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Q15836

- VAMP3_HUMAN

UniProt

Q15836 - VAMP3_HUMAN

Protein

Vesicle-associated membrane protein 3

Gene

VAMP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. calcium ion-dependent exocytosis Source: Ensembl
    2. exocytosis Source: ProtInc
    3. Golgi to plasma membrane protein transport Source: Ensembl
    4. membrane fusion Source: ProtInc
    5. positive regulation of receptor recycling Source: UniProtKB
    6. protein complex assembly Source: ProtInc
    7. retrograde transport, endosome to Golgi Source: UniProtKB
    8. substrate adhesion-dependent cell spreading Source: UniProtKB
    9. vesicle docking involved in exocytosis Source: ProtInc
    10. vesicle-mediated transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicle-associated membrane protein 3
    Short name:
    VAMP-3
    Alternative name(s):
    Cellubrevin
    Short name:
    CEB
    Synaptobrevin-3
    Gene namesi
    Name:VAMP3
    Synonyms:SYB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:12644. VAMP3.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. clathrin-coated vesicle Source: UniProtKB
    4. clathrin-coated vesicle membrane Source: Ensembl
    5. integral component of membrane Source: ProtInc
    6. neuron projection Source: UniProtKB-SubCell
    7. plasma membrane Source: UniProtKB
    8. recycling endosome Source: MGI
    9. secretory granule Source: Ensembl
    10. SNARE complex Source: Ensembl
    11. synapse Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37268.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 10099Vesicle-associated membrane protein 3PRO_0000206728Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ15836.
    PaxDbiQ15836.
    PRIDEiQ15836.

    PTM databases

    PhosphoSiteiQ15836.

    Miscellaneous databases

    PMAP-CutDBQ15836.

    Expressioni

    Gene expression databases

    ArrayExpressiQ15836.
    BgeeiQ15836.
    CleanExiHS_VAMP3.
    GenevestigatoriQ15836.

    Interactioni

    Subunit structurei

    Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PicalmO550122EBI-722343,EBI-915601From a different organism.

    Protein-protein interaction databases

    BioGridi114747. 17 interactions.
    IntActiQ15836. 12 interactions.
    STRINGi9606.ENSP00000054666.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15836.
    SMRiQ15836. Positions 11-75.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 7776CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 1002VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei78 – 9821Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 7461v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptobrevin family.Curated
    Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG266115.
    HOGENOMiHOG000042711.
    HOVERGENiHBG006675.
    InParanoidiQ15836.
    KOiK13505.
    OMAiTVADISW.
    OrthoDBiEOG7MSMRJ.
    PhylomeDBiQ15836.
    TreeFamiTF313666.

    Family and domain databases

    InterProiIPR001388. Synaptobrevin.
    IPR016444. Synaptobrevin/VAMP_met/fun.
    [Graphical view]
    PfamiPF00957. Synaptobrevin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
    PRINTSiPR00219. SYNAPTOBREVN.
    PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
    PS50892. V_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q15836-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA    50
    DALQAGASQF ETSAAKLKRK YWWKNCKMWA IGITVLVIFI IIIIVWVVSS 100
    Length:100
    Mass (Da):11,309
    Last modified:January 23, 2007 - v3
    Checksum:i347E9163157AFF42
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 771K → E in AAH05941. (PubMed:16710414)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64520 mRNA. Translation: AAB05814.1.
    BT007327 mRNA. Translation: AAP35991.1.
    Z98884 Genomic DNA. Translation: CAB63146.1.
    BC003570 mRNA. Translation: AAH03570.1.
    BC005941 mRNA. Translation: AAH05941.1.
    BC007050 mRNA. Translation: AAH07050.1.
    CCDSiCCDS88.1.
    RefSeqiNP_004772.1. NM_004781.3.
    UniGeneiHs.66708.

    Genome annotation databases

    EnsembliENST00000054666; ENSP00000054666; ENSG00000049245.
    GeneIDi9341.
    KEGGihsa:9341.
    UCSCiuc001aol.3. human.

    Polymorphism databases

    DMDMi2501082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64520 mRNA. Translation: AAB05814.1 .
    BT007327 mRNA. Translation: AAP35991.1 .
    Z98884 Genomic DNA. Translation: CAB63146.1 .
    BC003570 mRNA. Translation: AAH03570.1 .
    BC005941 mRNA. Translation: AAH05941.1 .
    BC007050 mRNA. Translation: AAH07050.1 .
    CCDSi CCDS88.1.
    RefSeqi NP_004772.1. NM_004781.3.
    UniGenei Hs.66708.

    3D structure databases

    ProteinModelPortali Q15836.
    SMRi Q15836. Positions 11-75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114747. 17 interactions.
    IntActi Q15836. 12 interactions.
    STRINGi 9606.ENSP00000054666.

    PTM databases

    PhosphoSitei Q15836.

    Polymorphism databases

    DMDMi 2501082.

    Proteomic databases

    MaxQBi Q15836.
    PaxDbi Q15836.
    PRIDEi Q15836.

    Protocols and materials databases

    DNASUi 9341.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000054666 ; ENSP00000054666 ; ENSG00000049245 .
    GeneIDi 9341.
    KEGGi hsa:9341.
    UCSCi uc001aol.3. human.

    Organism-specific databases

    CTDi 9341.
    GeneCardsi GC01P007765.
    HGNCi HGNC:12644. VAMP3.
    MIMi 603657. gene.
    neXtProti NX_Q15836.
    PharmGKBi PA37268.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG266115.
    HOGENOMi HOG000042711.
    HOVERGENi HBG006675.
    InParanoidi Q15836.
    KOi K13505.
    OMAi TVADISW.
    OrthoDBi EOG7MSMRJ.
    PhylomeDBi Q15836.
    TreeFami TF313666.

    Miscellaneous databases

    ChiTaRSi VAMP3. human.
    GeneWikii VAMP3.
    GenomeRNAii 9341.
    NextBioi 34987.
    PMAP-CutDB Q15836.
    PROi Q15836.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15836.
    Bgeei Q15836.
    CleanExi HS_VAMP3.
    Genevestigatori Q15836.

    Family and domain databases

    InterProi IPR001388. Synaptobrevin.
    IPR016444. Synaptobrevin/VAMP_met/fun.
    [Graphical view ]
    Pfami PF00957. Synaptobrevin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005409. Synaptobrevin_euk. 1 hit.
    PRINTSi PR00219. SYNAPTOBREVN.
    PROSITEi PS00417. SYNAPTOBREVIN. 1 hit.
    PS50892. V_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets."
      Bernstein A.M., Whiteheart S.W.
      Blood 93:571-579(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Urinary bladder.
    5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-14.
      Tissue: Platelet.
    6. "A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells."
      Ganley I.G., Espinosa E., Pfeffer S.R.
      J. Cell Biol. 180:159-172(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVAMP3_HUMAN
    AccessioniPrimary (citable) accession number: Q15836
    Secondary accession number(s): Q9BRV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3