Reviewed, UniProtKB/Swiss-Prot Q15904 (VAS1_HUMAN)

Names and origin

Protein names

Recommended name:
    V-type proton ATPase subunit S1
      Short name=V-ATPase subunit S1
Alternative name(s):
    Vacuolar proton pump subunit S1
    V-ATPase S1 accessory protein
    V-ATPase Ac45 subunit
    Protein XAP-3

Gene names

Name:	ATP6AP1
Synonyms:	ATP6IP1, ATP6S1, VATPS1, XAP3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells By similarity.
Subunit structure	Composed of at least 10 subunits.
Subcellular location	Vacuole membrane; Single-pass membrane protein By similarity.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the vacuolar ATPase subunit S1 family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Membrane Vacuole
Domain	Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting V-type ATPase, V1 domain Inferred from electronic annotation. Source: InterPro vacuole Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 41	41	Potential
	Chain	42 – 470	429	V-type proton ATPase subunit S1		PRO_0000002543
Regions
	Transmembrane	420 – 440	21	Potential
Amino acid modifications
	Glycosylation	170	1	N-linked (GlcNAc...) Potential
	Glycosylation	261	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	273	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	296	1	N-linked (GlcNAc...) Potential
	Glycosylation	303	1	N-linked (GlcNAc...) Potential
	Glycosylation	350	1	N-linked (GlcNAc...) Potential
	Glycosylation	357	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	229	1	V → A in AK026519. Ref.4
	Sequence conflict	307	1	A → T in AK026519. Ref.4
	Sequence conflict	335	1	S → F in AK026519. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q15904-1 [UniParc]. Last modified January 11, 2001. Version 2. Checksum: A71C7EF0E90D0652	FASTA	470	52,026
	10 20 30 40 50 60 MMAAMATARV RMGPRCAQAL WRMPWLPVFL SLAAAAAAAA AEQQVPLVLW SSDRDLWAPA 70 80 90 100 110 120 ADTHEGHITS DLQLSTYLDP ALELGPRNVL LFLQDKLSIE DFTAYGGVFG NKQDSAFSNL 130 140 150 160 170 180 ENALDLAPSS LVLPAVDWYA VSTLTTYLQE KLGASPLHVD LATLRELKLN ASLPALLLIR 190 200 210 220 230 240 LPYTASSGLM APREVLTGND EVIGQVLSTL KSEDVPYTAA LTAVRPSRVA RDVAVVAGGL 250 260 270 280 290 300 GRQLLQKQPV SPVIHPPVSY NDTAPRILFW AQNFSVAYKD QWEDLTPLTF GVQELNLTGS 310 320 330 340 350 360 FWNDSFARLS LTYERLFGTT VTFKFILANR LYPVSARHWF TMERLEVHSN GSVAYFNASQ 370 380 390 400 410 420 VTGPSIYSFH CEYVSSLSKK GSLLVARTQP SPWQMMLQDF QIQAFNVMGE QFSYASDCAS 430 440 450 460 470 FFSPGIWMGL LTSLFMLFIF TYGLHMILSL KTMDRFDDHK GPTISLTQIV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci." Chen E.Y., Zollo M., Mazzarella R.A., Ciccodicola A., Chen C.-N., Zuo L., Heiner C., Burough F.W., Ripetto M., Schlessinger D., D'Urso M. Hum. Mol. Genet. 5:659-668(1996) [PubMed: 8733135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	"Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection." Yokoi H., Hadano S., Kogi M., Kang X., Wakasa K., Ikeda J. Genomics 20:404-411(1994) [PubMed: 8034313] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 97-470. Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 128-470.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261 AND ASN-273, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L44140 Genomic DNA. No translation available. BC000724 mRNA. Translation: AAH00724.1. D16469 mRNA. Translation: BAA03938.1. Different initiation. AK026519 mRNA. No translation available.
IPI	IPI00784119.
RefSeq	NP_001174.2.
UniGene	Hs.6551
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15904. 2 interactions.
STRING	Q15904.
PTM databases
PhosphoSite	Q15904.
Proteomic databases
PRIDE	Q15904.
Genome annotation databases
Ensembl	ENST00000369762; ENSP00000358777; ENSG00000071553; Homo sapiens. [Genome view]
GeneID	537.
KEGG	hsa:537.
UCSC	uc004flf.1. human.
Organism-specific databases
CTD	537.
GeneCards	GC0XP153310.
HGNC	HGNC:868. ATP6AP1.
HPA	CAB015218.
MIM	300197. gene.
PharmGKB	PA25145.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q15904.
OMA	GEQFSYA
OrthoDB	EOG98D3F2
Enzyme and pathway databases
BRENDA	3.6.3.14. 247.
Gene expression databases
ArrayExpress	Q15904.
Bgee	Q15904.
CleanEx	HS_ATP6AP1.
Genevestigator	Q15904.
GermOnline	ENSG00000071553. Homo sapiens.
Family and domain databases
InterPro	IPR008388. ATPase_V1-cplx_s1su. [Graphical view]
PANTHER	PTHR12471. ATPase_V1_S1. 1 hit.
Pfam	PF05827. ATP-synt_S1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	2227.
SOURCE	Search...

Entry information

Entry name

VAS1_HUMAN

Accession

Primary (citable) accession number: Q15904

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 11, 2001
Last modified:	November 24, 2009
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.