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Protein

Vesicle-associated membrane protein 3

Gene

VAMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

GO - Molecular functioni

GO - Biological processi

  • calcium ion regulated exocytosis Source: Ensembl
  • exocytosis Source: ProtInc
  • Golgi to plasma membrane protein transport Source: Ensembl
  • membrane fusion Source: ProtInc
  • negative regulation of secretion by cell Source: UniProtKB
  • positive regulation of receptor recycling Source: UniProtKB
  • protein complex assembly Source: ProtInc
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • SNARE complex assembly Source: Ensembl
  • substrate adhesion-dependent cell spreading Source: UniProtKB
  • vesicle docking involved in exocytosis Source: ProtInc
  • vesicle fusion Source: GO_Central
  • vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049245-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SIGNORiQ15836.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 3
Short name:
VAMP-3
Alternative name(s):
Cellubrevin
Short name:
CEB
Synaptobrevin-3
Gene namesi
Name:VAMP3
Synonyms:SYB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12644. VAMP3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 77CytoplasmicSequence analysisAdd BLAST76
Transmembranei78 – 98Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini99 – 100VesicularSequence analysis2

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • cell junction Source: UniProtKB-KW
  • cell surface Source: Ensembl
  • clathrin-coated vesicle Source: UniProtKB
  • clathrin-coated vesicle membrane Source: Ensembl
  • cytosol Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • intracellular Source: UniProtKB
  • intracellular membrane-bounded organelle Source: UniProtKB
  • neuron projection Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
  • recycling endosome Source: MGI
  • secretory granule Source: Ensembl
  • SNARE complex Source: UniProtKB
  • synapse Source: UniProtKB-KW
  • trans-Golgi network membrane Source: Reactome
  • transport vesicle Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi9341.
OpenTargetsiENSG00000049245.
PharmGKBiPA37268.

Polymorphism and mutation databases

BioMutaiVAMP3.
DMDMi2501082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002067282 – 100Vesicle-associated membrane protein 3Add BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15836.
PaxDbiQ15836.
PeptideAtlasiQ15836.
PRIDEiQ15836.
TopDownProteomicsiQ15836.

PTM databases

iPTMnetiQ15836.
PhosphoSitePlusiQ15836.
SwissPalmiQ15836.

Miscellaneous databases

PMAP-CutDBQ15836.

Expressioni

Gene expression databases

BgeeiENSG00000049245.
CleanExiHS_VAMP3.
ExpressionAtlasiQ15836. baseline and differential.
GenevisibleiQ15836. HS.

Interactioni

Subunit structurei

Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L13Q9BXK53EBI-722343,EBI-747430
FIGFO439154EBI-722343,EBI-11750035
PicalmO550122EBI-722343,EBI-915601From a different organism.
SNAP23O001612EBI-722343,EBI-745000
STX4Q128468EBI-722343,EBI-744942

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114747. 59 interactors.
DIPiDIP-56422N.
IntActiQ15836. 25 interactors.
STRINGi9606.ENSP00000054666.

Structurei

3D structure databases

ProteinModelPortaliQ15836.
SMRiQ15836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 74v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiQ15836.
KOiK13505.
OMAiFTHACAF.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ15836.
TreeFamiTF313666.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA
60 70 80 90 100
DALQAGASQF ETSAAKLKRK YWWKNCKMWA IGITVLVIFI IIIIVWVVSS
Length:100
Mass (Da):11,309
Last modified:January 23, 2007 - v3
Checksum:i347E9163157AFF42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77K → E in AAH05941 (PubMed:16710414).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64520 mRNA. Translation: AAB05814.1.
BT007327 mRNA. Translation: AAP35991.1.
Z98884 Genomic DNA. Translation: CAB63146.1.
BC003570 mRNA. Translation: AAH03570.1.
BC005941 mRNA. Translation: AAH05941.1.
BC007050 mRNA. Translation: AAH07050.1.
CCDSiCCDS88.1.
RefSeqiNP_004772.1. NM_004781.3.
UniGeneiHs.66708.

Genome annotation databases

EnsembliENST00000054666; ENSP00000054666; ENSG00000049245.
GeneIDi9341.
KEGGihsa:9341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64520 mRNA. Translation: AAB05814.1.
BT007327 mRNA. Translation: AAP35991.1.
Z98884 Genomic DNA. Translation: CAB63146.1.
BC003570 mRNA. Translation: AAH03570.1.
BC005941 mRNA. Translation: AAH05941.1.
BC007050 mRNA. Translation: AAH07050.1.
CCDSiCCDS88.1.
RefSeqiNP_004772.1. NM_004781.3.
UniGeneiHs.66708.

3D structure databases

ProteinModelPortaliQ15836.
SMRiQ15836.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114747. 59 interactors.
DIPiDIP-56422N.
IntActiQ15836. 25 interactors.
STRINGi9606.ENSP00000054666.

PTM databases

iPTMnetiQ15836.
PhosphoSitePlusiQ15836.
SwissPalmiQ15836.

Polymorphism and mutation databases

BioMutaiVAMP3.
DMDMi2501082.

Proteomic databases

EPDiQ15836.
PaxDbiQ15836.
PeptideAtlasiQ15836.
PRIDEiQ15836.
TopDownProteomicsiQ15836.

Protocols and materials databases

DNASUi9341.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000054666; ENSP00000054666; ENSG00000049245.
GeneIDi9341.
KEGGihsa:9341.

Organism-specific databases

CTDi9341.
DisGeNETi9341.
GeneCardsiVAMP3.
HGNCiHGNC:12644. VAMP3.
MIMi603657. gene.
neXtProtiNX_Q15836.
OpenTargetsiENSG00000049245.
PharmGKBiPA37268.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiQ15836.
KOiK13505.
OMAiFTHACAF.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ15836.
TreeFamiTF313666.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049245-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SIGNORiQ15836.

Miscellaneous databases

ChiTaRSiVAMP3. human.
GeneWikiiVAMP3.
GenomeRNAii9341.
PMAP-CutDBQ15836.
PROiQ15836.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049245.
CleanExiHS_VAMP3.
ExpressionAtlasiQ15836. baseline and differential.
GenevisibleiQ15836. HS.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAMP3_HUMAN
AccessioniPrimary (citable) accession number: Q15836
Secondary accession number(s): Q9BRV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.