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Protein

Zinc finger protein 77

Gene

ZNF77

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri212 – 23423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 77
Alternative name(s):
ZNFpT1
Gene namesi
Name:ZNF77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13150. ZNF77.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37724.

Polymorphism and mutation databases

BioMutaiZNF77.
DMDMi85681869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Zinc finger protein 77PRO_0000047387Add
BLAST

Proteomic databases

MaxQBiQ15935.
PaxDbiQ15935.
PRIDEiQ15935.

PTM databases

iPTMnetiQ15935.
PhosphoSiteiQ15935.

Expressioni

Gene expression databases

BgeeiQ15935.
CleanExiHS_ZNF77.
GenevisibleiQ15935. HS.

Organism-specific databases

HPAiHPA023397.

Interactioni

Protein-protein interaction databases

BioGridi121822. 3 interactions.
STRINGi9606.ENSP00000319053.

Structurei

3D structure databases

ProteinModelPortaliQ15935.
SMRiQ15935. Positions 4-43, 140-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 9996KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri212 – 23423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15935.
KOiK09228.
OMAiCHSSLRE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ15935.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCVIFEEVA VNFTPEEWAL LDHAQRSLYR DVMLETCRNL ASLDCYIYVR
60 70 80 90 100
TSGSSSQRDV FGNGISNDEE IVKFTGSDSW SIFGENWRFD NTGDQHQIPQ
110 120 130 140 150
RHLRSQLGRL CESNEGHQCG ETLSQTANLL VHKSYPTEAK PSECTKCGKA
160 170 180 190 200
FENRQRSHTG QRPCKECGQA CSCLSCQSPP MKTQTVEKPC NCQDSRTASV
210 220 230 240 250
TYVKSLSSKK SYECQKCGKA FICPSSFRGH VNSHHGQKTH ACKVCGKTFM
260 270 280 290 300
YYSYLTRHVR THTGEKPYEC KECGKAFSCP SYFREHVRTH TGEKPYECKH
310 320 330 340 350
CGKSFSCYSS FRDHVRTHTG EKPCQCKHCG KAFTCYSSLR EHGRTHSGEK
360 370 380 390 400
PYECKECGKA FRYPSSLRAH MRMHTGEKPY VCKQCGKAFG CPTYFRRHVK
410 420 430 440 450
THSGVKPYQC KECGKAYSFS SSLRIHVRTH TGEKPFECKH CGKAFSCHSS
460 470 480 490 500
LREHVRTHSG EKPYECNQCG KAFSHAQYFQ KHVRSHSGVK PYECTECGKA
510 520 530 540
YSCSSSLRVH VRTHTGERPY ECKQCGKTFR YLASLQAHVR THAGA
Length:545
Mass (Da):61,964
Last modified:January 10, 2006 - v2
Checksum:i06AF93C62DA8A821
GO

Sequence cautioni

The sequence CAA46337.1 differs from that shown. Reason: Frameshift at positions 98 and 317. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011T → R in CAA46337 (PubMed:8478004).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31C → S.
Corresponds to variant rs12610412 [ dbSNP | Ensembl ].
VAR_052764
Natural varianti5 – 51I → V.
Corresponds to variant rs12609268 [ dbSNP | Ensembl ].
VAR_059895
Natural varianti20 – 201L → W.
Corresponds to variant rs34603238 [ dbSNP | Ensembl ].
VAR_033549
Natural varianti179 – 1791P → S.
Corresponds to variant rs34705382 [ dbSNP | Ensembl ].
VAR_033550
Natural varianti460 – 4601G → R.
Corresponds to variant rs35411355 [ dbSNP | Ensembl ].
VAR_033551

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043354 mRNA. Translation: AAH43354.2.
BC062561 mRNA. Translation: AAH62561.1.
X65230 mRNA. Translation: CAA46337.1. Frameshift.
AL365370 mRNA. Translation: CAB96946.1.
CCDSiCCDS12099.1.
PIRiI39313.
RefSeqiNP_067040.1. NM_021217.2.
UniGeneiHs.38004.

Genome annotation databases

EnsembliENST00000314531; ENSP00000319053; ENSG00000175691.
GeneIDi58492.
KEGGihsa:58492.
UCSCiuc002lws.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043354 mRNA. Translation: AAH43354.2.
BC062561 mRNA. Translation: AAH62561.1.
X65230 mRNA. Translation: CAA46337.1. Frameshift.
AL365370 mRNA. Translation: CAB96946.1.
CCDSiCCDS12099.1.
PIRiI39313.
RefSeqiNP_067040.1. NM_021217.2.
UniGeneiHs.38004.

3D structure databases

ProteinModelPortaliQ15935.
SMRiQ15935. Positions 4-43, 140-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121822. 3 interactions.
STRINGi9606.ENSP00000319053.

PTM databases

iPTMnetiQ15935.
PhosphoSiteiQ15935.

Polymorphism and mutation databases

BioMutaiZNF77.
DMDMi85681869.

Proteomic databases

MaxQBiQ15935.
PaxDbiQ15935.
PRIDEiQ15935.

Protocols and materials databases

DNASUi58492.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314531; ENSP00000319053; ENSG00000175691.
GeneIDi58492.
KEGGihsa:58492.
UCSCiuc002lws.5. human.

Organism-specific databases

CTDi58492.
GeneCardsiZNF77.
HGNCiHGNC:13150. ZNF77.
HPAiHPA023397.
MIMi194551. gene.
neXtProtiNX_Q15935.
PharmGKBiPA37724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15935.
KOiK09228.
OMAiCHSSLRE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ15935.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF77. human.
GenomeRNAii58492.
PROiQ15935.
SOURCEiSearch...

Gene expression databases

BgeeiQ15935.
CleanExiHS_ZNF77.
GenevisibleiQ15935. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 93-321.
  3. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-545.

Entry informationi

Entry nameiZNF77_HUMAN
AccessioniPrimary (citable) accession number: Q15935
Secondary accession number(s): Q86XJ3, Q9NPP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: January 10, 2006
Last modified: June 8, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.