Reviewed,
UniProtKB/Swiss-Prot Q15836 (VAMP3_HUMAN)
Last modified
November 25, 2008.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Vesicle-associated membrane protein 3 Short name=VAMP-3 Alternative name(s): Synaptobrevin-3 Cellubrevin Short name=CEB | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 100 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Trafficking protein from a constitutively recycling pathway By similarity. |
| Subcellular location | Membrane; Single-pass type IV membrane proteinProbable. Cell junction › synapse › synaptosomeBy similarity. |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Sequence similarities | Belongs to the synaptobrevin family. Contains 1 v-SNARE coiled-coil homology domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cell junction Membrane Synapse Synaptosome |
| Domain | Coiled coil Transmembrane |
| PTM | Phosphoprotein |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | membrane fusion Ref.1 Traceable author statement. Source: ProtInc protein complex assembly Ref.1Traceable author statement. Source: ProtInc vesicle docking during exocytosis Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Ref.1Traceable author statement. Source: ProtInc synapseInferred from electronic annotation. Source: UniProtKB-KW synaptosomeInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Chain | 2 – 100 | 99 | Vesicle-associated membrane protein 3 | PRO_0000206728 | |||||
Regions | |||||||||
| Topological domain | 2 – 77 | 76 | Cytoplasmic Potential | ||||||
| Transmembrane | 78 – 98 | 21 | Anchor for type IV membrane protein Potential | ||||||
| Topological domain | 99 – 100 | 2 | Vesicular Potential | ||||||
| Domain | 14 – 74 | 61 | v-SNARE coiled-coil homology | ||||||
Amino acid modifications | |||||||||
| Modified residue | 58 | 1 | Phosphoserine | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets." Bernstein A.M., Whiteheart S.W. Blood 93:571-579(1999) [PubMed: 9885218] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Urinary bladder. |
| [5] | "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-14. Tissue: Platelet. |
| [6] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U64520 mRNA. Translation: AAB05814.1. BT007327 mRNA. Translation: AAP35991.1. Z98884 Genomic DNA. Translation: CAB63146.1. BC003570 mRNA. Translation: AAH03570.1. BC007050 mRNA. Translation: AAH07050.1. | |
| RefSeq | NP_004772.1. |
| UniGene | Hs.66708 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1F83 based on UniProtKB P19065. |
| SMR | Q15836. Positions 11-78. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q15836. |
PTM databases | |
| PhosphoSite | Q15836. |
Genome annotation databases | |
| Ensembl | ENSG00000049245. Homo sapiens. [Contig view] |
| GeneID | 9341. |
| KEGG | hsa:9341. |
Organism-specific databases | |
| H-InvDB | HIX0000093. |
| HGNC | HGNC:12644. VAMP3. |
| MIM | 603657. gene. |
| PharmGKB | PA37268. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q15836. |
| HOVERGEN | Q15836. |
Gene expression databases | |
| ArrayExpress | Q15836. |
| CleanEx | HS_VAMP3. |
| GermOnline | ENSG00000049245. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001388. Synaptobrevin. IPR016444. Synaptobrevin_met/fun. [Graphical view] |
| Pfam | PF00957. Synaptobrevin. 1 hit. [Graphical view] |
| PIRSF | PIRSF005409. Synaptobrevin_euk. 1 hit. |
| PRINTS | PR00219. SYNAPTOBREVN. |
| ProDom | PD001229. Synaptobrevin. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00417. SYNAPTOBREVIN. 1 hit. PS50892. V_SNARE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 34987. |
| SOURCE | Search... |
Entry information
| Entry name | VAMP3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15836 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


