Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q15911 (ZFHX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger homeobox protein 3
Alternative name(s):
AT motif-binding factor 1
AT-binding transcription factor 1
Alpha-fetoprotein enhancer-binding protein
Zinc finger homeodomain protein 3
Short name=ZFH-3
Gene names
Name:ZFHX3
Synonyms:ATBF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length3703 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. Ref.6 Ref.9

Subunit structure

Interacts with FNBP3 By similarity. Interacts with ALKBH4 and PIAS3. Ref.7 Ref.16

Subcellular location

Nucleus.

Tissue specificity

Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Ref.9

Polymorphism

Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in individuals of European ancestry.

Sequence similarities

Contains 22 C2H2-type zinc fingers.

Contains 4 homeobox DNA-binding domains.

Ontologies

Keywords
   Biological processMyogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainHomeobox
Repeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

muscle organ development

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of myoblast differentiation

Inferred from direct assay Ref.6. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 10318867. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay Ref.6. Source: UniProtKB

positive regulation of myoblast differentiation

Inferred from direct assay Ref.6. Source: UniProtKB

regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Traceable author statement Ref.2. Source: UniProtKB

transcription from RNA polymerase II promoter

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

nucleus

Traceable author statement Ref.2. Source: UniProtKB

transcription factor complex

Inferred from direct assay PubMed 10318867. Source: MGI

   Molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.2. Source: UniProtKB

enzyme binding

Inferred from physical interaction Ref.7. Source: UniProtKB

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Non-traceable author statement Ref.2. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from direct assay Ref.6. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q15911-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q15911-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-914: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 37033703Zinc finger homeobox protein 3
PRO_0000046930

Regions

Zinc finger282 – 30524C2H2-type 1
Zinc finger640 – 66324C2H2-type 2
Zinc finger671 – 69424C2H2-type 3
Zinc finger726 – 75025C2H2-type 4
Zinc finger804 – 82825C2H2-type 5; atypical
Zinc finger945 – 96824C2H2-type 6; degenerate
Zinc finger984 – 100825C2H2-type 7; atypical
Zinc finger1040 – 106425C2H2-type 8; atypical
Zinc finger1088 – 111225C2H2-type 9; atypical
Zinc finger1223 – 124624C2H2-type 10; atypical
Zinc finger1252 – 127524C2H2-type 11
Zinc finger1360 – 138526C2H2-type 12
Zinc finger1401 – 142323C2H2-type 13
Zinc finger1429 – 145224C2H2-type 14
Zinc finger1545 – 156925C2H2-type 15
Zinc finger1596 – 162025C2H2-type 16
Zinc finger1983 – 200624C2H2-type 17
DNA binding2145 – 220460Homeobox 1
DNA binding2242 – 230160Homeobox 2
Zinc finger2328 – 235124C2H2-type 18; atypical
Zinc finger2530 – 255223C2H2-type 19
DNA binding2641 – 270060Homeobox 3
Zinc finger2711 – 273424C2H2-type 20
DNA binding2944 – 300360Homeobox 4
Zinc finger3024 – 304825C2H2-type 21
Zinc finger3529 – 355325C2H2-type 22
Compositional bias104 – 1074Poly-Pro
Compositional bias460 – 48930Poly-Glu
Compositional bias770 – 78415Poly-Ala
Compositional bias1723 – 174321Poly-Gln
Compositional bias1789 – 17946Poly-Gln
Compositional bias1852 – 18576Poly-Gln
Compositional bias2037 – 205216Poly-Pro
Compositional bias3197 – 320913Poly-Gln
Compositional bias3210 – 32145Poly-Pro
Compositional bias3227 – 32315Poly-Gln
Compositional bias3376 – 338914Poly-Gln
Compositional bias3392 – 33954Poly-Gln
Compositional bias3507 – 352721Poly-Gly
Compositional bias3597 – 36004Poly-Pro
Compositional bias3636 – 36394Poly-Ser

Amino acid modifications

Modified residue5331Phosphoserine Ref.15
Modified residue5711Phosphoserine Ref.8 Ref.15
Modified residue11971Phosphoserine Ref.11

Natural variations

Alternative sequence1 – 914914Missing in isoform B.
VSP_006825
Natural variant721S → A. Ref.1
Corresponds to variant rs7193297 [ dbSNP | Ensembl ].
VAR_026663
Natural variant1461S → G.
Corresponds to variant rs58480263 [ dbSNP | Ensembl ].
VAR_061927
Natural variant4281T → P.
Corresponds to variant rs16971436 [ dbSNP | Ensembl ].
VAR_026664
Natural variant4601E → Q.
Corresponds to variant rs2073852 [ dbSNP | Ensembl ].
VAR_019968
Natural variant7771V → A. Ref.1
Corresponds to variant rs4788682 [ dbSNP | Ensembl ].
VAR_026665
Natural variant9971A → S. Ref.5
Corresponds to variant rs2213978 [ dbSNP | Ensembl ].
VAR_052733
Natural variant33741A → V.
VAR_011694
Natural variant3377 – 33848Missing.
VAR_011695
Natural variant34211P → A.
Corresponds to variant rs8044440 [ dbSNP | Ensembl ].
VAR_026666
Natural variant35271G → GGG.
VAR_011696

Experimental info

Sequence conflict4221P → A Ref.1
Sequence conflict5791A → T Ref.1
Sequence conflict7671S → I Ref.1
Sequence conflict846 – 8494RHLG → HHRV Ref.1
Sequence conflict1150 – 119041EEAIE…LTDSP → GEWSHRHGRPRLGLGVHLLE TSRGLLFEGDVTDPAGPHVP Y Ref.5

Secondary structure

.................... 3703
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: 395F5D14A08112CB

FASTA3,703404,419
        10         20         30         40         50         60 
MEGCDSPVVS GKDNGCGIPQ HQQWTELNST HLPDKPSSME QSTGESHGPL DSLRAPFNER 

        70         80         90        100        110        120 
LAESTASAGP PSEPASKEVT CNECSASFAS LQTYMEHHCP SARPPPPLRE ESASDTGEEG 

       130        140        150        160        170        180 
DEESDVENLA GEIVYQPDGS AYIVESLSQL TQGGGACGSG SGSGPLPSLF LNSLPGAGGK 

       190        200        210        220        230        240 
QGDPSCAAPV YPQIINTFHI ASSFGKWFEG PDQAFPNTSA LAGLSPVLHS FRVFDVRHKS 

       250        260        270        280        290        300 
NKDYLNSDGS AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 

       310        320        330        340        350        360 
AVHDHRMTLS EDERKILSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP LVSTANLIGP 

       370        380        390        400        410        420 
GHSFYGKFSG IRMEGEEALP AGSAAGPEQP QAGLLTPSTL LNLGGLTSSV LKTPITSVPL 

       430        440        450        460        470        480 
GPLASSPTKS SEGKDSGAAE GEKQEVGDGD CFSEKVEPAE EEAEEEEEEE EAEEEEEEEE 

       490        500        510        520        530        540 
EEEEEEEDEG CKGLFPSELD EELEDRPHEE PGAAAGSSSK KDLALSNQSI SNSPLMPNVL 

       550        560        570        580        590        600 
QTLSRGTAST SSNSASSFVV FDGANRRNRL SFNSEGVRAN VAEGGRRLDF ADESANKDNA 

       610        620        630        640        650        660 
TAPEPNESTE GDDGGFVPHH QHAGSLCELG VGECPSGSGV ECPKCDTVLG SSRSLGGHMT 

       670        680        690        700        710        720 
MMHSRNSCKT LKCPKCNWHY KYQQTLEAHM KEKHPEPGGS CVYCKSGQPH PRLARGESYT 

       730        740        750        760        770        780 
CGYKPFRCEV CNYSTTTKGN LSIHMQSDKH LNNMQNLQNG GGEQVFSHTA GAAAAAVAAA 

       790        800        810        820        830        840 
AAAANISSSC GAPSPTKPKT KPTWRCEVCD YETNVARNLR IHMTSEKHMH NMMLLQQNMT 

       850        860        870        880        890        900 
QIQHNRHLGL GSLPSPAEAE LYQYYLAQNM NLPNLKMDSA ASDAQFMMSG FQLDPAGPMA 

       910        920        930        940        950        960 
AMTPALVGGE IPLDMRLGGG QLVSEELMNL GESFIQTNDP SLKLFQCAVC NKFTTDNLDM 

       970        980        990       1000       1010       1020 
LGLHMNVERS LSEDEWKAVM GDSYQCKLCR YNTQLKANFQ LHCKTDKHVQ KYQLVAHIKE 

      1030       1040       1050       1060       1070       1080 
GGKANEWRLK CVAIGNPVHL KCNACDYYTN SLEKLRLHTV NSRHEASLKL YKHLQQHESG 

      1090       1100       1110       1120       1130       1140 
VEGESCYYHC VLCNYSTKAK LNLIQHVRSM KHQRSESLRK LQRLQKGLPE EDEDLGQIFT 

      1150       1160       1170       1180       1190       1200 
IRRCPSTDPE EAIEDVEGPS ETAADPEELA KDQEGGASSS QAEKELTDSP ATSKRISFPG 

      1210       1220       1230       1240       1250       1260 
SSESPLSSKR PKTAEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP MLRCPLCQDM 

      1270       1280       1290       1300       1310       1320 
LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT TPEMVMPSSM FLPAAVPDRD GNSNLEEAGK 

      1330       1340       1350       1360       1370       1380 
QPETSEDLGK NILPSASTEQ SGDLKPSPAD PGSVREDSGF ICWKKGCNQV FKTSAALQTH 

      1390       1400       1410       1420       1430       1440 
FNEVHAKRPQ LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT 

      1450       1460       1470       1480       1490       1500 
FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE EDKEEESDLE 

      1510       1520       1530       1540       1550       1560 
DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC KESFTQKNIL 

      1570       1580       1590       1600       1610       1620 
LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT CNVAYSQSST LEIHMRSVLH 

      1630       1640       1650       1660       1670       1680 
QTKARAAKLE AASGSSNGTG NSSSISLSSS TPSPVSTSGS NTFTTSNPSS AGIAPSSNLL 

      1690       1700       1710       1720       1730       1740 
SQVPTESVGM PPLGNPIGAN IASPSEPKEA NRKKLADMIA SRQQQQQQQQ QQQQQQQQQQ 

      1750       1760       1770       1780       1790       1800 
QAQTLAQAQA QVQAHLQQEL QQQAALIQSQ LFNPTLLPHF PMTTETLLQL QQQQHLLFPF 

      1810       1820       1830       1840       1850       1860 
YIPSAEFQLN PEVSLPVTSG ALTLTGTGPG LLEDLKAQVQ VPQQSHQQIL PQQQQNQLSI 

      1870       1880       1890       1900       1910       1920 
AQSHSALLQP SQHPEKKNKL VIKEKEKESQ RERDSAEGGE GNTGPKETLP DALKAKEKKE 

      1930       1940       1950       1960       1970       1980 
LAPGGGSEPS MLPPRIASDA RGNATKALLE NFGFELVIQY NENKQKVQKK NGKTDQGENL 

      1990       2000       2010       2020       2030       2040 
EKLECDSCGK LFSNILILKS HQEHVHQNYF PFKQLERFAK QYRDHYDKLY PLRPQTPEPP 

      2050       2060       2070       2080       2090       2100 
PPPPPPPPPP LPAAPPQPAS TPAIPASAPP ITSPTIAPAQ PSVPLTQLSM PMELPIFSPL 

      2110       2120       2130       2140       2150       2160 
MMQTMPLQTL PAQLPPQLGP VEPLPADLAQ LYQHQLNPTL LQQQNKRPRT RITDDQLRVL 

      2170       2180       2190       2200       2210       2220 
RQYFDINNSP SEEQIKEMAD KSGLPQKVIK HWFRNTLFKE RQRNKDSPYN FSNPPITSLE 

      2230       2240       2250       2260       2270       2280 
ELKIDSRPPS PEPPKQEYWG SKRSSRTRFT DYQLRVLQDF FDANAYPKDD EFEQLSNLLN 

      2290       2300       2310       2320       2330       2340 
LPTRVIVVWF QNARQKARKN YENQGEGKDG ERRELTNDRY IRTSNLNYQC KKCSLVFQRI 

      2350       2360       2370       2380       2390       2400 
FDLIKHQKKL CYKDEDEEGQ DDSQNEDSMD AMEILTPTSS SCSTPMPSQA YSAPAPSANN 

      2410       2420       2430       2440       2450       2460 
TASSAFLQLT AEAEELATFN SKTEAGDEKP KLAEAPSAQP NQTQEKQGQP KPELQQQEQP 

      2470       2480       2490       2500       2510       2520 
EQKTNTPQQK LPQLVSLPSL PQPPPQAPPP QCPLPQSSPS PSQLSHLPLK PLHTSTPQQL 

      2530       2540       2550       2560       2570       2580 
ANLPPQLIPY QCDQCKLAFP SFEHWQEHQQ LHFLSAQNQF IHPQFLDRSL DMPFMLFDPS 

      2590       2600       2610       2620       2630       2640 
NPLLASQLLS GAIPQIPASS ATSPSTPTST MNTLKRKLEE KASASPGEND SGTGGEEPQR 

      2650       2660       2670       2680       2690       2700 
DKRLRTTITP EQLEILYQKY LLDSNPTRKM LDHIAHEVGL KKRVVQVWFQ NTRARERKGQ 

      2710       2720       2730       2740       2750       2760 
FRAVGPAQAH RRCPFCRALF KAKTALEAHI RSRHWHEAKR AGYNLTLSAM LLDCDGGLQM 

      2770       2780       2790       2800       2810       2820 
KGDIFDGTSF SHLPPSSSDG QGVPLSPVSK TMELSPRTLL SPSSIKVEGI EDFESPSMSS 

      2830       2840       2850       2860       2870       2880 
VNLNFDQTKL DNDDCSSVNT AITDTTTGDE GNADNDSATG IATETKSSSA PNEGLTKAAM 

      2890       2900       2910       2920       2930       2940 
MAMSEYEDRL SSGLVSPAPS FYSKEYDNEG TVDYSETSSL ADPCSPSPGA SGSAGKSGDS 

      2950       2960       2970       2980       2990       3000 
GDRPGQKRFR TQMTNLQLKV LKSCFNDYRT PTMLECEVLG NDIGLPKRVV QVWFQNARAK 

      3010       3020       3030       3040       3050       3060 
EKKSKLSMAK HFGINQTSYE GPKTECTLCG IKYSARLSVR DHIFSQQHIS KVKDTIGSQL 

      3070       3080       3090       3100       3110       3120 
DKEKEYFDPA TVRQLMAQQE LDRIKKANEV LGLAAQQQGM FDNTPLQALN LPTAYPALQG 

      3130       3140       3150       3160       3170       3180 
IPPVLLPGLN SPSLPGFTPS NTALTSPKPN LMGLPSTTVP SPGLPTSGLP NKPSSASLSS 

      3190       3200       3210       3220       3230       3240 
PTPAQATMAM GPQQPPQQQQ QQQQPQVQQP PPPPAAQPPP TPQLPLQQQQ QRKDKDSEKV 

      3250       3260       3270       3280       3290       3300 
KEKEKAHKGK GEPLPVPKKE KGEAPTATAA TISAPLPTME YAVDPAQLQA LQAALTSDPT 

      3310       3320       3330       3340       3350       3360 
ALLTSQFLPY FVPGFSPYYA PQIPGALQSG YLQPMYGMEG LFPYSPALSQ ALMGLSPGSL 

      3370       3380       3390       3400       3410       3420 
LQQYQQYQQS LQEAIQQQQQ RQLQQQQQQK VQQQQPKASQ TPVPPGAPSP DKDPAKESPK 

      3430       3440       3450       3460       3470       3480 
PEEQKNTPRE VSPLLPKLPE EPEAESKSAD SLYDPFIVPK VQYKLVCRKC QAGFSDEEAA 

      3490       3500       3510       3520       3530       3540 
RSHLKSLCFF GQSVVNLQEM VLHVPTGGGG GGSGGGGGGG GGGGGGGSYH CLACESALCG 

      3550       3560       3570       3580       3590       3600 
EEALSQHLES ALHKHRTITR AARNAKEHPS LLPHSACFPD PSTASTSQSA AHSNDSPPPP 

      3610       3620       3630       3640       3650       3660 
SAAAPSSASP HASRKSWPQV VSRASAAKPP SFPPLSSSST VTSSSCSTSG VQPSMPTDDY 

      3670       3680       3690       3700 
SEESDTDLSQ KSDGPASPVE GPKDPSCPKD SGLTSVGTDT FRL 

« Hide

Isoform B [UniParc].

Checksum: 457BA84E550E9AA4
Show »

FASTA2,789306,664

References

« Hide 'large scale' references
[1]"Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner."
Miura Y., Tam T., Ido A., Morinaga T., Miki T., Hashimoto T., Tamaoki T.
J. Biol. Chem. 270:26840-26848(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS ALA-72 AND ALA-777.
Tissue: Lung.
[2]"A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers."
Morinaga T., Yasuda H., Higashio K., Tamaoki T.
Mol. Cell. Biol. 11:6041-6049(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
Tissue: Hepatoma.
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D.
Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-1190 (ISOFORM A), VARIANT SER-997.
[6]"Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1."
Berry F.B., Miura Y., Mihara K., Kaspar P., Sakata N., Hashimoto-Tamaoki T., Tamaoki T.
J. Biol. Chem. 276:25057-25065(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS REGULATOR OF MYOBLASTS DIFFERENTIATION.
[7]"ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3."
Nojiri S., Joh T., Miura Y., Sakata N., Nomura T., Nakao H., Sobue S., Ohara H., Asai K., Ito M.
Biochem. Biophys. Res. Commun. 314:97-103(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PIAS3.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer."
Mori Y., Kataoka H., Miura Y., Kawaguchi M., Kubota E., Ogasawara N., Oshima T., Tanida S., Sasaki M., Ohara H., Mizoshita T., Tatematsu M., Asai K., Joh T.
Int. J. Cancer 121:241-247(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN GASTRIC CANCER, TISSUE SPECIFICITY.
[10]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke."
Gudbjartsson D.F., Holm H., Gretarsdottir S., Thorleifsson G., Walters G.B., Thorgeirsson G., Gulcher J., Mathiesen E.B., Njolstad I., Nyrnes A., Wilsgaard T., Hald E.M., Hveem K., Stoltenberg C., Kucera G., Stubblefield T., Carter S., Roden D. expand/collapse author list , Ng M.C.Y., Baum L., So W.Y., Wong K.S., Chan J.C.N., Gieger C., Wichmann H.-E., Gschwendtner A., Dichgans M., Kuhlenbaeumer G., Berger K., Ringelstein E.B., Bevan S., Markus H.S., Kostulas K., Hillert J., Sveinbjoernsdottir S., Valdimarsson E.M., Lochen M.-L., Ma R.C.W., Darbar D., Kong A., Arnar D.O., Thorsteinsdottir U., Stefansson K.
Nat. Genet. 41:876-878(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION AND ISCHEMIC STROKE.
[14]"Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry."
Benjamin E.J., Rice K.M., Arking D.E., Pfeufer A., van Noord C., Smith A.V., Schnabel R.B., Bis J.C., Boerwinkle E., Sinner M.F., Dehghan A., Lubitz S.A., D'Agostino R.B. Sr., Lumley T., Ehret G.B., Heeringa J., Aspelund T., Newton-Cheh C. expand/collapse author list , Larson M.G., Marciante K.D., Soliman E.Z., Rivadeneira F., Wang T.J., Eiriksdottir G., Levy D., Psaty B.M., Li M., Chamberlain A.M., Hofman A., Vasan R.S., Harris T.B., Rotter J.I., Kao W.H., Agarwal S.K., Stricker B.H.C., Wang K., Launer L.J., Smith N.L., Chakravarti A., Uitterlinden A.G., Wolf P.A., Sotoodehnia N., Koettgen A., van Duijn C.M., Meitinger T., Mueller M., Perz S., Steinbeck G., Wichmann H.-E., Lunetta K.L., Heckbert S.R., Gudnason V., Alonso A., Kaab S., Ellinor P.T., Witteman J.C.M.
Nat. Genet. 41:879-881(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION.
[15]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533 AND SER-571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Human ALKBH4 interacts with proteins associated with transcription."
Bjornstad L.G., Meza T.J., Otterlei M., Olafsrud S.M., Meza-Zepeda L.A., Falnes P.O.
PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ALKBH4.
[17]"Solution structure of the second and third homeobox domain of AT-binding transcription factor 1 (ATBF1)."
RIKEN structural genomics initiative (RSGI)
Submitted (JUN-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 2241-2305 AND 2629-2698.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L32832 mRNA. Translation: AAC14462.1.
D10250 mRNA. Translation: BAA01095.1.
AC004943 Genomic DNA. Translation: AAC79153.1.
AC132068 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59168.1.
CH471166 Genomic DNA. Translation: EAW59170.1.
AC002044 Genomic DNA. Translation: AAC31674.1.
PIRA41948.
RefSeqNP_001158238.1. NM_001164766.1.
NP_008816.3. NM_006885.3.
UniGeneHs.598297.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DA1NMR-A2146-2202[»]
2DA2NMR-A2243-2299[»]
2DA3NMR-A2632-2698[»]
ProteinModelPortalQ15911.
SMRQ15911. Positions 640-748, 981-1012, 1217-1266, 1367-1449, 1540-1618, 2146-2207, 2247-2305, 2636-2698, 2951-3004, 3020-3065.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106954. 8 interactions.
IntActQ15911. 2 interactions.
MINTMINT-1462085.
STRING9606.ENSP00000268489.

PTM databases

PhosphoSiteQ15911.

Polymorphism databases

DMDM108935822.

Proteomic databases

PaxDbQ15911.
PeptideAtlasQ15911.
PRIDEQ15911.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000268489; ENSP00000268489; ENSG00000140836. [Q15911-1]
ENST00000397992; ENSP00000438926; ENSG00000140836. [Q15911-2]
GeneID463.
KEGGhsa:463.
UCSCuc002fck.3. human. [Q15911-1]

Organism-specific databases

CTD463.
GeneCardsGC16M072816.
H-InvDBHIX0038876.
HGNCHGNC:777. ZFHX3.
HPAHPA059353.
MIM104155. gene.
neXtProtNX_Q15911.
PharmGKBPA162409676.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG301069.
HOGENOMHOG000155777.
HOVERGENHBG050606.
InParanoidQ15911.
KOK09378.
OMASVGMPPL.
OrthoDBEOG7FR7FH.
PhylomeDBQ15911.
TreeFamTF323288.

Gene expression databases

ArrayExpressQ15911.
BgeeQ15911.
CleanExHS_ZFHX3.
GenevestigatorQ15911.

Family and domain databases

Gene3D1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamPF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 4 hits.
PROSITEPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZFHX3. human.
EvolutionaryTraceQ15911.
GeneWikiATBF1.
GenomeRNAi463.
NextBio1915.
PROQ15911.
SOURCESearch...

Entry information

Entry nameZFHX3_HUMAN
AccessionPrimary (citable) accession number: Q15911
Secondary accession number(s): D3DWS8, O15101, Q13719
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 13, 2006
Last modified: April 16, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM