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Protein

Adipogenesis regulatory factor

Gene

ADIRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.2 Publications

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • cellular response to cisplatin Source: UniProtKB
  • cellular response to radiation Source: UniProtKB
  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of response to drug Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Adipogenesis regulatory factor
Alternative name(s):
Adipogenesis factor rich in obesity
Adipose most abundant gene transcript 2 protein
Adipose-specific protein 2
Short name:
apM-2
Gene namesi
Name:ADIRF
Synonyms:AFRO, APM2, C10orf116
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148671.13
HGNCiHGNC:24043 ADIRF
neXtProtiNX_Q15847

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10974
OpenTargetsiENSG00000148671
PharmGKBiPA134930409

Polymorphism and mutation databases

BioMutaiADIRF
DMDMi8927989

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646371 – 76Adipogenesis regulatory factorAdd BLAST76

Proteomic databases

PaxDbiQ15847
PeptideAtlasiQ15847
PRIDEiQ15847

PTM databases

iPTMnetiQ15847
PhosphoSitePlusiQ15847

Expressioni

Tissue specificityi

Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen.2 Publications

Inductioni

Up-regulated during pre-adipocyte differentiation. Up-regulated following DNA damage induced by UV irradiation.2 Publications

Gene expression databases

BgeeiENSG00000148671
CleanExiHS_C10orf116
ExpressionAtlasiQ15847 baseline and differential
GenevisibleiQ15847 HS

Organism-specific databases

HPAiHPA026810

Interactioni

Protein-protein interaction databases

BioGridi116171, 2 interactors
IntActiQ15847, 2 interactors
MINTiQ15847
STRINGi9606.ENSP00000361083

Structurei

3D structure databases

ProteinModelPortaliQ15847
SMRiQ15847
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J4HH Eukaryota
ENOG41117ZY LUCA
GeneTreeiENSGT00390000017446
HOGENOMiHOG000033996
HOVERGENiHBG002691
InParanoidiQ15847
KOiK21408
OMAiQVAKTTQ
OrthoDBiEOG091G0D6Q
PhylomeDBiQ15847
TreeFamiTF341403

Family and domain databases

InterProiView protein in InterPro
IPR034450 ADIRF
PANTHERiPTHR39227 PTHR39227, 1 hit

Sequencei

Sequence statusi: Complete.

Q15847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKGLQDLK QQVEGTAQEA VSAAGAAAQQ VVDQATEAGQ KAMDQLAKTT
60 70
QETIDKTANQ ASDTFSGIGK KFGLLK
Length:76
Mass (Da):7,855
Last modified:November 1, 1996 - v1
Checksum:iC95B41F13C4BA7B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45370 mRNA Translation: BAA08226.1
AL136982 Genomic DNA No translation available.
BC004471 mRNA Translation: AAH04471.1
CCDSiCCDS7381.1
RefSeqiNP_006820.1, NM_006829.2
UniGeneiHs.642660
Hs.714477

Genome annotation databases

EnsembliENST00000372013; ENSP00000361083; ENSG00000148671
ENST00000561504; ENSP00000475582; ENSG00000148671
GeneIDi10974
KEGGihsa:10974

Similar proteinsi

Entry informationi

Entry nameiADIRF_HUMAN
AccessioniPrimary (citable) accession number: Q15847
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM

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