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Q15849

- UT2_HUMAN

UniProt

Q15849 - UT2_HUMAN

Protein

Urea transporter 2

Gene

SLC14A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.2 Publications

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: MGI
    2. protein binding Source: IntAct
    3. urea transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. transmembrane transport Source: Reactome
    2. urea transport Source: ProtInc

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Protein family/group databases

    TCDBi1.A.28.1.6. the urea transporter (ut) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urea transporter 2
    Alternative name(s):
    Solute carrier family 14 member 2
    Urea transporter, kidney
    Gene namesi
    Name:SLC14A2
    Synonyms:HUT2, UT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:10919. SLC14A2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: ProtInc
    3. membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35811.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 920920Urea transporter 2PRO_0000065739Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei477 – 4771PhosphoserineBy similarity
    Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ15849.
    PRIDEiQ15849.

    PTM databases

    PhosphoSiteiQ15849.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.2 Publications

    Inductioni

    Isoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration.

    Gene expression databases

    ArrayExpressiQ15849.
    BgeeiQ15849.
    CleanExiHS_SLC14A2.
    GenevestigatoriQ15849.

    Organism-specific databases

    HPAiHPA050069.

    Interactioni

    Subunit structurei

    Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SNAPINO952955EBI-1633392,EBI-296723

    Protein-protein interaction databases

    IntActiQ15849. 2 interactions.
    STRINGi9606.ENSP00000255226.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15849.
    SMRiQ15849. Positions 96-438, 559-900.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei151 – 17020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei600 – 62021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei638 – 65821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei666 – 68621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei695 – 71521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei764 – 78421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei803 – 82321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei832 – 85221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei854 – 87421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the urea transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4413.
    HOGENOMiHOG000168437.
    HOVERGENiHBG073255.
    InParanoidiQ15849.
    KOiK08716.
    OMAiVCALFCA.
    OrthoDBiEOG7GBFX8.
    PhylomeDBiQ15849.

    Family and domain databases

    Gene3Di1.10.3430.10. 2 hits.
    InterProiIPR029020. Ammonium/urea_transptr.
    IPR004937. Urea_transporter.
    [Graphical view]
    PANTHERiPTHR10464. PTHR10464. 1 hit.
    PfamiPF03253. UT. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15849-1) [UniParc]FASTAAdd to Basket

    Also known as: UT-A1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK    50
    DLRSSNEDSH IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG 100
    DMKEYRIWLK DKHLALQFID WVLRGTAQVM FINNPLSGLI IFIGLLIQNP 150
    WWTITGGLGT VVSTLTALAL GQDRSAIASG LHGYNGMLVG LLMAVFSEKL 200
    DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF NIAVTLYLAA 250
    TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW 300
    TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC 350
    VLSCIAIGGM FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW 400
    AFCLATIIFL LLTTNNPAIF RLPLSKVTYP EANRIYYLTV KSGEEEKAPS 450
    GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH IEWSSIRRRS KVFGKGEHQE 500
    RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS WIRSSMAASG 550
    KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG 600
    ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL 650
    VGLLMAVFSD KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL 700
    PFNITVTLYL AATGHYNLFF PTTLLQPASA MPNITWSEVQ VPLLLRAIPV 750
    GIGQVYGCDN PWTGGIFLIA LFISSPLICL HAAIGSTMGM LAALTIATPF 800
    DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF AAYLGAALAN 850
    MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL 900
    SQERNRRASI ITKYQAYDVS 920
    Length:920
    Mass (Da):101,209
    Last modified:March 23, 2010 - v3
    Checksum:i23BF379DC0767619
    GO
    Isoform 2 (identifier: Q15849-2) [UniParc]FASTAAdd to Basket

    Also known as: UT-A2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-523: Missing.

    Show »
    Length:397
    Mass (Da):43,395
    Checksum:i310AD64B1DFA9623
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti195 – 1951V → A in AAL08485. (PubMed:11502588)Curated
    Sequence conflicti515 – 5151T → I in BAF85111. (PubMed:14702039)Curated
    Sequence conflicti723 – 7231T → A in AAL08485. (PubMed:11502588)Curated
    Sequence conflicti905 – 9051N → D in BAF85111. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371T → I.
    Corresponds to variant rs34461862 [ dbSNP | Ensembl ].
    VAR_057016
    Natural varianti132 – 1321I → V.3 Publications
    Corresponds to variant rs1484873 [ dbSNP | Ensembl ].
    VAR_060255
    Natural varianti443 – 4431G → S.
    Corresponds to variant rs35245152 [ dbSNP | Ensembl ].
    VAR_057017
    Natural varianti510 – 5101R → Q.3 Publications
    Corresponds to variant rs9960464 [ dbSNP | Ensembl ].
    VAR_060256
    Natural varianti750 – 7501V → I.
    Corresponds to variant rs1123617 [ dbSNP | Ensembl ].
    VAR_057018
    Natural varianti880 – 8801A → T.1 Publication
    Corresponds to variant rs3745009 [ dbSNP | Ensembl ].
    VAR_038690

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 523523Missing in isoform 2. 1 PublicationVSP_031171Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96969 mRNA. Translation: CAA65657.1.
    AF349446 mRNA. Translation: AAL08485.1.
    AK292422 mRNA. Translation: BAF85111.1.
    AC023421 Genomic DNA. No translation available.
    BC110446 mRNA. Translation: AAI10447.1.
    CCDSiCCDS11924.1. [Q15849-1]
    PIRiS71339.
    RefSeqiNP_001229621.1. NM_001242692.1. [Q15849-1]
    NP_009094.3. NM_007163.3. [Q15849-1]
    UniGeneiHs.710927.

    Genome annotation databases

    EnsembliENST00000255226; ENSP00000255226; ENSG00000132874. [Q15849-1]
    ENST00000586448; ENSP00000465953; ENSG00000132874. [Q15849-1]
    ENST00000589658; ENSP00000465349; ENSG00000132874. [Q15849-2]
    GeneIDi8170.
    KEGGihsa:8170.
    UCSCiuc002lbe.3. human. [Q15849-1]

    Polymorphism databases

    DMDMi292495053.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96969 mRNA. Translation: CAA65657.1 .
    AF349446 mRNA. Translation: AAL08485.1 .
    AK292422 mRNA. Translation: BAF85111.1 .
    AC023421 Genomic DNA. No translation available.
    BC110446 mRNA. Translation: AAI10447.1 .
    CCDSi CCDS11924.1. [Q15849-1 ]
    PIRi S71339.
    RefSeqi NP_001229621.1. NM_001242692.1. [Q15849-1 ]
    NP_009094.3. NM_007163.3. [Q15849-1 ]
    UniGenei Hs.710927.

    3D structure databases

    ProteinModelPortali Q15849.
    SMRi Q15849. Positions 96-438, 559-900.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q15849. 2 interactions.
    STRINGi 9606.ENSP00000255226.

    Protein family/group databases

    TCDBi 1.A.28.1.6. the urea transporter (ut) family.

    PTM databases

    PhosphoSitei Q15849.

    Polymorphism databases

    DMDMi 292495053.

    Proteomic databases

    PaxDbi Q15849.
    PRIDEi Q15849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255226 ; ENSP00000255226 ; ENSG00000132874 . [Q15849-1 ]
    ENST00000586448 ; ENSP00000465953 ; ENSG00000132874 . [Q15849-1 ]
    ENST00000589658 ; ENSP00000465349 ; ENSG00000132874 . [Q15849-2 ]
    GeneIDi 8170.
    KEGGi hsa:8170.
    UCSCi uc002lbe.3. human. [Q15849-1 ]

    Organism-specific databases

    CTDi 8170.
    GeneCardsi GC18P042747.
    H-InvDB HIX0014422.
    HGNCi HGNC:10919. SLC14A2.
    HPAi HPA050069.
    MIMi 601611. gene.
    neXtProti NX_Q15849.
    PharmGKBi PA35811.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4413.
    HOGENOMi HOG000168437.
    HOVERGENi HBG073255.
    InParanoidi Q15849.
    KOi K08716.
    OMAi VCALFCA.
    OrthoDBi EOG7GBFX8.
    PhylomeDBi Q15849.

    Enzyme and pathway databases

    Reactomei REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Miscellaneous databases

    ChiTaRSi SLC14A2. human.
    GeneWikii SLC14A2.
    GenomeRNAii 8170.
    NextBioi 30845.
    PROi Q15849.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15849.
    Bgeei Q15849.
    CleanExi HS_SLC14A2.
    Genevestigatori Q15849.

    Family and domain databases

    Gene3Di 1.10.3430.10. 2 hits.
    InterProi IPR029020. Ammonium/urea_transptr.
    IPR004937. Urea_transporter.
    [Graphical view ]
    PANTHERi PTHR10464. PTHR10464. 1 hit.
    Pfami PF03253. UT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a new urea transporter in the human kidney."
      Olives B., Sonia M., Mattei M.-G., Matassi G., Rousselet G., Ripoche P., Cartron J.-P., Bailly P.
      FEBS Lett. 386:156-160(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene."
      Bagnasco S.M., Peng T., Janech M.G., Karakashian A., Sands J.M.
      Am. J. Physiol. 281:F400-F406(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS VAL-132 AND GLN-510.
      Tissue: Kidney.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-132 AND GLN-510.
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-132; GLN-510 AND THR-880.
    6. "The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein."
      Mistry A.C., Mallick R., Froehlich O., Klein J.D., Rehm A., Chen G., Sands J.M.
      J. Biol. Chem. 282:30097-30106(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNAPIN.

    Entry informationi

    Entry nameiUT2_HUMAN
    AccessioniPrimary (citable) accession number: Q15849
    Secondary accession number(s): A8K8Q7, Q2TBD6, Q96PH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3