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Protein

Vacuolar protein sorting-associated protein 72 homolog

Gene

VPS72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi156 – 206Sequence analysisAdd BLAST51

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163159-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 72 homolog
Alternative name(s):
Protein YL-1
Transcription factor-like 1
Gene namesi
Name:VPS72
Synonyms:TCFL1, YL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11644. VPS72.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: ProtInc
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6944.
OpenTargetsiENSG00000163159.
PharmGKBiPA36396.

Polymorphism and mutation databases

DMDMi2499159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000662831 – 364Vacuolar protein sorting-associated protein 72 homologAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15906.
MaxQBiQ15906.
PaxDbiQ15906.
PeptideAtlasiQ15906.
PRIDEiQ15906.

PTM databases

iPTMnetiQ15906.
PhosphoSitePlusiQ15906.

Expressioni

Gene expression databases

BgeeiENSG00000163159.
CleanExiHS_VPS72.
GenevisibleiQ15906. HS.

Organism-specific databases

HPAiHPA065709.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ/H2AZ.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HMBOX1Q6NT763EBI-399189,EBI-2549423
MDFIQ997504EBI-399189,EBI-724076
RUVBL1Q9Y2656EBI-399189,EBI-353675

Protein-protein interaction databases

BioGridi112804. 41 interactors.
DIPiDIP-31767N.
IntActiQ15906. 33 interactors.
MINTiMINT-1444540.
STRINGi9606.ENSP00000357887.

Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 16Combined sources6
Helixi17 – 22Combined sources6
Helixi29 – 32Combined sources4
Helixi33 – 35Combined sources3
Beta strandi54 – 57Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FUGX-ray2.70C/F/I/L6-69[»]
ProteinModelPortaliQ15906.
SMRiQ15906.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 77Asp/Glu-rich (acidic)Add BLAST56
Compositional biasi333 – 354Pro-richAdd BLAST22
Compositional biasi341 – 350Poly-Pro10

Sequence similaritiesi

Belongs to the VPS72/YL1 family.Curated

Phylogenomic databases

eggNOGiKOG2897. Eukaryota.
ENOG41119RU. LUCA.
GeneTreeiENSGT00390000017503.
HOGENOMiHOG000033695.
HOVERGENiHBG083244.
InParanoidiQ15906.
KOiK11664.
OMAiCERTFVT.
OrthoDBiEOG091G0BQW.
PhylomeDBiQ15906.
TreeFamiTF314532.

Family and domain databases

InterProiIPR008895. Vps72/YL1.
IPR013272. Vps72/YL1_C.
[Graphical view]
PANTHERiPTHR13275. PTHR13275. 1 hit.
PfamiPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15906-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ
60 70 80 90 100
SDTEDEVDSD FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK
110 120 130 140 150
VNTPAGSSQK AREEKALLPL ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE
160 170 180 190 200
RQGQSRRRKG PHCERPLTQE ELLREAKITE ELNLRSLETY ERLEADKKKQ
210 220 230 240 250
VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDIEGLDPA PSVSALTPHA
260 270 280 290 300
GTGPVNPPAR CSRTFITFSD DATFEEWFPQ GRPPKVPVRE VCPVTHRPAL
310 320 330 340 350
YRDPVTDIPY ATARAFKIIR EAYKKYITAH GLPPTASALG PGPPPPEPLP
360
GSGPRALRQK IVIK
Length:364
Mass (Da):40,594
Last modified:November 1, 1996 - v1
Checksum:i0AEB90B62B2BCA4A
GO
Isoform 2 (identifier: Q15906-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-236: G → GSLCFSLSFVLR

Note: No experimental confirmation available.
Show »
Length:375
Mass (Da):41,848
Checksum:iDB81322C6CAECD8D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Y → H in BAD96655 (Ref. 3) Curated1
Sequence conflicti30Y → H in BAD96659 (Ref. 3) Curated1
Sequence conflicti53T → I in BAD96655 (Ref. 3) Curated1
Sequence conflicti53T → I in BAD96659 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035803318I → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047566236G → GSLCFSLSFVLR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43642 mRNA. Translation: BAA07757.1.
BT019356 mRNA. Translation: AAV38163.1.
BT019357 mRNA. Translation: AAV38164.1.
AK222935 mRNA. Translation: BAD96655.1.
AK222939 mRNA. Translation: BAD96659.1.
AL592424 Genomic DNA. Translation: CAI16385.1.
CH471121 Genomic DNA. Translation: EAW53462.1.
BC003151 mRNA. Translation: AAH03151.1.
CX163016 mRNA. No translation available.
CCDSiCCDS59201.1. [Q15906-2]
CCDS989.1. [Q15906-1]
PIRiJC4140.
RefSeqiNP_001258016.1. NM_001271087.1. [Q15906-2]
NP_005988.1. NM_005997.2. [Q15906-1]
UniGeneiHs.2430.

Genome annotation databases

EnsembliENST00000354473; ENSP00000346464; ENSG00000163159. [Q15906-2]
ENST00000368892; ENSP00000357887; ENSG00000163159. [Q15906-1]
GeneIDi6944.
KEGGihsa:6944.
UCSCiuc001exe.3. human. [Q15906-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43642 mRNA. Translation: BAA07757.1.
BT019356 mRNA. Translation: AAV38163.1.
BT019357 mRNA. Translation: AAV38164.1.
AK222935 mRNA. Translation: BAD96655.1.
AK222939 mRNA. Translation: BAD96659.1.
AL592424 Genomic DNA. Translation: CAI16385.1.
CH471121 Genomic DNA. Translation: EAW53462.1.
BC003151 mRNA. Translation: AAH03151.1.
CX163016 mRNA. No translation available.
CCDSiCCDS59201.1. [Q15906-2]
CCDS989.1. [Q15906-1]
PIRiJC4140.
RefSeqiNP_001258016.1. NM_001271087.1. [Q15906-2]
NP_005988.1. NM_005997.2. [Q15906-1]
UniGeneiHs.2430.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FUGX-ray2.70C/F/I/L6-69[»]
ProteinModelPortaliQ15906.
SMRiQ15906.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112804. 41 interactors.
DIPiDIP-31767N.
IntActiQ15906. 33 interactors.
MINTiMINT-1444540.
STRINGi9606.ENSP00000357887.

PTM databases

iPTMnetiQ15906.
PhosphoSitePlusiQ15906.

Polymorphism and mutation databases

DMDMi2499159.

Proteomic databases

EPDiQ15906.
MaxQBiQ15906.
PaxDbiQ15906.
PeptideAtlasiQ15906.
PRIDEiQ15906.

Protocols and materials databases

DNASUi6944.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354473; ENSP00000346464; ENSG00000163159. [Q15906-2]
ENST00000368892; ENSP00000357887; ENSG00000163159. [Q15906-1]
GeneIDi6944.
KEGGihsa:6944.
UCSCiuc001exe.3. human. [Q15906-1]

Organism-specific databases

CTDi6944.
DisGeNETi6944.
GeneCardsiVPS72.
HGNCiHGNC:11644. VPS72.
HPAiHPA065709.
MIMi600607. gene.
neXtProtiNX_Q15906.
OpenTargetsiENSG00000163159.
PharmGKBiPA36396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2897. Eukaryota.
ENOG41119RU. LUCA.
GeneTreeiENSGT00390000017503.
HOGENOMiHOG000033695.
HOVERGENiHBG083244.
InParanoidiQ15906.
KOiK11664.
OMAiCERTFVT.
OrthoDBiEOG091G0BQW.
PhylomeDBiQ15906.
TreeFamiTF314532.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163159-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiVPS72. human.
GeneWikiiVPS72.
GenomeRNAii6944.
PROiQ15906.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163159.
CleanExiHS_VPS72.
GenevisibleiQ15906. HS.

Family and domain databases

InterProiIPR008895. Vps72/YL1.
IPR013272. Vps72/YL1_C.
[Graphical view]
PANTHERiPTHR13275. PTHR13275. 1 hit.
PfamiPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVPS72_HUMAN
AccessioniPrimary (citable) accession number: Q15906
Secondary accession number(s): A6NLK9
, A6PW55, Q53GJ2, Q5U0R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.