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Q15848

- ADIPO_HUMAN

UniProt

Q15848 - ADIPO_HUMAN

Protein

Adiponectin

Gene

ADIPOQ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei62 – 621Not hydroxylated
    Sitei86 – 861Not hydroxylated
    Sitei104 – 1041Not hydroxylated
    Sitei230 – 2301Not glycosylated

    GO - Molecular functioni

    1. cytokine activity Source: BHF-UCL
    2. hormone activity Source: BHF-UCL
    3. identical protein binding Source: BHF-UCL
    4. protein binding Source: UniProtKB
    5. protein homodimerization activity Source: BHF-UCL
    6. receptor binding Source: UniProtKB
    7. sialic acid binding Source: UniProtKB

    GO - Biological processi

    1. adiponectin-activated signaling pathway Source: Ensembl
    2. brown fat cell differentiation Source: UniProtKB
    3. cellular response to cAMP Source: Ensembl
    4. cellular response to drug Source: UniProtKB
    5. cellular response to epinephrine stimulus Source: Ensembl
    6. cellular response to insulin stimulus Source: UniProtKB
    7. circadian rhythm Source: Ensembl
    8. detection of oxidative stress Source: UniProtKB
    9. fatty acid beta-oxidation Source: UniProtKB
    10. fatty acid oxidation Source: UniProtKB
    11. generation of precursor metabolites and energy Source: ProtInc
    12. glucose homeostasis Source: UniProtKB
    13. glucose metabolic process Source: UniProtKB
    14. low-density lipoprotein particle clearance Source: BHF-UCL
    15. membrane depolarization Source: Ensembl
    16. membrane hyperpolarization Source: Ensembl
    17. negative regulation of blood pressure Source: UniProtKB
    18. negative regulation of cell migration Source: UniProtKB
    19. negative regulation of DNA biosynthetic process Source: UniProtKB
    20. negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
    21. negative regulation of fat cell differentiation Source: BHF-UCL
    22. negative regulation of gluconeogenesis Source: BHF-UCL
    23. negative regulation of granulocyte differentiation Source: BHF-UCL
    24. negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
    25. negative regulation of hormone secretion Source: Ensembl
    26. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
    27. negative regulation of inflammatory response Source: UniProtKB
    28. negative regulation of intracellular protein transport Source: UniProtKB
    29. negative regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
    30. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    31. negative regulation of macrophage differentiation Source: BHF-UCL
    32. negative regulation of MAP kinase activity Source: UniProtKB
    33. negative regulation of metanephric mesenchymal cell migration Source: UniProtKB
    34. negative regulation of phagocytosis Source: BHF-UCL
    35. negative regulation of platelet-derived growth factor receptor-alpha signaling pathway Source: UniProtKB
    36. negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
    37. negative regulation of protein autophosphorylation Source: UniProtKB
    38. negative regulation of receptor binding Source: UniProtKB
    39. negative regulation of smooth muscle cell migration Source: UniProtKB
    40. negative regulation of smooth muscle cell proliferation Source: UniProtKB
    41. negative regulation of synaptic transmission Source: UniProtKB
    42. negative regulation of transcription, DNA-templated Source: UniProtKB
    43. negative regulation of tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
    44. negative regulation of tumor necrosis factor production Source: BHF-UCL
    45. positive regulation of blood pressure Source: Ensembl
    46. positive regulation of cAMP-dependent protein kinase activity Source: UniProtKB
    47. positive regulation of cellular protein metabolic process Source: BHF-UCL
    48. positive regulation of cholesterol efflux Source: BHF-UCL
    49. positive regulation of fatty acid metabolic process Source: BHF-UCL
    50. positive regulation of glucose import Source: BHF-UCL
    51. positive regulation of glycogen (starch) synthase activity Source: UniProtKB
    52. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    53. positive regulation of interleukin-8 production Source: UniProtKB
    54. positive regulation of metanephric glomerular visceral epithelial cell development Source: UniProtKB
    55. positive regulation of monocyte chemotactic protein-1 production Source: UniProtKB
    56. positive regulation of myeloid cell apoptotic process Source: BHF-UCL
    57. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    58. positive regulation of protein kinase A signaling Source: BHF-UCL
    59. positive regulation of protein phosphorylation Source: UniProtKB
    60. positive regulation of renal albumin absorption Source: UniProtKB
    61. positive regulation of signal transduction Source: BHF-UCL
    62. protein heterotrimerization Source: Ensembl
    63. protein homooligomerization Source: UniProtKB
    64. protein localization to plasma membrane Source: UniProtKB
    65. regulation of glucose metabolic process Source: UniProtKB
    66. response to activity Source: Ensembl
    67. response to ethanol Source: Ensembl
    68. response to glucocorticoid Source: Ensembl
    69. response to glucose Source: BHF-UCL
    70. response to hypoxia Source: Ensembl
    71. response to linoleic acid Source: Ensembl
    72. response to nutrient Source: Ensembl
    73. response to sucrose Source: Ensembl
    74. response to tumor necrosis factor Source: BHF-UCL

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_27161. Transcriptional regulation of white adipocyte differentiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adiponectin
    Alternative name(s):
    30 kDa adipocyte complement-related protein
    Adipocyte complement-related 30 kDa protein
    Short name:
    ACRP30
    Adipocyte, C1q and collagen domain-containing protein
    Adipose most abundant gene transcript 1 protein
    Short name:
    apM-1
    Gelatin-binding protein
    Gene namesi
    Name:ADIPOQ
    Synonyms:ACDC, ACRP30, APM1, GBP28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:13633. ADIPOQ.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. collagen trimer Source: UniProtKB-KW
    3. endoplasmic reticulum Source: UniProtKB
    4. extracellular region Source: Reactome
    5. extracellular space Source: UniProtKB
    6. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Adiponectin deficiency (ADPND) [MIM:612556]: A condition that results in very low concentrations of plasma adiponectin.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti112 – 1121R → C in ADPND; does not assemble into trimers resulting in impaired secretion from the cell. 2 Publications
    VAR_013274
    Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Pharmaceutical usei

    Adiponectin might be used in the treatment of diabetes type 2 and insulin resistance.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi20 – 201T → A: No change in sialylated isoforms. 1 Publication
    Mutagenesisi21 – 211T → A: Some loss of sialylated isoforms. 1 Publication
    Mutagenesisi22 – 221T → A: Abolishes sialylated isoforms. 1 Publication
    Mutagenesisi33 – 331K → R: No effect on formation of HMW multimers. 1 Publication
    Mutagenesisi36 – 361C → S: Impaired formation of MMW and HMW multimers. 2 Publications
    Mutagenesisi65 – 651K → R: Impaired formation of HMW multimers; when associated with R-68. 1 Publication
    Mutagenesisi68 – 681K → R: Impaired formation of HMW multimers; when associated with R-65. 1 Publication
    Mutagenesisi77 – 771K → R: Impaired formation of HMW multimers; when associated with R-101. 1 Publication
    Mutagenesisi101 – 1011K → R: Impaired formation of HMW multimers; when associated with R-77. 1 Publication

    Keywords - Diseasei

    Diabetes mellitus, Disease mutation, Obesity

    Organism-specific databases

    MIMi125853. phenotype.
    612556. phenotype.
    PharmGKBiPA134933118.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18182 PublicationsAdd
    BLAST
    Chaini19 – 244226AdiponectinPRO_0000003543Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211O-linked (GalNAc...)1 Publication
    Glycosylationi22 – 221O-linked (GalNAc...)1 Publication
    Modified residuei33 – 3315-hydroxylysineCurated
    Disulfide bondi36 – 36Interchain; in form MMW and form HMW2 Publications
    Modified residuei44 – 4414-hydroxyproline1 Publication
    Modified residuei47 – 4714-hydroxyproline1 Publication
    Modified residuei53 – 5314-hydroxyproline1 Publication
    Modified residuei65 – 6515-hydroxylysine1 Publication
    Glycosylationi65 – 651O-linked (Gal...); partial1 Publication
    Modified residuei68 – 6815-hydroxylysine1 Publication
    Glycosylationi68 – 681O-linked (Gal...); partial1 Publication
    Modified residuei71 – 7114-hydroxyproline; partial1 Publication
    Modified residuei76 – 7614-hydroxyproline; partial1 Publication
    Modified residuei77 – 7715-hydroxylysine1 Publication
    Glycosylationi77 – 771O-linked (Gal...); partial1 Publication
    Modified residuei91 – 9114-hydroxyproline1 Publication
    Modified residuei95 – 9514-hydroxyproline; partial1 Publication
    Modified residuei101 – 10115-hydroxylysine1 Publication
    Glycosylationi101 – 1011O-linked (Gal...); partial1 Publication

    Post-translational modificationi

    Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal peptide in mass fingerprinting.1 Publication
    HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes By similarity.By similarity
    O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    PaxDbiQ15848.
    PeptideAtlasiQ15848.
    PRIDEiQ15848.

    Expressioni

    Tissue specificityi

    Synthesized exclusively by adipocytes and secreted into plasma.

    Gene expression databases

    ArrayExpressiQ15848.
    BgeeiQ15848.
    CleanExiHS_ADIPOQ.
    GenevestigatoriQ15848.

    Organism-specific databases

    HPAiCAB046467.

    Interactioni

    Subunit structurei

    Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely additionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex) By similarity.By similarity

    Protein-protein interaction databases

    BioGridi114771. 3 interactions.
    STRINGi9606.ENSP00000320709.

    Structurei

    Secondary structure

    1
    244
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi114 – 1185
    Beta strandi134 – 1374
    Turni145 – 1473
    Beta strandi156 – 17722
    Beta strandi180 – 1878
    Beta strandi195 – 20511
    Beta strandi210 – 2156
    Beta strandi222 – 2254
    Beta strandi233 – 2419

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DOUX-ray2.00A104-244[»]
    ProteinModelPortaliQ15848.
    SMRiQ15848. Positions 109-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10766Collagen-likeAdd
    BLAST
    Domaini108 – 244137C1qPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The C1q domain is commonly called the globular domain.

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG136972.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiQ15848.
    KOiK07296.
    OMAiNANDEGH.
    OrthoDBiEOG70ZZPW.
    PhylomeDBiQ15848.
    TreeFamiTF329591.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR028572. Adiponectin.
    IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PANTHERiPTHR24022:SF81. PTHR24022:SF81. 1 hit.
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q15848-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLGAVLLL LALPGHDQET TTQGPGVLLP LPKGACTGWM AGIPGHPGHN    50
    GAPGRDGRDG TPGEKGEKGD PGLIGPKGDI GETGVPGAEG PRGFPGIQGR 100
    KGEPGEGAYV YRSAFSVGLE TYVTIPNMPI RFTKIFYNQQ NHYDGSTGKF 150
    HCNIPGLYYF AYHITVYMKD VKVSLFKKDK AMLFTYDQYQ ENNVDQASGS 200
    VLLHLEVGDQ VWLQVYGEGE RNGLYADNDN DSTFTGFLLY HDTN 244
    Length:244
    Mass (Da):26,414
    Last modified:November 1, 1996 - v1
    Checksum:i64D8C6C1204B1018
    GO

    Polymorphismi

    Genetic variations in ADIPOQ influence the variance in adiponectin serum levels and define the adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIMi:612556].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti84 – 841G → R Does not form high molecular weight multimers. 2 Publications
    VAR_013273
    Natural varianti90 – 901G → S Does not form high molecular weight multimers. 1 Publication
    Corresponds to variant rs62625753 [ dbSNP | Ensembl ].
    VAR_027395
    Natural varianti111 – 1111Y → H.1 Publication
    Corresponds to variant rs17366743 [ dbSNP | Ensembl ].
    VAR_027396
    Natural varianti112 – 1121R → C in ADPND; does not assemble into trimers resulting in impaired secretion from the cell. 2 Publications
    VAR_013274
    Natural varianti117 – 1171V → M.1 Publication
    VAR_013275
    Natural varianti164 – 1641I → T Associated with low plasma adiponectin concentration and diabetes mellitus type 2; does not assemble into trimers resulting in impaired secretion from the cell. 2 Publications
    Corresponds to variant rs185847354 [ dbSNP | Ensembl ].
    VAR_013276
    Natural varianti221 – 2211R → S.2 Publications
    Corresponds to variant rs138773406 [ dbSNP | Ensembl ].
    VAR_013277
    Natural varianti241 – 2411H → P.2 Publications
    Corresponds to variant rs141205818 [ dbSNP | Ensembl ].
    VAR_013278

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45371 mRNA. Translation: BAA08227.1.
    AB012165 Genomic DNA. Translation: BAA86716.1.
    AJ131460, AJ131461 Genomic DNA. Translation: CAB52413.1.
    BC054496 mRNA. Translation: AAH54496.1.
    BC096308 mRNA. Translation: AAH96308.1.
    BC096309 mRNA. Translation: AAH96309.1.
    BC096310 mRNA. Translation: AAH96310.1.
    BC096311 mRNA. Translation: AAH96311.1.
    CCDSiCCDS3284.1.
    PIRiJC4708.
    RefSeqiNP_001171271.1. NM_001177800.1.
    NP_004788.1. NM_004797.3.
    UniGeneiHs.80485.

    Genome annotation databases

    EnsembliENST00000320741; ENSP00000320709; ENSG00000181092.
    ENST00000444204; ENSP00000389814; ENSG00000181092.
    GeneIDi9370.
    KEGGihsa:9370.
    UCSCiuc003fra.3. human.

    Polymorphism databases

    DMDMi2493789.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Adiponectin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45371 mRNA. Translation: BAA08227.1 .
    AB012165 Genomic DNA. Translation: BAA86716.1 .
    AJ131460 , AJ131461 Genomic DNA. Translation: CAB52413.1 .
    BC054496 mRNA. Translation: AAH54496.1 .
    BC096308 mRNA. Translation: AAH96308.1 .
    BC096309 mRNA. Translation: AAH96309.1 .
    BC096310 mRNA. Translation: AAH96310.1 .
    BC096311 mRNA. Translation: AAH96311.1 .
    CCDSi CCDS3284.1.
    PIRi JC4708.
    RefSeqi NP_001171271.1. NM_001177800.1.
    NP_004788.1. NM_004797.3.
    UniGenei Hs.80485.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DOU X-ray 2.00 A 104-244 [» ]
    ProteinModelPortali Q15848.
    SMRi Q15848. Positions 109-243.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114771. 3 interactions.
    STRINGi 9606.ENSP00000320709.

    Polymorphism databases

    DMDMi 2493789.

    Proteomic databases

    PaxDbi Q15848.
    PeptideAtlasi Q15848.
    PRIDEi Q15848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320741 ; ENSP00000320709 ; ENSG00000181092 .
    ENST00000444204 ; ENSP00000389814 ; ENSG00000181092 .
    GeneIDi 9370.
    KEGGi hsa:9370.
    UCSCi uc003fra.3. human.

    Organism-specific databases

    CTDi 9370.
    GeneCardsi GC03P186560.
    HGNCi HGNC:13633. ADIPOQ.
    HPAi CAB046467.
    MIMi 125853. phenotype.
    605441. gene.
    612556. phenotype.
    neXtProti NX_Q15848.
    PharmGKBi PA134933118.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136972.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi Q15848.
    KOi K07296.
    OMAi NANDEGH.
    OrthoDBi EOG70ZZPW.
    PhylomeDBi Q15848.
    TreeFami TF329591.

    Enzyme and pathway databases

    Reactomei REACT_27161. Transcriptional regulation of white adipocyte differentiation.

    Miscellaneous databases

    ChiTaRSi ADIPOQ. human.
    GeneWikii Adiponectin.
    GenomeRNAii 9370.
    NextBioi 35094.
    PROi Q15848.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15848.
    Bgeei Q15848.
    CleanExi HS_ADIPOQ.
    Genevestigatori Q15848.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR028572. Adiponectin.
    IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    PANTHERi PTHR24022:SF81. PTHR24022:SF81. 1 hit.
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)."
      Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K.
      Biochem. Biophys. Res. Commun. 221:286-289(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adipose tissue.
    2. "Organization of the gene for gelatin-binding protein (GBP28)."
      Saito K., Tobe T., Minoshima S., Asakawa S., Sumiya J., Yoda M., Nakano Y., Shimizu N., Tomita M.
      Gene 229:67-73(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidemia (FCH)."
      Schaeffler A., Orso E., Palitzsch K.D., Buechler C., Drobnik W., Fuerst A., Schoelmerich J., Schmitz G.
      Biochem. Biophys. Res. Commun. 260:416-425(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-33.
    6. "Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma."
      Nakano Y., Tobe T., Choi-Miura N.H., Mazda T., Tomita M.
      J. Biochem. 120:803-812(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF N-TERMINUS, PARTIAL PROTEIN SEQUENCE.
    7. "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."
      Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., Matsuzawa Y.
      Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway."
      Ouchi N., Kihara S., Arita Y., Okamoto Y., Maeda K., Kuriyama H., Hotta K., Nishida M., Takahashi M., Muraguchi M., Ohmoto Y., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y.
      Circulation 102:1296-1301(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    9. Cited for: FUNCTION.
    10. "Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin."
      Waki H., Yamauchi T., Kamon J., Ito Y., Uchida S., Kita S., Hara K., Hada Y., Vasseur F., Froguel P., Kimura S., Nagai R., Kadowaki T.
      J. Biol. Chem. 278:40352-40363(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, DISULFIDE BOND, MUTAGENESIS OF CYS-36, CHARACTERIZATION OF VARIANTS ARG-84; SER-90; CYS-112 AND THR-164.
    11. "Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications."
      Richards A.A., Stephens T., Charlton H.K., Jones A., Macdonald G.A., Prins J.B., Whitehead J.P.
      Mol. Endocrinol. 20:1673-1687(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, HYDROXYLATION AT PRO-44; PRO-47; PRO-53; LYS-65; LYS-68; PRO-71; PRO-76; LYS-77; PRO-91; PRO-95 AND LYS-101, GLYCOSYLATION AT LYS-65; LYS-68; LYS-77 AND LYS-101, DISULFIDE BOND, LACK OF HYDROXYLATION AT PRO-62; PRO-86 AND PRO-104, LACK OF GLYCOSYLATION AT ASN-230, MUTAGENESIS OF LYS-33; CYS-36; LYS-65; LYS-68; LYS-77 AND LYS-101, IDENTIFICATION BY MASS SPECTROMETRY.
    12. "Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation."
      Richards A.A., Colgrave M.L., Zhang J., Webster J., Simpson F., Preston E., Wilks D., Hoehn K.L., Stephenson M., Macdonald G.A., Prins J.B., Cooney G.J., Xu A., Whitehead J.P.
      Mol. Endocrinol. 24:229-239(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT THR-21 AND THR-22, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY, MUTAGENESIS OF THR-20; THR-21 AND THR-22.
    13. "Crystal structure of a single-chain trimer of human adiponectin globular domain."
      Min X., Lemon B., Tang J., Liu Q., Zhang R., Walker N., Li Y., Wang Z.
      FEBS Lett. 586:912-917(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 104-244, SUBUNIT.
    14. Cited for: VARIANT ADPND CYS-112.
    15. "Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population."
      Hara K., Boutin P., Mori Y., Tobe K., Dina C., Yasuda K., Yamauchi T., Otabe S., Okada T., Eto K., Kadowaki H., Hagura R., Akanuma Y., Yazaki Y., Nagai R., Taniyama M., Matsubara K., Yoda M.
      , Nakano Y., Kimura S., Tomita M., Kimura S., Ito C., Froguel P., Kadowaki T.
      Diabetes 51:536-540(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-84; MET-117; THR-164; SER-221 AND PRO-241.
    16. "Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome."
      Kondo H., Shimomura I., Matsukawa Y., Kumada M., Takahashi M., Matsuda M., Ouchi N., Kihara S., Kawamoto T., Sumitsuji S., Funahashi T., Matsuzawa Y.
      Diabetes 51:2325-2328(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CYS-112; THR-164; SER-221 AND PRO-241, ASSOCIATION WITH LOW PLASMA ADIPONECTIN CONCENTRATION AND DIABETES MELLITUS TYPE 2.
    17. "Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians."
      Vasseur F., Helbecque N., Dina C., Lobbens S., Delannoy V., Gaget S., Boutin P., Vaxillaire M., Lepretre F., Dupont S., Hara K., Clement K., Bihain B., Kadowaki T., Froguel P.
      Hum. Mol. Genet. 11:2607-2614(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-84; SER-90 AND HIS-111.

    Entry informationi

    Entry nameiADIPO_HUMAN
    AccessioniPrimary (citable) accession number: Q15848
    Secondary accession number(s): Q58EX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 151 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and Thr-164 show impaired secretion of adiponectin in any form.
    HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion By similarity. In type 2 diabetic patients, both the ratios of HMW to total adiponectin and the degree of adiponectin glycosylation are significantly decreased as compared with healthy controls.By similarity

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3