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Protein

Zinc finger protein 141

Gene

ZNF141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a repressor. Plays a role in limb development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri171 – 19323C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • limb morphogenesis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: GO_Central
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 141
Gene namesi
Name:ZNF141
Synonyms:D4S90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:12926. ZNF141.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Polydactyly, postaxial A6 (PAPA6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal.
See also OMIM:615226
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti474 – 4741T → I in PAPA6. 1 Publication
Corresponds to variant rs587776959 [ dbSNP | Ensembl ].
VAR_069637

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiZNF141.
MIMi615226. phenotype.
Orphaneti295165. Postaxial polydactyly type A, bilateral.
PharmGKBiPA37513.

Polymorphism and mutation databases

BioMutaiZNF141.
DMDMi2501717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Zinc finger protein 141PRO_0000047424Add
BLAST

Proteomic databases

EPDiQ15928.
PaxDbiQ15928.
PeptideAtlasiQ15928.
PRIDEiQ15928.

PTM databases

iPTMnetiQ15928.
PhosphoSiteiQ15928.

Expressioni

Tissue specificityi

Ubiquitously low expression.

Gene expression databases

BgeeiENSG00000131127.
CleanExiHS_ZNF141.
ExpressionAtlasiQ15928. baseline and differential.
GenevisibleiQ15928. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000240499.

Structurei

3D structure databases

ProteinModelPortaliQ15928.
SMRiQ15928. Positions 4-44, 147-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri171 – 19323C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15928.
KOiK09228.
OMAiPITCEEC.
OrthoDBiEOG091G02KC.
PhylomeDBiQ15928.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLTFRDVA IEFSPEEWKC LDPDQQNLYR DVMLENYRNL VSLGVAISNP
60 70 80 90 100
DLVTCLEQRK EPYNVKIHKI VARPPAMCSH FTQDHWPVQG IEDSFHKLIL
110 120 130 140 150
RRYEKCGHDN LQLRKGCKSL NECKLQKGGY NEFNECLSTT QSKILQCKAS
160 170 180 190 200
VKVVSKFSNS NKRKTRHTGE KHFKECGKSF QKFSHLTQHK VIHAGEKPYT
210 220 230 240 250
CEECGKAFKW SLIFNEHKRI HTGEKPFTCE ECGSIFTTSS HFAKHKIIHT
260 270 280 290 300
GEKPYKCEEC GKAFNRFTTL TKHKRIHAGE KPITCEECRK IFTSSSNFAK
310 320 330 340 350
HKRIHTGEKP YKCEECGKAF NRSTTLTKHK RIHTGEKPYT CEECGKAFRQ
360 370 380 390 400
SSKLNEHKKV HTGERPYKCD ECGKAFGRSR VLNEHKKIHT GEKPYKCEEC
410 420 430 440 450
GKAFRRSTDR SQHKKIHSAD KPYKCKECDK AFKQFSLLSQ HKKIHTVDKP
460 470
YKCKDCDKAF KRFSHLNKHK KIHT
Length:474
Mass (Da):55,249
Last modified:November 1, 1997 - v1
Checksum:i6133202F1DB207E8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241K → E.
Corresponds to variant rs2229296 [ dbSNP | Ensembl ].
VAR_019973
Natural varianti349 – 3491R → K.
Corresponds to variant rs955417 [ dbSNP | Ensembl ].
VAR_012026
Natural varianti358 – 3581K → N.
Corresponds to variant rs2018645 [ dbSNP | Ensembl ].
VAR_012027
Natural varianti474 – 4741T → I in PAPA6. 1 Publication
Corresponds to variant rs587776959 [ dbSNP | Ensembl ].
VAR_069637

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15309 mRNA. Translation: AAC37529.1.
BC074853 mRNA. Translation: AAH74853.3.
CCDSiCCDS33931.1.
PIRiI54338.
RefSeqiNP_003432.1. NM_003441.2.
UniGeneiHs.654355.

Genome annotation databases

EnsembliENST00000240499; ENSP00000240499; ENSG00000131127.
GeneIDi7700.
KEGGihsa:7700.
UCSCiuc003gaa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15309 mRNA. Translation: AAC37529.1.
BC074853 mRNA. Translation: AAH74853.3.
CCDSiCCDS33931.1.
PIRiI54338.
RefSeqiNP_003432.1. NM_003441.2.
UniGeneiHs.654355.

3D structure databases

ProteinModelPortaliQ15928.
SMRiQ15928. Positions 4-44, 147-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000240499.

PTM databases

iPTMnetiQ15928.
PhosphoSiteiQ15928.

Polymorphism and mutation databases

BioMutaiZNF141.
DMDMi2501717.

Proteomic databases

EPDiQ15928.
PaxDbiQ15928.
PeptideAtlasiQ15928.
PRIDEiQ15928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240499; ENSP00000240499; ENSG00000131127.
GeneIDi7700.
KEGGihsa:7700.
UCSCiuc003gaa.3. human.

Organism-specific databases

CTDi7700.
GeneCardsiZNF141.
HGNCiHGNC:12926. ZNF141.
MalaCardsiZNF141.
MIMi194648. gene.
615226. phenotype.
neXtProtiNX_Q15928.
Orphaneti295165. Postaxial polydactyly type A, bilateral.
PharmGKBiPA37513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15928.
KOiK09228.
OMAiPITCEEC.
OrthoDBiEOG091G02KC.
PhylomeDBiQ15928.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF141. human.
GenomeRNAii7700.
PROiQ15928.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131127.
CleanExiHS_ZNF141.
ExpressionAtlasiQ15928. baseline and differential.
GenevisibleiQ15928. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN141_HUMAN
AccessioniPrimary (citable) accession number: Q15928
Secondary accession number(s): Q6DK07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.