSNP | Ensembl ].
VAR_024841
Natural varianti51 – 511R → G.2 Publications
Corresponds to variant rs4504745 [ dbSNP | Ensembl ].
VAR_024842
Natural varianti401 – 4011S → N.
Corresponds to variant rs3210752 [ dbSNP | Ensembl ].
VAR_059896

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054606 mRNA. Translation: BAB70771.1.
AL445222 Genomic DNA. Translation: CAH72928.1.
BC062309 mRNA. Translation: AAH62309.1.
X65232 mRNA. Translation: CAA46339.1.
CCDSiCCDS6871.1.
PIRiI39315.
RefSeqiNP_009066.2. NM_007135.2.
UniGeneiHs.522399.

Genome annotation databases

EnsembliENST00000342483; ENSP00000362446; ENSG00000196152.
GeneIDi7633.
UCSCiuc004bqw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054606 mRNA. Translation: BAB70771.1.
AL445222 Genomic DNA. Translation: CAH72928.1.
BC062309 mRNA. Translation: AAH62309.1.
X65232 mRNA. Translation: CAA46339.1.
CCDSiCCDS6871.1.
PIRiI39315.
RefSeqiNP_009066.2. NM_007135.2.
UniGeneiHs.522399.

3D structure databases

ProteinModelPortaliQ15937.
SMRiQ15937. Positions 149-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113451. 3 interactions.
IntActiQ15937. 2 interactions.
STRINGi9606.ENSP00000362446.

PTM databases

iPTMnetiQ15937.
PhosphoSiteiQ15937.

Polymorphism and mutation databases

BioMutaiZNF79.
DMDMi85681870.

Proteomic databases

MaxQBiQ15937.
PaxDbiQ15937.
PeptideAtlasiQ15937.
PRIDEiQ15937.

Protocols and materials databases

DNASUi7633.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342483; ENSP00000362446; ENSG00000196152.
GeneIDi7633.
UCSCiuc004bqw.5. human.

Organism-specific databases

CTDi7633.
GeneCardsiZNF79.
HGNCiHGNC:13153. ZNF79.
HPAiHPA028977.
MIMi194552. gene.
neXtProtiNX_Q15937.
PharmGKBiPA37727.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15937.
OMAiQPGMNSQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ15937.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF79. human.
GeneWikiiZNF79.
GenomeRNAii7633.
NextBioi29736.
PROiQ15937.
SOURCEiSearch...

Gene expression databases

BgeeiQ15937.
CleanExiHS_ZNF79.
ExpressionAtlasiQ15937. baseline and differential.
GenevisibleiQ15937. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-31 AND GLY-51.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-31 AND GLY-51.
    Tissue: Lung.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 345-454.

Entry informationi

Entry nameiZNF79_HUMAN
AccessioniPrimary (citable) accession number: Q15937
Secondary accession number(s): Q5VVW1, Q96NV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 10, 2006
Last modified: May 11, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.