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Q15849

- UT2_HUMAN

UniProt

Q15849 - UT2_HUMAN

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Protein

Urea transporter 2

Gene

SLC14A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.2 Publications

GO - Molecular functioni

  1. cell adhesion molecule binding Source: MGI
  2. urea transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. transmembrane transport Source: Reactome
  2. urea transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi1.A.28.1.6. the urea transporter (ut) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
Gene namesi
Name:SLC14A2
Synonyms:HUT2, UT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:10919. SLC14A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei151 – 17020HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Transmembranei272 – 29120HelicalSequence AnalysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence AnalysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence AnalysisAdd
BLAST
Transmembranei600 – 62021HelicalSequence AnalysisAdd
BLAST
Transmembranei638 – 65821HelicalSequence AnalysisAdd
BLAST
Transmembranei666 – 68621HelicalSequence AnalysisAdd
BLAST
Transmembranei695 – 71521HelicalSequence AnalysisAdd
BLAST
Transmembranei764 – 78421HelicalSequence AnalysisAdd
BLAST
Transmembranei803 – 82321HelicalSequence AnalysisAdd
BLAST
Transmembranei832 – 85221HelicalSequence AnalysisAdd
BLAST
Transmembranei854 – 87421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Urea transporter 2PRO_0000065739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei477 – 4771PhosphoserineBy similarity
Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15849.
PRIDEiQ15849.

PTM databases

PhosphoSiteiQ15849.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.2 Publications

Inductioni

Isoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration.

Gene expression databases

BgeeiQ15849.
CleanExiHS_SLC14A2.
ExpressionAtlasiQ15849. baseline and differential.
GenevestigatoriQ15849.

Organism-specific databases

HPAiHPA050069.

Interactioni

Subunit structurei

Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNAPINO952955EBI-1633392,EBI-296723

Protein-protein interaction databases

IntActiQ15849. 2 interactions.
STRINGi9606.ENSP00000255226.

Structurei

3D structure databases

ProteinModelPortaliQ15849.
SMRiQ15849. Positions 96-438, 559-900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4413.
GeneTreeiENSGT00390000018729.
HOGENOMiHOG000168437.
HOVERGENiHBG073255.
InParanoidiQ15849.
KOiK08716.
OMAiVCALFCA.
OrthoDBiEOG7GBFX8.
PhylomeDBiQ15849.

Family and domain databases

Gene3Di1.10.3430.10. 2 hits.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15849-1) [UniParc]FASTAAdd to Basket

Also known as: UT-A1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK
60 70 80 90 100
DLRSSNEDSH IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG
110 120 130 140 150
DMKEYRIWLK DKHLALQFID WVLRGTAQVM FINNPLSGLI IFIGLLIQNP
160 170 180 190 200
WWTITGGLGT VVSTLTALAL GQDRSAIASG LHGYNGMLVG LLMAVFSEKL
210 220 230 240 250
DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF NIAVTLYLAA
260 270 280 290 300
TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW
310 320 330 340 350
TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC
360 370 380 390 400
VLSCIAIGGM FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW
410 420 430 440 450
AFCLATIIFL LLTTNNPAIF RLPLSKVTYP EANRIYYLTV KSGEEEKAPS
460 470 480 490 500
GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH IEWSSIRRRS KVFGKGEHQE
510 520 530 540 550
RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS WIRSSMAASG
560 570 580 590 600
KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG
610 620 630 640 650
ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL
660 670 680 690 700
VGLLMAVFSD KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL
710 720 730 740 750
PFNITVTLYL AATGHYNLFF PTTLLQPASA MPNITWSEVQ VPLLLRAIPV
760 770 780 790 800
GIGQVYGCDN PWTGGIFLIA LFISSPLICL HAAIGSTMGM LAALTIATPF
810 820 830 840 850
DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF AAYLGAALAN
860 870 880 890 900
MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL
910 920
SQERNRRASI ITKYQAYDVS
Length:920
Mass (Da):101,209
Last modified:March 23, 2010 - v3
Checksum:i23BF379DC0767619
GO
Isoform 2 (identifier: Q15849-2) [UniParc]FASTAAdd to Basket

Also known as: UT-A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-523: Missing.

Show »
Length:397
Mass (Da):43,395
Checksum:i310AD64B1DFA9623
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951V → A in AAL08485. (PubMed:11502588)Curated
Sequence conflicti515 – 5151T → I in BAF85111. (PubMed:14702039)Curated
Sequence conflicti723 – 7231T → A in AAL08485. (PubMed:11502588)Curated
Sequence conflicti905 – 9051N → D in BAF85111. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371T → I.
Corresponds to variant rs34461862 [ dbSNP | Ensembl ].
VAR_057016
Natural varianti132 – 1321I → V.3 Publications
Corresponds to variant rs1484873 [ dbSNP | Ensembl ].
VAR_060255
Natural varianti443 – 4431G → S.
Corresponds to variant rs35245152 [ dbSNP | Ensembl ].
VAR_057017
Natural varianti510 – 5101R → Q.3 Publications
Corresponds to variant rs9960464 [ dbSNP | Ensembl ].
VAR_060256
Natural varianti750 – 7501V → I.
Corresponds to variant rs1123617 [ dbSNP | Ensembl ].
VAR_057018
Natural varianti880 – 8801A → T.1 Publication
Corresponds to variant rs3745009 [ dbSNP | Ensembl ].
VAR_038690

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 523523Missing in isoform 2. 1 PublicationVSP_031171Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96969 mRNA. Translation: CAA65657.1.
AF349446 mRNA. Translation: AAL08485.1.
AK292422 mRNA. Translation: BAF85111.1.
AC023421 Genomic DNA. No translation available.
BC110446 mRNA. Translation: AAI10447.1.
CCDSiCCDS11924.1. [Q15849-1]
PIRiS71339.
RefSeqiNP_001229621.1. NM_001242692.1. [Q15849-1]
NP_009094.3. NM_007163.3. [Q15849-1]
UniGeneiHs.710927.

Genome annotation databases

EnsembliENST00000255226; ENSP00000255226; ENSG00000132874. [Q15849-1]
ENST00000586448; ENSP00000465953; ENSG00000132874. [Q15849-1]
ENST00000589658; ENSP00000465349; ENSG00000132874. [Q15849-1]
GeneIDi8170.
KEGGihsa:8170.
UCSCiuc002lbe.3. human. [Q15849-1]

Polymorphism databases

DMDMi292495053.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96969 mRNA. Translation: CAA65657.1 .
AF349446 mRNA. Translation: AAL08485.1 .
AK292422 mRNA. Translation: BAF85111.1 .
AC023421 Genomic DNA. No translation available.
BC110446 mRNA. Translation: AAI10447.1 .
CCDSi CCDS11924.1. [Q15849-1 ]
PIRi S71339.
RefSeqi NP_001229621.1. NM_001242692.1. [Q15849-1 ]
NP_009094.3. NM_007163.3. [Q15849-1 ]
UniGenei Hs.710927.

3D structure databases

ProteinModelPortali Q15849.
SMRi Q15849. Positions 96-438, 559-900.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q15849. 2 interactions.
STRINGi 9606.ENSP00000255226.

Protein family/group databases

TCDBi 1.A.28.1.6. the urea transporter (ut) family.

PTM databases

PhosphoSitei Q15849.

Polymorphism databases

DMDMi 292495053.

Proteomic databases

PaxDbi Q15849.
PRIDEi Q15849.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255226 ; ENSP00000255226 ; ENSG00000132874 . [Q15849-1 ]
ENST00000586448 ; ENSP00000465953 ; ENSG00000132874 . [Q15849-1 ]
ENST00000589658 ; ENSP00000465349 ; ENSG00000132874 . [Q15849-1 ]
GeneIDi 8170.
KEGGi hsa:8170.
UCSCi uc002lbe.3. human. [Q15849-1 ]

Organism-specific databases

CTDi 8170.
GeneCardsi GC18P042792.
H-InvDB HIX0014422.
HGNCi HGNC:10919. SLC14A2.
HPAi HPA050069.
MIMi 601611. gene.
neXtProti NX_Q15849.
PharmGKBi PA35811.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4413.
GeneTreei ENSGT00390000018729.
HOGENOMi HOG000168437.
HOVERGENi HBG073255.
InParanoidi Q15849.
KOi K08716.
OMAi VCALFCA.
OrthoDBi EOG7GBFX8.
PhylomeDBi Q15849.

Enzyme and pathway databases

Reactomei REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSi SLC14A2. human.
GeneWikii SLC14A2.
GenomeRNAii 8170.
NextBioi 30845.
PROi Q15849.
SOURCEi Search...

Gene expression databases

Bgeei Q15849.
CleanExi HS_SLC14A2.
ExpressionAtlasi Q15849. baseline and differential.
Genevestigatori Q15849.

Family and domain databases

Gene3Di 1.10.3430.10. 2 hits.
InterProi IPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view ]
PANTHERi PTHR10464. PTHR10464. 1 hit.
Pfami PF03253. UT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a new urea transporter in the human kidney."
    Olives B., Sonia M., Mattei M.-G., Matassi G., Rousselet G., Ripoche P., Cartron J.-P., Bailly P.
    FEBS Lett. 386:156-160(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene."
    Bagnasco S.M., Peng T., Janech M.G., Karakashian A., Sands J.M.
    Am. J. Physiol. 281:F400-F406(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS VAL-132 AND GLN-510.
    Tissue: Kidney.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-132 AND GLN-510.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-132; GLN-510 AND THR-880.
  6. "The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein."
    Mistry A.C., Mallick R., Froehlich O., Klein J.D., Rehm A., Chen G., Sands J.M.
    J. Biol. Chem. 282:30097-30106(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNAPIN.

Entry informationi

Entry nameiUT2_HUMAN
AccessioniPrimary (citable) accession number: Q15849
Secondary accession number(s): A8K8Q7, Q2TBD6, Q96PH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: October 29, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3