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Protein

Zinc finger homeobox protein 3

Gene

ZFHX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri282 – 30524C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri640 – 66324C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri671 – 69424C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri726 – 75025C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri804 – 82825C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri945 – 96824C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri984 – 100825C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1040 – 106425C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1088 – 111225C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1223 – 124624C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1252 – 127524C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1360 – 138526C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1401 – 142323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1429 – 145224C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1545 – 156925C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1596 – 162025C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1983 – 200624C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
DNA bindingi2145 – 220460Homeobox 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi2242 – 230160Homeobox 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2328 – 235124C2H2-type 18; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2530 – 255223C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
DNA bindingi2641 – 270060Homeobox 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2711 – 273424C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
DNA bindingi2944 – 300360Homeobox 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3024 – 304825C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3529 – 355325C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • sequence-specific DNA binding Source: InterPro
  • sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • brain development Source: Ensembl
  • cell cycle arrest Source: Ensembl
  • muscle organ development Source: UniProtKB-KW
  • negative regulation of myoblast differentiation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of myoblast differentiation Source: UniProtKB
  • regulation of neuron differentiation Source: Ensembl
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Myogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger homeobox protein 3
Alternative name(s):
AT motif-binding factor 1
AT-binding transcription factor 1
Alpha-fetoprotein enhancer-binding protein
Zinc finger homeodomain protein 3
Short name:
ZFH-3
Gene namesi
Name:ZFHX3
Synonyms:ATBF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:777. ZFHX3.

Subcellular locationi

GO - Cellular componenti

  • intracellular membrane-bounded organelle Source: HPA
  • mitochondrion Source: Ensembl
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409676.

Polymorphism and mutation databases

BioMutaiZFHX3.
DMDMi108935822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 37033703Zinc finger homeobox protein 3PRO_0000046930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei428 – 4281Phosphothreonine1 Publication
Modified residuei533 – 5331Phosphoserine1 Publication
Modified residuei571 – 5711Phosphoserine2 Publications
Modified residuei1197 – 11971Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15911.
PaxDbiQ15911.
PeptideAtlasiQ15911.
PRIDEiQ15911.

PTM databases

PhosphoSiteiQ15911.

Expressioni

Tissue specificityi

Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level).1 Publication

Gene expression databases

BgeeiQ15911.
CleanExiHS_ZFHX3.
GenevestigatoriQ15911.

Organism-specific databases

HPAiHPA059353.
HPA061332.

Interactioni

Subunit structurei

Interacts with FNBP3 (By similarity). Interacts with ALKBH4 and PIAS3.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-10237226,EBI-10171697

Protein-protein interaction databases

BioGridi106954. 10 interactions.
IntActiQ15911. 3 interactions.
MINTiMINT-1462085.
STRINGi9606.ENSP00000268489.

Structurei

Secondary structure

1
3703
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2154 – 216613Combined sources
Helixi2174 – 21829Combined sources
Helixi2186 – 220116Combined sources
Helixi2251 – 226313Combined sources
Helixi2269 – 227810Combined sources
Helixi2283 – 229715Combined sources
Turni2650 – 26523Combined sources
Helixi2653 – 266210Combined sources
Helixi2668 – 267811Combined sources
Helixi2682 – 269716Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DA1NMR-A2146-2202[»]
2DA2NMR-A2243-2299[»]
2DA3NMR-A2632-2698[»]
ProteinModelPortaliQ15911.
SMRiQ15911. Positions 661-748, 1216-1252, 1401-1461, 1537-1618, 2146-2207, 2247-2305, 2636-2698, 2947-3004, 3020-3065.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15911.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 1074Poly-Pro
Compositional biasi460 – 48930Poly-GluAdd
BLAST
Compositional biasi770 – 78415Poly-AlaAdd
BLAST
Compositional biasi1723 – 174321Poly-GlnAdd
BLAST
Compositional biasi1789 – 17946Poly-Gln
Compositional biasi1852 – 18576Poly-Gln
Compositional biasi2037 – 205216Poly-ProAdd
BLAST
Compositional biasi3197 – 320913Poly-GlnAdd
BLAST
Compositional biasi3210 – 32145Poly-Pro
Compositional biasi3227 – 32315Poly-Gln
Compositional biasi3376 – 338914Poly-GlnAdd
BLAST
Compositional biasi3392 – 33954Poly-Gln
Compositional biasi3507 – 352721Poly-GlyAdd
BLAST
Compositional biasi3597 – 36004Poly-Pro
Compositional biasi3636 – 36394Poly-Ser

Sequence similaritiesi

Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 4 homeobox DNA-binding domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri282 – 30524C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri640 – 66324C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri671 – 69424C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri726 – 75025C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri804 – 82825C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri945 – 96824C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri984 – 100825C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1040 – 106425C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1088 – 111225C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1223 – 124624C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1252 – 127524C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1360 – 138526C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1401 – 142323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1429 – 145224C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1545 – 156925C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1596 – 162025C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1983 – 200624C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2328 – 235124C2H2-type 18; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2530 – 255223C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2711 – 273424C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3024 – 304825C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3529 – 355325C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG301069.
GeneTreeiENSGT00530000063717.
HOGENOMiHOG000155777.
HOVERGENiHBG050606.
InParanoidiQ15911.
KOiK09378.
OMAiSVGMPPL.
OrthoDBiEOG7FR7FH.
PhylomeDBiQ15911.
TreeFamiTF323288.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 4 hits.
PROSITEiPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q15911-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGCDSPVVS GKDNGCGIPQ HQQWTELNST HLPDKPSSME QSTGESHGPL
60 70 80 90 100
DSLRAPFNER LAESTASAGP PSEPASKEVT CNECSASFAS LQTYMEHHCP
110 120 130 140 150
SARPPPPLRE ESASDTGEEG DEESDVENLA GEIVYQPDGS AYIVESLSQL
160 170 180 190 200
TQGGGACGSG SGSGPLPSLF LNSLPGAGGK QGDPSCAAPV YPQIINTFHI
210 220 230 240 250
ASSFGKWFEG PDQAFPNTSA LAGLSPVLHS FRVFDVRHKS NKDYLNSDGS
260 270 280 290 300
AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH
310 320 330 340 350
AVHDHRMTLS EDERKILSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP
360 370 380 390 400
LVSTANLIGP GHSFYGKFSG IRMEGEEALP AGSAAGPEQP QAGLLTPSTL
410 420 430 440 450
LNLGGLTSSV LKTPITSVPL GPLASSPTKS SEGKDSGAAE GEKQEVGDGD
460 470 480 490 500
CFSEKVEPAE EEAEEEEEEE EAEEEEEEEE EEEEEEEDEG CKGLFPSELD
510 520 530 540 550
EELEDRPHEE PGAAAGSSSK KDLALSNQSI SNSPLMPNVL QTLSRGTAST
560 570 580 590 600
SSNSASSFVV FDGANRRNRL SFNSEGVRAN VAEGGRRLDF ADESANKDNA
610 620 630 640 650
TAPEPNESTE GDDGGFVPHH QHAGSLCELG VGECPSGSGV ECPKCDTVLG
660 670 680 690 700
SSRSLGGHMT MMHSRNSCKT LKCPKCNWHY KYQQTLEAHM KEKHPEPGGS
710 720 730 740 750
CVYCKSGQPH PRLARGESYT CGYKPFRCEV CNYSTTTKGN LSIHMQSDKH
760 770 780 790 800
LNNMQNLQNG GGEQVFSHTA GAAAAAVAAA AAAANISSSC GAPSPTKPKT
810 820 830 840 850
KPTWRCEVCD YETNVARNLR IHMTSEKHMH NMMLLQQNMT QIQHNRHLGL
860 870 880 890 900
GSLPSPAEAE LYQYYLAQNM NLPNLKMDSA ASDAQFMMSG FQLDPAGPMA
910 920 930 940 950
AMTPALVGGE IPLDMRLGGG QLVSEELMNL GESFIQTNDP SLKLFQCAVC
960 970 980 990 1000
NKFTTDNLDM LGLHMNVERS LSEDEWKAVM GDSYQCKLCR YNTQLKANFQ
1010 1020 1030 1040 1050
LHCKTDKHVQ KYQLVAHIKE GGKANEWRLK CVAIGNPVHL KCNACDYYTN
1060 1070 1080 1090 1100
SLEKLRLHTV NSRHEASLKL YKHLQQHESG VEGESCYYHC VLCNYSTKAK
1110 1120 1130 1140 1150
LNLIQHVRSM KHQRSESLRK LQRLQKGLPE EDEDLGQIFT IRRCPSTDPE
1160 1170 1180 1190 1200
EAIEDVEGPS ETAADPEELA KDQEGGASSS QAEKELTDSP ATSKRISFPG
1210 1220 1230 1240 1250
SSESPLSSKR PKTAEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP
1260 1270 1280 1290 1300
MLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT TPEMVMPSSM
1310 1320 1330 1340 1350
FLPAAVPDRD GNSNLEEAGK QPETSEDLGK NILPSASTEQ SGDLKPSPAD
1360 1370 1380 1390 1400
PGSVREDSGF ICWKKGCNQV FKTSAALQTH FNEVHAKRPQ LPVSDRHVYK
1410 1420 1430 1440 1450
YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT FQALKKHLET
1460 1470 1480 1490 1500
SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE EDKEEESDLE
1510 1520 1530 1540 1550
DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC
1560 1570 1580 1590 1600
KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT
1610 1620 1630 1640 1650
CNVAYSQSST LEIHMRSVLH QTKARAAKLE AASGSSNGTG NSSSISLSSS
1660 1670 1680 1690 1700
TPSPVSTSGS NTFTTSNPSS AGIAPSSNLL SQVPTESVGM PPLGNPIGAN
1710 1720 1730 1740 1750
IASPSEPKEA NRKKLADMIA SRQQQQQQQQ QQQQQQQQQQ QAQTLAQAQA
1760 1770 1780 1790 1800
QVQAHLQQEL QQQAALIQSQ LFNPTLLPHF PMTTETLLQL QQQQHLLFPF
1810 1820 1830 1840 1850
YIPSAEFQLN PEVSLPVTSG ALTLTGTGPG LLEDLKAQVQ VPQQSHQQIL
1860 1870 1880 1890 1900
PQQQQNQLSI AQSHSALLQP SQHPEKKNKL VIKEKEKESQ RERDSAEGGE
1910 1920 1930 1940 1950
GNTGPKETLP DALKAKEKKE LAPGGGSEPS MLPPRIASDA RGNATKALLE
1960 1970 1980 1990 2000
NFGFELVIQY NENKQKVQKK NGKTDQGENL EKLECDSCGK LFSNILILKS
2010 2020 2030 2040 2050
HQEHVHQNYF PFKQLERFAK QYRDHYDKLY PLRPQTPEPP PPPPPPPPPP
2060 2070 2080 2090 2100
LPAAPPQPAS TPAIPASAPP ITSPTIAPAQ PSVPLTQLSM PMELPIFSPL
2110 2120 2130 2140 2150
MMQTMPLQTL PAQLPPQLGP VEPLPADLAQ LYQHQLNPTL LQQQNKRPRT
2160 2170 2180 2190 2200
RITDDQLRVL RQYFDINNSP SEEQIKEMAD KSGLPQKVIK HWFRNTLFKE
2210 2220 2230 2240 2250
RQRNKDSPYN FSNPPITSLE ELKIDSRPPS PEPPKQEYWG SKRSSRTRFT
2260 2270 2280 2290 2300
DYQLRVLQDF FDANAYPKDD EFEQLSNLLN LPTRVIVVWF QNARQKARKN
2310 2320 2330 2340 2350
YENQGEGKDG ERRELTNDRY IRTSNLNYQC KKCSLVFQRI FDLIKHQKKL
2360 2370 2380 2390 2400
CYKDEDEEGQ DDSQNEDSMD AMEILTPTSS SCSTPMPSQA YSAPAPSANN
2410 2420 2430 2440 2450
TASSAFLQLT AEAEELATFN SKTEAGDEKP KLAEAPSAQP NQTQEKQGQP
2460 2470 2480 2490 2500
KPELQQQEQP EQKTNTPQQK LPQLVSLPSL PQPPPQAPPP QCPLPQSSPS
2510 2520 2530 2540 2550
PSQLSHLPLK PLHTSTPQQL ANLPPQLIPY QCDQCKLAFP SFEHWQEHQQ
2560 2570 2580 2590 2600
LHFLSAQNQF IHPQFLDRSL DMPFMLFDPS NPLLASQLLS GAIPQIPASS
2610 2620 2630 2640 2650
ATSPSTPTST MNTLKRKLEE KASASPGEND SGTGGEEPQR DKRLRTTITP
2660 2670 2680 2690 2700
EQLEILYQKY LLDSNPTRKM LDHIAHEVGL KKRVVQVWFQ NTRARERKGQ
2710 2720 2730 2740 2750
FRAVGPAQAH RRCPFCRALF KAKTALEAHI RSRHWHEAKR AGYNLTLSAM
2760 2770 2780 2790 2800
LLDCDGGLQM KGDIFDGTSF SHLPPSSSDG QGVPLSPVSK TMELSPRTLL
2810 2820 2830 2840 2850
SPSSIKVEGI EDFESPSMSS VNLNFDQTKL DNDDCSSVNT AITDTTTGDE
2860 2870 2880 2890 2900
GNADNDSATG IATETKSSSA PNEGLTKAAM MAMSEYEDRL SSGLVSPAPS
2910 2920 2930 2940 2950
FYSKEYDNEG TVDYSETSSL ADPCSPSPGA SGSAGKSGDS GDRPGQKRFR
2960 2970 2980 2990 3000
TQMTNLQLKV LKSCFNDYRT PTMLECEVLG NDIGLPKRVV QVWFQNARAK
3010 3020 3030 3040 3050
EKKSKLSMAK HFGINQTSYE GPKTECTLCG IKYSARLSVR DHIFSQQHIS
3060 3070 3080 3090 3100
KVKDTIGSQL DKEKEYFDPA TVRQLMAQQE LDRIKKANEV LGLAAQQQGM
3110 3120 3130 3140 3150
FDNTPLQALN LPTAYPALQG IPPVLLPGLN SPSLPGFTPS NTALTSPKPN
3160 3170 3180 3190 3200
LMGLPSTTVP SPGLPTSGLP NKPSSASLSS PTPAQATMAM GPQQPPQQQQ
3210 3220 3230 3240 3250
QQQQPQVQQP PPPPAAQPPP TPQLPLQQQQ QRKDKDSEKV KEKEKAHKGK
3260 3270 3280 3290 3300
GEPLPVPKKE KGEAPTATAA TISAPLPTME YAVDPAQLQA LQAALTSDPT
3310 3320 3330 3340 3350
ALLTSQFLPY FVPGFSPYYA PQIPGALQSG YLQPMYGMEG LFPYSPALSQ
3360 3370 3380 3390 3400
ALMGLSPGSL LQQYQQYQQS LQEAIQQQQQ RQLQQQQQQK VQQQQPKASQ
3410 3420 3430 3440 3450
TPVPPGAPSP DKDPAKESPK PEEQKNTPRE VSPLLPKLPE EPEAESKSAD
3460 3470 3480 3490 3500
SLYDPFIVPK VQYKLVCRKC QAGFSDEEAA RSHLKSLCFF GQSVVNLQEM
3510 3520 3530 3540 3550
VLHVPTGGGG GGSGGGGGGG GGGGGGGSYH CLACESALCG EEALSQHLES
3560 3570 3580 3590 3600
ALHKHRTITR AARNAKEHPS LLPHSACFPD PSTASTSQSA AHSNDSPPPP
3610 3620 3630 3640 3650
SAAAPSSASP HASRKSWPQV VSRASAAKPP SFPPLSSSST VTSSSCSTSG
3660 3670 3680 3690 3700
VQPSMPTDDY SEESDTDLSQ KSDGPASPVE GPKDPSCPKD SGLTSVGTDT

FRL
Length:3,703
Mass (Da):404,419
Last modified:June 13, 2006 - v2
Checksum:i395F5D14A08112CB
GO
Isoform B (identifier: Q15911-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-914: Missing.

Show »
Length:2,789
Mass (Da):306,664
Checksum:i457BA84E550E9AA4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti422 – 4221P → A (PubMed:7592926).Curated
Sequence conflicti579 – 5791A → T (PubMed:7592926).Curated
Sequence conflicti767 – 7671S → I (PubMed:7592926).Curated
Sequence conflicti846 – 8494RHLG → HHRV (PubMed:7592926).Curated
Sequence conflicti1150 – 119041EEAIE…LTDSP → GEWSHRHGRPRLGLGVHLLE TSRGLLFEGDVTDPAGPHVP Y (PubMed:10493829).CuratedAdd
BLAST

Polymorphismi

Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in individuals of European ancestry.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721S → A.1 Publication
Corresponds to variant rs7193297 [ dbSNP | Ensembl ].
VAR_026663
Natural varianti146 – 1461S → G.
Corresponds to variant rs58480263 [ dbSNP | Ensembl ].
VAR_061927
Natural varianti428 – 4281T → P.
Corresponds to variant rs16971436 [ dbSNP | Ensembl ].
VAR_026664
Natural varianti460 – 4601E → Q.
Corresponds to variant rs2073852 [ dbSNP | Ensembl ].
VAR_019968
Natural varianti777 – 7771V → A.1 Publication
Corresponds to variant rs4788682 [ dbSNP | Ensembl ].
VAR_026665
Natural varianti997 – 9971A → S.1 Publication
Corresponds to variant rs2213978 [ dbSNP | Ensembl ].
VAR_052733
Natural varianti3374 – 33741A → V.
VAR_011694
Natural varianti3377 – 33848Missing .
VAR_011695
Natural varianti3421 – 34211P → A.
Corresponds to variant rs8044440 [ dbSNP | Ensembl ].
VAR_026666
Natural varianti3527 – 35271G → GGG.
VAR_011696

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 914914Missing in isoform B. 1 PublicationVSP_006825Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32832 mRNA. Translation: AAC14462.1.
D10250 mRNA. Translation: BAA01095.1.
AC004943 Genomic DNA. Translation: AAC79153.1.
AC132068 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59168.1.
CH471166 Genomic DNA. Translation: EAW59170.1.
AC002044 Genomic DNA. Translation: AAC31674.1.
CCDSiCCDS10908.1. [Q15911-1]
CCDS54035.1. [Q15911-2]
PIRiA41948.
RefSeqiNP_001158238.1. NM_001164766.1. [Q15911-2]
NP_008816.3. NM_006885.3. [Q15911-1]
UniGeneiHs.598297.

Genome annotation databases

EnsembliENST00000268489; ENSP00000268489; ENSG00000140836. [Q15911-1]
ENST00000397992; ENSP00000438926; ENSG00000140836. [Q15911-2]
GeneIDi463.
KEGGihsa:463.
UCSCiuc002fck.3. human. [Q15911-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32832 mRNA. Translation: AAC14462.1.
D10250 mRNA. Translation: BAA01095.1.
AC004943 Genomic DNA. Translation: AAC79153.1.
AC132068 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59168.1.
CH471166 Genomic DNA. Translation: EAW59170.1.
AC002044 Genomic DNA. Translation: AAC31674.1.
CCDSiCCDS10908.1. [Q15911-1]
CCDS54035.1. [Q15911-2]
PIRiA41948.
RefSeqiNP_001158238.1. NM_001164766.1. [Q15911-2]
NP_008816.3. NM_006885.3. [Q15911-1]
UniGeneiHs.598297.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DA1NMR-A2146-2202[»]
2DA2NMR-A2243-2299[»]
2DA3NMR-A2632-2698[»]
ProteinModelPortaliQ15911.
SMRiQ15911. Positions 661-748, 1216-1252, 1401-1461, 1537-1618, 2146-2207, 2247-2305, 2636-2698, 2947-3004, 3020-3065.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106954. 10 interactions.
IntActiQ15911. 3 interactions.
MINTiMINT-1462085.
STRINGi9606.ENSP00000268489.

PTM databases

PhosphoSiteiQ15911.

Polymorphism and mutation databases

BioMutaiZFHX3.
DMDMi108935822.

Proteomic databases

MaxQBiQ15911.
PaxDbiQ15911.
PeptideAtlasiQ15911.
PRIDEiQ15911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268489; ENSP00000268489; ENSG00000140836. [Q15911-1]
ENST00000397992; ENSP00000438926; ENSG00000140836. [Q15911-2]
GeneIDi463.
KEGGihsa:463.
UCSCiuc002fck.3. human. [Q15911-1]

Organism-specific databases

CTDi463.
GeneCardsiGC16M072816.
H-InvDBHIX0038876.
HGNCiHGNC:777. ZFHX3.
HPAiHPA059353.
HPA061332.
MIMi104155. gene.
neXtProtiNX_Q15911.
PharmGKBiPA162409676.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG301069.
GeneTreeiENSGT00530000063717.
HOGENOMiHOG000155777.
HOVERGENiHBG050606.
InParanoidiQ15911.
KOiK09378.
OMAiSVGMPPL.
OrthoDBiEOG7FR7FH.
PhylomeDBiQ15911.
TreeFamiTF323288.

Miscellaneous databases

ChiTaRSiZFHX3. human.
EvolutionaryTraceiQ15911.
GeneWikiiATBF1.
GenomeRNAii463.
NextBioi1915.
PROiQ15911.
SOURCEiSearch...

Gene expression databases

BgeeiQ15911.
CleanExiHS_ZFHX3.
GenevestigatoriQ15911.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 4 hits.
PROSITEiPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner."
    Miura Y., Tam T., Ido A., Morinaga T., Miki T., Hashimoto T., Tamaoki T.
    J. Biol. Chem. 270:26840-26848(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS ALA-72 AND ALA-777.
    Tissue: Lung.
  2. "A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers."
    Morinaga T., Yasuda H., Higashio K., Tamaoki T.
    Mol. Cell. Biol. 11:6041-6049(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
    Tissue: Hepatoma.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-1190 (ISOFORM A), VARIANT SER-997.
  6. "Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1."
    Berry F.B., Miura Y., Mihara K., Kaspar P., Sakata N., Hashimoto-Tamaoki T., Tamaoki T.
    J. Biol. Chem. 276:25057-25065(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS REGULATOR OF MYOBLASTS DIFFERENTIATION.
  7. "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3."
    Nojiri S., Joh T., Miura Y., Sakata N., Nomura T., Nakao H., Sobue S., Ohara H., Asai K., Ito M.
    Biochem. Biophys. Res. Commun. 314:97-103(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIAS3.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: FUNCTION IN GASTRIC CANCER, TISSUE SPECIFICITY.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION AND ISCHEMIC STROKE.
  14. "Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry."
    Benjamin E.J., Rice K.M., Arking D.E., Pfeufer A., van Noord C., Smith A.V., Schnabel R.B., Bis J.C., Boerwinkle E., Sinner M.F., Dehghan A., Lubitz S.A., D'Agostino R.B. Sr., Lumley T., Ehret G.B., Heeringa J., Aspelund T., Newton-Cheh C.
    , Larson M.G., Marciante K.D., Soliman E.Z., Rivadeneira F., Wang T.J., Eiriksdottir G., Levy D., Psaty B.M., Li M., Chamberlain A.M., Hofman A., Vasan R.S., Harris T.B., Rotter J.I., Kao W.H., Agarwal S.K., Stricker B.H.C., Wang K., Launer L.J., Smith N.L., Chakravarti A., Uitterlinden A.G., Wolf P.A., Sotoodehnia N., Koettgen A., van Duijn C.M., Meitinger T., Mueller M., Perz S., Steinbeck G., Wichmann H.-E., Lunetta K.L., Heckbert S.R., Gudnason V., Alonso A., Kaab S., Ellinor P.T., Witteman J.C.M.
    Nat. Genet. 41:879-881(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533 AND SER-571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Human ALKBH4 interacts with proteins associated with transcription."
    Bjornstad L.G., Meza T.J., Otterlei M., Olafsrud S.M., Meza-Zepeda L.A., Falnes P.O.
    PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALKBH4.
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  18. "Solution structure of the second and third homeobox domain of AT-binding transcription factor 1 (ATBF1)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 2241-2305 AND 2629-2698.

Entry informationi

Entry nameiZFHX3_HUMAN
AccessioniPrimary (citable) accession number: Q15911
Secondary accession number(s): D3DWS8, O15101, Q13719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 13, 2006
Last modified: May 27, 2015
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.