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Q15911

- ZFHX3_HUMAN

UniProt

Q15911 - ZFHX3_HUMAN

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Protein
Zinc finger homeobox protein 3
Gene
ZFHX3, ATBF1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri282 – 30524C2H2-type 1
Add
BLAST
Zinc fingeri640 – 66324C2H2-type 2
Add
BLAST
Zinc fingeri671 – 69424C2H2-type 3
Add
BLAST
Zinc fingeri726 – 75025C2H2-type 4
Add
BLAST
Zinc fingeri804 – 82825C2H2-type 5; atypical
Add
BLAST
Zinc fingeri945 – 96824C2H2-type 6; degenerate
Add
BLAST
Zinc fingeri984 – 100825C2H2-type 7; atypical
Add
BLAST
Zinc fingeri1040 – 106425C2H2-type 8; atypical
Add
BLAST
Zinc fingeri1088 – 111225C2H2-type 9; atypical
Add
BLAST
Zinc fingeri1223 – 124624C2H2-type 10; atypical
Add
BLAST
Zinc fingeri1252 – 127524C2H2-type 11
Add
BLAST
Zinc fingeri1360 – 138526C2H2-type 12
Add
BLAST
Zinc fingeri1401 – 142323C2H2-type 13
Add
BLAST
Zinc fingeri1429 – 145224C2H2-type 14
Add
BLAST
Zinc fingeri1545 – 156925C2H2-type 15
Add
BLAST
Zinc fingeri1596 – 162025C2H2-type 16
Add
BLAST
Zinc fingeri1983 – 200624C2H2-type 17
Add
BLAST
DNA bindingi2145 – 220460Homeobox 1
Add
BLAST
DNA bindingi2242 – 230160Homeobox 2
Add
BLAST
Zinc fingeri2328 – 235124C2H2-type 18; atypical
Add
BLAST
Zinc fingeri2530 – 255223C2H2-type 19
Add
BLAST
DNA bindingi2641 – 270060Homeobox 3
Add
BLAST
Zinc fingeri2711 – 273424C2H2-type 20
Add
BLAST
DNA bindingi2944 – 300360Homeobox 4
Add
BLAST
Zinc fingeri3024 – 304825C2H2-type 21
Add
BLAST
Zinc fingeri3529 – 355325C2H2-type 22
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: UniProtKB
  2. enzyme binding Source: UniProtKB
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  5. transcription regulatory region DNA binding Source: UniProtKB
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. muscle organ development Source: UniProtKB-KW
  4. negative regulation of myoblast differentiation Source: UniProtKB
  5. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  6. negative regulation of transcription, DNA-templated Source: UniProtKB
  7. positive regulation of myoblast differentiation Source: UniProtKB
  8. regulation of neuron differentiation Source: Ensembl
  9. regulation of transcription, DNA-templated Source: UniProtKB
  10. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Myogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger homeobox protein 3
Alternative name(s):
AT motif-binding factor 1
AT-binding transcription factor 1
Alpha-fetoprotein enhancer-binding protein
Zinc finger homeodomain protein 3
Short name:
ZFH-3
Gene namesi
Name:ZFHX3
Synonyms:ATBF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:777. ZFHX3.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 37033703Zinc finger homeobox protein 3
PRO_0000046930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei533 – 5331Phosphoserine1 Publication
Modified residuei571 – 5711Phosphoserine2 Publications
Modified residuei1197 – 11971Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15911.
PaxDbiQ15911.
PeptideAtlasiQ15911.
PRIDEiQ15911.

PTM databases

PhosphoSiteiQ15911.

Expressioni

Tissue specificityi

Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ15911.
BgeeiQ15911.
CleanExiHS_ZFHX3.
GenevestigatoriQ15911.

Organism-specific databases

HPAiHPA059353.

Interactioni

Subunit structurei

Interacts with FNBP3 By similarity. Interacts with ALKBH4 and PIAS3.2 Publications

Protein-protein interaction databases

BioGridi106954. 8 interactions.
IntActiQ15911. 2 interactions.
MINTiMINT-1462085.
STRINGi9606.ENSP00000268489.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2154 – 216613
Helixi2174 – 21829
Helixi2186 – 220116
Helixi2251 – 226313
Helixi2269 – 227810
Helixi2283 – 229715
Turni2650 – 26523
Helixi2653 – 266210
Helixi2668 – 267811
Helixi2682 – 269716

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DA1NMR-A2146-2202[»]
2DA2NMR-A2243-2299[»]
2DA3NMR-A2632-2698[»]
ProteinModelPortaliQ15911.
SMRiQ15911. Positions 661-701, 716-748, 1216-1252, 1366-1452, 1537-1618, 2146-2207, 2247-2305, 2636-2698, 2947-3004, 3020-3065.

Miscellaneous databases

EvolutionaryTraceiQ15911.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 1074Poly-Pro
Compositional biasi460 – 48930Poly-Glu
Add
BLAST
Compositional biasi770 – 78415Poly-Ala
Add
BLAST
Compositional biasi1723 – 174321Poly-Gln
Add
BLAST
Compositional biasi1789 – 17946Poly-Gln
Compositional biasi1852 – 18576Poly-Gln
Compositional biasi2037 – 205216Poly-Pro
Add
BLAST
Compositional biasi3197 – 320913Poly-Gln
Add
BLAST
Compositional biasi3210 – 32145Poly-Pro
Compositional biasi3227 – 32315Poly-Gln
Compositional biasi3376 – 338914Poly-Gln
Add
BLAST
Compositional biasi3392 – 33954Poly-Gln
Compositional biasi3507 – 352721Poly-Gly
Add
BLAST
Compositional biasi3597 – 36004Poly-Pro
Compositional biasi3636 – 36394Poly-Ser

Sequence similaritiesi

Contains 22 C2H2-type zinc fingers.

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG301069.
HOGENOMiHOG000155777.
HOVERGENiHBG050606.
InParanoidiQ15911.
KOiK09378.
OMAiSVGMPPL.
OrthoDBiEOG7FR7FH.
PhylomeDBiQ15911.
TreeFamiTF323288.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 4 hits.
PROSITEiPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q15911-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEGCDSPVVS GKDNGCGIPQ HQQWTELNST HLPDKPSSME QSTGESHGPL     50
DSLRAPFNER LAESTASAGP PSEPASKEVT CNECSASFAS LQTYMEHHCP 100
SARPPPPLRE ESASDTGEEG DEESDVENLA GEIVYQPDGS AYIVESLSQL 150
TQGGGACGSG SGSGPLPSLF LNSLPGAGGK QGDPSCAAPV YPQIINTFHI 200
ASSFGKWFEG PDQAFPNTSA LAGLSPVLHS FRVFDVRHKS NKDYLNSDGS 250
AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 300
AVHDHRMTLS EDERKILSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP 350
LVSTANLIGP GHSFYGKFSG IRMEGEEALP AGSAAGPEQP QAGLLTPSTL 400
LNLGGLTSSV LKTPITSVPL GPLASSPTKS SEGKDSGAAE GEKQEVGDGD 450
CFSEKVEPAE EEAEEEEEEE EAEEEEEEEE EEEEEEEDEG CKGLFPSELD 500
EELEDRPHEE PGAAAGSSSK KDLALSNQSI SNSPLMPNVL QTLSRGTAST 550
SSNSASSFVV FDGANRRNRL SFNSEGVRAN VAEGGRRLDF ADESANKDNA 600
TAPEPNESTE GDDGGFVPHH QHAGSLCELG VGECPSGSGV ECPKCDTVLG 650
SSRSLGGHMT MMHSRNSCKT LKCPKCNWHY KYQQTLEAHM KEKHPEPGGS 700
CVYCKSGQPH PRLARGESYT CGYKPFRCEV CNYSTTTKGN LSIHMQSDKH 750
LNNMQNLQNG GGEQVFSHTA GAAAAAVAAA AAAANISSSC GAPSPTKPKT 800
KPTWRCEVCD YETNVARNLR IHMTSEKHMH NMMLLQQNMT QIQHNRHLGL 850
GSLPSPAEAE LYQYYLAQNM NLPNLKMDSA ASDAQFMMSG FQLDPAGPMA 900
AMTPALVGGE IPLDMRLGGG QLVSEELMNL GESFIQTNDP SLKLFQCAVC 950
NKFTTDNLDM LGLHMNVERS LSEDEWKAVM GDSYQCKLCR YNTQLKANFQ 1000
LHCKTDKHVQ KYQLVAHIKE GGKANEWRLK CVAIGNPVHL KCNACDYYTN 1050
SLEKLRLHTV NSRHEASLKL YKHLQQHESG VEGESCYYHC VLCNYSTKAK 1100
LNLIQHVRSM KHQRSESLRK LQRLQKGLPE EDEDLGQIFT IRRCPSTDPE 1150
EAIEDVEGPS ETAADPEELA KDQEGGASSS QAEKELTDSP ATSKRISFPG 1200
SSESPLSSKR PKTAEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP 1250
MLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT TPEMVMPSSM 1300
FLPAAVPDRD GNSNLEEAGK QPETSEDLGK NILPSASTEQ SGDLKPSPAD 1350
PGSVREDSGF ICWKKGCNQV FKTSAALQTH FNEVHAKRPQ LPVSDRHVYK 1400
YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT FQALKKHLET 1450
SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE EDKEEESDLE 1500
DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC 1550
KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT 1600
CNVAYSQSST LEIHMRSVLH QTKARAAKLE AASGSSNGTG NSSSISLSSS 1650
TPSPVSTSGS NTFTTSNPSS AGIAPSSNLL SQVPTESVGM PPLGNPIGAN 1700
IASPSEPKEA NRKKLADMIA SRQQQQQQQQ QQQQQQQQQQ QAQTLAQAQA 1750
QVQAHLQQEL QQQAALIQSQ LFNPTLLPHF PMTTETLLQL QQQQHLLFPF 1800
YIPSAEFQLN PEVSLPVTSG ALTLTGTGPG LLEDLKAQVQ VPQQSHQQIL 1850
PQQQQNQLSI AQSHSALLQP SQHPEKKNKL VIKEKEKESQ RERDSAEGGE 1900
GNTGPKETLP DALKAKEKKE LAPGGGSEPS MLPPRIASDA RGNATKALLE 1950
NFGFELVIQY NENKQKVQKK NGKTDQGENL EKLECDSCGK LFSNILILKS 2000
HQEHVHQNYF PFKQLERFAK QYRDHYDKLY PLRPQTPEPP PPPPPPPPPP 2050
LPAAPPQPAS TPAIPASAPP ITSPTIAPAQ PSVPLTQLSM PMELPIFSPL 2100
MMQTMPLQTL PAQLPPQLGP VEPLPADLAQ LYQHQLNPTL LQQQNKRPRT 2150
RITDDQLRVL RQYFDINNSP SEEQIKEMAD KSGLPQKVIK HWFRNTLFKE 2200
RQRNKDSPYN FSNPPITSLE ELKIDSRPPS PEPPKQEYWG SKRSSRTRFT 2250
DYQLRVLQDF FDANAYPKDD EFEQLSNLLN LPTRVIVVWF QNARQKARKN 2300
YENQGEGKDG ERRELTNDRY IRTSNLNYQC KKCSLVFQRI FDLIKHQKKL 2350
CYKDEDEEGQ DDSQNEDSMD AMEILTPTSS SCSTPMPSQA YSAPAPSANN 2400
TASSAFLQLT AEAEELATFN SKTEAGDEKP KLAEAPSAQP NQTQEKQGQP 2450
KPELQQQEQP EQKTNTPQQK LPQLVSLPSL PQPPPQAPPP QCPLPQSSPS 2500
PSQLSHLPLK PLHTSTPQQL ANLPPQLIPY QCDQCKLAFP SFEHWQEHQQ 2550
LHFLSAQNQF IHPQFLDRSL DMPFMLFDPS NPLLASQLLS GAIPQIPASS 2600
ATSPSTPTST MNTLKRKLEE KASASPGEND SGTGGEEPQR DKRLRTTITP 2650
EQLEILYQKY LLDSNPTRKM LDHIAHEVGL KKRVVQVWFQ NTRARERKGQ 2700
FRAVGPAQAH RRCPFCRALF KAKTALEAHI RSRHWHEAKR AGYNLTLSAM 2750
LLDCDGGLQM KGDIFDGTSF SHLPPSSSDG QGVPLSPVSK TMELSPRTLL 2800
SPSSIKVEGI EDFESPSMSS VNLNFDQTKL DNDDCSSVNT AITDTTTGDE 2850
GNADNDSATG IATETKSSSA PNEGLTKAAM MAMSEYEDRL SSGLVSPAPS 2900
FYSKEYDNEG TVDYSETSSL ADPCSPSPGA SGSAGKSGDS GDRPGQKRFR 2950
TQMTNLQLKV LKSCFNDYRT PTMLECEVLG NDIGLPKRVV QVWFQNARAK 3000
EKKSKLSMAK HFGINQTSYE GPKTECTLCG IKYSARLSVR DHIFSQQHIS 3050
KVKDTIGSQL DKEKEYFDPA TVRQLMAQQE LDRIKKANEV LGLAAQQQGM 3100
FDNTPLQALN LPTAYPALQG IPPVLLPGLN SPSLPGFTPS NTALTSPKPN 3150
LMGLPSTTVP SPGLPTSGLP NKPSSASLSS PTPAQATMAM GPQQPPQQQQ 3200
QQQQPQVQQP PPPPAAQPPP TPQLPLQQQQ QRKDKDSEKV KEKEKAHKGK 3250
GEPLPVPKKE KGEAPTATAA TISAPLPTME YAVDPAQLQA LQAALTSDPT 3300
ALLTSQFLPY FVPGFSPYYA PQIPGALQSG YLQPMYGMEG LFPYSPALSQ 3350
ALMGLSPGSL LQQYQQYQQS LQEAIQQQQQ RQLQQQQQQK VQQQQPKASQ 3400
TPVPPGAPSP DKDPAKESPK PEEQKNTPRE VSPLLPKLPE EPEAESKSAD 3450
SLYDPFIVPK VQYKLVCRKC QAGFSDEEAA RSHLKSLCFF GQSVVNLQEM 3500
VLHVPTGGGG GGSGGGGGGG GGGGGGGSYH CLACESALCG EEALSQHLES 3550
ALHKHRTITR AARNAKEHPS LLPHSACFPD PSTASTSQSA AHSNDSPPPP 3600
SAAAPSSASP HASRKSWPQV VSRASAAKPP SFPPLSSSST VTSSSCSTSG 3650
VQPSMPTDDY SEESDTDLSQ KSDGPASPVE GPKDPSCPKD SGLTSVGTDT 3700
FRL 3703
Length:3,703
Mass (Da):404,419
Last modified:June 13, 2006 - v2
Checksum:i395F5D14A08112CB
GO
Isoform B (identifier: Q15911-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-914: Missing.

Show »
Length:2,789
Mass (Da):306,664
Checksum:i457BA84E550E9AA4
GO

Polymorphismi

Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in individuals of European ancestry.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721S → A.1 Publication
Corresponds to variant rs7193297 [ dbSNP | Ensembl ].
VAR_026663
Natural varianti146 – 1461S → G.
Corresponds to variant rs58480263 [ dbSNP | Ensembl ].
VAR_061927
Natural varianti428 – 4281T → P.
Corresponds to variant rs16971436 [ dbSNP | Ensembl ].
VAR_026664
Natural varianti460 – 4601E → Q.
Corresponds to variant rs2073852 [ dbSNP | Ensembl ].
VAR_019968
Natural varianti777 – 7771V → A.1 Publication
Corresponds to variant rs4788682 [ dbSNP | Ensembl ].
VAR_026665
Natural varianti997 – 9971A → S.1 Publication
Corresponds to variant rs2213978 [ dbSNP | Ensembl ].
VAR_052733
Natural varianti3374 – 33741A → V.
VAR_011694
Natural varianti3377 – 33848Missing.
VAR_011695
Natural varianti3421 – 34211P → A.
Corresponds to variant rs8044440 [ dbSNP | Ensembl ].
VAR_026666
Natural varianti3527 – 35271G → GGG.
VAR_011696

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 914914Missing in isoform B.
VSP_006825Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti422 – 4221P → A1 Publication
Sequence conflicti579 – 5791A → T1 Publication
Sequence conflicti767 – 7671S → I1 Publication
Sequence conflicti846 – 8494RHLG → HHRV1 Publication
Sequence conflicti1150 – 119041EEAIE…LTDSP → GEWSHRHGRPRLGLGVHLLE TSRGLLFEGDVTDPAGPHVP Y1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L32832 mRNA. Translation: AAC14462.1.
D10250 mRNA. Translation: BAA01095.1.
AC004943 Genomic DNA. Translation: AAC79153.1.
AC132068 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59168.1.
CH471166 Genomic DNA. Translation: EAW59170.1.
AC002044 Genomic DNA. Translation: AAC31674.1.
CCDSiCCDS10908.1. [Q15911-1]
CCDS54035.1. [Q15911-2]
PIRiA41948.
RefSeqiNP_001158238.1. NM_001164766.1. [Q15911-2]
NP_008816.3. NM_006885.3. [Q15911-1]
UniGeneiHs.598297.

Genome annotation databases

EnsembliENST00000268489; ENSP00000268489; ENSG00000140836. [Q15911-1]
ENST00000397992; ENSP00000438926; ENSG00000140836. [Q15911-2]
GeneIDi463.
KEGGihsa:463.
UCSCiuc002fck.3. human. [Q15911-1]

Polymorphism databases

DMDMi108935822.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L32832 mRNA. Translation: AAC14462.1 .
D10250 mRNA. Translation: BAA01095.1 .
AC004943 Genomic DNA. Translation: AAC79153.1 .
AC132068 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59168.1 .
CH471166 Genomic DNA. Translation: EAW59170.1 .
AC002044 Genomic DNA. Translation: AAC31674.1 .
CCDSi CCDS10908.1. [Q15911-1 ]
CCDS54035.1. [Q15911-2 ]
PIRi A41948.
RefSeqi NP_001158238.1. NM_001164766.1. [Q15911-2 ]
NP_008816.3. NM_006885.3. [Q15911-1 ]
UniGenei Hs.598297.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DA1 NMR - A 2146-2202 [» ]
2DA2 NMR - A 2243-2299 [» ]
2DA3 NMR - A 2632-2698 [» ]
ProteinModelPortali Q15911.
SMRi Q15911. Positions 661-701, 716-748, 1216-1252, 1366-1452, 1537-1618, 2146-2207, 2247-2305, 2636-2698, 2947-3004, 3020-3065.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106954. 8 interactions.
IntActi Q15911. 2 interactions.
MINTi MINT-1462085.
STRINGi 9606.ENSP00000268489.

PTM databases

PhosphoSitei Q15911.

Polymorphism databases

DMDMi 108935822.

Proteomic databases

MaxQBi Q15911.
PaxDbi Q15911.
PeptideAtlasi Q15911.
PRIDEi Q15911.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268489 ; ENSP00000268489 ; ENSG00000140836 . [Q15911-1 ]
ENST00000397992 ; ENSP00000438926 ; ENSG00000140836 . [Q15911-2 ]
GeneIDi 463.
KEGGi hsa:463.
UCSCi uc002fck.3. human. [Q15911-1 ]

Organism-specific databases

CTDi 463.
GeneCardsi GC16M072816.
H-InvDB HIX0038876.
HGNCi HGNC:777. ZFHX3.
HPAi HPA059353.
MIMi 104155. gene.
neXtProti NX_Q15911.
PharmGKBi PA162409676.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301069.
HOGENOMi HOG000155777.
HOVERGENi HBG050606.
InParanoidi Q15911.
KOi K09378.
OMAi SVGMPPL.
OrthoDBi EOG7FR7FH.
PhylomeDBi Q15911.
TreeFami TF323288.

Miscellaneous databases

ChiTaRSi ZFHX3. human.
EvolutionaryTracei Q15911.
GeneWikii ATBF1.
GenomeRNAii 463.
NextBioi 1915.
PROi Q15911.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15911.
Bgeei Q15911.
CleanExi HS_ZFHX3.
Genevestigatori Q15911.

Family and domain databases

Gene3Di 1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view ]
Pfami PF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 4 hits.
PROSITEi PS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
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Publicationsi

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  1. "Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner."
    Miura Y., Tam T., Ido A., Morinaga T., Miki T., Hashimoto T., Tamaoki T.
    J. Biol. Chem. 270:26840-26848(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS ALA-72 AND ALA-777.
    Tissue: Lung.
  2. "A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers."
    Morinaga T., Yasuda H., Higashio K., Tamaoki T.
    Mol. Cell. Biol. 11:6041-6049(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
    Tissue: Hepatoma.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-1190 (ISOFORM A), VARIANT SER-997.
  6. "Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1."
    Berry F.B., Miura Y., Mihara K., Kaspar P., Sakata N., Hashimoto-Tamaoki T., Tamaoki T.
    J. Biol. Chem. 276:25057-25065(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS REGULATOR OF MYOBLASTS DIFFERENTIATION.
  7. "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3."
    Nojiri S., Joh T., Miura Y., Sakata N., Nomura T., Nakao H., Sobue S., Ohara H., Asai K., Ito M.
    Biochem. Biophys. Res. Commun. 314:97-103(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIAS3.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: FUNCTION IN GASTRIC CANCER, TISSUE SPECIFICITY.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION AND ISCHEMIC STROKE.
  14. "Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry."
    Benjamin E.J., Rice K.M., Arking D.E., Pfeufer A., van Noord C., Smith A.V., Schnabel R.B., Bis J.C., Boerwinkle E., Sinner M.F., Dehghan A., Lubitz S.A., D'Agostino R.B. Sr., Lumley T., Ehret G.B., Heeringa J., Aspelund T., Newton-Cheh C.
    , Larson M.G., Marciante K.D., Soliman E.Z., Rivadeneira F., Wang T.J., Eiriksdottir G., Levy D., Psaty B.M., Li M., Chamberlain A.M., Hofman A., Vasan R.S., Harris T.B., Rotter J.I., Kao W.H., Agarwal S.K., Stricker B.H.C., Wang K., Launer L.J., Smith N.L., Chakravarti A., Uitterlinden A.G., Wolf P.A., Sotoodehnia N., Koettgen A., van Duijn C.M., Meitinger T., Mueller M., Perz S., Steinbeck G., Wichmann H.-E., Lunetta K.L., Heckbert S.R., Gudnason V., Alonso A., Kaab S., Ellinor P.T., Witteman J.C.M.
    Nat. Genet. 41:879-881(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533 AND SER-571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Human ALKBH4 interacts with proteins associated with transcription."
    Bjornstad L.G., Meza T.J., Otterlei M., Olafsrud S.M., Meza-Zepeda L.A., Falnes P.O.
    PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALKBH4.
  17. "Solution structure of the second and third homeobox domain of AT-binding transcription factor 1 (ATBF1)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 2241-2305 AND 2629-2698.

Entry informationi

Entry nameiZFHX3_HUMAN
AccessioniPrimary (citable) accession number: Q15911
Secondary accession number(s): D3DWS8, O15101, Q13719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 13, 2006
Last modified: July 9, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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