SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q15849

- UT2_HUMAN

UniProt

Q15849 - UT2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Urea transporter 2
Gene
SLC14A2, HUT2, UT2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.2 Publications

GO - Molecular functioni

  1. cell adhesion molecule binding Source: MGI
  2. protein binding Source: IntAct
  3. urea transmembrane transporter activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. transmembrane transport Source: Reactome
  2. urea transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi1.A.28.1.6. the urea transporter (ut) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
Gene namesi
Name:SLC14A2
Synonyms:HUT2, UT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:10919. SLC14A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei151 – 17020Helical; Reviewed prediction
Add
BLAST
Transmembranei176 – 19621Helical; Reviewed prediction
Add
BLAST
Transmembranei204 – 22421Helical; Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST
Transmembranei272 – 29120Helical; Reviewed prediction
Add
BLAST
Transmembranei302 – 32221Helical; Reviewed prediction
Add
BLAST
Transmembranei346 – 36621Helical; Reviewed prediction
Add
BLAST
Transmembranei370 – 39021Helical; Reviewed prediction
Add
BLAST
Transmembranei392 – 41221Helical; Reviewed prediction
Add
BLAST
Transmembranei600 – 62021Helical; Reviewed prediction
Add
BLAST
Transmembranei638 – 65821Helical; Reviewed prediction
Add
BLAST
Transmembranei666 – 68621Helical; Reviewed prediction
Add
BLAST
Transmembranei695 – 71521Helical; Reviewed prediction
Add
BLAST
Transmembranei764 – 78421Helical; Reviewed prediction
Add
BLAST
Transmembranei803 – 82321Helical; Reviewed prediction
Add
BLAST
Transmembranei832 – 85221Helical; Reviewed prediction
Add
BLAST
Transmembranei854 – 87421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Urea transporter 2
PRO_0000065739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei477 – 4771Phosphoserine By similarity
Glycosylationi733 – 7331N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15849.
PRIDEiQ15849.

PTM databases

PhosphoSiteiQ15849.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.2 Publications

Inductioni

Isoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration.

Gene expression databases

ArrayExpressiQ15849.
BgeeiQ15849.
CleanExiHS_SLC14A2.
GenevestigatoriQ15849.

Organism-specific databases

HPAiHPA050069.

Interactioni

Subunit structurei

Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNAPINO952955EBI-1633392,EBI-296723

Protein-protein interaction databases

IntActiQ15849. 2 interactions.
STRINGi9606.ENSP00000255226.

Structurei

3D structure databases

ProteinModelPortaliQ15849.
SMRiQ15849. Positions 96-438, 559-900.

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4413.
HOGENOMiHOG000168437.
HOVERGENiHBG073255.
InParanoidiQ15849.
KOiK08716.
OMAiVCALFCA.
OrthoDBiEOG7GBFX8.
PhylomeDBiQ15849.

Family and domain databases

Gene3Di1.10.3430.10. 2 hits.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15849-1) [UniParc]FASTAAdd to Basket

Also known as: UT-A1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK    50
DLRSSNEDSH IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG 100
DMKEYRIWLK DKHLALQFID WVLRGTAQVM FINNPLSGLI IFIGLLIQNP 150
WWTITGGLGT VVSTLTALAL GQDRSAIASG LHGYNGMLVG LLMAVFSEKL 200
DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF NIAVTLYLAA 250
TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW 300
TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC 350
VLSCIAIGGM FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW 400
AFCLATIIFL LLTTNNPAIF RLPLSKVTYP EANRIYYLTV KSGEEEKAPS 450
GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH IEWSSIRRRS KVFGKGEHQE 500
RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS WIRSSMAASG 550
KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG 600
ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL 650
VGLLMAVFSD KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL 700
PFNITVTLYL AATGHYNLFF PTTLLQPASA MPNITWSEVQ VPLLLRAIPV 750
GIGQVYGCDN PWTGGIFLIA LFISSPLICL HAAIGSTMGM LAALTIATPF 800
DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF AAYLGAALAN 850
MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL 900
SQERNRRASI ITKYQAYDVS 920
Length:920
Mass (Da):101,209
Last modified:March 23, 2010 - v3
Checksum:i23BF379DC0767619
GO
Isoform 2 (identifier: Q15849-2) [UniParc]FASTAAdd to Basket

Also known as: UT-A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-523: Missing.

Show »
Length:397
Mass (Da):43,395
Checksum:i310AD64B1DFA9623
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371T → I.
Corresponds to variant rs34461862 [ dbSNP | Ensembl ].
VAR_057016
Natural varianti132 – 1321I → V.3 Publications
Corresponds to variant rs1484873 [ dbSNP | Ensembl ].
VAR_060255
Natural varianti443 – 4431G → S.
Corresponds to variant rs35245152 [ dbSNP | Ensembl ].
VAR_057017
Natural varianti510 – 5101R → Q.3 Publications
Corresponds to variant rs9960464 [ dbSNP | Ensembl ].
VAR_060256
Natural varianti750 – 7501V → I.
Corresponds to variant rs1123617 [ dbSNP | Ensembl ].
VAR_057018
Natural varianti880 – 8801A → T.1 Publication
Corresponds to variant rs3745009 [ dbSNP | Ensembl ].
VAR_038690

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 523523Missing in isoform 2.
VSP_031171Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951V → A in AAL08485. 1 Publication
Sequence conflicti515 – 5151T → I in BAF85111. 1 Publication
Sequence conflicti723 – 7231T → A in AAL08485. 1 Publication
Sequence conflicti905 – 9051N → D in BAF85111. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96969 mRNA. Translation: CAA65657.1.
AF349446 mRNA. Translation: AAL08485.1.
AK292422 mRNA. Translation: BAF85111.1.
AC023421 Genomic DNA. No translation available.
BC110446 mRNA. Translation: AAI10447.1.
CCDSiCCDS11924.1. [Q15849-1]
PIRiS71339.
RefSeqiNP_001229621.1. NM_001242692.1. [Q15849-1]
NP_009094.3. NM_007163.3. [Q15849-1]
UniGeneiHs.710927.

Genome annotation databases

EnsembliENST00000255226; ENSP00000255226; ENSG00000132874. [Q15849-1]
ENST00000586448; ENSP00000465953; ENSG00000132874. [Q15849-1]
ENST00000589658; ENSP00000465349; ENSG00000132874. [Q15849-2]
GeneIDi8170.
KEGGihsa:8170.
UCSCiuc002lbe.3. human. [Q15849-1]

Polymorphism databases

DMDMi292495053.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96969 mRNA. Translation: CAA65657.1 .
AF349446 mRNA. Translation: AAL08485.1 .
AK292422 mRNA. Translation: BAF85111.1 .
AC023421 Genomic DNA. No translation available.
BC110446 mRNA. Translation: AAI10447.1 .
CCDSi CCDS11924.1. [Q15849-1 ]
PIRi S71339.
RefSeqi NP_001229621.1. NM_001242692.1. [Q15849-1 ]
NP_009094.3. NM_007163.3. [Q15849-1 ]
UniGenei Hs.710927.

3D structure databases

ProteinModelPortali Q15849.
SMRi Q15849. Positions 96-438, 559-900.
ModBasei Search...

Protein-protein interaction databases

IntActi Q15849. 2 interactions.
STRINGi 9606.ENSP00000255226.

Protein family/group databases

TCDBi 1.A.28.1.6. the urea transporter (ut) family.

PTM databases

PhosphoSitei Q15849.

Polymorphism databases

DMDMi 292495053.

Proteomic databases

PaxDbi Q15849.
PRIDEi Q15849.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255226 ; ENSP00000255226 ; ENSG00000132874 . [Q15849-1 ]
ENST00000586448 ; ENSP00000465953 ; ENSG00000132874 . [Q15849-1 ]
ENST00000589658 ; ENSP00000465349 ; ENSG00000132874 . [Q15849-2 ]
GeneIDi 8170.
KEGGi hsa:8170.
UCSCi uc002lbe.3. human. [Q15849-1 ]

Organism-specific databases

CTDi 8170.
GeneCardsi GC18P042747.
H-InvDB HIX0014422.
HGNCi HGNC:10919. SLC14A2.
HPAi HPA050069.
MIMi 601611. gene.
neXtProti NX_Q15849.
PharmGKBi PA35811.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4413.
HOGENOMi HOG000168437.
HOVERGENi HBG073255.
InParanoidi Q15849.
KOi K08716.
OMAi VCALFCA.
OrthoDBi EOG7GBFX8.
PhylomeDBi Q15849.

Enzyme and pathway databases

Reactomei REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSi SLC14A2. human.
GeneWikii SLC14A2.
GenomeRNAii 8170.
NextBioi 30845.
PROi Q15849.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15849.
Bgeei Q15849.
CleanExi HS_SLC14A2.
Genevestigatori Q15849.

Family and domain databases

Gene3Di 1.10.3430.10. 2 hits.
InterProi IPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view ]
PANTHERi PTHR10464. PTHR10464. 1 hit.
Pfami PF03253. UT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a new urea transporter in the human kidney."
    Olives B., Sonia M., Mattei M.-G., Matassi G., Rousselet G., Ripoche P., Cartron J.-P., Bailly P.
    FEBS Lett. 386:156-160(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene."
    Bagnasco S.M., Peng T., Janech M.G., Karakashian A., Sands J.M.
    Am. J. Physiol. 281:F400-F406(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS VAL-132 AND GLN-510.
    Tissue: Kidney.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-132 AND GLN-510.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-132; GLN-510 AND THR-880.
  6. "The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein."
    Mistry A.C., Mallick R., Froehlich O., Klein J.D., Rehm A., Chen G., Sands J.M.
    J. Biol. Chem. 282:30097-30106(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNAPIN.

Entry informationi

Entry nameiUT2_HUMAN
AccessioniPrimary (citable) accession number: Q15849
Secondary accession number(s): A8K8Q7, Q2TBD6, Q96PH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi