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Protein

Clusterin-like protein 1

Gene

CLUL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Clusterin-like protein 1
Alternative name(s):
Retinal-specific clusterin-like protein
Gene namesi
Name:CLUL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:2096. CLUL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26621.

Polymorphism and mutation databases

BioMutaiCLUL1.
DMDMi78099959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 466446Clusterin-like protein 1PRO_0000005552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 333By similarity
Disulfide bondi116 ↔ 325By similarity
Disulfide bondi119 ↔ 322By similarity
Disulfide bondi124 ↔ 315By similarity
Disulfide bondi131 ↔ 305By similarity
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence analysis
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence analysis
Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence analysis
Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15846.
PaxDbiQ15846.
PeptideAtlasiQ15846.
PRIDEiQ15846.

PTM databases

iPTMnetiQ15846.
PhosphoSiteiQ15846.

Expressioni

Gene expression databases

BgeeiQ15846.
CleanExiHS_CLUL1.
ExpressionAtlasiQ15846. baseline and differential.
GenevisibleiQ15846. HS.

Organism-specific databases

HPAiCAB025264.
HPA041066.
HPA044243.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341128.

Structurei

3D structure databases

ProteinModelPortaliQ15846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili57 – 11155Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the clusterin family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IIR2. Eukaryota.
ENOG410YW4X. LUCA.
GeneTreeiENSGT00530000063668.
HOVERGENiHBG050998.
InParanoidiQ15846.
OrthoDBiEOG7D2FDN.
PhylomeDBiQ15846.
TreeFamiTF333030.

Family and domain databases

InterProiIPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPLLVFIV CLLWLKDSHC APTWKDKTAI SENLKSFSEV GEIDADEEVK
60 70 80 90 100
KALTGIKQMK IMMERKEKEH TNLMSTLKKC REEKQEALKL LNEVQEHLEE
110 120 130 140 150
EERLCRESLA DSWGECRSCL ENNCMRIYTT CQPSWSSVKN KIERFFRKIY
160 170 180 190 200
QFLFPFHEDN EKDLPISEKL IEEDAQLTQM EDVFSQLTVD VNSLFNRSFN
210 220 230 240 250
VFRQMQQEFD QTFQSHFISD TDLTEPYFFP AFSKEPMTKA DLEQCWDIPN
260 270 280 290 300
FFQLFCNFSV SIYESVSETI TKMLKAIEDL PKQDKAPDHG GLISKMLPGQ
310 320 330 340 350
DRGLCGELDQ NLSRCFKFHE KCQKCQAHLS EDCPDVPALH TELDEAIRLV
360 370 380 390 400
NVSNQQYGQI LQMTRKHLED TAYLVEKMRG QFGWVSELAN QAPETEIIFN
410 420 430 440 450
SIQVVPRIHE GNISKQDETM MTDLSILPSS NFTLKIPLEE SAESSNFIGY
460
VVAKALQHFK EHFKTW
Length:466
Mass (Da):54,215
Last modified:November 1, 1996 - v1
Checksum:i41A603D0FD6439C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395889 mRNA. Translation: AAM73723.1.
D63813 mRNA. Translation: BAA09882.1.
BC025381 mRNA. Translation: AAH25381.1.
DQ980621 mRNA. Translation: ABJ97142.1.
CCDSiCCDS42405.1.
RefSeqiNP_001305451.1. NM_001318522.1.
NP_055225.1. NM_014410.4.
NP_954636.1. NM_199167.1.
XP_011523954.1. XM_011525652.1.
XP_011523955.1. XM_011525653.1.
UniGeneiHs.732341.

Genome annotation databases

EnsembliENST00000338387; ENSP00000341128; ENSG00000079101.
ENST00000400606; ENSP00000383449; ENSG00000079101.
ENST00000579494; ENSP00000464642; ENSG00000079101.
GeneIDi27098.
KEGGihsa:27098.
UCSCiuc002kkp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395889 mRNA. Translation: AAM73723.1.
D63813 mRNA. Translation: BAA09882.1.
BC025381 mRNA. Translation: AAH25381.1.
DQ980621 mRNA. Translation: ABJ97142.1.
CCDSiCCDS42405.1.
RefSeqiNP_001305451.1. NM_001318522.1.
NP_055225.1. NM_014410.4.
NP_954636.1. NM_199167.1.
XP_011523954.1. XM_011525652.1.
XP_011523955.1. XM_011525653.1.
UniGeneiHs.732341.

3D structure databases

ProteinModelPortaliQ15846.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341128.

PTM databases

iPTMnetiQ15846.
PhosphoSiteiQ15846.

Polymorphism and mutation databases

BioMutaiCLUL1.
DMDMi78099959.

Proteomic databases

EPDiQ15846.
PaxDbiQ15846.
PeptideAtlasiQ15846.
PRIDEiQ15846.

Protocols and materials databases

DNASUi27098.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338387; ENSP00000341128; ENSG00000079101.
ENST00000400606; ENSP00000383449; ENSG00000079101.
ENST00000579494; ENSP00000464642; ENSG00000079101.
GeneIDi27098.
KEGGihsa:27098.
UCSCiuc002kkp.4. human.

Organism-specific databases

CTDi27098.
GeneCardsiCLUL1.
HGNCiHGNC:2096. CLUL1.
HPAiCAB025264.
HPA041066.
HPA044243.
neXtProtiNX_Q15846.
PharmGKBiPA26621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIR2. Eukaryota.
ENOG410YW4X. LUCA.
GeneTreeiENSGT00530000063668.
HOVERGENiHBG050998.
InParanoidiQ15846.
OrthoDBiEOG7D2FDN.
PhylomeDBiQ15846.
TreeFamiTF333030.

Miscellaneous databases

ChiTaRSiCLUL1. human.
GenomeRNAii27098.
PROiQ15846.

Gene expression databases

BgeeiQ15846.
CleanExiHS_CLUL1.
ExpressionAtlasiQ15846. baseline and differential.
GenevisibleiQ15846. HS.

Family and domain databases

InterProiIPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene."
    Zhang Q., Beltran W.A., Mao Z., Li K., Johnson J.L., Acland G.M., Aguirre G.D.
    Invest. Ophthalmol. Vis. Sci. 44:4542-4549(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression profile of active genes in human retina."
    Shimizu A., Nishida K., Kinoshita S., Inazawa J., Okubo K., Matsubara K.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Neuroretina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Mapping of transcription start sites of human retina expressed genes."
    Roni V., Carpio R., Wissinger B.
    BMC Genomics 8:42-42(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-17.
    Tissue: Retina.

Entry informationi

Entry nameiCLUL1_HUMAN
AccessioniPrimary (citable) accession number: Q15846
Secondary accession number(s): A0FDN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.