Q15911 (ZFHX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger homeobox protein 3

Alternative name(s):
AT motif-binding factor
AT-binding transcription factor 1
Alpha-fetoprotein enhancer-binding protein
Zinc finger homeodomain protein 3
Short name=ZFH-3

Gene names

Name:	ZFHX3
Synonyms:	ATBF1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3703 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. Ref.6 Ref.9
Subunit structure	Interacts with FNBP3 By similarity. Interacts with PIAS3. Ref.7
Subcellular location	Nucleus.
Tissue specificity	Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Ref.9
Polymorphism	Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in individuals of European ancestry.
Sequence similarities	Contains 22 C2H2-type zinc fingers. Contains 4 homeobox DNA-binding domains.

Ontologies

Keywords
Biological process	Myogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Homeobox Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	muscle organ development Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of myoblast differentiation Inferred from direct assay Ref.6. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 10318867. Source: MGI negative regulation of transcription, DNA-dependent Inferred from direct assay Ref.6. Source: UniProtKB positive regulation of myoblast differentiation Inferred from direct assay Ref.6. Source: UniProtKB
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara transcription factor complex Inferred from direct assay PubMed 10318867. Source: MGI
Molecular_function	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Traceable author statement Ref.2. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription regulatory region DNA binding Inferred from direct assay Ref.6. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q15911-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q15911-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-914: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 3703

3703

Zinc finger homeobox protein 3

PRO_0000046930

Regions

Zinc finger

282 – 305

24

C2H2-type 1

Zinc finger

640 – 663

24

C2H2-type 2

Zinc finger

671 – 694

24

C2H2-type 3

Zinc finger

726 – 750

25

C2H2-type 4

Zinc finger

804 – 828

25

C2H2-type 5; atypical

Zinc finger

945 – 968

24

C2H2-type 6; degenerate

Zinc finger

984 – 1008

25

C2H2-type 7; atypical

Zinc finger

1040 – 1064

25

C2H2-type 8; atypical

Zinc finger

1088 – 1112

25

C2H2-type 9; atypical

Zinc finger

1223 – 1246

24

C2H2-type 10; atypical

Zinc finger

1252 – 1275

24

C2H2-type 11

Zinc finger

1360 – 1385

26

C2H2-type 12

Zinc finger

1401 – 1423

23

C2H2-type 13

Zinc finger

1429 – 1452

24

C2H2-type 14

Zinc finger

1545 – 1569

25

C2H2-type 15

Zinc finger

1596 – 1620

25

C2H2-type 16

Zinc finger

1983 – 2006

24

C2H2-type 17

DNA binding

2145 – 2204

60

Homeobox 1

DNA binding

2242 – 2301

60

Homeobox 2

Zinc finger

2328 – 2351

24

C2H2-type 18; atypical

Zinc finger

2530 – 2552

23

C2H2-type 19

DNA binding

2641 – 2700

60

Homeobox 3

Zinc finger

2711 – 2734

24

C2H2-type 20

DNA binding

2944 – 3003

60

Homeobox 4

Zinc finger

3024 – 3048

25

C2H2-type 21

Zinc finger

3529 – 3553

25

C2H2-type 22

Compositional bias

104 – 107

4

Poly-Pro

Compositional bias

460 – 489

30

Poly-Glu

Compositional bias

770 – 784

15

Poly-Ala

Compositional bias

1723 – 1743

21

Poly-Gln

Compositional bias

1789 – 1794

6

Poly-Gln

Compositional bias

1852 – 1857

6

Poly-Gln

Compositional bias

2037 – 2052

16

Poly-Pro

Compositional bias

3197 – 3209

13

Poly-Gln

Compositional bias

3210 – 3214

5

Poly-Pro

Compositional bias

3227 – 3231

5

Poly-Gln

Compositional bias

3376 – 3389

14

Poly-Gln

Compositional bias

3392 – 3395

4

Poly-Gln

Compositional bias

3507 – 3527

21

Poly-Gly

Compositional bias

3597 – 3600

4

Poly-Pro

Compositional bias

3636 – 3639

4

Poly-Ser

Amino acid modifications

Modified residue

533

1

Phosphoserine Ref.14

Modified residue

571

1

Phosphoserine Ref.8 Ref.14

Modified residue

1197

1

Phosphoserine Ref.11

Modified residue

1590

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 914

914

Missing in isoform B.

VSP_006825

Natural variant

72

1

S → A. Ref.1
Corresponds to variant rs7193297 [ dbSNP | Ensembl ].

VAR_026663

Natural variant

146

1

S → G.
Corresponds to variant rs58480263 [ dbSNP | Ensembl ].

VAR_061927

Natural variant

428

1

T → P.
Corresponds to variant rs16971436 [ dbSNP | Ensembl ].

VAR_026664

Natural variant

460

1

E → Q.
Corresponds to variant rs2073852 [ dbSNP | Ensembl ].

VAR_019968

Natural variant

777

1

V → A. Ref.1
Corresponds to variant rs4788682 [ dbSNP | Ensembl ].

VAR_026665

Natural variant

997

1

A → S. Ref.5
Corresponds to variant rs2213978 [ dbSNP | Ensembl ].

VAR_052733

Natural variant

3374

1

A → V.

VAR_011694

Natural variant

3377 – 3384

8

Missing.

VAR_011695

Natural variant

3421

1

P → A.
Corresponds to variant rs8044440 [ dbSNP | Ensembl ].

VAR_026666

Natural variant

3527

1

G → GGG.

VAR_011696

Experimental info

Sequence conflict

422

1

P → A Ref.1

Sequence conflict

579

1

A → T Ref.1

Sequence conflict

767

1

S → I Ref.1

Sequence conflict

846 – 849

4

RHLG → HHRV Ref.1

Sequence conflict

1150 – 1190

41

EEAIE…LTDSP → GEWSHRHGRPRLGLGVHLLE TSRGLLFEGDVTDPAGPHVP Y Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

3703

Helix Strand Turn

Details...

Helix

2154 – 2166

13

Helix

2174 – 2182

9

Helix

2186 – 2201

16

Helix

2251 – 2263

13

Helix

2269 – 2278

10

Helix

2283 – 2297

15

Turn

2650 – 2652

3

Helix

2653 – 2662

10

Helix

2668 – 2678

11

Helix

2682 – 2697

16

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified June 13, 2006. Version 2. Checksum: 395F5D14A08112CB	FASTA	3,703	404,419
	10 20 30 40 50 60 MEGCDSPVVS GKDNGCGIPQ HQQWTELNST HLPDKPSSME QSTGESHGPL DSLRAPFNER 70 80 90 100 110 120 LAESTASAGP PSEPASKEVT CNECSASFAS LQTYMEHHCP SARPPPPLRE ESASDTGEEG 130 140 150 160 170 180 DEESDVENLA GEIVYQPDGS AYIVESLSQL TQGGGACGSG SGSGPLPSLF LNSLPGAGGK 190 200 210 220 230 240 QGDPSCAAPV YPQIINTFHI ASSFGKWFEG PDQAFPNTSA LAGLSPVLHS FRVFDVRHKS 250 260 270 280 290 300 NKDYLNSDGS AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 310 320 330 340 350 360 AVHDHRMTLS EDERKILSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP LVSTANLIGP 370 380 390 400 410 420 GHSFYGKFSG IRMEGEEALP AGSAAGPEQP QAGLLTPSTL LNLGGLTSSV LKTPITSVPL 430 440 450 460 470 480 GPLASSPTKS SEGKDSGAAE GEKQEVGDGD CFSEKVEPAE EEAEEEEEEE EAEEEEEEEE 490 500 510 520 530 540 EEEEEEEDEG CKGLFPSELD EELEDRPHEE PGAAAGSSSK KDLALSNQSI SNSPLMPNVL 550 560 570 580 590 600 QTLSRGTAST SSNSASSFVV FDGANRRNRL SFNSEGVRAN VAEGGRRLDF ADESANKDNA 610 620 630 640 650 660 TAPEPNESTE GDDGGFVPHH QHAGSLCELG VGECPSGSGV ECPKCDTVLG SSRSLGGHMT 670 680 690 700 710 720 MMHSRNSCKT LKCPKCNWHY KYQQTLEAHM KEKHPEPGGS CVYCKSGQPH PRLARGESYT 730 740 750 760 770 780 CGYKPFRCEV CNYSTTTKGN LSIHMQSDKH LNNMQNLQNG GGEQVFSHTA GAAAAAVAAA 790 800 810 820 830 840 AAAANISSSC GAPSPTKPKT KPTWRCEVCD YETNVARNLR IHMTSEKHMH NMMLLQQNMT 850 860 870 880 890 900 QIQHNRHLGL GSLPSPAEAE LYQYYLAQNM NLPNLKMDSA ASDAQFMMSG FQLDPAGPMA 910 920 930 940 950 960 AMTPALVGGE IPLDMRLGGG QLVSEELMNL GESFIQTNDP SLKLFQCAVC NKFTTDNLDM 970 980 990 1000 1010 1020 LGLHMNVERS LSEDEWKAVM GDSYQCKLCR YNTQLKANFQ LHCKTDKHVQ KYQLVAHIKE 1030 1040 1050 1060 1070 1080 GGKANEWRLK CVAIGNPVHL KCNACDYYTN SLEKLRLHTV NSRHEASLKL YKHLQQHESG 1090 1100 1110 1120 1130 1140 VEGESCYYHC VLCNYSTKAK LNLIQHVRSM KHQRSESLRK LQRLQKGLPE EDEDLGQIFT 1150 1160 1170 1180 1190 1200 IRRCPSTDPE EAIEDVEGPS ETAADPEELA KDQEGGASSS QAEKELTDSP ATSKRISFPG 1210 1220 1230 1240 1250 1260 SSESPLSSKR PKTAEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP MLRCPLCQDM 1270 1280 1290 1300 1310 1320 LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT TPEMVMPSSM FLPAAVPDRD GNSNLEEAGK 1330 1340 1350 1360 1370 1380 QPETSEDLGK NILPSASTEQ SGDLKPSPAD PGSVREDSGF ICWKKGCNQV FKTSAALQTH 1390 1400 1410 1420 1430 1440 FNEVHAKRPQ LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT 1450 1460 1470 1480 1490 1500 FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE EDKEEESDLE 1510 1520 1530 1540 1550 1560 DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC KESFTQKNIL 1570 1580 1590 1600 1610 1620 LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT CNVAYSQSST LEIHMRSVLH 1630 1640 1650 1660 1670 1680 QTKARAAKLE AASGSSNGTG NSSSISLSSS TPSPVSTSGS NTFTTSNPSS AGIAPSSNLL 1690 1700 1710 1720 1730 1740 SQVPTESVGM PPLGNPIGAN IASPSEPKEA NRKKLADMIA SRQQQQQQQQ QQQQQQQQQQ 1750 1760 1770 1780 1790 1800 QAQTLAQAQA QVQAHLQQEL QQQAALIQSQ LFNPTLLPHF PMTTETLLQL QQQQHLLFPF 1810 1820 1830 1840 1850 1860 YIPSAEFQLN PEVSLPVTSG ALTLTGTGPG LLEDLKAQVQ VPQQSHQQIL PQQQQNQLSI 1870 1880 1890 1900 1910 1920 AQSHSALLQP SQHPEKKNKL VIKEKEKESQ RERDSAEGGE GNTGPKETLP DALKAKEKKE 1930 1940 1950 1960 1970 1980 LAPGGGSEPS MLPPRIASDA RGNATKALLE NFGFELVIQY NENKQKVQKK NGKTDQGENL 1990 2000 2010 2020 2030 2040 EKLECDSCGK LFSNILILKS HQEHVHQNYF PFKQLERFAK QYRDHYDKLY PLRPQTPEPP 2050 2060 2070 2080 2090 2100 PPPPPPPPPP LPAAPPQPAS TPAIPASAPP ITSPTIAPAQ PSVPLTQLSM PMELPIFSPL 2110 2120 2130 2140 2150 2160 MMQTMPLQTL PAQLPPQLGP VEPLPADLAQ LYQHQLNPTL LQQQNKRPRT RITDDQLRVL 2170 2180 2190 2200 2210 2220 RQYFDINNSP SEEQIKEMAD KSGLPQKVIK HWFRNTLFKE RQRNKDSPYN FSNPPITSLE 2230 2240 2250 2260 2270 2280 ELKIDSRPPS PEPPKQEYWG SKRSSRTRFT DYQLRVLQDF FDANAYPKDD EFEQLSNLLN 2290 2300 2310 2320 2330 2340 LPTRVIVVWF QNARQKARKN YENQGEGKDG ERRELTNDRY IRTSNLNYQC KKCSLVFQRI 2350 2360 2370 2380 2390 2400 FDLIKHQKKL CYKDEDEEGQ DDSQNEDSMD AMEILTPTSS SCSTPMPSQA YSAPAPSANN 2410 2420 2430 2440 2450 2460 TASSAFLQLT AEAEELATFN SKTEAGDEKP KLAEAPSAQP NQTQEKQGQP KPELQQQEQP 2470 2480 2490 2500 2510 2520 EQKTNTPQQK LPQLVSLPSL PQPPPQAPPP QCPLPQSSPS PSQLSHLPLK PLHTSTPQQL 2530 2540 2550 2560 2570 2580 ANLPPQLIPY QCDQCKLAFP SFEHWQEHQQ LHFLSAQNQF IHPQFLDRSL DMPFMLFDPS 2590 2600 2610 2620 2630 2640 NPLLASQLLS GAIPQIPASS ATSPSTPTST MNTLKRKLEE KASASPGEND SGTGGEEPQR 2650 2660 2670 2680 2690 2700 DKRLRTTITP EQLEILYQKY LLDSNPTRKM LDHIAHEVGL KKRVVQVWFQ NTRARERKGQ 2710 2720 2730 2740 2750 2760 FRAVGPAQAH RRCPFCRALF KAKTALEAHI RSRHWHEAKR AGYNLTLSAM LLDCDGGLQM 2770 2780 2790 2800 2810 2820 KGDIFDGTSF SHLPPSSSDG QGVPLSPVSK TMELSPRTLL SPSSIKVEGI EDFESPSMSS 2830 2840 2850 2860 2870 2880 VNLNFDQTKL DNDDCSSVNT AITDTTTGDE GNADNDSATG IATETKSSSA PNEGLTKAAM 2890 2900 2910 2920 2930 2940 MAMSEYEDRL SSGLVSPAPS FYSKEYDNEG TVDYSETSSL ADPCSPSPGA SGSAGKSGDS 2950 2960 2970 2980 2990 3000 GDRPGQKRFR TQMTNLQLKV LKSCFNDYRT PTMLECEVLG NDIGLPKRVV QVWFQNARAK 3010 3020 3030 3040 3050 3060 EKKSKLSMAK HFGINQTSYE GPKTECTLCG IKYSARLSVR DHIFSQQHIS KVKDTIGSQL 3070 3080 3090 3100 3110 3120 DKEKEYFDPA TVRQLMAQQE LDRIKKANEV LGLAAQQQGM FDNTPLQALN LPTAYPALQG 3130 3140 3150 3160 3170 3180 IPPVLLPGLN SPSLPGFTPS NTALTSPKPN LMGLPSTTVP SPGLPTSGLP NKPSSASLSS 3190 3200 3210 3220 3230 3240 PTPAQATMAM GPQQPPQQQQ QQQQPQVQQP PPPPAAQPPP TPQLPLQQQQ QRKDKDSEKV 3250 3260 3270 3280 3290 3300 KEKEKAHKGK GEPLPVPKKE KGEAPTATAA TISAPLPTME YAVDPAQLQA LQAALTSDPT 3310 3320 3330 3340 3350 3360 ALLTSQFLPY FVPGFSPYYA PQIPGALQSG YLQPMYGMEG LFPYSPALSQ ALMGLSPGSL 3370 3380 3390 3400 3410 3420 LQQYQQYQQS LQEAIQQQQQ RQLQQQQQQK VQQQQPKASQ TPVPPGAPSP DKDPAKESPK 3430 3440 3450 3460 3470 3480 PEEQKNTPRE VSPLLPKLPE EPEAESKSAD SLYDPFIVPK VQYKLVCRKC QAGFSDEEAA 3490 3500 3510 3520 3530 3540 RSHLKSLCFF GQSVVNLQEM VLHVPTGGGG GGSGGGGGGG GGGGGGGSYH CLACESALCG 3550 3560 3570 3580 3590 3600 EEALSQHLES ALHKHRTITR AARNAKEHPS LLPHSACFPD PSTASTSQSA AHSNDSPPPP 3610 3620 3630 3640 3650 3660 SAAAPSSASP HASRKSWPQV VSRASAAKPP SFPPLSSSST VTSSSCSTSG VQPSMPTDDY 3670 3680 3690 3700 SEESDTDLSQ KSDGPASPVE GPKDPSCPKD SGLTSVGTDT FRL
	Isoform B [UniParc]. Checksum: 457BA84E550E9AA4	FASTA	2,789	306,664
	10 20 30 40 50 60 MRLGGGQLVS EELMNLGESF IQTNDPSLKL FQCAVCNKFT TDNLDMLGLH MNVERSLSED 70 80 90 100 110 120 EWKAVMGDSY QCKLCRYNTQ LKANFQLHCK TDKHVQKYQL VAHIKEGGKA NEWRLKCVAI 130 140 150 160 170 180 GNPVHLKCNA CDYYTNSLEK LRLHTVNSRH EASLKLYKHL QQHESGVEGE SCYYHCVLCN 190 200 210 220 230 240 YSTKAKLNLI QHVRSMKHQR SESLRKLQRL QKGLPEEDED LGQIFTIRRC PSTDPEEAIE 250 260 270 280 290 300 DVEGPSETAA DPEELAKDQE GGASSSQAEK ELTDSPATSK RISFPGSSES PLSSKRPKTA 310 320 330 340 350 360 EEIKPEQMYQ CPYCKYSNAD VNRLRVHAMT QHSVQPMLRC PLCQDMLNNK IHLQLHLTHL 370 380 390 400 410 420 HSVAPDCVEK LIMTVTTPEM VMPSSMFLPA AVPDRDGNSN LEEAGKQPET SEDLGKNILP 430 440 450 460 470 480 SASTEQSGDL KPSPADPGSV REDSGFICWK KGCNQVFKTS AALQTHFNEV HAKRPQLPVS 490 500 510 520 530 540 DRHVYKYRCN QCSLAFKTIE KLQLHSQYHV IRAATMCCLC QRSFRTFQAL KKHLETSHLE 550 560 570 580 590 600 LSEADIQQLY GGLLANGDLL AMGDPTLAED HTIIVEEDKE EESDLEDKQS PTGSDSGSVQ 610 620 630 640 650 660 EDSGSEPKRA LPFRKGPNFT MEKFLDPSRP YKCTVCKESF TQKNILLVHY NSVSHLHKLK 670 680 690 700 710 720 RALQESATGQ PEPTSSPDNK PFKCNTCNVA YSQSSTLEIH MRSVLHQTKA RAAKLEAASG 730 740 750 760 770 780 SSNGTGNSSS ISLSSSTPSP VSTSGSNTFT TSNPSSAGIA PSSNLLSQVP TESVGMPPLG 790 800 810 820 830 840 NPIGANIASP SEPKEANRKK LADMIASRQQ QQQQQQQQQQ QQQQQQQAQT LAQAQAQVQA 850 860 870 880 890 900 HLQQELQQQA ALIQSQLFNP TLLPHFPMTT ETLLQLQQQQ HLLFPFYIPS AEFQLNPEVS 910 920 930 940 950 960 LPVTSGALTL TGTGPGLLED LKAQVQVPQQ SHQQILPQQQ QNQLSIAQSH SALLQPSQHP 970 980 990 1000 1010 1020 EKKNKLVIKE KEKESQRERD SAEGGEGNTG PKETLPDALK AKEKKELAPG GGSEPSMLPP 1030 1040 1050 1060 1070 1080 RIASDARGNA TKALLENFGF ELVIQYNENK QKVQKKNGKT DQGENLEKLE CDSCGKLFSN 1090 1100 1110 1120 1130 1140 ILILKSHQEH VHQNYFPFKQ LERFAKQYRD HYDKLYPLRP QTPEPPPPPP PPPPPPLPAA 1150 1160 1170 1180 1190 1200 PPQPASTPAI PASAPPITSP TIAPAQPSVP LTQLSMPMEL PIFSPLMMQT MPLQTLPAQL 1210 1220 1230 1240 1250 1260 PPQLGPVEPL PADLAQLYQH QLNPTLLQQQ NKRPRTRITD DQLRVLRQYF DINNSPSEEQ 1270 1280 1290 1300 1310 1320 IKEMADKSGL PQKVIKHWFR NTLFKERQRN KDSPYNFSNP PITSLEELKI DSRPPSPEPP 1330 1340 1350 1360 1370 1380 KQEYWGSKRS SRTRFTDYQL RVLQDFFDAN AYPKDDEFEQ LSNLLNLPTR VIVVWFQNAR 1390 1400 1410 1420 1430 1440 QKARKNYENQ GEGKDGERRE LTNDRYIRTS NLNYQCKKCS LVFQRIFDLI KHQKKLCYKD 1450 1460 1470 1480 1490 1500 EDEEGQDDSQ NEDSMDAMEI LTPTSSSCST PMPSQAYSAP APSANNTASS AFLQLTAEAE 1510 1520 1530 1540 1550 1560 ELATFNSKTE AGDEKPKLAE APSAQPNQTQ EKQGQPKPEL QQQEQPEQKT NTPQQKLPQL 1570 1580 1590 1600 1610 1620 VSLPSLPQPP PQAPPPQCPL PQSSPSPSQL SHLPLKPLHT STPQQLANLP PQLIPYQCDQ 1630 1640 1650 1660 1670 1680 CKLAFPSFEH WQEHQQLHFL SAQNQFIHPQ FLDRSLDMPF MLFDPSNPLL ASQLLSGAIP 1690 1700 1710 1720 1730 1740 QIPASSATSP STPTSTMNTL KRKLEEKASA SPGENDSGTG GEEPQRDKRL RTTITPEQLE 1750 1760 1770 1780 1790 1800 ILYQKYLLDS NPTRKMLDHI AHEVGLKKRV VQVWFQNTRA RERKGQFRAV GPAQAHRRCP 1810 1820 1830 1840 1850 1860 FCRALFKAKT ALEAHIRSRH WHEAKRAGYN LTLSAMLLDC DGGLQMKGDI FDGTSFSHLP 1870 1880 1890 1900 1910 1920 PSSSDGQGVP LSPVSKTMEL SPRTLLSPSS IKVEGIEDFE SPSMSSVNLN FDQTKLDNDD 1930 1940 1950 1960 1970 1980 CSSVNTAITD TTTGDEGNAD NDSATGIATE TKSSSAPNEG LTKAAMMAMS EYEDRLSSGL 1990 2000 2010 2020 2030 2040 VSPAPSFYSK EYDNEGTVDY SETSSLADPC SPSPGASGSA GKSGDSGDRP GQKRFRTQMT 2050 2060 2070 2080 2090 2100 NLQLKVLKSC FNDYRTPTML ECEVLGNDIG LPKRVVQVWF QNARAKEKKS KLSMAKHFGI 2110 2120 2130 2140 2150 2160 NQTSYEGPKT ECTLCGIKYS ARLSVRDHIF SQQHISKVKD TIGSQLDKEK EYFDPATVRQ 2170 2180 2190 2200 2210 2220 LMAQQELDRI KKANEVLGLA AQQQGMFDNT PLQALNLPTA YPALQGIPPV LLPGLNSPSL 2230 2240 2250 2260 2270 2280 PGFTPSNTAL TSPKPNLMGL PSTTVPSPGL PTSGLPNKPS SASLSSPTPA QATMAMGPQQ 2290 2300 2310 2320 2330 2340 PPQQQQQQQQ PQVQQPPPPP AAQPPPTPQL PLQQQQQRKD KDSEKVKEKE KAHKGKGEPL 2350 2360 2370 2380 2390 2400 PVPKKEKGEA PTATAATISA PLPTMEYAVD PAQLQALQAA LTSDPTALLT SQFLPYFVPG 2410 2420 2430 2440 2450 2460 FSPYYAPQIP GALQSGYLQP MYGMEGLFPY SPALSQALMG LSPGSLLQQY QQYQQSLQEA 2470 2480 2490 2500 2510 2520 IQQQQQRQLQ QQQQQKVQQQ QPKASQTPVP PGAPSPDKDP AKESPKPEEQ KNTPREVSPL 2530 2540 2550 2560 2570 2580 LPKLPEEPEA ESKSADSLYD PFIVPKVQYK LVCRKCQAGF SDEEAARSHL KSLCFFGQSV 2590 2600 2610 2620 2630 2640 VNLQEMVLHV PTGGGGGGSG GGGGGGGGGG GGGSYHCLAC ESALCGEEAL SQHLESALHK 2650 2660 2670 2680 2690 2700 HRTITRAARN AKEHPSLLPH SACFPDPSTA STSQSAAHSN DSPPPPSAAA PSSASPHASR 2710 2720 2730 2740 2750 2760 KSWPQVVSRA SAAKPPSFPP LSSSSTVTSS SCSTSGVQPS MPTDDYSEES DTDLSQKSDG 2770 2780 PASPVEGPKD PSCPKDSGLT SVGTDTFRL

References

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[1]	"Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner." Miura Y., Tam T., Ido A., Morinaga T., Miki T., Hashimoto T., Tamaoki T. J. Biol. Chem. 270:26840-26848(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS ALA-72 AND ALA-777. Tissue: Lung.
[2]	"A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers." Morinaga T., Yasuda H., Higashio K., Tamaoki T. Mol. Cell. Biol. 11:6041-6049(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). Tissue: Hepatoma.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-1190 (ISOFORM A), VARIANT SER-997.
[6]	"Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1." Berry F.B., Miura Y., Mihara K., Kaspar P., Sakata N., Hashimoto-Tamaoki T., Tamaoki T. J. Biol. Chem. 276:25057-25065(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS REGULATOR OF MYOBLASTS DIFFERENTIATION.
[7]	"ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3." Nojiri S., Joh T., Miura Y., Sakata N., Nomura T., Nakao H., Sobue S., Ohara H., Asai K., Ito M. Biochem. Biophys. Res. Commun. 314:97-103(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PIAS3.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer." Mori Y., Kataoka H., Miura Y., Kawaguchi M., Kubota E., Ogasawara N., Oshima T., Tanida S., Sasaki M., Ohara H., Mizoshita T., Tatematsu M., Asai K., Joh T. Int. J. Cancer 121:241-247(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN GASTRIC CANCER, TISSUE SPECIFICITY.
[10]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1197, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke." Gudbjartsson D.F., Holm H., Gretarsdottir S., Thorleifsson G., Walters G.B., Thorgeirsson G., Gulcher J., Mathiesen E.B., Njolstad I., Nyrnes A., Wilsgaard T., Hald E.M., Hveem K., Stoltenberg C., Kucera G., Stubblefield T., Carter S., Roden D. , Ng M.C.Y., Baum L., So W.Y., Wong K.S., Chan J.C.N., Gieger C., Wichmann H.-E., Gschwendtner A., Dichgans M., Kuhlenbaeumer G., Berger K., Ringelstein E.B., Bevan S., Markus H.S., Kostulas K., Hillert J., Sveinbjoernsdottir S., Valdimarsson E.M., Lochen M.-L., Ma R.C.W., Darbar D., Kong A., Arnar D.O., Thorsteinsdottir U., Stefansson K. Nat. Genet. 41:876-878(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION AND ISCHEMIC STROKE.
[13]	"Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry." Benjamin E.J., Rice K.M., Arking D.E., Pfeufer A., van Noord C., Smith A.V., Schnabel R.B., Bis J.C., Boerwinkle E., Sinner M.F., Dehghan A., Lubitz S.A., D'Agostino R.B. Sr., Lumley T., Ehret G.B., Heeringa J., Aspelund T., Newton-Cheh C. , Larson M.G., Marciante K.D., Soliman E.Z., Rivadeneira F., Wang T.J., Eiriksdottir G., Levy D., Psaty B.M., Li M., Chamberlain A.M., Hofman A., Vasan R.S., Harris T.B., Rotter J.I., Kao W.H., Agarwal S.K., Stricker B.H.C., Wang K., Launer L.J., Smith N.L., Chakravarti A., Uitterlinden A.G., Wolf P.A., Sotoodehnia N., Koettgen A., van Duijn C.M., Meitinger T., Mueller M., Perz S., Steinbeck G., Wichmann H.-E., Lunetta K.L., Heckbert S.R., Gudnason V., Alonso A., Kaab S., Ellinor P.T., Witteman J.C.M. Nat. Genet. 41:879-881(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ASSOCIATION WITH ATRIAL FIBRILLATION.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533 AND SER-571, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Solution structure of the second and third homeobox domain of AT-binding transcription factor 1 (ATBF1)." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 2241-2305 AND 2629-2698.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L32832 mRNA. Translation: AAC14462.1.
D10250 mRNA. Translation: BAA01095.1.
AC004943 Genomic DNA. Translation: AAC79153.1.
AC132068 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59168.1.
CH471166 Genomic DNA. Translation: EAW59170.1.
AC002044 Genomic DNA. Translation: AAC31674.1.

IPI

IPI00014186.
IPI00219003.

PIR

A41948.

RefSeq

NP_001158238.1. NM_001164766.1.
NP_008816.3. NM_006885.3.

UniGene

Hs.598297.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DA1	NMR	-	A	2146-2202	[»]
2DA2	NMR	-	A	2243-2299	[»]
2DA3	NMR	-	A	2632-2698	[»]

ProteinModelPortal

Q15911.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q15911. 2 interactions.

MINT

MINT-1462085.

STRING

9606.ENSP00000268489.

PTM databases

PhosphoSite

Q15911.

Polymorphism databases

DMDM

108935822.

Proteomic databases

PaxDb

Q15911.

PeptideAtlas

Q15911.

PRIDE

Q15911.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000268489; ENSP00000268489; ENSG00000140836.
ENST00000397992; ENSP00000438926; ENSG00000140836.

GeneID

463.

KEGG

hsa:463.

UCSC

uc002fck.3. human.

Organism-specific databases

CTD

463.

GeneCards

GC16M072816.

H-InvDB

HIX0038876.

HGNC

HGNC:777. ZFHX3.

MIM

104155. gene.

neXtProt

NX_Q15911.

PharmGKB

PA162409676.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG301069.

HOGENOM

HOG000155777.

HOVERGEN

HBG050606.

InParanoid

Q15911.

KO

K09378.

OMA

SMDAMEI.

OrthoDB

EOG4Z0B4P.

PhylomeDB

Q15911.

Gene expression databases

ArrayExpress

Q15911.

Bgee

Q15911.

CleanEx

HS_ZFHX3.

Genevestigator

Q15911.

GermOnline

ENSG00000140836. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.60. 4 hits.
3.30.160.60. 2 hits.

InterPro

IPR017970. Homeobox_CS.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]

Pfam

PF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 1 hit.
[Graphical view]

SMART

SM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 4 hits.

PROSITE

PS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

ZFHX3. human.

EvolutionaryTrace

Q15911.

GenomeRNAi

463.

NextBio

1915.

SOURCE

Search...

Entry information

Entry name

ZFHX3_HUMAN

Accession

Primary (citable) accession number: Q15911
Secondary accession number(s): D3DWS8, O15101, Q13719

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	June 13, 2006
Last modified:	May 1, 2013
This is version 131 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.