SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q15915

- ZIC1_HUMAN

UniProt

Q15915 - ZIC1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger protein ZIC 1

Gene
ZIC1, ZIC, ZNF201
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri225 – 26036C2H2-type 1; atypicalAdd
BLAST
Zinc fingeri269 – 29628C2H2-type 2; atypicalAdd
BLAST
Zinc fingeri302 – 32625C2H2-type 3Add
BLAST
Zinc fingeri332 – 35625C2H2-type 4Add
BLAST
Zinc fingeri362 – 38423C2H2-type 5Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. adult walking behavior Source: Ensembl
  2. brain development Source: UniProtKB
  3. cell differentiation Source: UniProtKB-KW
  4. inner ear morphogenesis Source: UniProtKB
  5. pattern specification process Source: UniProtKB
  6. positive regulation of protein import into nucleus Source: UniProtKB
  7. positive regulation of transcription, DNA-templated Source: UniProtKB
  8. regulation of smoothened signaling pathway Source: UniProtKB
  9. spinal cord development Source: Ensembl
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ15915.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZIC 1
Alternative name(s):
Zinc finger protein 201
Zinc finger protein of the cerebellum 1
Gene namesi
Name:ZIC1
Synonyms:ZIC, ZNF201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:12872. ZIC1.

Subcellular locationi

Nucleus. Cytoplasm By similarity
Note: Localizes in the cytoplasm in presence of MDFIC overexpression By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti269212. Isolated Dandy-Walker malformation with hydrocephalus.
269215. Isolated Dandy-Walker malformation without hydrocephalus.
PharmGKBiPA37461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Zinc finger protein ZIC 1PRO_0000047244Add
BLAST

Proteomic databases

PaxDbiQ15915.
PRIDEiQ15915.

Expressioni

Tissue specificityi

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.1 Publication

Gene expression databases

BgeeiQ15915.
CleanExiHS_ZIC1.
GenevestigatoriQ15915.

Organism-specific databases

HPAiHPA004098.

Interactioni

Subunit structurei

Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation By similarity.

Protein-protein interaction databases

BioGridi113377. 3 interactions.
STRINGi9606.ENSP00000282928.

Structurei

3D structure databases

ProteinModelPortaliQ15915.
SMRiQ15915. Positions 219-386.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi72 – 765Poly-Ala
Compositional biasi79 – 824Poly-His
Compositional biasi110 – 1167Poly-Ala
Compositional biasi386 – 44055Ser-richAdd
BLAST

Domaini

The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri225 – 26036C2H2-type 1; atypicalAdd
BLAST
Zinc fingeri269 – 29628C2H2-type 2; atypicalAdd
BLAST
Zinc fingeri302 – 32625C2H2-type 3Add
BLAST
Zinc fingeri332 – 35625C2H2-type 4Add
BLAST
Zinc fingeri362 – 38423C2H2-type 5Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000232057.
HOVERGENiHBG007135.
InParanoidiQ15915.
KOiK09224.
OMAiNMNMAAH.
PhylomeDBiQ15915.
TreeFamiTF351425.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15915-1 [UniParc]FASTAAdd to Basket

« Hide

MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN    50
PSSHELASAG QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF 100
LFRNRGFGDA AAAASAQHSL FAASAGGFGG PHGHTDAAGH LLFPGLHEQA 150
AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ VTSPRSEHYA APQLHGYGPM 200
NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK SCNKTFSTMH 250
ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK 300
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK 350
KHMHVHTSDK PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG 400
YESSTPPTIV SPSTDNPTTS SLSPSSSAVH HTAGHSALSS NFNEWYV 447
Length:447
Mass (Da):48,309
Last modified:October 14, 2008 - v2
Checksum:i4DA3E32C99BF1AAE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti377 – 3771L → V in BAA11179. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D76435 mRNA. Translation: BAA11179.1.
CH471052 Genomic DNA. Translation: EAW78915.1.
BC104848 mRNA. Translation: AAI04849.1.
BC104850 mRNA. Translation: AAI04851.1.
CCDSiCCDS3136.1.
RefSeqiNP_003403.2. NM_003412.3.
UniGeneiHs.598590.
Hs.647962.

Genome annotation databases

EnsembliENST00000282928; ENSP00000282928; ENSG00000152977.
GeneIDi7545.
KEGGihsa:7545.
UCSCiuc003ewe.3. human.

Polymorphism databases

DMDMi209572702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D76435 mRNA. Translation: BAA11179.1 .
CH471052 Genomic DNA. Translation: EAW78915.1 .
BC104848 mRNA. Translation: AAI04849.1 .
BC104850 mRNA. Translation: AAI04851.1 .
CCDSi CCDS3136.1.
RefSeqi NP_003403.2. NM_003412.3.
UniGenei Hs.598590.
Hs.647962.

3D structure databases

ProteinModelPortali Q15915.
SMRi Q15915. Positions 219-386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113377. 3 interactions.
STRINGi 9606.ENSP00000282928.

Polymorphism databases

DMDMi 209572702.

Proteomic databases

PaxDbi Q15915.
PRIDEi Q15915.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282928 ; ENSP00000282928 ; ENSG00000152977 .
GeneIDi 7545.
KEGGi hsa:7545.
UCSCi uc003ewe.3. human.

Organism-specific databases

CTDi 7545.
GeneCardsi GC03P147111.
HGNCi HGNC:12872. ZIC1.
HPAi HPA004098.
MIMi 600470. gene.
neXtProti NX_Q15915.
Orphaneti 269212. Isolated Dandy-Walker malformation with hydrocephalus.
269215. Isolated Dandy-Walker malformation without hydrocephalus.
PharmGKBi PA37461.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000232057.
HOVERGENi HBG007135.
InParanoidi Q15915.
KOi K09224.
OMAi NMNMAAH.
PhylomeDBi Q15915.
TreeFami TF351425.

Enzyme and pathway databases

SignaLinki Q15915.

Miscellaneous databases

GeneWikii ZIC1.
GenomeRNAii 7545.
NextBioi 29521.
PROi Q15915.
SOURCEi Search...

Gene expression databases

Bgeei Q15915.
CleanExi HS_ZIC1.
Genevestigatori Q15915.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma."
    Yokota N., Aruga J., Takai S., Yamada K., Hamazaki M., Iwase T., Sugimura H., Mikoshiba K.
    Cancer Res. 56:377-383(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiZIC1_HUMAN
AccessioniPrimary (citable) accession number: Q15915
Secondary accession number(s): Q2M3N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi