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Protein

Zinc finger protein 77

Gene

ZNF77

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 234C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 77
Alternative name(s):
ZNFpT1
Gene namesi
Name:ZNF77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000175691.8
HGNCiHGNC:13150 ZNF77
MIMi194551 gene
neXtProtiNX_Q15935

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi58492
OpenTargetsiENSG00000175691
PharmGKBiPA37724

Polymorphism and mutation databases

BioMutaiZNF77
DMDMi85681869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473871 – 545Zinc finger protein 77Add BLAST545

Proteomic databases

EPDiQ15935
MaxQBiQ15935
PaxDbiQ15935
PeptideAtlasiQ15935
PRIDEiQ15935

PTM databases

iPTMnetiQ15935
PhosphoSitePlusiQ15935

Expressioni

Gene expression databases

BgeeiENSG00000175691
CleanExiHS_ZNF77
GenevisibleiQ15935 HS

Organism-specific databases

HPAiHPA023397

Interactioni

Protein-protein interaction databases

BioGridi121822, 4 interactors
IntActiQ15935, 8 interactors
STRINGi9606.ENSP00000319053

Structurei

3D structure databases

ProteinModelPortaliQ15935
SMRiQ15935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 99KRABPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 234C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ15935
KOiK09228
OMAiCHSSLRE
OrthoDBiEOG091G02KC
PhylomeDBiQ15935
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

Q15935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCVIFEEVA VNFTPEEWAL LDHAQRSLYR DVMLETCRNL ASLDCYIYVR
60 70 80 90 100
TSGSSSQRDV FGNGISNDEE IVKFTGSDSW SIFGENWRFD NTGDQHQIPQ
110 120 130 140 150
RHLRSQLGRL CESNEGHQCG ETLSQTANLL VHKSYPTEAK PSECTKCGKA
160 170 180 190 200
FENRQRSHTG QRPCKECGQA CSCLSCQSPP MKTQTVEKPC NCQDSRTASV
210 220 230 240 250
TYVKSLSSKK SYECQKCGKA FICPSSFRGH VNSHHGQKTH ACKVCGKTFM
260 270 280 290 300
YYSYLTRHVR THTGEKPYEC KECGKAFSCP SYFREHVRTH TGEKPYECKH
310 320 330 340 350
CGKSFSCYSS FRDHVRTHTG EKPCQCKHCG KAFTCYSSLR EHGRTHSGEK
360 370 380 390 400
PYECKECGKA FRYPSSLRAH MRMHTGEKPY VCKQCGKAFG CPTYFRRHVK
410 420 430 440 450
THSGVKPYQC KECGKAYSFS SSLRIHVRTH TGEKPFECKH CGKAFSCHSS
460 470 480 490 500
LREHVRTHSG EKPYECNQCG KAFSHAQYFQ KHVRSHSGVK PYECTECGKA
510 520 530 540
YSCSSSLRVH VRTHTGERPY ECKQCGKTFR YLASLQAHVR THAGA
Length:545
Mass (Da):61,964
Last modified:January 10, 2006 - v2
Checksum:i06AF93C62DA8A821
GO

Sequence cautioni

The sequence CAA46337 differs from that shown. Reason: Frameshift at positions 98 and 317.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201T → R in CAA46337 (PubMed:8478004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0527643C → S. Corresponds to variant dbSNP:rs12610412Ensembl.1
Natural variantiVAR_0598955I → V. Corresponds to variant dbSNP:rs12609268Ensembl.1
Natural variantiVAR_03354920L → W. Corresponds to variant dbSNP:rs34603238Ensembl.1
Natural variantiVAR_033550179P → S. Corresponds to variant dbSNP:rs34705382Ensembl.1
Natural variantiVAR_033551460G → R. Corresponds to variant dbSNP:rs35411355Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043354 mRNA Translation: AAH43354.2
BC062561 mRNA Translation: AAH62561.1
X65230 mRNA Translation: CAA46337.1 Frameshift.
AL365370 mRNA Translation: CAB96946.1
CCDSiCCDS12099.1
PIRiI39313
RefSeqiNP_067040.1, NM_021217.2
UniGeneiHs.38004

Genome annotation databases

EnsembliENST00000314531; ENSP00000319053; ENSG00000175691
GeneIDi58492
KEGGihsa:58492
UCSCiuc002lws.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF77_HUMAN
AccessioniPrimary (citable) accession number: Q15935
Secondary accession number(s): Q86XJ3, Q9NPP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: January 10, 2006
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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