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Protein

Voltage-dependent R-type calcium channel subunit alpha-1E

Gene

CACNA1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei309Calcium ion selectivity and permeabilityBy similarity1
Sitei657Calcium ion selectivity and permeabilityBy similarity1
Sitei1372Calcium ion selectivity and permeabilityBy similarity1
Sitei1663Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi426 – 437PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi1752 – 1763PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • membrane depolarization Source: Reactome
  • membrane depolarization during action potential Source: GO_Central
  • regulation of insulin secretion Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32618-MONOMER.
ReactomeiR-HSA-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-HSA-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent R-type calcium channel subunit alpha-1E
Alternative name(s):
Brain calcium channel II
Short name:
BII
Calcium channel, L type, alpha-1 polypeptide, isoform 6
Voltage-gated calcium channel subunit alpha Cav2.3
Gene namesi
Name:CACNA1E
Synonyms:CACH6, CACNL1A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1392. CACNA1E.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 89CytoplasmicSequence analysisAdd BLAST89
Transmembranei90 – 108Helical; Name=S1 of repeat IAdd BLAST19
Topological domaini109 – 127ExtracellularSequence analysisAdd BLAST19
Transmembranei128 – 146Helical; Name=S2 of repeat IAdd BLAST19
Topological domaini147 – 158CytoplasmicSequence analysisAdd BLAST12
Transmembranei159 – 173Helical; Name=S3 of repeat IAdd BLAST15
Topological domaini174 – 185ExtracellularSequence analysisAdd BLAST12
Transmembranei186 – 205Helical; Name=S4 of repeat IAdd BLAST20
Topological domaini206 – 223CytoplasmicSequence analysisAdd BLAST18
Transmembranei224 – 244Helical; Name=S5 of repeat IAdd BLAST21
Topological domaini245 – 326ExtracellularSequence analysisAdd BLAST82
Transmembranei327 – 350Helical; Name=S6 of repeat IAdd BLAST24
Topological domaini351 – 476CytoplasmicSequence analysisAdd BLAST126
Transmembranei477 – 496Helical; Name=S1 of repeat IIAdd BLAST20
Topological domaini497 – 509ExtracellularSequence analysisAdd BLAST13
Transmembranei510 – 529Helical; Name=S2 of repeat IIAdd BLAST20
Topological domaini530 – 538CytoplasmicSequence analysis9
Transmembranei539 – 557Helical; Name=S3 of repeat IIAdd BLAST19
Topological domaini558 – 567ExtracellularSequence analysis10
Transmembranei568 – 586Helical; Name=S4 of repeat IIAdd BLAST19
Topological domaini587 – 605CytoplasmicSequence analysisAdd BLAST19
Transmembranei606 – 625Helical; Name=S5 of repeat IIAdd BLAST20
Topological domaini626 – 678ExtracellularSequence analysisAdd BLAST53
Transmembranei679 – 703Helical; Name=S6 of repeat IIAdd BLAST25
Topological domaini704 – 1148CytoplasmicSequence analysisAdd BLAST445
Transmembranei1149 – 1165Helical; Name=S1 of repeat IIIAdd BLAST17
Topological domaini1166 – 1189ExtracellularSequence analysisAdd BLAST24
Transmembranei1190 – 1209Helical; Name=S2 of repeat IIIAdd BLAST20
Topological domaini1210 – 1217CytoplasmicSequence analysis8
Transmembranei1218 – 1240Helical; Name=S3 of repeat IIIAdd BLAST23
Topological domaini1241 – 1254ExtracellularSequence analysisAdd BLAST14
Transmembranei1255 – 1272Helical; Name=S4 of repeat IIIAdd BLAST18
Topological domaini1273 – 1291CytoplasmicSequence analysisAdd BLAST19
Transmembranei1292 – 1311Helical; Name=S5 of repeat IIIAdd BLAST20
Topological domaini1312 – 1398ExtracellularSequence analysisAdd BLAST87
Transmembranei1399 – 1422Helical; Name=S6 of repeat IIIAdd BLAST24
Topological domaini1423 – 1479CytoplasmicSequence analysisAdd BLAST57
Transmembranei1480 – 1498Helical; Name=S1 of repeat IVAdd BLAST19
Topological domaini1499 – 1513ExtracellularSequence analysisAdd BLAST15
Transmembranei1514 – 1533Helical; Name=S2 of repeat IVAdd BLAST20
Topological domaini1534 – 1541CytoplasmicSequence analysis8
Transmembranei1542 – 1560Helical; Name=S3 of repeat IVAdd BLAST19
Topological domaini1561 – 1571ExtracellularSequence analysisAdd BLAST11
Transmembranei1572 – 1590Helical; Name=S4 of repeat IVAdd BLAST19
Topological domaini1591 – 1609CytoplasmicSequence analysisAdd BLAST19
Transmembranei1610 – 1629Helical; Name=S5 of repeat IVAdd BLAST20
Topological domaini1630 – 1698ExtracellularSequence analysisAdd BLAST69
Transmembranei1699 – 1724Helical; Name=S6 of repeat IVAdd BLAST26
Topological domaini1725 – 2313CytoplasmicSequence analysisAdd BLAST589

GO - Cellular componenti

  • plasma membrane Source: Reactome
  • voltage-gated calcium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi777.
OpenTargetsiENSG00000198216.
PharmGKBiPA26009.

Chemistry databases

ChEMBLiCHEMBL1687682.
GuidetoPHARMACOLOGYi534.

Polymorphism and mutation databases

BioMutaiCACNA1E.
DMDMi209572758.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539381 – 2313Voltage-dependent R-type calcium channel subunit alpha-1EAdd BLAST2313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Modified residuei427PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1
Modified residuei736PhosphoserineBy similarity1
Modified residuei745PhosphoserineBy similarity1
Modified residuei793PhosphoserineBy similarity1
Modified residuei815PhosphoserineBy similarity1
Modified residuei855PhosphoserineBy similarity1
Modified residuei947PhosphoserineBy similarity1
Modified residuei1097PhosphoserineBy similarity1
Glycosylationi1566N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1571N-linked (GlcNAc...)Sequence analysis1
Modified residuei1734Phosphoserine; by PKASequence analysis1
Modified residuei2094PhosphoserineBy similarity1
Modified residuei2113PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ15878.
PaxDbiQ15878.
PeptideAtlasiQ15878.
PRIDEiQ15878.

PTM databases

iPTMnetiQ15878.
PhosphoSitePlusiQ15878.

Expressioni

Tissue specificityi

Expressed in neuronal tissues and in kidney.

Gene expression databases

BgeeiENSG00000198216.
CleanExiHS_CACNA1E.
ExpressionAtlasiQ15878. baseline and differential.
GenevisibleiQ15878. HS.

Interactioni

Subunit structurei

Interacts with EFHC1. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.1 Publication

Protein-protein interaction databases

BioGridi107231. 2 interactors.
STRINGi9606.ENSP00000356545.

Chemistry databases

BindingDBiQ15878.

Structurei

Secondary structure

12313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1868 – 1882Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BXLX-ray2.30B1867-1887[»]
ProteinModelPortaliQ15878.
SMRiQ15878.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15878.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati76 – 354IAdd BLAST279
Repeati462 – 706IIAdd BLAST245
Repeati1140 – 1426IIIAdd BLAST287
Repeati1463 – 1726IVAdd BLAST264
Domaini1739 – 1774EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni374 – 391Binding to the beta subunitBy similarityAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi716 – 721Poly-Glu6
Compositional biasi748 – 753Poly-Arg6
Compositional biasi767 – 772Poly-Arg6
Compositional biasi1228 – 1231Poly-Val4
Compositional biasi2284 – 2288Poly-Arg5

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 EF-hand domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INF5. Eukaryota.
ENOG410YD06. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.
InParanoidiQ15878.
KOiK04852.
OMAiSVQPSNH.
OrthoDBiEOG091G0TKO.
PhylomeDBiQ15878.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005449. VDCC_R_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF57. PTHR10037:SF57. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01633. RVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15878-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM
60 70 80 90 100
ALYNPIPVRQ NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII
110 120 130 140 150
ANCIVLALEQ HLPEDDKTPM SRRLEKTEPY FIGIFCFEAG IKIVALGFIF
160 170 180 190 200
HKGSYLRNGW NVMDFIVVLS GILATAGTHF NTHVDLRTLR AVRVLRPLKL
210 220 230 240 250
VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL EFYSGKLHRA
260 270 280 290 300
CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL
310 320 330 340 350
TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL
360 370 380 390 400
SGEFAKERER VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK
410 420 430 440 450
NAGTSALEVL RRATIKRSRT EAMTRDSSDE HCVDISSVGT PLARASIKSA
460 470 480 490 500
KVDGVSYFRH KERLLRISIR HMVKSQVFYW IVLSLVALNT ACVAIVHHNQ
510 520 530 540 550
PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDFGVTVG
560 570 580 590 600
SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM
610 620 630 640 650
KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV
660 670 680 690 700
FQILTGEDWN EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA
710 720 730 740 750
IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPSIERDR
760 770 780 790 800
RRRHHMSMWE PRSSHLRERR RRHHMSVWEQ RTSQLRKHMQ MSSQEALNRE
810 820 830 840 850
EAPTMNPLNP LNPLSSLNPL NAHPSLYRRP RAIEGLALGL ALEKFEEERI
860 870 880 890 900
SRGGSLKGDG GDRSSALDNQ RTPLSLGQRE PPWLARPCHG NCDPTQQEAG
910 920 930 940 950
GGEAVVTFED RARHRQSQRR SRHRRVRTEG KESSSASRSR SASQERSLDE
960 970 980 990 1000
AMPTEGEKDH ELRGNHGAKE PTIQEERAQD LRRTNSLMVS RGSGLAGGLD
1010 1020 1030 1040 1050
EADTPLVLPH PELEVGKHVV LTEQEPEGSS EQALLGNVQL DMGRVISQSE
1060 1070 1080 1090 1100
PDLSCITANT DKATTESTSV TVAIPDVDPL VDSTVVHISN KTDGEASPLK
1110 1120 1130 1140 1150
EAEIREDEEE VEKKKQKKEK RETGKAMVPH SSMFIFSTTN PIRRACHYIV
1160 1170 1180 1190 1200
NLRYFEMCIL LVIAASSIAL AAEDPVLTNS ERNKVLRYFD YVFTGVFTFE
1210 1220 1230 1240 1250
MVIKMIDQGL ILQDGSYFRD LWNILDFVVV VGALVAFALA NALGTNKGRD
1260 1270 1280 1290 1300
IKTIKSLRVL RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM
1310 1320 1330 1340 1350
FIFAVIAVQL FKGKFFYCTD SSKDTEKECI GNYVDHEKNK MEVKGREWKR
1360 1370 1380 1390 1400
HEFHYDNIIW ALLTLFTVST GEGWPQVLQH SVDVTEEDRG PSRSNRMEMS
1410 1420 1430 1440 1450
IFYVVYFVVF PFFFVNIFVA LIIITFQEQG DKMMEECSLE KNERACIDFA
1460 1470 1480 1490 1500
ISAKPLTRYM PQNRHTFQYR VWHFVVSPSF EYTIMAMIAL NTVVLMMKYY
1510 1520 1530 1540 1550
SAPCTYELAL KYLNIAFTMV FSLECVLKVI AFGFLNYFRD TWNIFDFITV
1560 1570 1580 1590 1600
IGSITEIILT DSKLVNTSGF NMSFLKLFRA ARLIKLLRQG YTIRILLWTF
1610 1620 1630 1640 1650
VQSFKALPYV CLLIAMLFFI YAIIGMQVFG NIKLDEESHI NRHNNFRSFF
1660 1670 1680 1690 1700
GSLMLLFRSA TGEAWQEIML SCLGEKGCEP DTTAPSGQNE NERCGTDLAY
1710 1720 1730 1740 1750
VYFVSFIFFC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEFVRVWAE
1760 1770 1780 1790 1800
YDRAACGRIH YTEMYEMLTL MSPPLGLGKR CPSKVAYKRL VLMNMPVAED
1810 1820 1830 1840 1850
MTVHFTSTLM ALIRTALDIK IAKGGADRQQ LDSELQKETL AIWPHLSQKM
1860 1870 1880 1890 1900
LDLLVPMPKA SDLTVGKIYA AMMIMDYYKQ SKVKKQRQQL EEQKNAPMFQ
1910 1920 1930 1940 1950
RMEPSSLPQE IIANAKALPY LQQDPVSGLS GRSGYPSMSP LSPQDIFQLA
1960 1970 1980 1990 2000
CMDPADDGQF QERQSLEPEV SELKSVQPSN HGIYLPSDTQ EHAGSGRASS
2010 2020 2030 2040 2050
MPRLTVDPQV VTDPSSMRRS FSTIRDKRSN SSWLEEFSME RSSENTYKSR
2060 2070 2080 2090 2100
RRSYHSSLRL SAHRLNSDSG HKSDTHRSGG RERGRSKERK HLLSPDVSRC
2110 2120 2130 2140 2150
NSEERGTQAD WESPERRQSR SPSEGRSQTP NRQGTGSLSE SSIPSVSDTS
2160 2170 2180 2190 2200
TPRRSRRQLP PVPPKPRPLL SYSSLIRHAG SISPPADGSE EGSPLTSQAL
2210 2220 2230 2240 2250
ESNNACLTES SNSPHPQQSQ HASPQRYISE PYLALHEDSH ASDCGEEETL
2260 2270 2280 2290 2300
TFEAAVATSL GRSNTIGSAP PLRHSWQMPN GHYRRRRRGG PGPGMMCGAV
2310
NNLLSDTEED DKC
Length:2,313
Mass (Da):261,731
Last modified:October 14, 2008 - v3
Checksum:iCCC7F309C27C42F1
GO
Isoform 2 (identifier: Q15878-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E-1

The sequence of this isoform differs from the canonical sequence as follows:
     748-766: Missing.
     1967-2009: Missing.

Show »
Length:2,251
Mass (Da):254,604
Checksum:i73640AD59C386BB2
GO
Isoform 3 (identifier: Q15878-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E-3

The sequence of this isoform differs from the canonical sequence as follows:
     1967-2009: Missing.

Show »
Length:2,270
Mass (Da):257,116
Checksum:iD424C3592C9BD5F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti648M → I in AAA72125 (PubMed:7536609).Curated1
Sequence conflicti836 – 838LAL → WP in AAA72125 (PubMed:7536609).Curated3
Sequence conflicti2077R → P in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2077R → P in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2084G → R in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2084G → R in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2206C → W in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2206C → W in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2219S → R in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2219S → R in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2245G → V in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2245G → V in AAA59205 (PubMed:8071363).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031912859D → E.Corresponds to variant rs35737760dbSNPEnsembl.1
Natural variantiVAR_0469961955A → T.1 PublicationCorresponds to variant rs704326dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000937748 – 766Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0248171967 – 2009Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27745 mRNA. Translation: AAA72125.1.
L29384 mRNA. Translation: AAA59204.1.
L29385 mRNA. Translation: AAA59205.1.
AL161734
, AL160059, AL359270, AL590998 Genomic DNA. Translation: CAH72675.1.
AL161734
, AL160059, AL359270, AL590998 Genomic DNA. Translation: CAH72676.1.
AL161734
, AL160059, AL359270, AL590998 Genomic DNA. Translation: CAH72677.1.
AL359270
, AL160059, AL161734, AL590998 Genomic DNA. Translation: CAI14653.1.
AL359270
, AL160059, AL161734, AL590998 Genomic DNA. Translation: CAI14654.1.
AL359270
, AL160059, AL161734, AL590998 Genomic DNA. Translation: CAI14655.1.
AL160059
, AL161734, AL359270, AL590998 Genomic DNA. Translation: CAI17081.1.
AL160059
, AL161734, AL359270, AL590998 Genomic DNA. Translation: CAI17082.1.
AL160059
, AL161734, AL359270, AL590998 Genomic DNA. Translation: CAI17083.1.
AL590998
, AL160059, AL161734, AL359270 Genomic DNA. Translation: CAI22327.1.
AL590998
, AL160059, AL161734, AL359270 Genomic DNA. Translation: CAI22328.1.
AL590998
, AL160059, AL161734, AL359270 Genomic DNA. Translation: CAI22329.1.
CCDSiCCDS53443.1. [Q15878-3]
CCDS55664.1. [Q15878-1]
CCDS55665.1. [Q15878-2]
PIRiA54972.
B54972.
RefSeqiNP_000712.2. NM_000721.3. [Q15878-3]
NP_001192222.1. NM_001205293.1. [Q15878-1]
NP_001192223.1. NM_001205294.1. [Q15878-2]
UniGeneiHs.437444.
Hs.611396.

Genome annotation databases

EnsembliENST00000358338; ENSP00000351101; ENSG00000198216. [Q15878-2]
ENST00000367567; ENSP00000356539; ENSG00000198216. [Q15878-3]
ENST00000367570; ENSP00000356542; ENSG00000198216. [Q15878-3]
ENST00000367573; ENSP00000356545; ENSG00000198216. [Q15878-1]
ENST00000621551; ENSP00000483914; ENSG00000198216. [Q15878-1]
ENST00000621791; ENSP00000481619; ENSG00000198216. [Q15878-2]
GeneIDi777.
KEGGihsa:777.
UCSCiuc001gow.5. human. [Q15878-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27745 mRNA. Translation: AAA72125.1.
L29384 mRNA. Translation: AAA59204.1.
L29385 mRNA. Translation: AAA59205.1.
AL161734
, AL160059, AL359270, AL590998 Genomic DNA. Translation: CAH72675.1.
AL161734
, AL160059, AL359270, AL590998 Genomic DNA. Translation: CAH72676.1.
AL161734
, AL160059, AL359270, AL590998 Genomic DNA. Translation: CAH72677.1.
AL359270
, AL160059, AL161734, AL590998 Genomic DNA. Translation: CAI14653.1.
AL359270
, AL160059, AL161734, AL590998 Genomic DNA. Translation: CAI14654.1.
AL359270
, AL160059, AL161734, AL590998 Genomic DNA. Translation: CAI14655.1.
AL160059
, AL161734, AL359270, AL590998 Genomic DNA. Translation: CAI17081.1.
AL160059
, AL161734, AL359270, AL590998 Genomic DNA. Translation: CAI17082.1.
AL160059
, AL161734, AL359270, AL590998 Genomic DNA. Translation: CAI17083.1.
AL590998
, AL160059, AL161734, AL359270 Genomic DNA. Translation: CAI22327.1.
AL590998
, AL160059, AL161734, AL359270 Genomic DNA. Translation: CAI22328.1.
AL590998
, AL160059, AL161734, AL359270 Genomic DNA. Translation: CAI22329.1.
CCDSiCCDS53443.1. [Q15878-3]
CCDS55664.1. [Q15878-1]
CCDS55665.1. [Q15878-2]
PIRiA54972.
B54972.
RefSeqiNP_000712.2. NM_000721.3. [Q15878-3]
NP_001192222.1. NM_001205293.1. [Q15878-1]
NP_001192223.1. NM_001205294.1. [Q15878-2]
UniGeneiHs.437444.
Hs.611396.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BXLX-ray2.30B1867-1887[»]
ProteinModelPortaliQ15878.
SMRiQ15878.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107231. 2 interactors.
STRINGi9606.ENSP00000356545.

Chemistry databases

BindingDBiQ15878.
ChEMBLiCHEMBL1687682.
GuidetoPHARMACOLOGYi534.

PTM databases

iPTMnetiQ15878.
PhosphoSitePlusiQ15878.

Polymorphism and mutation databases

BioMutaiCACNA1E.
DMDMi209572758.

Proteomic databases

MaxQBiQ15878.
PaxDbiQ15878.
PeptideAtlasiQ15878.
PRIDEiQ15878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358338; ENSP00000351101; ENSG00000198216. [Q15878-2]
ENST00000367567; ENSP00000356539; ENSG00000198216. [Q15878-3]
ENST00000367570; ENSP00000356542; ENSG00000198216. [Q15878-3]
ENST00000367573; ENSP00000356545; ENSG00000198216. [Q15878-1]
ENST00000621551; ENSP00000483914; ENSG00000198216. [Q15878-1]
ENST00000621791; ENSP00000481619; ENSG00000198216. [Q15878-2]
GeneIDi777.
KEGGihsa:777.
UCSCiuc001gow.5. human. [Q15878-1]

Organism-specific databases

CTDi777.
DisGeNETi777.
GeneCardsiCACNA1E.
HGNCiHGNC:1392. CACNA1E.
MIMi601013. gene.
neXtProtiNX_Q15878.
OpenTargetsiENSG00000198216.
PharmGKBiPA26009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INF5. Eukaryota.
ENOG410YD06. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.
InParanoidiQ15878.
KOiK04852.
OMAiSVQPSNH.
OrthoDBiEOG091G0TKO.
PhylomeDBiQ15878.
TreeFamiTF312805.

Enzyme and pathway databases

BioCyciZFISH:G66-32618-MONOMER.
ReactomeiR-HSA-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-HSA-422356. Regulation of insulin secretion.

Miscellaneous databases

ChiTaRSiCACNA1E. human.
EvolutionaryTraceiQ15878.
GeneWikiiR-type_calcium_channel.
GenomeRNAii777.
PROiQ15878.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198216.
CleanExiHS_CACNA1E.
ExpressionAtlasiQ15878. baseline and differential.
GenevisibleiQ15878. HS.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005449. VDCC_R_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF57. PTHR10037:SF57. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01633. RVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAC1E_HUMAN
AccessioniPrimary (citable) accession number: Q15878
Secondary accession number(s): B1AM12
, B1AM13, B1AM14, Q14580, Q14581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 163 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.