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Protein

Urea transporter 2

Gene

SLC14A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.2 Publications

GO - Molecular functioni

GO - Biological processi

  • response to water deprivation Source: Ensembl
  • transmembrane transport Source: Reactome
  • urea transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132874-MONOMER.
ReactomeiR-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi1.A.28.1.6. the urea transporter (ut) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
Gene namesi
Name:SLC14A2
Synonyms:HUT2, UT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:10919. SLC14A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei151 – 170HelicalSequence analysisAdd BLAST20
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei272 – 291HelicalSequence analysisAdd BLAST20
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Transmembranei666 – 686HelicalSequence analysisAdd BLAST21
Transmembranei695 – 715HelicalSequence analysisAdd BLAST21
Transmembranei764 – 784HelicalSequence analysisAdd BLAST21
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21
Transmembranei832 – 852HelicalSequence analysisAdd BLAST21
Transmembranei854 – 874HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8170.
OpenTargetsiENSG00000132874.
PharmGKBiPA35811.

Chemistry databases

DrugBankiDB03904. Urea.

Polymorphism and mutation databases

BioMutaiSLC14A2.
DMDMi292495053.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657391 – 920Urea transporter 2Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei477PhosphoserineBy similarity1
Glycosylationi733N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15849.
PRIDEiQ15849.

PTM databases

iPTMnetiQ15849.
PhosphoSitePlusiQ15849.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.2 Publications

Inductioni

Isoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration.

Gene expression databases

BgeeiENSG00000132874.
CleanExiHS_SLC14A2.
ExpressionAtlasiQ15849. baseline and differential.
GenevisibleiQ15849. HS.

Interactioni

Subunit structurei

Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNAPINO952955EBI-1633392,EBI-296723

GO - Molecular functioni

  • cell adhesion molecule binding Source: MGI

Protein-protein interaction databases

BioGridi113822. 1 interactor.
IntActiQ15849. 2 interactors.
STRINGi9606.ENSP00000255226.

Structurei

3D structure databases

ProteinModelPortaliQ15849.
SMRiQ15849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEWG. Eukaryota.
COG4413. LUCA.
GeneTreeiENSGT00390000018729.
HOGENOMiHOG000168437.
HOVERGENiHBG073255.
InParanoidiQ15849.
KOiK08716.
OMAiEFTSPSW.
OrthoDBiEOG091G095L.
PhylomeDBiQ15849.

Family and domain databases

Gene3Di1.10.3430.10. 2 hits.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15849-1) [UniParc]FASTAAdd to basket
Also known as: UT-A1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK
60 70 80 90 100
DLRSSNEDSH IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG
110 120 130 140 150
DMKEYRIWLK DKHLALQFID WVLRGTAQVM FINNPLSGLI IFIGLLIQNP
160 170 180 190 200
WWTITGGLGT VVSTLTALAL GQDRSAIASG LHGYNGMLVG LLMAVFSEKL
210 220 230 240 250
DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF NIAVTLYLAA
260 270 280 290 300
TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW
310 320 330 340 350
TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC
360 370 380 390 400
VLSCIAIGGM FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW
410 420 430 440 450
AFCLATIIFL LLTTNNPAIF RLPLSKVTYP EANRIYYLTV KSGEEEKAPS
460 470 480 490 500
GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH IEWSSIRRRS KVFGKGEHQE
510 520 530 540 550
RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS WIRSSMAASG
560 570 580 590 600
KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG
610 620 630 640 650
ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL
660 670 680 690 700
VGLLMAVFSD KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL
710 720 730 740 750
PFNITVTLYL AATGHYNLFF PTTLLQPASA MPNITWSEVQ VPLLLRAIPV
760 770 780 790 800
GIGQVYGCDN PWTGGIFLIA LFISSPLICL HAAIGSTMGM LAALTIATPF
810 820 830 840 850
DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF AAYLGAALAN
860 870 880 890 900
MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL
910 920
SQERNRRASI ITKYQAYDVS
Length:920
Mass (Da):101,209
Last modified:March 23, 2010 - v3
Checksum:i23BF379DC0767619
GO
Isoform 2 (identifier: Q15849-2) [UniParc]FASTAAdd to basket
Also known as: UT-A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-523: Missing.

Show »
Length:397
Mass (Da):43,395
Checksum:i310AD64B1DFA9623
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195V → A in AAL08485 (PubMed:11502588).Curated1
Sequence conflicti515T → I in BAF85111 (PubMed:14702039).Curated1
Sequence conflicti723T → A in AAL08485 (PubMed:11502588).Curated1
Sequence conflicti905N → D in BAF85111 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05701637T → I.Corresponds to variant rs34461862dbSNPEnsembl.1
Natural variantiVAR_060255132I → V.3 PublicationsCorresponds to variant rs1484873dbSNPEnsembl.1
Natural variantiVAR_057017443G → S.Corresponds to variant rs35245152dbSNPEnsembl.1
Natural variantiVAR_060256510R → Q.3 PublicationsCorresponds to variant rs9960464dbSNPEnsembl.1
Natural variantiVAR_057018750V → I.Corresponds to variant rs1123617dbSNPEnsembl.1
Natural variantiVAR_038690880A → T.1 PublicationCorresponds to variant rs3745009dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0311711 – 523Missing in isoform 2. 1 PublicationAdd BLAST523

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96969 mRNA. Translation: CAA65657.1.
AF349446 mRNA. Translation: AAL08485.1.
AK292422 mRNA. Translation: BAF85111.1.
AC023421 Genomic DNA. No translation available.
BC110446 mRNA. Translation: AAI10447.1.
CCDSiCCDS11924.1. [Q15849-1]
PIRiS71339.
RefSeqiNP_001229621.1. NM_001242692.1. [Q15849-1]
NP_009094.3. NM_007163.3. [Q15849-1]
XP_016881504.1. XM_017026015.1. [Q15849-1]
UniGeneiHs.710927.

Genome annotation databases

EnsembliENST00000255226; ENSP00000255226; ENSG00000132874. [Q15849-1]
ENST00000586448; ENSP00000465953; ENSG00000132874. [Q15849-1]
GeneIDi8170.
KEGGihsa:8170.
UCSCiuc002lbe.4. human. [Q15849-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96969 mRNA. Translation: CAA65657.1.
AF349446 mRNA. Translation: AAL08485.1.
AK292422 mRNA. Translation: BAF85111.1.
AC023421 Genomic DNA. No translation available.
BC110446 mRNA. Translation: AAI10447.1.
CCDSiCCDS11924.1. [Q15849-1]
PIRiS71339.
RefSeqiNP_001229621.1. NM_001242692.1. [Q15849-1]
NP_009094.3. NM_007163.3. [Q15849-1]
XP_016881504.1. XM_017026015.1. [Q15849-1]
UniGeneiHs.710927.

3D structure databases

ProteinModelPortaliQ15849.
SMRiQ15849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113822. 1 interactor.
IntActiQ15849. 2 interactors.
STRINGi9606.ENSP00000255226.

Chemistry databases

DrugBankiDB03904. Urea.

Protein family/group databases

TCDBi1.A.28.1.6. the urea transporter (ut) family.

PTM databases

iPTMnetiQ15849.
PhosphoSitePlusiQ15849.

Polymorphism and mutation databases

BioMutaiSLC14A2.
DMDMi292495053.

Proteomic databases

PaxDbiQ15849.
PRIDEiQ15849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255226; ENSP00000255226; ENSG00000132874. [Q15849-1]
ENST00000586448; ENSP00000465953; ENSG00000132874. [Q15849-1]
GeneIDi8170.
KEGGihsa:8170.
UCSCiuc002lbe.4. human. [Q15849-1]

Organism-specific databases

CTDi8170.
DisGeNETi8170.
GeneCardsiSLC14A2.
H-InvDBHIX0014422.
HGNCiHGNC:10919. SLC14A2.
MIMi601611. gene.
neXtProtiNX_Q15849.
OpenTargetsiENSG00000132874.
PharmGKBiPA35811.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEWG. Eukaryota.
COG4413. LUCA.
GeneTreeiENSGT00390000018729.
HOGENOMiHOG000168437.
HOVERGENiHBG073255.
InParanoidiQ15849.
KOiK08716.
OMAiEFTSPSW.
OrthoDBiEOG091G095L.
PhylomeDBiQ15849.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132874-MONOMER.
ReactomeiR-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSiSLC14A2. human.
GeneWikiiSLC14A2.
GenomeRNAii8170.
PROiQ15849.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132874.
CleanExiHS_SLC14A2.
ExpressionAtlasiQ15849. baseline and differential.
GenevisibleiQ15849. HS.

Family and domain databases

Gene3Di1.10.3430.10. 2 hits.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUT2_HUMAN
AccessioniPrimary (citable) accession number: Q15849
Secondary accession number(s): A8K8Q7, Q2TBD6, Q96PH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.