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Q15911

- ZFHX3_HUMAN

UniProt

Q15911 - ZFHX3_HUMAN

Protein

Zinc finger homeobox protein 3

Gene

ZFHX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri282 – 30524C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri640 – 66324C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri671 – 69424C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri726 – 75025C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri804 – 82825C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri945 – 96824C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri984 – 100825C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1040 – 106425C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1088 – 111225C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1223 – 124624C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1252 – 127524C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1360 – 138526C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1401 – 142323C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1429 – 145224C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1545 – 156925C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1596 – 162025C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1983 – 200624C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi2145 – 220460Homeobox 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi2242 – 230160Homeobox 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri2328 – 235124C2H2-type 18; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri2530 – 255223C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi2641 – 270060Homeobox 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri2711 – 273424C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi2944 – 300360Homeobox 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri3024 – 304825C2H2-type 21PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri3529 – 355325C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cell cycle arrest Source: Ensembl
    3. muscle organ development Source: UniProtKB-KW
    4. negative regulation of myoblast differentiation Source: UniProtKB
    5. negative regulation of transcription, DNA-templated Source: UniProtKB
    6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    7. positive regulation of myoblast differentiation Source: UniProtKB
    8. regulation of neuron differentiation Source: Ensembl
    9. regulation of transcription, DNA-templated Source: UniProtKB
    10. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Myogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger homeobox protein 3
    Alternative name(s):
    AT motif-binding factor 1
    AT-binding transcription factor 1
    Alpha-fetoprotein enhancer-binding protein
    Zinc finger homeodomain protein 3
    Short name:
    ZFH-3
    Gene namesi
    Name:ZFHX3
    Synonyms:ATBF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:777. ZFHX3.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: UniProtKB
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162409676.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 37033703Zinc finger homeobox protein 3PRO_0000046930Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei533 – 5331Phosphoserine1 Publication
    Modified residuei571 – 5711Phosphoserine2 Publications
    Modified residuei1197 – 11971Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15911.
    PaxDbiQ15911.
    PeptideAtlasiQ15911.
    PRIDEiQ15911.

    PTM databases

    PhosphoSiteiQ15911.

    Expressioni

    Tissue specificityi

    Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ15911.
    BgeeiQ15911.
    CleanExiHS_ZFHX3.
    GenevestigatoriQ15911.

    Organism-specific databases

    HPAiHPA059353.

    Interactioni

    Subunit structurei

    Interacts with FNBP3 By similarity. Interacts with ALKBH4 and PIAS3.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi106954. 8 interactions.
    IntActiQ15911. 2 interactions.
    MINTiMINT-1462085.
    STRINGi9606.ENSP00000268489.

    Structurei

    Secondary structure

    1
    3703
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2154 – 216613
    Helixi2174 – 21829
    Helixi2186 – 220116
    Helixi2251 – 226313
    Helixi2269 – 227810
    Helixi2283 – 229715
    Turni2650 – 26523
    Helixi2653 – 266210
    Helixi2668 – 267811
    Helixi2682 – 269716

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DA1NMR-A2146-2202[»]
    2DA2NMR-A2243-2299[»]
    2DA3NMR-A2632-2698[»]
    ProteinModelPortaliQ15911.
    SMRiQ15911. Positions 661-701, 716-748, 1216-1252, 1366-1452, 1537-1618, 2146-2207, 2247-2305, 2636-2698, 2947-3004, 3020-3065.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15911.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi104 – 1074Poly-Pro
    Compositional biasi460 – 48930Poly-GluAdd
    BLAST
    Compositional biasi770 – 78415Poly-AlaAdd
    BLAST
    Compositional biasi1723 – 174321Poly-GlnAdd
    BLAST
    Compositional biasi1789 – 17946Poly-Gln
    Compositional biasi1852 – 18576Poly-Gln
    Compositional biasi2037 – 205216Poly-ProAdd
    BLAST
    Compositional biasi3197 – 320913Poly-GlnAdd
    BLAST
    Compositional biasi3210 – 32145Poly-Pro
    Compositional biasi3227 – 32315Poly-Gln
    Compositional biasi3376 – 338914Poly-GlnAdd
    BLAST
    Compositional biasi3392 – 33954Poly-Gln
    Compositional biasi3507 – 352721Poly-GlyAdd
    BLAST
    Compositional biasi3597 – 36004Poly-Pro
    Compositional biasi3636 – 36394Poly-Ser

    Sequence similaritiesi

    Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 4 homeobox DNA-binding domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri282 – 30524C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri640 – 66324C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri671 – 69424C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri726 – 75025C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri804 – 82825C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri945 – 96824C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri984 – 100825C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1040 – 106425C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1088 – 111225C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1223 – 124624C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1252 – 127524C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1360 – 138526C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1401 – 142323C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1429 – 145224C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1545 – 156925C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1596 – 162025C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1983 – 200624C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri2328 – 235124C2H2-type 18; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri2530 – 255223C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri2711 – 273424C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri3024 – 304825C2H2-type 21PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri3529 – 355325C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Homeobox, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG301069.
    HOGENOMiHOG000155777.
    HOVERGENiHBG050606.
    InParanoidiQ15911.
    KOiK09378.
    OMAiSVGMPPL.
    OrthoDBiEOG7FR7FH.
    PhylomeDBiQ15911.
    TreeFamiTF323288.

    Family and domain databases

    Gene3Di1.10.10.60. 4 hits.
    3.30.160.60. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR003604. Znf_U1.
    [Graphical view]
    PfamiPF00046. Homeobox. 4 hits.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 4 hits.
    SM00355. ZnF_C2H2. 23 hits.
    SM00451. ZnF_U1. 7 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 4 hits.
    PROSITEiPS00027. HOMEOBOX_1. 2 hits.
    PS50071. HOMEOBOX_2. 4 hits.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q15911-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGCDSPVVS GKDNGCGIPQ HQQWTELNST HLPDKPSSME QSTGESHGPL     50
    DSLRAPFNER LAESTASAGP PSEPASKEVT CNECSASFAS LQTYMEHHCP 100
    SARPPPPLRE ESASDTGEEG DEESDVENLA GEIVYQPDGS AYIVESLSQL 150
    TQGGGACGSG SGSGPLPSLF LNSLPGAGGK QGDPSCAAPV YPQIINTFHI 200
    ASSFGKWFEG PDQAFPNTSA LAGLSPVLHS FRVFDVRHKS NKDYLNSDGS 250
    AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 300
    AVHDHRMTLS EDERKILSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP 350
    LVSTANLIGP GHSFYGKFSG IRMEGEEALP AGSAAGPEQP QAGLLTPSTL 400
    LNLGGLTSSV LKTPITSVPL GPLASSPTKS SEGKDSGAAE GEKQEVGDGD 450
    CFSEKVEPAE EEAEEEEEEE EAEEEEEEEE EEEEEEEDEG CKGLFPSELD 500
    EELEDRPHEE PGAAAGSSSK KDLALSNQSI SNSPLMPNVL QTLSRGTAST 550
    SSNSASSFVV FDGANRRNRL SFNSEGVRAN VAEGGRRLDF ADESANKDNA 600
    TAPEPNESTE GDDGGFVPHH QHAGSLCELG VGECPSGSGV ECPKCDTVLG 650
    SSRSLGGHMT MMHSRNSCKT LKCPKCNWHY KYQQTLEAHM KEKHPEPGGS 700
    CVYCKSGQPH PRLARGESYT CGYKPFRCEV CNYSTTTKGN LSIHMQSDKH 750
    LNNMQNLQNG GGEQVFSHTA GAAAAAVAAA AAAANISSSC GAPSPTKPKT 800
    KPTWRCEVCD YETNVARNLR IHMTSEKHMH NMMLLQQNMT QIQHNRHLGL 850
    GSLPSPAEAE LYQYYLAQNM NLPNLKMDSA ASDAQFMMSG FQLDPAGPMA 900
    AMTPALVGGE IPLDMRLGGG QLVSEELMNL GESFIQTNDP SLKLFQCAVC 950
    NKFTTDNLDM LGLHMNVERS LSEDEWKAVM GDSYQCKLCR YNTQLKANFQ 1000
    LHCKTDKHVQ KYQLVAHIKE GGKANEWRLK CVAIGNPVHL KCNACDYYTN 1050
    SLEKLRLHTV NSRHEASLKL YKHLQQHESG VEGESCYYHC VLCNYSTKAK 1100
    LNLIQHVRSM KHQRSESLRK LQRLQKGLPE EDEDLGQIFT IRRCPSTDPE 1150
    EAIEDVEGPS ETAADPEELA KDQEGGASSS QAEKELTDSP ATSKRISFPG 1200
    SSESPLSSKR PKTAEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP 1250
    MLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT TPEMVMPSSM 1300
    FLPAAVPDRD GNSNLEEAGK QPETSEDLGK NILPSASTEQ SGDLKPSPAD 1350
    PGSVREDSGF ICWKKGCNQV FKTSAALQTH FNEVHAKRPQ LPVSDRHVYK 1400
    YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT FQALKKHLET 1450
    SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE EDKEEESDLE 1500
    DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC 1550
    KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT 1600
    CNVAYSQSST LEIHMRSVLH QTKARAAKLE AASGSSNGTG NSSSISLSSS 1650
    TPSPVSTSGS NTFTTSNPSS AGIAPSSNLL SQVPTESVGM PPLGNPIGAN 1700
    IASPSEPKEA NRKKLADMIA SRQQQQQQQQ QQQQQQQQQQ QAQTLAQAQA 1750
    QVQAHLQQEL QQQAALIQSQ LFNPTLLPHF PMTTETLLQL QQQQHLLFPF 1800
    YIPSAEFQLN PEVSLPVTSG ALTLTGTGPG LLEDLKAQVQ VPQQSHQQIL 1850
    PQQQQNQLSI AQSHSALLQP SQHPEKKNKL VIKEKEKESQ RERDSAEGGE 1900
    GNTGPKETLP DALKAKEKKE LAPGGGSEPS MLPPRIASDA RGNATKALLE 1950
    NFGFELVIQY NENKQKVQKK NGKTDQGENL EKLECDSCGK LFSNILILKS 2000
    HQEHVHQNYF PFKQLERFAK QYRDHYDKLY PLRPQTPEPP PPPPPPPPPP 2050
    LPAAPPQPAS TPAIPASAPP ITSPTIAPAQ PSVPLTQLSM PMELPIFSPL 2100
    MMQTMPLQTL PAQLPPQLGP VEPLPADLAQ LYQHQLNPTL LQQQNKRPRT 2150
    RITDDQLRVL RQYFDINNSP SEEQIKEMAD KSGLPQKVIK HWFRNTLFKE 2200
    RQRNKDSPYN FSNPPITSLE ELKIDSRPPS PEPPKQEYWG SKRSSRTRFT 2250
    DYQLRVLQDF FDANAYPKDD EFEQLSNLLN LPTRVIVVWF QNARQKARKN 2300
    YENQGEGKDG ERRELTNDRY IRTSNLNYQC KKCSLVFQRI FDLIKHQKKL 2350
    CYKDEDEEGQ DDSQNEDSMD AMEILTPTSS SCSTPMPSQA YSAPAPSANN 2400
    TASSAFLQLT AEAEELATFN SKTEAGDEKP KLAEAPSAQP NQTQEKQGQP 2450
    KPELQQQEQP EQKTNTPQQK LPQLVSLPSL PQPPPQAPPP QCPLPQSSPS 2500
    PSQLSHLPLK PLHTSTPQQL ANLPPQLIPY QCDQCKLAFP SFEHWQEHQQ 2550
    LHFLSAQNQF IHPQFLDRSL DMPFMLFDPS NPLLASQLLS GAIPQIPASS 2600
    ATSPSTPTST MNTLKRKLEE KASASPGEND SGTGGEEPQR DKRLRTTITP 2650
    EQLEILYQKY LLDSNPTRKM LDHIAHEVGL KKRVVQVWFQ NTRARERKGQ 2700
    FRAVGPAQAH RRCPFCRALF KAKTALEAHI RSRHWHEAKR AGYNLTLSAM 2750
    LLDCDGGLQM KGDIFDGTSF SHLPPSSSDG QGVPLSPVSK TMELSPRTLL 2800
    SPSSIKVEGI EDFESPSMSS VNLNFDQTKL DNDDCSSVNT AITDTTTGDE 2850
    GNADNDSATG IATETKSSSA PNEGLTKAAM MAMSEYEDRL SSGLVSPAPS 2900
    FYSKEYDNEG TVDYSETSSL ADPCSPSPGA SGSAGKSGDS GDRPGQKRFR 2950
    TQMTNLQLKV LKSCFNDYRT PTMLECEVLG NDIGLPKRVV QVWFQNARAK 3000
    EKKSKLSMAK HFGINQTSYE GPKTECTLCG IKYSARLSVR DHIFSQQHIS 3050
    KVKDTIGSQL DKEKEYFDPA TVRQLMAQQE LDRIKKANEV LGLAAQQQGM 3100
    FDNTPLQALN LPTAYPALQG IPPVLLPGLN SPSLPGFTPS NTALTSPKPN 3150
    LMGLPSTTVP SPGLPTSGLP NKPSSASLSS PTPAQATMAM GPQQPPQQQQ 3200
    QQQQPQVQQP PPPPAAQPPP TPQLPLQQQQ QRKDKDSEKV KEKEKAHKGK 3250
    GEPLPVPKKE KGEAPTATAA TISAPLPTME YAVDPAQLQA LQAALTSDPT 3300
    ALLTSQFLPY FVPGFSPYYA PQIPGALQSG YLQPMYGMEG LFPYSPALSQ 3350
    ALMGLSPGSL LQQYQQYQQS LQEAIQQQQQ RQLQQQQQQK VQQQQPKASQ 3400
    TPVPPGAPSP DKDPAKESPK PEEQKNTPRE VSPLLPKLPE EPEAESKSAD 3450
    SLYDPFIVPK VQYKLVCRKC QAGFSDEEAA RSHLKSLCFF GQSVVNLQEM 3500
    VLHVPTGGGG GGSGGGGGGG GGGGGGGSYH CLACESALCG EEALSQHLES 3550
    ALHKHRTITR AARNAKEHPS LLPHSACFPD PSTASTSQSA AHSNDSPPPP 3600
    SAAAPSSASP HASRKSWPQV VSRASAAKPP SFPPLSSSST VTSSSCSTSG 3650
    VQPSMPTDDY SEESDTDLSQ KSDGPASPVE GPKDPSCPKD SGLTSVGTDT 3700
    FRL 3703
    Length:3,703
    Mass (Da):404,419
    Last modified:June 13, 2006 - v2
    Checksum:i395F5D14A08112CB
    GO
    Isoform B (identifier: Q15911-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-914: Missing.

    Show »
    Length:2,789
    Mass (Da):306,664
    Checksum:i457BA84E550E9AA4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti422 – 4221P → A(PubMed:7592926)Curated
    Sequence conflicti579 – 5791A → T(PubMed:7592926)Curated
    Sequence conflicti767 – 7671S → I(PubMed:7592926)Curated
    Sequence conflicti846 – 8494RHLG → HHRV(PubMed:7592926)Curated
    Sequence conflicti1150 – 119041EEAIE…LTDSP → GEWSHRHGRPRLGLGVHLLE TSRGLLFEGDVTDPAGPHVP Y(PubMed:10493829)CuratedAdd
    BLAST

    Polymorphismi

    Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in individuals of European ancestry.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721S → A.1 Publication
    Corresponds to variant rs7193297 [ dbSNP | Ensembl ].
    VAR_026663
    Natural varianti146 – 1461S → G.
    Corresponds to variant rs58480263 [ dbSNP | Ensembl ].
    VAR_061927
    Natural varianti428 – 4281T → P.
    Corresponds to variant rs16971436 [ dbSNP | Ensembl ].
    VAR_026664
    Natural varianti460 – 4601E → Q.
    Corresponds to variant rs2073852 [ dbSNP | Ensembl ].
    VAR_019968
    Natural varianti777 – 7771V → A.1 Publication
    Corresponds to variant rs4788682 [ dbSNP | Ensembl ].
    VAR_026665
    Natural varianti997 – 9971A → S.1 Publication
    Corresponds to variant rs2213978 [ dbSNP | Ensembl ].
    VAR_052733
    Natural varianti3374 – 33741A → V.
    VAR_011694
    Natural varianti3377 – 33848Missing.
    VAR_011695
    Natural varianti3421 – 34211P → A.
    Corresponds to variant rs8044440 [ dbSNP | Ensembl ].
    VAR_026666
    Natural varianti3527 – 35271G → GGG.
    VAR_011696

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 914914Missing in isoform B. 1 PublicationVSP_006825Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32832 mRNA. Translation: AAC14462.1.
    D10250 mRNA. Translation: BAA01095.1.
    AC004943 Genomic DNA. Translation: AAC79153.1.
    AC132068 Genomic DNA. No translation available.
    CH471166 Genomic DNA. Translation: EAW59168.1.
    CH471166 Genomic DNA. Translation: EAW59170.1.
    AC002044 Genomic DNA. Translation: AAC31674.1.
    CCDSiCCDS10908.1. [Q15911-1]
    CCDS54035.1. [Q15911-2]
    PIRiA41948.
    RefSeqiNP_001158238.1. NM_001164766.1. [Q15911-2]
    NP_008816.3. NM_006885.3. [Q15911-1]
    UniGeneiHs.598297.

    Genome annotation databases

    EnsembliENST00000268489; ENSP00000268489; ENSG00000140836. [Q15911-1]
    ENST00000397992; ENSP00000438926; ENSG00000140836. [Q15911-2]
    GeneIDi463.
    KEGGihsa:463.
    UCSCiuc002fck.3. human. [Q15911-1]

    Polymorphism databases

    DMDMi108935822.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32832 mRNA. Translation: AAC14462.1 .
    D10250 mRNA. Translation: BAA01095.1 .
    AC004943 Genomic DNA. Translation: AAC79153.1 .
    AC132068 Genomic DNA. No translation available.
    CH471166 Genomic DNA. Translation: EAW59168.1 .
    CH471166 Genomic DNA. Translation: EAW59170.1 .
    AC002044 Genomic DNA. Translation: AAC31674.1 .
    CCDSi CCDS10908.1. [Q15911-1 ]
    CCDS54035.1. [Q15911-2 ]
    PIRi A41948.
    RefSeqi NP_001158238.1. NM_001164766.1. [Q15911-2 ]
    NP_008816.3. NM_006885.3. [Q15911-1 ]
    UniGenei Hs.598297.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DA1 NMR - A 2146-2202 [» ]
    2DA2 NMR - A 2243-2299 [» ]
    2DA3 NMR - A 2632-2698 [» ]
    ProteinModelPortali Q15911.
    SMRi Q15911. Positions 661-701, 716-748, 1216-1252, 1366-1452, 1537-1618, 2146-2207, 2247-2305, 2636-2698, 2947-3004, 3020-3065.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106954. 8 interactions.
    IntActi Q15911. 2 interactions.
    MINTi MINT-1462085.
    STRINGi 9606.ENSP00000268489.

    PTM databases

    PhosphoSitei Q15911.

    Polymorphism databases

    DMDMi 108935822.

    Proteomic databases

    MaxQBi Q15911.
    PaxDbi Q15911.
    PeptideAtlasi Q15911.
    PRIDEi Q15911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268489 ; ENSP00000268489 ; ENSG00000140836 . [Q15911-1 ]
    ENST00000397992 ; ENSP00000438926 ; ENSG00000140836 . [Q15911-2 ]
    GeneIDi 463.
    KEGGi hsa:463.
    UCSCi uc002fck.3. human. [Q15911-1 ]

    Organism-specific databases

    CTDi 463.
    GeneCardsi GC16M072816.
    H-InvDB HIX0038876.
    HGNCi HGNC:777. ZFHX3.
    HPAi HPA059353.
    MIMi 104155. gene.
    neXtProti NX_Q15911.
    PharmGKBi PA162409676.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301069.
    HOGENOMi HOG000155777.
    HOVERGENi HBG050606.
    InParanoidi Q15911.
    KOi K09378.
    OMAi SVGMPPL.
    OrthoDBi EOG7FR7FH.
    PhylomeDBi Q15911.
    TreeFami TF323288.

    Miscellaneous databases

    ChiTaRSi ZFHX3. human.
    EvolutionaryTracei Q15911.
    GeneWikii ATBF1.
    GenomeRNAii 463.
    NextBioi 1915.
    PROi Q15911.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15911.
    Bgeei Q15911.
    CleanExi HS_ZFHX3.
    Genevestigatori Q15911.

    Family and domain databases

    Gene3Di 1.10.10.60. 4 hits.
    3.30.160.60. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR003604. Znf_U1.
    [Graphical view ]
    Pfami PF00046. Homeobox. 4 hits.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 4 hits.
    SM00355. ZnF_C2H2. 23 hits.
    SM00451. ZnF_U1. 7 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 4 hits.
    PROSITEi PS00027. HOMEOBOX_1. 2 hits.
    PS50071. HOMEOBOX_2. 4 hits.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner."
      Miura Y., Tam T., Ido A., Morinaga T., Miki T., Hashimoto T., Tamaoki T.
      J. Biol. Chem. 270:26840-26848(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS ALA-72 AND ALA-777.
      Tissue: Lung.
    2. "A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers."
      Morinaga T., Yasuda H., Higashio K., Tamaoki T.
      Mol. Cell. Biol. 11:6041-6049(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
      Tissue: Hepatoma.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-1190 (ISOFORM A), VARIANT SER-997.
    6. "Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1."
      Berry F.B., Miura Y., Mihara K., Kaspar P., Sakata N., Hashimoto-Tamaoki T., Tamaoki T.
      J. Biol. Chem. 276:25057-25065(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS REGULATOR OF MYOBLASTS DIFFERENTIATION.
    7. "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3."
      Nojiri S., Joh T., Miura Y., Sakata N., Nomura T., Nakao H., Sobue S., Ohara H., Asai K., Ito M.
      Biochem. Biophys. Res. Commun. 314:97-103(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PIAS3.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: FUNCTION IN GASTRIC CANCER, TISSUE SPECIFICITY.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION AND ISCHEMIC STROKE.
    14. "Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry."
      Benjamin E.J., Rice K.M., Arking D.E., Pfeufer A., van Noord C., Smith A.V., Schnabel R.B., Bis J.C., Boerwinkle E., Sinner M.F., Dehghan A., Lubitz S.A., D'Agostino R.B. Sr., Lumley T., Ehret G.B., Heeringa J., Aspelund T., Newton-Cheh C.
      , Larson M.G., Marciante K.D., Soliman E.Z., Rivadeneira F., Wang T.J., Eiriksdottir G., Levy D., Psaty B.M., Li M., Chamberlain A.M., Hofman A., Vasan R.S., Harris T.B., Rotter J.I., Kao W.H., Agarwal S.K., Stricker B.H.C., Wang K., Launer L.J., Smith N.L., Chakravarti A., Uitterlinden A.G., Wolf P.A., Sotoodehnia N., Koettgen A., van Duijn C.M., Meitinger T., Mueller M., Perz S., Steinbeck G., Wichmann H.-E., Lunetta K.L., Heckbert S.R., Gudnason V., Alonso A., Kaab S., Ellinor P.T., Witteman J.C.M.
      Nat. Genet. 41:879-881(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533 AND SER-571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Human ALKBH4 interacts with proteins associated with transcription."
      Bjornstad L.G., Meza T.J., Otterlei M., Olafsrud S.M., Meza-Zepeda L.A., Falnes P.O.
      PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ALKBH4.
    17. "Solution structure of the second and third homeobox domain of AT-binding transcription factor 1 (ATBF1)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 2241-2305 AND 2629-2698.

    Entry informationi

    Entry nameiZFHX3_HUMAN
    AccessioniPrimary (citable) accession number: Q15911
    Secondary accession number(s): D3DWS8, O15101, Q13719
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3