Q15928 (ZN141_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 141

Gene names

Name:	ZNF141
Synonyms:	D4S90

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation as a repressor. Candidate gene for Wolf-Hirschhorn (4p-) syndrome (WHS).
Subcellular location	Nucleus Potential.
Tissue specificity	Ubiquitously low expression.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anatomical structure morphogenesis Traceable author statement. Source: ProtInc regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Zinc finger protein 141		PRO_0000047424
Regions
	Domain	4 – 75	72	KRAB
	Zinc finger	171 – 193	23	C2H2-type 1; atypical
	Zinc finger	199 – 221	23	C2H2-type 2
	Zinc finger	227 – 249	23	C2H2-type 3
	Zinc finger	255 – 277	23	C2H2-type 4
	Zinc finger	283 – 305	23	C2H2-type 5
	Zinc finger	311 – 333	23	C2H2-type 6
	Zinc finger	339 – 361	23	C2H2-type 7
	Zinc finger	367 – 389	23	C2H2-type 8
	Zinc finger	395 – 417	23	C2H2-type 9
	Zinc finger	423 – 445	23	C2H2-type 10
	Zinc finger	451 – 473	23	C2H2-type 11
Natural variations
	Natural variant	124	1	K → E. Corresponds to variant rs2229296 [ dbSNP | Ensembl ].		VAR_019973
	Natural variant	349	1	R → K. Corresponds to variant rs955417 [ dbSNP | Ensembl ].		VAR_012026
	Natural variant	358	1	K → N. Corresponds to variant rs2018645 [ dbSNP | Ensembl ].		VAR_012027

Sequences

	Sequence		Length	Mass (Da)
	Q15928 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 6133202F1DB207E8	FASTA	474	55,249
	10 20 30 40 50 60 MELLTFRDVA IEFSPEEWKC LDPDQQNLYR DVMLENYRNL VSLGVAISNP DLVTCLEQRK 70 80 90 100 110 120 EPYNVKIHKI VARPPAMCSH FTQDHWPVQG IEDSFHKLIL RRYEKCGHDN LQLRKGCKSL 130 140 150 160 170 180 NECKLQKGGY NEFNECLSTT QSKILQCKAS VKVVSKFSNS NKRKTRHTGE KHFKECGKSF 190 200 210 220 230 240 QKFSHLTQHK VIHAGEKPYT CEECGKAFKW SLIFNEHKRI HTGEKPFTCE ECGSIFTTSS 250 260 270 280 290 300 HFAKHKIIHT GEKPYKCEEC GKAFNRFTTL TKHKRIHAGE KPITCEECRK IFTSSSNFAK 310 320 330 340 350 360 HKRIHTGEKP YKCEECGKAF NRSTTLTKHK RIHTGEKPYT CEECGKAFRQ SSKLNEHKKV 370 380 390 400 410 420 HTGERPYKCD ECGKAFGRSR VLNEHKKIHT GEKPYKCEEC GKAFRRSTDR SQHKKIHSAD 430 440 450 460 470 KPYKCKECDK AFKQFSLLSQ HKKIHTVDKP YKCKDCDKAF KRFSHLNKHK KIHT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome." Tommerup N., Aagaard L., Lund C.L., Boel E., Baxendale S., Bates G.P., Lehrach H., Vissing H. Hum. Mol. Genet. 2:1571-1575(1993) [PubMed: 8268908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Insulinoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L15309 mRNA. Translation: AAC37529.1. BC074853 mRNA. Translation: AAH74853.3.
IPI	IPI00456864.
PIR	I54338.
RefSeq	NP_003432.1. NM_003441.2.
UniGene	Hs.654355.
3D structure databases
ProteinModelPortal	Q15928.
SMR	Q15928. Positions 1-52, 140-474.
ModBase	Search...
Protein-protein interaction databases
STRING	Q15928.
PTM databases
PhosphoSite	Q15928.
Polymorphism databases
DMDM	2501717.
Proteomic databases
PRIDE	Q15928.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000240499; ENSP00000240499; ENSG00000131127.
GeneID	7700.
KEGG	hsa:7700.
UCSC	uc003gaa.2. human.
Organism-specific databases
CTD	7700.
GeneCards	GC04P000303.
HGNC	HGNC:12926. ZNF141.
MIM	194648. gene.
neXtProt	NX_Q15928.
PharmGKB	PA37513.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18633.
HOGENOM	HBG717200.
HOVERGEN	HBG018163.
InParanoid	Q15928.
OMA	PITCEEC.
PhylomeDB	Q15928.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q15928.
CleanEx	HS_ZNF141.
Genevestigator	Q15928.
Family and domain databases
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 11 hits.
KO	K09228.
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 9 hits. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 11 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 11 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	29846.
SOURCE	Search...

Entry information

Entry name

ZN141_HUMAN

Accession

Primary (citable) accession number: Q15928
Secondary accession number(s): Q6DK07

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.