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Q15904

- VAS1_HUMAN

UniProt

Q15904 - VAS1_HUMAN

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Protein

V-type proton ATPase subunit S1

Gene
ATP6AP1, ATP6IP1, ATP6S1, VATPS1, XAP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. proton-transporting ATPase activity, rotational mechanism Source: InterPro
  3. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro
  4. Rab GTPase binding Source: UniProt
  5. transporter activity Source: ProtInc

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. establishment of organelle localization Source: UniProt
  3. pH reduction Source: UniProt
  4. positive regulation of bone resorption Source: UniProt
  5. positive regulation of ERK1 and ERK2 cascade Source: UniProt
  6. positive regulation of exocytosis Source: UniProt
  7. positive regulation of osteoblast differentiation Source: UniProt
  8. positive regulation of osteoclast development Source: UniProt
  9. proton transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS01034-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit S1
Short name:
V-ATPase subunit S1
Alternative name(s):
Protein XAP-3
V-ATPase Ac45 subunit
V-ATPase S1 accessory protein
Vacuolar proton pump subunit S1
Gene namesi
Name:ATP6AP1
Synonyms:ATP6IP1, ATP6S1, VATPS1, XAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:868. ATP6AP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 419378Vacuolar Reviewed predictionAdd
BLAST
Transmembranei420 – 44021Helical; Reviewed predictionAdd
BLAST
Topological domaini441 – 47030Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. proton-transporting two-sector ATPase complex Source: ProtInc
  4. proton-transporting V-type ATPase, V1 domain Source: InterPro
  5. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25145.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141 Reviewed predictionAdd
BLAST
Chaini42 – 470429V-type proton ATPase subunit S1PRO_0000002543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...)1 Publication
Glycosylationi273 – 2731N-linked (GlcNAc...)1 Publication
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi357 – 3571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ15904.
PaxDbiQ15904.
PRIDEiQ15904.

PTM databases

PhosphoSiteiQ15904.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ15904.
BgeeiQ15904.
CleanExiHS_ATP6AP1.
GenevestigatoriQ15904.

Organism-specific databases

HPAiCAB015218.

Interactioni

Subunit structurei

Composed of at least 10 subunits.

Protein-protein interaction databases

BioGridi107019. 10 interactions.
IntActiQ15904. 5 interactions.
MINTiMINT-4722342.
STRINGi9606.ENSP00000358777.

Structurei

3D structure databases

ProteinModelPortaliQ15904.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322101.
HOGENOMiHOG000000706.
HOVERGENiHBG001090.
InParanoidiQ15904.
KOiK03662.
OMAiGHITSDM.
PhylomeDBiQ15904.
TreeFamiTF325819.

Family and domain databases

InterProiIPR008388. ATPase_V1-cplx_s1su.
IPR024722. BIG/ATPase_V1_suS1.
[Graphical view]
PANTHERiPTHR12471. PTHR12471. 1 hit.
PfamiPF05827. ATP-synt_S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15904-1 [UniParc]FASTAAdd to Basket

« Hide

MMAAMATARV RMGPRCAQAL WRMPWLPVFL SLAAAAAAAA AEQQVPLVLW    50
SSDRDLWAPA ADTHEGHITS DLQLSTYLDP ALELGPRNVL LFLQDKLSIE 100
DFTAYGGVFG NKQDSAFSNL ENALDLAPSS LVLPAVDWYA VSTLTTYLQE 150
KLGASPLHVD LATLRELKLN ASLPALLLIR LPYTASSGLM APREVLTGND 200
EVIGQVLSTL KSEDVPYTAA LTAVRPSRVA RDVAVVAGGL GRQLLQKQPV 250
SPVIHPPVSY NDTAPRILFW AQNFSVAYKD QWEDLTPLTF GVQELNLTGS 300
FWNDSFARLS LTYERLFGTT VTFKFILANR LYPVSARHWF TMERLEVHSN 350
GSVAYFNASQ VTGPSIYSFH CEYVSSLSKK GSLLVARTQP SPWQMMLQDF 400
QIQAFNVMGE QFSYASDCAS FFSPGIWMGL LTSLFMLFIF TYGLHMILSL 450
KTMDRFDDHK GPTISLTQIV 470
Length:470
Mass (Da):52,026
Last modified:January 11, 2001 - v2
Checksum:iA71C7EF0E90D0652
GO

Sequence cautioni

The sequence BAA03938.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAB66785.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681I → V in BAC11520. 1 Publication
Sequence conflicti74 – 741L → P in BAC11520. 1 Publication
Sequence conflicti229 – 2291V → A in AK026519. 1 Publication
Sequence conflicti307 – 3071A → T in AK026519. 1 Publication
Sequence conflicti335 – 3351S → F in AK026519. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L44140 Genomic DNA. No translation available.
AL136851 mRNA. Translation: CAB66785.1. Different initiation.
AK026519 mRNA. No translation available.
AK289452 mRNA. Translation: BAF82141.1.
AK075284 mRNA. Translation: BAC11520.1.
BX936347, BX936385 Genomic DNA. Translation: CAI43213.3.
BX936385, BX936347 Genomic DNA. Translation: CAI95782.2.
CH471172 Genomic DNA. Translation: EAW72715.1.
BC000724 mRNA. Translation: AAH00724.1.
D16469 mRNA. Translation: BAA03938.1. Different initiation.
CCDSiCCDS35451.1.
RefSeqiNP_001174.2. NM_001183.5.
UniGeneiHs.633817.
Hs.6551.

Genome annotation databases

EnsembliENST00000369762; ENSP00000358777; ENSG00000071553.
ENST00000594478; ENSP00000472265; ENSG00000269668.
GeneIDi537.
KEGGihsa:537.
UCSCiuc004flf.1. human.

Polymorphism databases

DMDMi12230759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L44140 Genomic DNA. No translation available.
AL136851 mRNA. Translation: CAB66785.1 . Different initiation.
AK026519 mRNA. No translation available.
AK289452 mRNA. Translation: BAF82141.1 .
AK075284 mRNA. Translation: BAC11520.1 .
BX936347 , BX936385 Genomic DNA. Translation: CAI43213.3 .
BX936385 , BX936347 Genomic DNA. Translation: CAI95782.2 .
CH471172 Genomic DNA. Translation: EAW72715.1 .
BC000724 mRNA. Translation: AAH00724.1 .
D16469 mRNA. Translation: BAA03938.1 . Different initiation.
CCDSi CCDS35451.1.
RefSeqi NP_001174.2. NM_001183.5.
UniGenei Hs.633817.
Hs.6551.

3D structure databases

ProteinModelPortali Q15904.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107019. 10 interactions.
IntActi Q15904. 5 interactions.
MINTi MINT-4722342.
STRINGi 9606.ENSP00000358777.

Chemistry

BindingDBi Q15904.
ChEMBLi CHEMBL4790.

PTM databases

PhosphoSitei Q15904.

Polymorphism databases

DMDMi 12230759.

Proteomic databases

MaxQBi Q15904.
PaxDbi Q15904.
PRIDEi Q15904.

Protocols and materials databases

DNASUi 537.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369762 ; ENSP00000358777 ; ENSG00000071553 .
ENST00000594478 ; ENSP00000472265 ; ENSG00000269668 .
GeneIDi 537.
KEGGi hsa:537.
UCSCi uc004flf.1. human.

Organism-specific databases

CTDi 537.
GeneCardsi GC0XP153657.
HGNCi HGNC:868. ATP6AP1.
HPAi CAB015218.
MIMi 300197. gene.
neXtProti NX_Q15904.
PharmGKBi PA25145.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322101.
HOGENOMi HOG000000706.
HOVERGENi HBG001090.
InParanoidi Q15904.
KOi K03662.
OMAi GHITSDM.
PhylomeDBi Q15904.
TreeFami TF325819.

Enzyme and pathway databases

BioCyci MetaCyc:HS01034-MONOMER.

Miscellaneous databases

GeneWikii ATP6AP1.
GenomeRNAii 537.
NextBioi 2227.
PROi Q15904.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15904.
Bgeei Q15904.
CleanExi HS_ATP6AP1.
Genevestigatori Q15904.

Family and domain databases

InterProi IPR008388. ATPase_V1-cplx_s1su.
IPR024722. BIG/ATPase_V1_suS1.
[Graphical view ]
PANTHERi PTHR12471. PTHR12471. 1 hit.
Pfami PF05827. ATP-synt_S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."
    Chen E.Y., Zollo M., Mazzarella R.A., Ciccodicola A., Chen C.-N., Zuo L., Heiner C., Burough F.W., Ripetto M., Schlessinger D., D'Urso M.
    Hum. Mol. Genet. 5:659-668(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  8. "Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection."
    Yokoi H., Hadano S., Kogi M., Kang X., Wakasa K., Ikeda J.
    Genomics 20:404-411(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 97-470.
    Tissue: Brain.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261 AND ASN-273.
    Tissue: Liver.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVAS1_HUMAN
AccessioniPrimary (citable) accession number: Q15904
Secondary accession number(s): A6ZKI4, Q8NBT4, Q9H0C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: September 3, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi