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Protein

Zinc finger protein ZIC 1

Gene

ZIC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri225 – 26036C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29628C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32625C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35625C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ15915.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZIC 1
Alternative name(s):
Zinc finger protein 201
Zinc finger protein of the cerebellum 1
Gene namesi
Name:ZIC1
Synonyms:ZIC, ZNF201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12872. ZIC1.

Subcellular locationi

  • Nucleus
  • Cytoplasm By similarity

  • Note: Localizes in the cytoplasm in presence of MDFIC overexpression.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti269212. Isolated Dandy-Walker malformation with hydrocephalus.
269215. Isolated Dandy-Walker malformation without hydrocephalus.
PharmGKBiPA37461.

Polymorphism and mutation databases

BioMutaiZIC1.
DMDMi209572702.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Zinc finger protein ZIC 1PRO_0000047244Add
BLAST

Proteomic databases

PaxDbiQ15915.
PRIDEiQ15915.

Expressioni

Tissue specificityi

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.1 Publication

Gene expression databases

BgeeiQ15915.
CleanExiHS_ZIC1.
ExpressionAtlasiQ15915. baseline and differential.
GenevisibleiQ15915. HS.

Organism-specific databases

HPAiHPA004098.

Interactioni

Subunit structurei

Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation (By similarity).By similarity

Protein-protein interaction databases

BioGridi113377. 3 interactions.
STRINGi9606.ENSP00000282928.

Structurei

3D structure databases

ProteinModelPortaliQ15915.
SMRiQ15915. Positions 219-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi72 – 765Poly-Ala
Compositional biasi79 – 824Poly-His
Compositional biasi110 – 1167Poly-Ala
Compositional biasi386 – 44055Ser-richAdd
BLAST

Domaini

The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.By similarity

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri225 – 26036C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29628C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32625C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35625C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000232057.
HOVERGENiHBG007135.
InParanoidiQ15915.
KOiK09224.
OMAiNMNMAAH.
PhylomeDBiQ15915.
TreeFamiTF351425.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN
60 70 80 90 100
PSSHELASAG QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF
110 120 130 140 150
LFRNRGFGDA AAAASAQHSL FAASAGGFGG PHGHTDAAGH LLFPGLHEQA
160 170 180 190 200
AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ VTSPRSEHYA APQLHGYGPM
210 220 230 240 250
NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK SCNKTFSTMH
260 270 280 290 300
ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK
310 320 330 340 350
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK
360 370 380 390 400
KHMHVHTSDK PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG
410 420 430 440
YESSTPPTIV SPSTDNPTTS SLSPSSSAVH HTAGHSALSS NFNEWYV
Length:447
Mass (Da):48,309
Last modified:October 14, 2008 - v2
Checksum:i4DA3E32C99BF1AAE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti377 – 3771L → V in BAA11179 (PubMed:8542595).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D76435 mRNA. Translation: BAA11179.1.
CH471052 Genomic DNA. Translation: EAW78915.1.
BC104848 mRNA. Translation: AAI04849.1.
BC104850 mRNA. Translation: AAI04851.1.
CCDSiCCDS3136.1.
RefSeqiNP_003403.2. NM_003412.3.
UniGeneiHs.598590.
Hs.647962.

Genome annotation databases

EnsembliENST00000282928; ENSP00000282928; ENSG00000152977.
GeneIDi7545.
KEGGihsa:7545.
UCSCiuc003ewe.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D76435 mRNA. Translation: BAA11179.1.
CH471052 Genomic DNA. Translation: EAW78915.1.
BC104848 mRNA. Translation: AAI04849.1.
BC104850 mRNA. Translation: AAI04851.1.
CCDSiCCDS3136.1.
RefSeqiNP_003403.2. NM_003412.3.
UniGeneiHs.598590.
Hs.647962.

3D structure databases

ProteinModelPortaliQ15915.
SMRiQ15915. Positions 219-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113377. 3 interactions.
STRINGi9606.ENSP00000282928.

Polymorphism and mutation databases

BioMutaiZIC1.
DMDMi209572702.

Proteomic databases

PaxDbiQ15915.
PRIDEiQ15915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282928; ENSP00000282928; ENSG00000152977.
GeneIDi7545.
KEGGihsa:7545.
UCSCiuc003ewe.3. human.

Organism-specific databases

CTDi7545.
GeneCardsiGC03P147111.
HGNCiHGNC:12872. ZIC1.
HPAiHPA004098.
MIMi600470. gene.
neXtProtiNX_Q15915.
Orphaneti269212. Isolated Dandy-Walker malformation with hydrocephalus.
269215. Isolated Dandy-Walker malformation without hydrocephalus.
PharmGKBiPA37461.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000232057.
HOVERGENiHBG007135.
InParanoidiQ15915.
KOiK09224.
OMAiNMNMAAH.
PhylomeDBiQ15915.
TreeFamiTF351425.

Enzyme and pathway databases

SignaLinkiQ15915.

Miscellaneous databases

ChiTaRSiZIC1. human.
GeneWikiiZIC1.
GenomeRNAii7545.
NextBioi29521.
PROiQ15915.
SOURCEiSearch...

Gene expression databases

BgeeiQ15915.
CleanExiHS_ZIC1.
ExpressionAtlasiQ15915. baseline and differential.
GenevisibleiQ15915. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma."
    Yokota N., Aruga J., Takai S., Yamada K., Hamazaki M., Iwase T., Sugimura H., Mikoshiba K.
    Cancer Res. 56:377-383(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiZIC1_HUMAN
AccessioniPrimary (citable) accession number: Q15915
Secondary accession number(s): Q2M3N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: July 22, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.