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Q15847

- ADIRF_HUMAN

UniProt

Q15847 - ADIRF_HUMAN

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Protein

Adipogenesis regulatory factor

Gene

ADIRF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.2 Publications

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. cellular response to cisplatin Source: UniProtKB
  3. cellular response to radiation Source: UniProtKB
  4. positive regulation of fat cell differentiation Source: UniProtKB
  5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  6. regulation of response to drug Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Adipogenesis regulatory factor
Alternative name(s):
Adipogenesis factor rich in obesity
Adipose most abundant gene transcript 2 protein
Adipose-specific protein 2
Short name:
apM-2
Gene namesi
Name:ADIRF
Synonyms:AFRO, APM2, C10orf116
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:24043. ADIRF.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. extracellular vesicular exosome Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930409.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Adipogenesis regulatory factorPRO_0000064637Add
BLAST

Proteomic databases

MaxQBiQ15847.
PaxDbiQ15847.
PeptideAtlasiQ15847.
PRIDEiQ15847.

PTM databases

PhosphoSiteiQ15847.

Expressioni

Tissue specificityi

Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen.2 Publications

Inductioni

Up-regulated during pre-adipocyte differentiation. Up-regulated following DNA damage induced by UV irradiation.2 Publications

Gene expression databases

BgeeiQ15847.
CleanExiHS_C10orf116.
ExpressionAtlasiQ15847. baseline and differential.
GenevestigatoriQ15847.

Organism-specific databases

HPAiHPA026810.

Interactioni

Protein-protein interaction databases

BioGridi116171. 3 interactions.
IntActiQ15847. 2 interactions.
MINTiMINT-8247484.
STRINGi9606.ENSP00000361083.

Structurei

3D structure databases

ProteinModelPortaliQ15847.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG85818.
HOGENOMiHOG000033996.
HOVERGENiHBG002691.
InParanoidiQ15847.
OrthoDBiEOG7QG470.
PhylomeDBiQ15847.
TreeFamiTF341403.

Sequencei

Sequence statusi: Complete.

Q15847-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKGLQDLK QQVEGTAQEA VSAAGAAAQQ VVDQATEAGQ KAMDQLAKTT
60 70
QETIDKTANQ ASDTFSGIGK KFGLLK
Length:76
Mass (Da):7,855
Last modified:November 1, 1996 - v1
Checksum:iC95B41F13C4BA7B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45370 mRNA. Translation: BAA08226.1.
AL136982 Genomic DNA. No translation available.
BC004471 mRNA. Translation: AAH04471.1.
CCDSiCCDS7381.1.
RefSeqiNP_006820.1. NM_006829.2.
UniGeneiHs.642660.
Hs.714477.

Genome annotation databases

EnsembliENST00000372013; ENSP00000361083; ENSG00000148671.
ENST00000561504; ENSP00000475582; ENSG00000148671.
GeneIDi10974.
KEGGihsa:10974.
UCSCiuc001ked.2. human.

Polymorphism databases

DMDMi8927989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45370 mRNA. Translation: BAA08226.1 .
AL136982 Genomic DNA. No translation available.
BC004471 mRNA. Translation: AAH04471.1 .
CCDSi CCDS7381.1.
RefSeqi NP_006820.1. NM_006829.2.
UniGenei Hs.642660.
Hs.714477.

3D structure databases

ProteinModelPortali Q15847.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116171. 3 interactions.
IntActi Q15847. 2 interactions.
MINTi MINT-8247484.
STRINGi 9606.ENSP00000361083.

PTM databases

PhosphoSitei Q15847.

Polymorphism databases

DMDMi 8927989.

Proteomic databases

MaxQBi Q15847.
PaxDbi Q15847.
PeptideAtlasi Q15847.
PRIDEi Q15847.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372013 ; ENSP00000361083 ; ENSG00000148671 .
ENST00000561504 ; ENSP00000475582 ; ENSG00000148671 .
GeneIDi 10974.
KEGGi hsa:10974.
UCSCi uc001ked.2. human.

Organism-specific databases

CTDi 10974.
GeneCardsi GC10P088728.
HGNCi HGNC:24043. ADIRF.
HPAi HPA026810.
neXtProti NX_Q15847.
PharmGKBi PA134930409.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85818.
HOGENOMi HOG000033996.
HOVERGENi HBG002691.
InParanoidi Q15847.
OrthoDBi EOG7QG470.
PhylomeDBi Q15847.
TreeFami TF341403.

Miscellaneous databases

GenomeRNAii 10974.
NextBioi 41700.
PROi Q15847.

Gene expression databases

Bgeei Q15847.
CleanExi HS_C10orf116.
ExpressionAtlasi Q15847. baseline and differential.
Genevestigatori Q15847.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Maeda K.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adipose tissue.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  4. Richardson M.
    Submitted (SEP-2004) to UniProtKB
    Cited for: TISSUE SPECIFICITY.
  5. "APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status."
    Scott B.J., Qutob S., Liu Q.Y., Ng C.E.
    Int. J. Cancer 125:1193-1204(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN RESISTANCE TO CISPLATIN, INDUCTION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPARgamma and C/EBPalpha."
    Ni Y., Ji C., Wang B., Qiu J., Wang J., Guo X.
    J. Bioenerg. Biomembr. 45:219-228(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiADIRF_HUMAN
AccessioniPrimary (citable) accession number: Q15847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM

External Data

Dasty 3