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Q15847 (ADIRF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adipogenesis regulatory factor
Alternative name(s):
Adipogenesis factor rich in obesity
Adipose most abundant gene transcript 2 protein
Adipose-specific protein 2
Short name=apM-2
Gene names
Name:ADIRF
Synonyms:AFRO, APM2, C10orf116
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length76 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. Ref.5 Ref.7

Subcellular location

Nucleus Ref.7.

Tissue specificity

Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen. Ref.4 Ref.7

Induction

Up-regulated during pre-adipocyte differentiation. Up-regulated following DNA damage induced by UV irradiation. Ref.5 Ref.7

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7676Adipogenesis regulatory factor
PRO_0000064637

Sequences

Sequence LengthMass (Da)Tools
Q15847 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C95B41F13C4BA7B1

FASTA767,855
        10         20         30         40         50         60 
MASKGLQDLK QQVEGTAQEA VSAAGAAAQQ VVDQATEAGQ KAMDQLAKTT QETIDKTANQ 

        70 
ASDTFSGIGK KFGLLK 

« Hide

References

« Hide 'large scale' references
[1]Maeda K.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adipose tissue.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[4]Richardson M.
Submitted (SEP-2004) to UniProtKB
Cited for: TISSUE SPECIFICITY.
[5]"APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status."
Scott B.J., Qutob S., Liu Q.Y., Ng C.E.
Int. J. Cancer 125:1193-1204(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN RESISTANCE TO CISPLATIN, INDUCTION.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPARgamma and C/EBPalpha."
Ni Y., Ji C., Wang B., Qiu J., Wang J., Guo X.
J. Bioenerg. Biomembr. 45:219-228(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D45370 mRNA. Translation: BAA08226.1.
AL136982 Genomic DNA. No translation available.
BC004471 mRNA. Translation: AAH04471.1.
CCDSCCDS7381.1.
RefSeqNP_006820.1. NM_006829.2.
UniGeneHs.642660.
Hs.714477.

3D structure databases

ProteinModelPortalQ15847.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116171. 3 interactions.
IntActQ15847. 2 interactions.
MINTMINT-8247484.
STRING9606.ENSP00000361083.

PTM databases

PhosphoSiteQ15847.

Polymorphism databases

DMDM8927989.

Proteomic databases

MaxQBQ15847.
PaxDbQ15847.
PeptideAtlasQ15847.
PRIDEQ15847.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372013; ENSP00000361083; ENSG00000148671.
ENST00000561504; ENSP00000475582; ENSG00000148671.
GeneID10974.
KEGGhsa:10974.
UCSCuc001ked.2. human.

Organism-specific databases

CTD10974.
GeneCardsGC10P088728.
HGNCHGNC:24043. ADIRF.
HPAHPA026810.
neXtProtNX_Q15847.
PharmGKBPA134930409.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85818.
HOGENOMHOG000033996.
HOVERGENHBG002691.
InParanoidQ15847.
OrthoDBEOG7QG470.
PhylomeDBQ15847.
TreeFamTF341403.

Gene expression databases

ArrayExpressQ15847.
BgeeQ15847.
CleanExHS_C10orf116.
GenevestigatorQ15847.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi10974.
NextBio41700.
PROQ15847.

Entry information

Entry nameADIRF_HUMAN
AccessionPrimary (citable) accession number: Q15847
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM