SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q15836

- VAMP3_HUMAN

UniProt

Q15836 - VAMP3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Vesicle-associated membrane protein 3
Gene
VAMP3, SYB3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

GO - Molecular functioni

  1. SNAP receptor activity Source: RefGenome
  2. SNARE binding Source: RefGenome
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. Golgi to plasma membrane protein transport Source: Ensembl
  2. calcium ion-dependent exocytosis Source: Ensembl
  3. exocytosis Source: ProtInc
  4. membrane fusion Source: ProtInc
  5. neurotransmitter secretion Source: RefGenome
  6. positive regulation of receptor recycling Source: UniProtKB
  7. protein complex assembly Source: ProtInc
  8. retrograde transport, endosome to Golgi Source: UniProtKB
  9. substrate adhesion-dependent cell spreading Source: UniProtKB
  10. vesicle docking involved in exocytosis Source: ProtInc
  11. vesicle fusion Source: RefGenome
  12. vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 3
Short name:
VAMP-3
Alternative name(s):
Cellubrevin
Short name:
CEB
Synaptobrevin-3
Gene namesi
Name:VAMP3
Synonyms:SYB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:12644. VAMP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 7776Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei78 – 9821Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST
Topological domaini99 – 1002Vesicular Reviewed prediction

GO - Cellular componenti

  1. SNARE complex Source: RefGenome
  2. apical plasma membrane Source: Ensembl
  3. cell junction Source: UniProtKB-KW
  4. clathrin-coated vesicle Source: UniProtKB
  5. clathrin-coated vesicle membrane Source: Ensembl
  6. integral component of membrane Source: ProtInc
  7. neuron projection Source: UniProtKB-SubCell
  8. plasma membrane Source: UniProtKB
  9. recycling endosome Source: MGI
  10. secretory granule Source: Ensembl
  11. synaptic vesicle Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 10099Vesicle-associated membrane protein 3
PRO_0000206728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ15836.
PaxDbiQ15836.
PRIDEiQ15836.

PTM databases

PhosphoSiteiQ15836.

Miscellaneous databases

PMAP-CutDBQ15836.

Expressioni

Gene expression databases

ArrayExpressiQ15836.
BgeeiQ15836.
CleanExiHS_VAMP3.
GenevestigatoriQ15836.

Interactioni

Subunit structurei

Interacts with BVES (via the C-terminus cytoplasmic tail) By similarity. Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
PicalmO550122EBI-722343,EBI-915601From a different organism.

Protein-protein interaction databases

BioGridi114747. 17 interactions.
IntActiQ15836. 12 interactions.
STRINGi9606.ENSP00000054666.

Structurei

3D structure databases

ProteinModelPortaliQ15836.
SMRiQ15836. Positions 11-75.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 7461v-SNARE coiled-coil homology
Add
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG266115.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiQ15836.
KOiK13505.
OMAiTVADISW.
OrthoDBiEOG7MSMRJ.
PhylomeDBiQ15836.
TreeFamiTF313666.

Family and domain databases

InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP_met/fun.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15836-1 [UniParc]FASTAAdd to Basket

« Hide

MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA    50
DALQAGASQF ETSAAKLKRK YWWKNCKMWA IGITVLVIFI IIIIVWVVSS 100
Length:100
Mass (Da):11,309
Last modified:January 23, 2007 - v3
Checksum:i347E9163157AFF42
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771K → E in AAH05941. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64520 mRNA. Translation: AAB05814.1.
BT007327 mRNA. Translation: AAP35991.1.
Z98884 Genomic DNA. Translation: CAB63146.1.
BC003570 mRNA. Translation: AAH03570.1.
BC005941 mRNA. Translation: AAH05941.1.
BC007050 mRNA. Translation: AAH07050.1.
CCDSiCCDS88.1.
RefSeqiNP_004772.1. NM_004781.3.
UniGeneiHs.66708.

Genome annotation databases

EnsembliENST00000054666; ENSP00000054666; ENSG00000049245.
GeneIDi9341.
KEGGihsa:9341.
UCSCiuc001aol.3. human.

Polymorphism databases

DMDMi2501082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64520 mRNA. Translation: AAB05814.1 .
BT007327 mRNA. Translation: AAP35991.1 .
Z98884 Genomic DNA. Translation: CAB63146.1 .
BC003570 mRNA. Translation: AAH03570.1 .
BC005941 mRNA. Translation: AAH05941.1 .
BC007050 mRNA. Translation: AAH07050.1 .
CCDSi CCDS88.1.
RefSeqi NP_004772.1. NM_004781.3.
UniGenei Hs.66708.

3D structure databases

ProteinModelPortali Q15836.
SMRi Q15836. Positions 11-75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114747. 17 interactions.
IntActi Q15836. 12 interactions.
STRINGi 9606.ENSP00000054666.

PTM databases

PhosphoSitei Q15836.

Polymorphism databases

DMDMi 2501082.

Proteomic databases

MaxQBi Q15836.
PaxDbi Q15836.
PRIDEi Q15836.

Protocols and materials databases

DNASUi 9341.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000054666 ; ENSP00000054666 ; ENSG00000049245 .
GeneIDi 9341.
KEGGi hsa:9341.
UCSCi uc001aol.3. human.

Organism-specific databases

CTDi 9341.
GeneCardsi GC01P007765.
HGNCi HGNC:12644. VAMP3.
MIMi 603657. gene.
neXtProti NX_Q15836.
PharmGKBi PA37268.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG266115.
HOGENOMi HOG000042711.
HOVERGENi HBG006675.
InParanoidi Q15836.
KOi K13505.
OMAi TVADISW.
OrthoDBi EOG7MSMRJ.
PhylomeDBi Q15836.
TreeFami TF313666.

Miscellaneous databases

ChiTaRSi VAMP3. human.
GeneWikii VAMP3.
GenomeRNAii 9341.
NextBioi 34987.
PMAP-CutDB Q15836.
PROi Q15836.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15836.
Bgeei Q15836.
CleanExi HS_VAMP3.
Genevestigatori Q15836.

Family and domain databases

InterProi IPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP_met/fun.
[Graphical view ]
Pfami PF00957. Synaptobrevin. 1 hit.
[Graphical view ]
PIRSFi PIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSi PR00219. SYNAPTOBREVN.
PROSITEi PS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets."
    Bernstein A.M., Whiteheart S.W.
    Blood 93:571-579(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Urinary bladder.
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-14.
    Tissue: Platelet.
  6. "A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells."
    Ganley I.G., Espinosa E., Pfeffer S.R.
    J. Cell Biol. 180:159-172(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVAMP3_HUMAN
AccessioniPrimary (citable) accession number: Q15836
Secondary accession number(s): Q9BRV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi