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Q15847

- ADIRF_HUMAN

UniProt

Q15847 - ADIRF_HUMAN

Protein

Adipogenesis regulatory factor

Gene

ADIRF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.2 Publications

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. cellular response to cisplatin Source: UniProtKB
    3. cellular response to radiation Source: UniProtKB
    4. positive regulation of fat cell differentiation Source: UniProtKB
    5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    6. regulation of response to drug Source: UniProtKB
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adipogenesis regulatory factor
    Alternative name(s):
    Adipogenesis factor rich in obesity
    Adipose most abundant gene transcript 2 protein
    Adipose-specific protein 2
    Short name:
    apM-2
    Gene namesi
    Name:ADIRF
    Synonyms:AFRO, APM2, C10orf116
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:24043. ADIRF.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. extracellular vesicular exosome Source: UniProt
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134930409.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7676Adipogenesis regulatory factorPRO_0000064637Add
    BLAST

    Proteomic databases

    MaxQBiQ15847.
    PaxDbiQ15847.
    PeptideAtlasiQ15847.
    PRIDEiQ15847.

    PTM databases

    PhosphoSiteiQ15847.

    Expressioni

    Tissue specificityi

    Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen.2 Publications

    Inductioni

    Up-regulated during pre-adipocyte differentiation. Up-regulated following DNA damage induced by UV irradiation.2 Publications

    Gene expression databases

    ArrayExpressiQ15847.
    BgeeiQ15847.
    CleanExiHS_C10orf116.
    GenevestigatoriQ15847.

    Organism-specific databases

    HPAiHPA026810.

    Interactioni

    Protein-protein interaction databases

    BioGridi116171. 3 interactions.
    IntActiQ15847. 2 interactions.
    MINTiMINT-8247484.
    STRINGi9606.ENSP00000361083.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15847.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG85818.
    HOGENOMiHOG000033996.
    HOVERGENiHBG002691.
    InParanoidiQ15847.
    OrthoDBiEOG7QG470.
    PhylomeDBiQ15847.
    TreeFamiTF341403.

    Sequencei

    Sequence statusi: Complete.

    Q15847-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKGLQDLK QQVEGTAQEA VSAAGAAAQQ VVDQATEAGQ KAMDQLAKTT   50
    QETIDKTANQ ASDTFSGIGK KFGLLK 76
    Length:76
    Mass (Da):7,855
    Last modified:November 1, 1996 - v1
    Checksum:iC95B41F13C4BA7B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45370 mRNA. Translation: BAA08226.1.
    AL136982 Genomic DNA. No translation available.
    BC004471 mRNA. Translation: AAH04471.1.
    CCDSiCCDS7381.1.
    RefSeqiNP_006820.1. NM_006829.2.
    UniGeneiHs.642660.
    Hs.714477.

    Genome annotation databases

    EnsembliENST00000372013; ENSP00000361083; ENSG00000148671.
    ENST00000561504; ENSP00000475582; ENSG00000148671.
    GeneIDi10974.
    KEGGihsa:10974.
    UCSCiuc001ked.2. human.

    Polymorphism databases

    DMDMi8927989.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45370 mRNA. Translation: BAA08226.1 .
    AL136982 Genomic DNA. No translation available.
    BC004471 mRNA. Translation: AAH04471.1 .
    CCDSi CCDS7381.1.
    RefSeqi NP_006820.1. NM_006829.2.
    UniGenei Hs.642660.
    Hs.714477.

    3D structure databases

    ProteinModelPortali Q15847.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116171. 3 interactions.
    IntActi Q15847. 2 interactions.
    MINTi MINT-8247484.
    STRINGi 9606.ENSP00000361083.

    PTM databases

    PhosphoSitei Q15847.

    Polymorphism databases

    DMDMi 8927989.

    Proteomic databases

    MaxQBi Q15847.
    PaxDbi Q15847.
    PeptideAtlasi Q15847.
    PRIDEi Q15847.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372013 ; ENSP00000361083 ; ENSG00000148671 .
    ENST00000561504 ; ENSP00000475582 ; ENSG00000148671 .
    GeneIDi 10974.
    KEGGi hsa:10974.
    UCSCi uc001ked.2. human.

    Organism-specific databases

    CTDi 10974.
    GeneCardsi GC10P088728.
    HGNCi HGNC:24043. ADIRF.
    HPAi HPA026810.
    neXtProti NX_Q15847.
    PharmGKBi PA134930409.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85818.
    HOGENOMi HOG000033996.
    HOVERGENi HBG002691.
    InParanoidi Q15847.
    OrthoDBi EOG7QG470.
    PhylomeDBi Q15847.
    TreeFami TF341403.

    Miscellaneous databases

    GenomeRNAii 10974.
    NextBioi 41700.
    PROi Q15847.

    Gene expression databases

    ArrayExpressi Q15847.
    Bgeei Q15847.
    CleanExi HS_C10orf116.
    Genevestigatori Q15847.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Maeda K.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adipose tissue.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    4. Richardson M.
      Submitted (SEP-2004) to UniProtKB
      Cited for: TISSUE SPECIFICITY.
    5. "APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status."
      Scott B.J., Qutob S., Liu Q.Y., Ng C.E.
      Int. J. Cancer 125:1193-1204(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN RESISTANCE TO CISPLATIN, INDUCTION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPARgamma and C/EBPalpha."
      Ni Y., Ji C., Wang B., Qiu J., Wang J., Guo X.
      J. Bioenerg. Biomembr. 45:219-228(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiADIRF_HUMAN
    AccessioniPrimary (citable) accession number: Q15847
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM

    External Data

    Dasty 3