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Q15834

- CC85B_HUMAN

UniProt

Q15834 - CC85B_HUMAN

Protein

Coiled-coil domain-containing protein 85B

Gene

CCDC85B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. negative regulation of cell growth Source: UniProtKB
    3. negative regulation of fat cell differentiation Source: UniProtKB
    4. negative regulation of transcription, DNA-templated Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Differentiation, Growth regulation, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 85B
    Alternative name(s):
    Hepatitis delta antigen-interacting protein A
    Short name:
    Delta-interacting protein A
    Gene namesi
    Name:CCDC85B
    Synonyms:DIPA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:24926. CCDC85B.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi131 – 1311L → A: Loss of interaction with TCF7L2 and loss of suppression of CTNNB1 activity. Loss of cell growth inhibition. 1 Publication

    Organism-specific databases

    PharmGKBiPA144596453.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 202202Coiled-coil domain-containing protein 85BPRO_0000079908Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ15834.
    PaxDbiQ15834.
    PRIDEiQ15834.

    Expressioni

    Tissue specificityi

    Widely expressed including liver.

    Inductioni

    Up-regulated by doxorubicin.1 Publication

    Gene expression databases

    BgeeiQ15834.
    CleanExiHS_CCDC85B.
    GenevestigatoriQ15834.

    Organism-specific databases

    HPAiHPA054415.

    Interactioni

    Subunit structurei

    Interacts with CEBPB By similarity. May interact with CEBPD By similarity. Interacts with MCRS1. Interacts with TCF7L2; competes with CTNNB1. Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG). This interaction affects viral genomic replication in intact cells.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    C19orf25Q9UFG52EBI-739674,EBI-741214
    CHCHD3Q9NX632EBI-739674,EBI-743375
    KANSL1Q7Z3B32EBI-739674,EBI-740244
    KRT17Q046952EBI-739674,EBI-297873
    KRT6AP025382EBI-739674,EBI-702198
    PKN1Q165122EBI-739674,EBI-602382

    Protein-protein interaction databases

    BioGridi116198. 130 interactions.
    IntActiQ15834. 129 interactions.
    MINTiMINT-1433910.
    STRINGi9606.ENSP00000311695.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15834.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili43 – 9048Sequence AnalysisAdd
    BLAST
    Coiled coili118 – 14730Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC85 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG283239.
    HOGENOMiHOG000234335.
    HOVERGENiHBG107255.
    InParanoidiQ15834.
    KOiK16758.
    OMAiAREWQLF.
    OrthoDBiEOG7V49ZJ.
    PhylomeDBiQ15834.
    TreeFamiTF320243.

    Family and domain databases

    InterProiIPR019359. DUF2216_coiled-coil.
    [Graphical view]
    PfamiPF10226. DUF2216. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15834-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAEAGGLEE LTDEEMAALG KEELVRRLRR EEAARLAALV QRGRLMQEVN    50
    RQLQGHLGEI RELKQLNRRL QAENRELRDL CCFLDSERQR GRRAARQWQL 100
    FGTQASRAVR EDLGGCWQKL AELEGRQEEL LRENLALKEL CLALGEEWGP 150
    RGGPSGAGGS GAGPAPELAL PPCGPRDLGD GSSSTGSVGS PDQLPLACSP 200
    DD 202
    Length:202
    Mass (Da):22,091
    Last modified:March 7, 2006 - v2
    Checksum:iEA92D1B712A54047
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341A → T in AAB05928. (PubMed:8810253)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63825 mRNA. Translation: AAB05928.1.
    AK312109 mRNA. Translation: BAG35045.1.
    CH471076 Genomic DNA. Translation: EAW74468.1.
    BC008796 mRNA. Translation: AAH08796.1.
    CCDSiCCDS8120.1.
    RefSeqiNP_006839.2. NM_006848.2.
    UniGeneiHs.66713.

    Genome annotation databases

    EnsembliENST00000312579; ENSP00000311695; ENSG00000175602.
    GeneIDi11007.
    KEGGihsa:11007.
    UCSCiuc001ogf.3. human.

    Polymorphism databases

    DMDMi92090801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63825 mRNA. Translation: AAB05928.1 .
    AK312109 mRNA. Translation: BAG35045.1 .
    CH471076 Genomic DNA. Translation: EAW74468.1 .
    BC008796 mRNA. Translation: AAH08796.1 .
    CCDSi CCDS8120.1.
    RefSeqi NP_006839.2. NM_006848.2.
    UniGenei Hs.66713.

    3D structure databases

    ProteinModelPortali Q15834.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116198. 130 interactions.
    IntActi Q15834. 129 interactions.
    MINTi MINT-1433910.
    STRINGi 9606.ENSP00000311695.

    Polymorphism databases

    DMDMi 92090801.

    Proteomic databases

    MaxQBi Q15834.
    PaxDbi Q15834.
    PRIDEi Q15834.

    Protocols and materials databases

    DNASUi 11007.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312579 ; ENSP00000311695 ; ENSG00000175602 .
    GeneIDi 11007.
    KEGGi hsa:11007.
    UCSCi uc001ogf.3. human.

    Organism-specific databases

    CTDi 11007.
    GeneCardsi GC11P065657.
    HGNCi HGNC:24926. CCDC85B.
    HPAi HPA054415.
    MIMi 605360. gene.
    neXtProti NX_Q15834.
    PharmGKBi PA144596453.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283239.
    HOGENOMi HOG000234335.
    HOVERGENi HBG107255.
    InParanoidi Q15834.
    KOi K16758.
    OMAi AREWQLF.
    OrthoDBi EOG7V49ZJ.
    PhylomeDBi Q15834.
    TreeFami TF320243.

    Miscellaneous databases

    GeneWikii CCDC85B.
    GenomeRNAii 11007.
    NextBioi 41813.
    PROi Q15834.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15834.
    CleanExi HS_CCDC85B.
    Genevestigatori Q15834.

    Family and domain databases

    InterProi IPR019359. DUF2216_coiled-coil.
    [Graphical view ]
    Pfami PF10226. DUF2216. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution."
      Brazas R., Ganem D.
      Science 274:90-94(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Promyelocytic leukemia.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    5. "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription."
      Du X., Wang Q., Hirohashi Y., Greene M.I.
      Exp. Mol. Pathol. 81:184-190(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MCRS1, SUBCELLULAR LOCATION.
    6. "Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner."
      Iwai A., Hijikata M., Hishiki T., Isono O., Chiba T., Shimotohno K.
      Oncogene 27:1520-1526(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TCF7L2, INDUCTION BY DOXORUBICIN, MUTAGENESIS OF LEU-131, SUBCELLULAR LOCATION.
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCC85B_HUMAN
    AccessioniPrimary (citable) accession number: Q15834
    Secondary accession number(s): B2R598, Q96HA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a complex with DIPA.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3