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Q15915 (ZIC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein ZIC 1
Alternative name(s):
Zinc finger protein 201
Zinc finger protein of the cerebellum 1
Gene names
Name:ZIC1
Synonyms:ZIC, ZNF201
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' By similarity.

Subunit structure

Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation By similarity.

Subcellular location

Nucleus. Cytoplasm By similarity. Note: Localizes in the cytoplasm in presence of MDFIC overexpression By similarity.

Tissue specificity

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. Ref.1

Domain

The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation By similarity.

Sequence similarities

Belongs to the GLI C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
Transcription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult walking behavior

Inferred from electronic annotation. Source: Ensembl

behavior

Inferred from sequence or structural similarity. Source: UniProtKB

brain development

Inferred from direct assay Ref.1. Source: UniProtKB

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

inner ear morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

pattern specification process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein import into nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of smoothened signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

spinal cord development

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Zinc finger protein ZIC 1
PRO_0000047244

Regions

Zinc finger225 – 26036C2H2-type 1; atypical
Zinc finger269 – 29628C2H2-type 2; atypical
Zinc finger302 – 32625C2H2-type 3
Zinc finger332 – 35625C2H2-type 4
Zinc finger362 – 38423C2H2-type 5
Compositional bias72 – 765Poly-Ala
Compositional bias79 – 824Poly-His
Compositional bias110 – 1167Poly-Ala
Compositional bias386 – 44055Ser-rich

Experimental info

Sequence conflict3771L → V in BAA11179. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q15915 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 4DA3E32C99BF1AAE

FASTA44748,309
        10         20         30         40         50         60 
MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN PSSHELASAG 

        70         80         90        100        110        120 
QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF LFRNRGFGDA AAAASAQHSL 

       130        140        150        160        170        180 
FAASAGGFGG PHGHTDAAGH LLFPGLHEQA AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ 

       190        200        210        220        230        240 
VTSPRSEHYA APQLHGYGPM NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK 

       250        260        270        280        290        300 
SCNKTFSTMH ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK 

       310        320        330        340        350        360 
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK KHMHVHTSDK 

       370        380        390        400        410        420 
PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG YESSTPPTIV SPSTDNPTTS 

       430        440 
SLSPSSSAVH HTAGHSALSS NFNEWYV 

« Hide

References

« Hide 'large scale' references
[1]"Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma."
Yokota N., Aruga J., Takai S., Yamada K., Hamazaki M., Iwase T., Sugimura H., Mikoshiba K.
Cancer Res. 56:377-383(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Cerebellum.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D76435 mRNA. Translation: BAA11179.1.
CH471052 Genomic DNA. Translation: EAW78915.1.
BC104848 mRNA. Translation: AAI04849.1.
BC104850 mRNA. Translation: AAI04851.1.
RefSeqNP_003403.2. NM_003412.3.
UniGeneHs.598590.
Hs.647962.

3D structure databases

ProteinModelPortalQ15915.
SMRQ15915. Positions 182-386.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113377. 3 interactions.
STRING9606.ENSP00000282928.

Polymorphism databases

DMDM209572702.

Proteomic databases

PaxDbQ15915.
PRIDEQ15915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282928; ENSP00000282928; ENSG00000152977.
GeneID7545.
KEGGhsa:7545.
UCSCuc003ewe.3. human.

Organism-specific databases

CTD7545.
GeneCardsGC03P147111.
HGNCHGNC:12872. ZIC1.
HPAHPA004098.
MIM600470. gene.
neXtProtNX_Q15915.
Orphanet217. Isolated Dandy-Walker malformation.
PharmGKBPA37461.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000232057.
HOVERGENHBG007135.
InParanoidQ15915.
KOK09224.
OMANMNMAAH.
PhylomeDBQ15915.
TreeFamTF351425.

Enzyme and pathway databases

SignaLinkQ15915.

Gene expression databases

BgeeQ15915.
CleanExHS_ZIC1.
GenevestigatorQ15915.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZIC1.
GenomeRNAi7545.
NextBio29521.
PROQ15915.
SOURCESearch...

Entry information

Entry nameZIC1_HUMAN
AccessionPrimary (citable) accession number: Q15915
Secondary accession number(s): Q2M3N1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: March 19, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM