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Protein

Zinc finger protein 77

Gene

ZNF77

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 234C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 77
Alternative name(s):
ZNFpT1
Gene namesi
Name:ZNF77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13150. ZNF77.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175691.
PharmGKBiPA37724.

Polymorphism and mutation databases

BioMutaiZNF77.
DMDMi85681869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473871 – 545Zinc finger protein 77Add BLAST545

Proteomic databases

MaxQBiQ15935.
PaxDbiQ15935.
PeptideAtlasiQ15935.
PRIDEiQ15935.

PTM databases

iPTMnetiQ15935.
PhosphoSitePlusiQ15935.

Expressioni

Gene expression databases

BgeeiENSG00000175691.
CleanExiHS_ZNF77.
GenevisibleiQ15935. HS.

Organism-specific databases

HPAiHPA023397.

Interactioni

Protein-protein interaction databases

BioGridi121822. 3 interactors.
STRINGi9606.ENSP00000319053.

Structurei

3D structure databases

ProteinModelPortaliQ15935.
SMRiQ15935.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 99KRABPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 234C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15935.
KOiK09228.
OMAiCHSSLRE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ15935.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCVIFEEVA VNFTPEEWAL LDHAQRSLYR DVMLETCRNL ASLDCYIYVR
60 70 80 90 100
TSGSSSQRDV FGNGISNDEE IVKFTGSDSW SIFGENWRFD NTGDQHQIPQ
110 120 130 140 150
RHLRSQLGRL CESNEGHQCG ETLSQTANLL VHKSYPTEAK PSECTKCGKA
160 170 180 190 200
FENRQRSHTG QRPCKECGQA CSCLSCQSPP MKTQTVEKPC NCQDSRTASV
210 220 230 240 250
TYVKSLSSKK SYECQKCGKA FICPSSFRGH VNSHHGQKTH ACKVCGKTFM
260 270 280 290 300
YYSYLTRHVR THTGEKPYEC KECGKAFSCP SYFREHVRTH TGEKPYECKH
310 320 330 340 350
CGKSFSCYSS FRDHVRTHTG EKPCQCKHCG KAFTCYSSLR EHGRTHSGEK
360 370 380 390 400
PYECKECGKA FRYPSSLRAH MRMHTGEKPY VCKQCGKAFG CPTYFRRHVK
410 420 430 440 450
THSGVKPYQC KECGKAYSFS SSLRIHVRTH TGEKPFECKH CGKAFSCHSS
460 470 480 490 500
LREHVRTHSG EKPYECNQCG KAFSHAQYFQ KHVRSHSGVK PYECTECGKA
510 520 530 540
YSCSSSLRVH VRTHTGERPY ECKQCGKTFR YLASLQAHVR THAGA
Length:545
Mass (Da):61,964
Last modified:January 10, 2006 - v2
Checksum:i06AF93C62DA8A821
GO

Sequence cautioni

The sequence CAA46337 differs from that shown. Reason: Frameshift at positions 98 and 317.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201T → R in CAA46337 (PubMed:8478004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0527643C → S.Corresponds to variant rs12610412dbSNPEnsembl.1
Natural variantiVAR_0598955I → V.Corresponds to variant rs12609268dbSNPEnsembl.1
Natural variantiVAR_03354920L → W.Corresponds to variant rs34603238dbSNPEnsembl.1
Natural variantiVAR_033550179P → S.Corresponds to variant rs34705382dbSNPEnsembl.1
Natural variantiVAR_033551460G → R.Corresponds to variant rs35411355dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043354 mRNA. Translation: AAH43354.2.
BC062561 mRNA. Translation: AAH62561.1.
X65230 mRNA. Translation: CAA46337.1. Frameshift.
AL365370 mRNA. Translation: CAB96946.1.
CCDSiCCDS12099.1.
PIRiI39313.
RefSeqiNP_067040.1. NM_021217.2.
UniGeneiHs.38004.

Genome annotation databases

EnsembliENST00000314531; ENSP00000319053; ENSG00000175691.
GeneIDi58492.
KEGGihsa:58492.
UCSCiuc002lws.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043354 mRNA. Translation: AAH43354.2.
BC062561 mRNA. Translation: AAH62561.1.
X65230 mRNA. Translation: CAA46337.1. Frameshift.
AL365370 mRNA. Translation: CAB96946.1.
CCDSiCCDS12099.1.
PIRiI39313.
RefSeqiNP_067040.1. NM_021217.2.
UniGeneiHs.38004.

3D structure databases

ProteinModelPortaliQ15935.
SMRiQ15935.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121822. 3 interactors.
STRINGi9606.ENSP00000319053.

PTM databases

iPTMnetiQ15935.
PhosphoSitePlusiQ15935.

Polymorphism and mutation databases

BioMutaiZNF77.
DMDMi85681869.

Proteomic databases

MaxQBiQ15935.
PaxDbiQ15935.
PeptideAtlasiQ15935.
PRIDEiQ15935.

Protocols and materials databases

DNASUi58492.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314531; ENSP00000319053; ENSG00000175691.
GeneIDi58492.
KEGGihsa:58492.
UCSCiuc002lws.5. human.

Organism-specific databases

CTDi58492.
GeneCardsiZNF77.
HGNCiHGNC:13150. ZNF77.
HPAiHPA023397.
MIMi194551. gene.
neXtProtiNX_Q15935.
OpenTargetsiENSG00000175691.
PharmGKBiPA37724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15935.
KOiK09228.
OMAiCHSSLRE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ15935.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF77. human.
GenomeRNAii58492.
PROiQ15935.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175691.
CleanExiHS_ZNF77.
GenevisibleiQ15935. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF77_HUMAN
AccessioniPrimary (citable) accession number: Q15935
Secondary accession number(s): Q86XJ3, Q9NPP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: January 10, 2006
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.