SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q15878

- CAC1E_HUMAN

UniProt

Q15878 - CAC1E_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Voltage-dependent R-type calcium channel subunit alpha-1E

Gene
CACNA1E, CACH6, CACNL1A6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei309 – 3091Calcium ion selectivity and permeability By similarity
Sitei657 – 6571Calcium ion selectivity and permeability By similarity
Sitei1372 – 13721Calcium ion selectivity and permeability By similarity
Sitei1663 – 16631Calcium ion selectivity and permeability By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi426 – 43712 By similarityAdd
BLAST
Calcium bindingi1752 – 176312 By similarityAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. high voltage-gated calcium channel activity Source: RefGenome
  3. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. behavioral fear response Source: Ensembl
  2. behavioral response to pain Source: Ensembl
  3. calcium ion import Source: RefGenome
  4. energy reserve metabolic process Source: Reactome
  5. glucose homeostasis Source: Ensembl
  6. locomotory behavior Source: Ensembl
  7. membrane depolarization Source: Reactome
  8. membrane depolarization during action potential Source: RefGenome
  9. regulation of heart rate Source: Ensembl
  10. regulation of insulin secretion Source: Reactome
  11. regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  12. regulation of somatostatin secretion Source: Ensembl
  13. sensory perception of pain Source: Ensembl
  14. small molecule metabolic process Source: Reactome
  15. sperm motility Source: Ensembl
  16. synaptic transmission Source: RefGenome
  17. transmission of nerve impulse Source: Ensembl
  18. transport Source: ProtInc
  19. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
REACT_18325. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent R-type calcium channel subunit alpha-1E
Alternative name(s):
Brain calcium channel II
Short name:
BII
Calcium channel, L type, alpha-1 polypeptide, isoform 6
Voltage-gated calcium channel subunit alpha Cav2.3
Gene namesi
Name:CACNA1E
Synonyms:CACH6, CACNL1A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1392. CACNA1E.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8989Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei90 – 10819Helical; Name=S1 of repeat IAdd
BLAST
Topological domaini109 – 12719Extracellular Reviewed predictionAdd
BLAST
Transmembranei128 – 14619Helical; Name=S2 of repeat IAdd
BLAST
Topological domaini147 – 15812Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei159 – 17315Helical; Name=S3 of repeat IAdd
BLAST
Topological domaini174 – 18512Extracellular Reviewed predictionAdd
BLAST
Transmembranei186 – 20520Helical; Name=S4 of repeat IAdd
BLAST
Topological domaini206 – 22318Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei224 – 24421Helical; Name=S5 of repeat IAdd
BLAST
Topological domaini245 – 32682Extracellular Reviewed predictionAdd
BLAST
Transmembranei327 – 35024Helical; Name=S6 of repeat IAdd
BLAST
Topological domaini351 – 476126Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei477 – 49620Helical; Name=S1 of repeat IIAdd
BLAST
Topological domaini497 – 50913Extracellular Reviewed predictionAdd
BLAST
Transmembranei510 – 52920Helical; Name=S2 of repeat IIAdd
BLAST
Topological domaini530 – 5389Cytoplasmic Reviewed prediction
Transmembranei539 – 55719Helical; Name=S3 of repeat IIAdd
BLAST
Topological domaini558 – 56710Extracellular Reviewed prediction
Transmembranei568 – 58619Helical; Name=S4 of repeat IIAdd
BLAST
Topological domaini587 – 60519Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei606 – 62520Helical; Name=S5 of repeat IIAdd
BLAST
Topological domaini626 – 67853Extracellular Reviewed predictionAdd
BLAST
Transmembranei679 – 70325Helical; Name=S6 of repeat IIAdd
BLAST
Topological domaini704 – 1148445Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1149 – 116517Helical; Name=S1 of repeat IIIAdd
BLAST
Topological domaini1166 – 118924Extracellular Reviewed predictionAdd
BLAST
Transmembranei1190 – 120920Helical; Name=S2 of repeat IIIAdd
BLAST
Topological domaini1210 – 12178Cytoplasmic Reviewed prediction
Transmembranei1218 – 124023Helical; Name=S3 of repeat IIIAdd
BLAST
Topological domaini1241 – 125414Extracellular Reviewed predictionAdd
BLAST
Transmembranei1255 – 127218Helical; Name=S4 of repeat IIIAdd
BLAST
Topological domaini1273 – 129119Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1292 – 131120Helical; Name=S5 of repeat IIIAdd
BLAST
Topological domaini1312 – 139887Extracellular Reviewed predictionAdd
BLAST
Transmembranei1399 – 142224Helical; Name=S6 of repeat IIIAdd
BLAST
Topological domaini1423 – 147957Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1480 – 149819Helical; Name=S1 of repeat IVAdd
BLAST
Topological domaini1499 – 151315Extracellular Reviewed predictionAdd
BLAST
Transmembranei1514 – 153320Helical; Name=S2 of repeat IVAdd
BLAST
Topological domaini1534 – 15418Cytoplasmic Reviewed prediction
Transmembranei1542 – 156019Helical; Name=S3 of repeat IVAdd
BLAST
Topological domaini1561 – 157111Extracellular Reviewed predictionAdd
BLAST
Transmembranei1572 – 159019Helical; Name=S4 of repeat IVAdd
BLAST
Topological domaini1591 – 160919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1610 – 162920Helical; Name=S5 of repeat IVAdd
BLAST
Topological domaini1630 – 169869Extracellular Reviewed predictionAdd
BLAST
Transmembranei1699 – 172426Helical; Name=S6 of repeat IVAdd
BLAST
Topological domaini1725 – 2313589Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. plasma membrane Source: RefGenome
  2. voltage-gated calcium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23132313Voltage-dependent R-type calcium channel subunit alpha-1EPRO_0000053938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi254 – 2541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1566 – 15661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1571 – 15711N-linked (GlcNAc...) Reviewed prediction
Modified residuei1734 – 17341Phosphoserine; by PKA Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15878.
PRIDEiQ15878.

PTM databases

PhosphoSiteiQ15878.

Expressioni

Tissue specificityi

Expressed in neuronal tissues and in kidney.

Gene expression databases

ArrayExpressiQ15878.
BgeeiQ15878.
CleanExiHS_CACNA1E.
GenevestigatoriQ15878.

Organism-specific databases

HPAiHPA042515.

Interactioni

Subunit structurei

Interacts with EFHC1. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.1 Publication

Protein-protein interaction databases

BioGridi107231. 3 interactions.
STRINGi9606.ENSP00000356545.

Structurei

Secondary structure

1
2313
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1868 – 188215

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BXLX-ray2.30B1867-1887[»]
ProteinModelPortaliQ15878.
SMRiQ15878. Positions 358-402, 1249-1276.

Miscellaneous databases

EvolutionaryTraceiQ15878.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati76 – 354279IAdd
BLAST
Repeati462 – 706245IIAdd
BLAST
Repeati1140 – 1426287IIIAdd
BLAST
Repeati1463 – 1726264IVAdd
BLAST
Domaini1739 – 177436EF-handAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni374 – 39118Binding to the beta subunit By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi716 – 7216Poly-Glu
Compositional biasi748 – 7536Poly-Arg
Compositional biasi767 – 7726Poly-Arg
Compositional biasi1228 – 12314Poly-Val
Compositional biasi2284 – 22885Poly-Arg

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 EF-hand domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.
InParanoidiQ15878.
KOiK04852.
OMAiHMQMSSQ.
OrthoDBiEOG7T1RBQ.
PhylomeDBiQ15878.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005449. VDCC_R_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF57. PTHR10037:SF57. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01633. RVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15878-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha-1E

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM     50
ALYNPIPVRQ NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII 100
ANCIVLALEQ HLPEDDKTPM SRRLEKTEPY FIGIFCFEAG IKIVALGFIF 150
HKGSYLRNGW NVMDFIVVLS GILATAGTHF NTHVDLRTLR AVRVLRPLKL 200
VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL EFYSGKLHRA 250
CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL 300
TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL 350
SGEFAKERER VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK 400
NAGTSALEVL RRATIKRSRT EAMTRDSSDE HCVDISSVGT PLARASIKSA 450
KVDGVSYFRH KERLLRISIR HMVKSQVFYW IVLSLVALNT ACVAIVHHNQ 500
PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDFGVTVG 550
SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM 600
KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV 650
FQILTGEDWN EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA 700
IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPSIERDR 750
RRRHHMSMWE PRSSHLRERR RRHHMSVWEQ RTSQLRKHMQ MSSQEALNRE 800
EAPTMNPLNP LNPLSSLNPL NAHPSLYRRP RAIEGLALGL ALEKFEEERI 850
SRGGSLKGDG GDRSSALDNQ RTPLSLGQRE PPWLARPCHG NCDPTQQEAG 900
GGEAVVTFED RARHRQSQRR SRHRRVRTEG KESSSASRSR SASQERSLDE 950
AMPTEGEKDH ELRGNHGAKE PTIQEERAQD LRRTNSLMVS RGSGLAGGLD 1000
EADTPLVLPH PELEVGKHVV LTEQEPEGSS EQALLGNVQL DMGRVISQSE 1050
PDLSCITANT DKATTESTSV TVAIPDVDPL VDSTVVHISN KTDGEASPLK 1100
EAEIREDEEE VEKKKQKKEK RETGKAMVPH SSMFIFSTTN PIRRACHYIV 1150
NLRYFEMCIL LVIAASSIAL AAEDPVLTNS ERNKVLRYFD YVFTGVFTFE 1200
MVIKMIDQGL ILQDGSYFRD LWNILDFVVV VGALVAFALA NALGTNKGRD 1250
IKTIKSLRVL RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM 1300
FIFAVIAVQL FKGKFFYCTD SSKDTEKECI GNYVDHEKNK MEVKGREWKR 1350
HEFHYDNIIW ALLTLFTVST GEGWPQVLQH SVDVTEEDRG PSRSNRMEMS 1400
IFYVVYFVVF PFFFVNIFVA LIIITFQEQG DKMMEECSLE KNERACIDFA 1450
ISAKPLTRYM PQNRHTFQYR VWHFVVSPSF EYTIMAMIAL NTVVLMMKYY 1500
SAPCTYELAL KYLNIAFTMV FSLECVLKVI AFGFLNYFRD TWNIFDFITV 1550
IGSITEIILT DSKLVNTSGF NMSFLKLFRA ARLIKLLRQG YTIRILLWTF 1600
VQSFKALPYV CLLIAMLFFI YAIIGMQVFG NIKLDEESHI NRHNNFRSFF 1650
GSLMLLFRSA TGEAWQEIML SCLGEKGCEP DTTAPSGQNE NERCGTDLAY 1700
VYFVSFIFFC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEFVRVWAE 1750
YDRAACGRIH YTEMYEMLTL MSPPLGLGKR CPSKVAYKRL VLMNMPVAED 1800
MTVHFTSTLM ALIRTALDIK IAKGGADRQQ LDSELQKETL AIWPHLSQKM 1850
LDLLVPMPKA SDLTVGKIYA AMMIMDYYKQ SKVKKQRQQL EEQKNAPMFQ 1900
RMEPSSLPQE IIANAKALPY LQQDPVSGLS GRSGYPSMSP LSPQDIFQLA 1950
CMDPADDGQF QERQSLEPEV SELKSVQPSN HGIYLPSDTQ EHAGSGRASS 2000
MPRLTVDPQV VTDPSSMRRS FSTIRDKRSN SSWLEEFSME RSSENTYKSR 2050
RRSYHSSLRL SAHRLNSDSG HKSDTHRSGG RERGRSKERK HLLSPDVSRC 2100
NSEERGTQAD WESPERRQSR SPSEGRSQTP NRQGTGSLSE SSIPSVSDTS 2150
TPRRSRRQLP PVPPKPRPLL SYSSLIRHAG SISPPADGSE EGSPLTSQAL 2200
ESNNACLTES SNSPHPQQSQ HASPQRYISE PYLALHEDSH ASDCGEEETL 2250
TFEAAVATSL GRSNTIGSAP PLRHSWQMPN GHYRRRRRGG PGPGMMCGAV 2300
NNLLSDTEED DKC 2313
Length:2,313
Mass (Da):261,731
Last modified:October 14, 2008 - v3
Checksum:iCCC7F309C27C42F1
GO
Isoform 2 (identifier: Q15878-2) [UniParc]FASTAAdd to Basket

Also known as: Alpha-1E-1

The sequence of this isoform differs from the canonical sequence as follows:
     748-766: Missing.
     1967-2009: Missing.

Show »
Length:2,251
Mass (Da):254,604
Checksum:i73640AD59C386BB2
GO
Isoform 3 (identifier: Q15878-3) [UniParc]FASTAAdd to Basket

Also known as: Alpha-1E-3

The sequence of this isoform differs from the canonical sequence as follows:
     1967-2009: Missing.

Show »
Length:2,270
Mass (Da):257,116
Checksum:iD424C3592C9BD5F5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti859 – 8591D → E.
Corresponds to variant rs35737760 [ dbSNP | Ensembl ].
VAR_031912
Natural varianti1955 – 19551A → T.1 Publication
Corresponds to variant rs704326 [ dbSNP | Ensembl ].
VAR_046996

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei748 – 76619Missing in isoform 2. VSP_000937Add
BLAST
Alternative sequencei1967 – 200943Missing in isoform 2 and isoform 3. VSP_024817Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti648 – 6481M → I in AAA72125. 1 Publication
Sequence conflicti836 – 8383LAL → WP in AAA72125. 1 Publication
Sequence conflicti2077 – 20771R → P in AAA59204. 1 Publication
Sequence conflicti2077 – 20771R → P in AAA59205. 1 Publication
Sequence conflicti2084 – 20841G → R in AAA59204. 1 Publication
Sequence conflicti2084 – 20841G → R in AAA59205. 1 Publication
Sequence conflicti2206 – 22061C → W in AAA59204. 1 Publication
Sequence conflicti2206 – 22061C → W in AAA59205. 1 Publication
Sequence conflicti2219 – 22191S → R in AAA59204. 1 Publication
Sequence conflicti2219 – 22191S → R in AAA59205. 1 Publication
Sequence conflicti2245 – 22451G → V in AAA59204. 1 Publication
Sequence conflicti2245 – 22451G → V in AAA59205. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27745 mRNA. Translation: AAA72125.1.
L29384 mRNA. Translation: AAA59204.1.
L29385 mRNA. Translation: AAA59205.1.
AL161734
, AL160059, AL359270, AL590998 Genomic DNA. Translation: CAH72675.1.
AL161734
, AL160059, AL359270, AL590998 Genomic DNA. Translation: CAH72676.1.
AL161734
, AL160059, AL359270, AL590998 Genomic DNA. Translation: CAH72677.1.
AL359270
, AL160059, AL161734, AL590998 Genomic DNA. Translation: CAI14653.1.
AL359270
, AL160059, AL161734, AL590998 Genomic DNA. Translation: CAI14654.1.
AL359270
, AL160059, AL161734, AL590998 Genomic DNA. Translation: CAI14655.1.
AL160059
, AL161734, AL359270, AL590998 Genomic DNA. Translation: CAI17081.1.
AL160059
, AL161734, AL359270, AL590998 Genomic DNA. Translation: CAI17082.1.
AL160059
, AL161734, AL359270, AL590998 Genomic DNA. Translation: CAI17083.1.
AL590998
, AL160059, AL161734, AL359270 Genomic DNA. Translation: CAI22327.1.
AL590998
, AL160059, AL161734, AL359270 Genomic DNA. Translation: CAI22328.1.
AL590998
, AL160059, AL161734, AL359270 Genomic DNA. Translation: CAI22329.1.
CCDSiCCDS53443.1. [Q15878-3]
CCDS55664.1. [Q15878-1]
CCDS55665.1. [Q15878-2]
PIRiA54972.
B54972.
RefSeqiNP_000712.2. NM_000721.3. [Q15878-3]
NP_001192222.1. NM_001205293.1. [Q15878-1]
NP_001192223.1. NM_001205294.1. [Q15878-2]
UniGeneiHs.437444.

Genome annotation databases

EnsembliENST00000367570; ENSP00000356542; ENSG00000198216. [Q15878-3]
ENST00000367573; ENSP00000356545; ENSG00000198216. [Q15878-1]
ENST00000526775; ENSP00000434814; ENSG00000198216. [Q15878-2]
GeneIDi777.
KEGGihsa:777.
UCSCiuc001gow.3. human. [Q15878-3]
uc009wxs.3. human. [Q15878-2]
uc009wxt.3. human. [Q15878-1]

Polymorphism databases

DMDMi209572758.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27745 mRNA. Translation: AAA72125.1 .
L29384 mRNA. Translation: AAA59204.1 .
L29385 mRNA. Translation: AAA59205.1 .
AL161734
, AL160059 , AL359270 , AL590998 Genomic DNA. Translation: CAH72675.1 .
AL161734
, AL160059 , AL359270 , AL590998 Genomic DNA. Translation: CAH72676.1 .
AL161734
, AL160059 , AL359270 , AL590998 Genomic DNA. Translation: CAH72677.1 .
AL359270
, AL160059 , AL161734 , AL590998 Genomic DNA. Translation: CAI14653.1 .
AL359270
, AL160059 , AL161734 , AL590998 Genomic DNA. Translation: CAI14654.1 .
AL359270
, AL160059 , AL161734 , AL590998 Genomic DNA. Translation: CAI14655.1 .
AL160059
, AL161734 , AL359270 , AL590998 Genomic DNA. Translation: CAI17081.1 .
AL160059
, AL161734 , AL359270 , AL590998 Genomic DNA. Translation: CAI17082.1 .
AL160059
, AL161734 , AL359270 , AL590998 Genomic DNA. Translation: CAI17083.1 .
AL590998
, AL160059 , AL161734 , AL359270 Genomic DNA. Translation: CAI22327.1 .
AL590998
, AL160059 , AL161734 , AL359270 Genomic DNA. Translation: CAI22328.1 .
AL590998
, AL160059 , AL161734 , AL359270 Genomic DNA. Translation: CAI22329.1 .
CCDSi CCDS53443.1. [Q15878-3 ]
CCDS55664.1. [Q15878-1 ]
CCDS55665.1. [Q15878-2 ]
PIRi A54972.
B54972.
RefSeqi NP_000712.2. NM_000721.3. [Q15878-3 ]
NP_001192222.1. NM_001205293.1. [Q15878-1 ]
NP_001192223.1. NM_001205294.1. [Q15878-2 ]
UniGenei Hs.437444.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BXL X-ray 2.30 B 1867-1887 [» ]
ProteinModelPortali Q15878.
SMRi Q15878. Positions 358-402, 1249-1276.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107231. 3 interactions.
STRINGi 9606.ENSP00000356545.

Chemistry

BindingDBi Q15878.
ChEMBLi CHEMBL1687682.
GuidetoPHARMACOLOGYi 534.

PTM databases

PhosphoSitei Q15878.

Polymorphism databases

DMDMi 209572758.

Proteomic databases

PaxDbi Q15878.
PRIDEi Q15878.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367570 ; ENSP00000356542 ; ENSG00000198216 . [Q15878-3 ]
ENST00000367573 ; ENSP00000356545 ; ENSG00000198216 . [Q15878-1 ]
ENST00000526775 ; ENSP00000434814 ; ENSG00000198216 . [Q15878-2 ]
GeneIDi 777.
KEGGi hsa:777.
UCSCi uc001gow.3. human. [Q15878-3 ]
uc009wxs.3. human. [Q15878-2 ]
uc009wxt.3. human. [Q15878-1 ]

Organism-specific databases

CTDi 777.
GeneCardsi GC01P181382.
HGNCi HGNC:1392. CACNA1E.
HPAi HPA042515.
MIMi 601013. gene.
neXtProti NX_Q15878.
PharmGKBi PA26009.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231530.
HOVERGENi HBG050763.
InParanoidi Q15878.
KOi K04852.
OMAi HMQMSSQ.
OrthoDBi EOG7T1RBQ.
PhylomeDBi Q15878.
TreeFami TF312805.

Enzyme and pathway databases

Reactomei REACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
REACT_18325. Regulation of insulin secretion.

Miscellaneous databases

EvolutionaryTracei Q15878.
GeneWikii R-type_calcium_channel.
GenomeRNAii 777.
NextBioi 3140.
PROi Q15878.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15878.
Bgeei Q15878.
CleanExi HS_CACNA1E.
Genevestigatori Q15878.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005449. VDCC_R_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
PANTHERi PTHR10037:SF57. PTHR10037:SF57. 1 hit.
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01633. RVDCCALPHA1.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit."
    Schneider T., Wei X., Olcese R., Costantin J.L., Neely A., Palade P., Perez-Reyes E., Qin N., Zhou J., Crawford G.D., Smith R.G., Appel S.H., Stefani E., Birnbaumer M.
    Recept. Channels 2:255-270(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-1955.
    Tissue: Brain.
  2. "Structure and functional characterization of neuronal alpha 1E calcium channel subtypes."
    Williams M.E., Marubio L.M., Deal C.R., Hans M., Brust P.F., Philipson L.H., Miller R.J., Johnson E.C., Harpold M.M., Ellis S.B.
    J. Biol. Chem. 269:22347-22357(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
    Tissue: Hippocampus.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: INTERACTION WITH CACNA1E.
  5. "Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+."
    Mori M.X., Vander Kooi C.W., Leahy D.J., Yue D.T.
    Structure 16:607-620(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1867-1885.

Entry informationi

Entry nameiCAC1E_HUMAN
AccessioniPrimary (citable) accession number: Q15878
Secondary accession number(s): B1AM12
, B1AM13, B1AM14, Q14580, Q14581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi