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Q15849 (UT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
Gene names
Name:SLC14A2
Synonyms:HUT2, UT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length920 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Ref.1 Ref.2

Subunit structure

Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane. Ref.6

Subcellular location

Apical cell membrane; Multi-pass membrane protein.

Tissue specificity

Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney. Ref.1 Ref.2

Induction

Isoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration.

Sequence similarities

Belongs to the urea transporter family.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SNAPINO952955EBI-1633392,EBI-296723

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q15849-1)

Also known as: UT-A1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q15849-2)

Also known as: UT-A2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-523: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 920920Urea transporter 2
PRO_0000065739

Regions

Transmembrane151 – 17020Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane233 – 25321Helical; Potential
Transmembrane272 – 29120Helical; Potential
Transmembrane302 – 32221Helical; Potential
Transmembrane346 – 36621Helical; Potential
Transmembrane370 – 39021Helical; Potential
Transmembrane392 – 41221Helical; Potential
Transmembrane600 – 62021Helical; Potential
Transmembrane638 – 65821Helical; Potential
Transmembrane666 – 68621Helical; Potential
Transmembrane695 – 71521Helical; Potential
Transmembrane764 – 78421Helical; Potential
Transmembrane803 – 82321Helical; Potential
Transmembrane832 – 85221Helical; Potential
Transmembrane854 – 87421Helical; Potential

Amino acid modifications

Modified residue4771Phosphoserine By similarity
Glycosylation7331N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 523523Missing in isoform 2.
VSP_031171
Natural variant371T → I.
Corresponds to variant rs34461862 [ dbSNP | Ensembl ].
VAR_057016
Natural variant1321I → V. Ref.2 Ref.3 Ref.5
Corresponds to variant rs1484873 [ dbSNP | Ensembl ].
VAR_060255
Natural variant4431G → S.
Corresponds to variant rs35245152 [ dbSNP | Ensembl ].
VAR_057017
Natural variant5101R → Q. Ref.2 Ref.3 Ref.5
Corresponds to variant rs9960464 [ dbSNP | Ensembl ].
VAR_060256
Natural variant7501V → I.
Corresponds to variant rs1123617 [ dbSNP | Ensembl ].
VAR_057018
Natural variant8801A → T. Ref.5
Corresponds to variant rs3745009 [ dbSNP | Ensembl ].
VAR_038690

Experimental info

Sequence conflict1951V → A in AAL08485. Ref.2
Sequence conflict5151T → I in BAF85111. Ref.3
Sequence conflict7231T → A in AAL08485. Ref.2
Sequence conflict9051N → D in BAF85111. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (UT-A1) [UniParc].

Last modified March 23, 2010. Version 3.
Checksum: 23BF379DC0767619

FASTA920101,209
        10         20         30         40         50         60 
MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK DLRSSNEDSH 

        70         80         90        100        110        120 
IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG DMKEYRIWLK DKHLALQFID 

       130        140        150        160        170        180 
WVLRGTAQVM FINNPLSGLI IFIGLLIQNP WWTITGGLGT VVSTLTALAL GQDRSAIASG 

       190        200        210        220        230        240 
LHGYNGMLVG LLMAVFSEKL DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF 

       250        260        270        280        290        300 
NIAVTLYLAA TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW 

       310        320        330        340        350        360 
TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC VLSCIAIGGM 

       370        380        390        400        410        420 
FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW AFCLATIIFL LLTTNNPAIF 

       430        440        450        460        470        480 
RLPLSKVTYP EANRIYYLTV KSGEEEKAPS GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH 

       490        500        510        520        530        540 
IEWSSIRRRS KVFGKGEHQE RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS 

       550        560        570        580        590        600 
WIRSSMAASG KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG 

       610        620        630        640        650        660 
ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL VGLLMAVFSD 

       670        680        690        700        710        720 
KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL PFNITVTLYL AATGHYNLFF 

       730        740        750        760        770        780 
PTTLLQPASA MPNITWSEVQ VPLLLRAIPV GIGQVYGCDN PWTGGIFLIA LFISSPLICL 

       790        800        810        820        830        840 
HAAIGSTMGM LAALTIATPF DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF 

       850        860        870        880        890        900 
AAYLGAALAN MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL 

       910        920 
SQERNRRASI ITKYQAYDVS 

« Hide

Isoform 2 (UT-A2) [UniParc].

Checksum: 310AD64B1DFA9623
Show »

FASTA39743,395

References

« Hide 'large scale' references
[1]"Molecular characterization of a new urea transporter in the human kidney."
Olives B., Sonia M., Mattei M.-G., Matassi G., Rousselet G., Ripoche P., Cartron J.-P., Bailly P.
FEBS Lett. 386:156-160(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
Tissue: Kidney.
[2]"Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene."
Bagnasco S.M., Peng T., Janech M.G., Karakashian A., Sands J.M.
Am. J. Physiol. 281:F400-F406(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS VAL-132 AND GLN-510.
Tissue: Kidney.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-132 AND GLN-510.
Tissue: Testis.
[4]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-132; GLN-510 AND THR-880.
[6]"The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein."
Mistry A.C., Mallick R., Froehlich O., Klein J.D., Rehm A., Chen G., Sands J.M.
J. Biol. Chem. 282:30097-30106(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SNAPIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X96969 mRNA. Translation: CAA65657.1.
AF349446 mRNA. Translation: AAL08485.1.
AK292422 mRNA. Translation: BAF85111.1.
AC023421 Genomic DNA. No translation available.
BC110446 mRNA. Translation: AAI10447.1.
PIRS71339.
RefSeqNP_001229621.1. NM_001242692.1.
NP_009094.3. NM_007163.3.
UniGeneHs.710927.

3D structure databases

ProteinModelPortalQ15849.
SMRQ15849. Positions 96-438, 559-900.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ15849. 2 interactions.
STRING9606.ENSP00000255226.

Protein family/group databases

TCDB1.A.28.1.6. the urea transporter (ut) family.

PTM databases

PhosphoSiteQ15849.

Polymorphism databases

DMDM292495053.

Proteomic databases

PaxDbQ15849.
PRIDEQ15849.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255226; ENSP00000255226; ENSG00000132874. [Q15849-1]
ENST00000586448; ENSP00000465953; ENSG00000132874. [Q15849-1]
ENST00000589658; ENSP00000465349; ENSG00000132874. [Q15849-2]
GeneID8170.
KEGGhsa:8170.
UCSCuc002lbe.3. human. [Q15849-1]

Organism-specific databases

CTD8170.
GeneCardsGC18P042747.
H-InvDBHIX0014422.
HGNCHGNC:10919. SLC14A2.
HPAHPA050069.
MIM601611. gene.
neXtProtNX_Q15849.
PharmGKBPA35811.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4413.
HOGENOMHOG000168437.
HOVERGENHBG073255.
InParanoidQ15849.
KOK08716.
OMAVCALFCA.
OrthoDBEOG7GBFX8.
PhylomeDBQ15849.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

ArrayExpressQ15849.
BgeeQ15849.
CleanExHS_SLC14A2.
GenevestigatorQ15849.

Family and domain databases

InterProIPR004937. Urea_transporter.
[Graphical view]
PANTHERPTHR10464. PTHR10464. 1 hit.
PfamPF03253. UT. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC14A2. human.
GeneWikiSLC14A2.
GenomeRNAi8170.
NextBio30845.
PROQ15849.
SOURCESearch...

Entry information

Entry nameUT2_HUMAN
AccessionPrimary (citable) accession number: Q15849
Secondary accession number(s): A8K8Q7, Q2TBD6, Q96PH5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: April 16, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM