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Protein

Zinc finger and BTB domain-containing protein 6

Gene

ZBTB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri301 – 323C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 405C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32279-MONOMER.
SignaLinkiQ15916.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 6
Alternative name(s):
Zinc finger protein 482
Zinc finger protein with interaction domain
Gene namesi
Name:ZBTB6
Synonyms:ZID, ZNF482
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:16764. ZBTB6.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186130.
PharmGKBiPA134939601.

Polymorphism and mutation databases

BioMutaiZBTB6.
DMDMi46577664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476081 – 424Zinc finger and BTB domain-containing protein 6Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15916.
MaxQBiQ15916.
PaxDbiQ15916.
PeptideAtlasiQ15916.
PRIDEiQ15916.

PTM databases

iPTMnetiQ15916.
PhosphoSitePlusiQ15916.

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain.1 Publication

Gene expression databases

BgeeiENSG00000186130.
CleanExiHS_ZBTB6.
GenevisibleiQ15916. HS.

Organism-specific databases

HPAiHPA054111.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ05EBI-7227791,EBI-10175576
SUMO1P631653EBI-7227791,EBI-80140
ZBTB26Q9HCK05EBI-7227791,EBI-3918996

Protein-protein interaction databases

BioGridi115991. 7 interactors.
DIPiDIP-2653N.
IntActiQ15916. 6 interactors.
MINTiMINT-1193121.
STRINGi9606.ENSP00000362763.

Structurei

3D structure databases

ProteinModelPortaliQ15916.
SMRiQ15916.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri301 – 323C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 405C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000232051.
HOVERGENiHBG056199.
InParanoidiQ15916.
KOiK10493.
OMAiEKLPRHD.
OrthoDBiEOG091G04SQ.
PhylomeDBiQ15916.
TreeFamiTF333162.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI
60 70 80 90 100
LAACSTFMRD QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL
110 120 130 140 150
LKYLTAASYL QMVHIVEKCT EALSKYLEID LSMKNNNQHT DLCQSSDPDV
160 170 180 190 200
KNEDENSDKD CEIIEISEDS PVNIDFHVKE EESNALQSTV ESLTSERKEM
210 220 230 240 250
KSPELSTVDI GFKDNEICIL HVESISTAGV ENGQFSQPCT SSKASMYFSE
260 270 280 290 300
TQHSLINSTV ESRVAEVPGN QDQGLFCENT EGSYGTVSEI QNLEEGYSLR
310 320 330 340 350
HQCPRCPRGF LHVENYLRHL KMHKLFLCLQ CGKTFTQKKN LNRHIRGHMG
360 370 380 390 400
IRPFQCTVCL KTFTAKSTLQ DHLNIHSGDR PYKCHCCDMD FKHKSALKKH
410 420
LTSVHGRSSG EKLSRPDLKR QSLL
Length:424
Mass (Da):48,236
Last modified:November 1, 1996 - v1
Checksum:i304AE4BCAE62A3BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82018 mRNA. Translation: CAA57543.1.
AK292401 mRNA. Translation: BAF85090.1.
CH471090 Genomic DNA. Translation: EAW87552.1.
BC037282 mRNA. Translation: AAH37282.1.
CCDSiCCDS6846.1.
PIRiI39310.
RefSeqiNP_006617.1. NM_006626.5.
UniGeneiHs.654596.

Genome annotation databases

EnsembliENST00000373659; ENSP00000362763; ENSG00000186130.
GeneIDi10773.
KEGGihsa:10773.
UCSCiuc004bnh.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82018 mRNA. Translation: CAA57543.1.
AK292401 mRNA. Translation: BAF85090.1.
CH471090 Genomic DNA. Translation: EAW87552.1.
BC037282 mRNA. Translation: AAH37282.1.
CCDSiCCDS6846.1.
PIRiI39310.
RefSeqiNP_006617.1. NM_006626.5.
UniGeneiHs.654596.

3D structure databases

ProteinModelPortaliQ15916.
SMRiQ15916.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115991. 7 interactors.
DIPiDIP-2653N.
IntActiQ15916. 6 interactors.
MINTiMINT-1193121.
STRINGi9606.ENSP00000362763.

PTM databases

iPTMnetiQ15916.
PhosphoSitePlusiQ15916.

Polymorphism and mutation databases

BioMutaiZBTB6.
DMDMi46577664.

Proteomic databases

EPDiQ15916.
MaxQBiQ15916.
PaxDbiQ15916.
PeptideAtlasiQ15916.
PRIDEiQ15916.

Protocols and materials databases

DNASUi10773.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373659; ENSP00000362763; ENSG00000186130.
GeneIDi10773.
KEGGihsa:10773.
UCSCiuc004bnh.5. human.

Organism-specific databases

CTDi10773.
GeneCardsiZBTB6.
HGNCiHGNC:16764. ZBTB6.
HPAiHPA054111.
MIMi605976. gene.
neXtProtiNX_Q15916.
OpenTargetsiENSG00000186130.
PharmGKBiPA134939601.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000232051.
HOVERGENiHBG056199.
InParanoidiQ15916.
KOiK10493.
OMAiEKLPRHD.
OrthoDBiEOG091G04SQ.
PhylomeDBiQ15916.
TreeFamiTF333162.

Enzyme and pathway databases

BioCyciZFISH:G66-32279-MONOMER.
SignaLinkiQ15916.

Miscellaneous databases

GenomeRNAii10773.
PROiQ15916.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186130.
CleanExiHS_ZBTB6.
GenevisibleiQ15916. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBTB6_HUMAN
AccessioniPrimary (citable) accession number: Q15916
Secondary accession number(s): A8K8N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.