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Protein

Coiled-coil domain-containing protein 85B

Gene

CCDC85B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Differentiation, Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175602-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 85B
Alternative name(s):
Hepatitis delta antigen-interacting protein A
Short name:
Delta-interacting protein A
Gene namesi
Name:CCDC85B
Synonyms:DIPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24926. CCDC85B.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131L → A: Loss of interaction with TCF7L2 and loss of suppression of CTNNB1 activity. Loss of cell growth inhibition. 1 Publication1

Organism-specific databases

DisGeNETi11007.
OpenTargetsiENSG00000175602.
PharmGKBiPA144596453.

Polymorphism and mutation databases

BioMutaiCCDC85B.
DMDMi92090801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799081 – 202Coiled-coil domain-containing protein 85BAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15834.
MaxQBiQ15834.
PaxDbiQ15834.
PeptideAtlasiQ15834.
PRIDEiQ15834.

PTM databases

iPTMnetiQ15834.
PhosphoSitePlusiQ15834.

Expressioni

Tissue specificityi

Widely expressed including liver.

Inductioni

Up-regulated by doxorubicin.1 Publication

Gene expression databases

BgeeiENSG00000175602.
CleanExiHS_CCDC85B.
GenevisibleiQ15834. HS.

Organism-specific databases

HPAiHPA054415.

Interactioni

Subunit structurei

Interacts with CEBPB (By similarity). May interact with CEBPD (By similarity). Interacts with MCRS1. Interacts with TCF7L2; competes with CTNNB1. Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG). This interaction affects viral genomic replication in intact cells.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
C19orf25Q9UFG52EBI-739674,EBI-741214
CHCHD3Q9NX632EBI-739674,EBI-743375
FAM74A6Q5TZK33EBI-739674,EBI-10247271
KANSL1Q7Z3B32EBI-739674,EBI-740244
KRT17Q046952EBI-739674,EBI-297873
KRT6AP025382EBI-739674,EBI-702198
PKN1Q165122EBI-739674,EBI-602382
TTC25Q96NG33EBI-739674,EBI-1046387
ZNF564Q8TBZ83EBI-739674,EBI-10273713

Protein-protein interaction databases

BioGridi116198. 147 interactors.
IntActiQ15834. 137 interactors.
MINTiMINT-1433910.
STRINGi9606.ENSP00000311695.

Structurei

3D structure databases

ProteinModelPortaliQ15834.
SMRiQ15834.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 90Sequence analysisAdd BLAST48
Coiled coili118 – 147Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the CCDC85 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3819. Eukaryota.
ENOG410YXPD. LUCA.
GeneTreeiENSGT00390000003531.
HOGENOMiHOG000234335.
HOVERGENiHBG107255.
InParanoidiQ15834.
KOiK16758.
OMAiGHHAAKV.
OrthoDBiEOG091G0MA4.
PhylomeDBiQ15834.
TreeFamiTF320243.

Family and domain databases

InterProiIPR019359. CCDC85.
[Graphical view]
PfamiPF10226. CCDC85. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEAGGLEE LTDEEMAALG KEELVRRLRR EEAARLAALV QRGRLMQEVN
60 70 80 90 100
RQLQGHLGEI RELKQLNRRL QAENRELRDL CCFLDSERQR GRRAARQWQL
110 120 130 140 150
FGTQASRAVR EDLGGCWQKL AELEGRQEEL LRENLALKEL CLALGEEWGP
160 170 180 190 200
RGGPSGAGGS GAGPAPELAL PPCGPRDLGD GSSSTGSVGS PDQLPLACSP

DD
Length:202
Mass (Da):22,091
Last modified:March 7, 2006 - v2
Checksum:iEA92D1B712A54047
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → T in AAB05928 (PubMed:8810253).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63825 mRNA. Translation: AAB05928.1.
AK312109 mRNA. Translation: BAG35045.1.
CH471076 Genomic DNA. Translation: EAW74468.1.
BC008796 mRNA. Translation: AAH08796.1.
CCDSiCCDS8120.1.
RefSeqiNP_006839.2. NM_006848.2.
UniGeneiHs.66713.

Genome annotation databases

EnsembliENST00000312579; ENSP00000311695; ENSG00000175602.
GeneIDi11007.
KEGGihsa:11007.
UCSCiuc001ogf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63825 mRNA. Translation: AAB05928.1.
AK312109 mRNA. Translation: BAG35045.1.
CH471076 Genomic DNA. Translation: EAW74468.1.
BC008796 mRNA. Translation: AAH08796.1.
CCDSiCCDS8120.1.
RefSeqiNP_006839.2. NM_006848.2.
UniGeneiHs.66713.

3D structure databases

ProteinModelPortaliQ15834.
SMRiQ15834.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116198. 147 interactors.
IntActiQ15834. 137 interactors.
MINTiMINT-1433910.
STRINGi9606.ENSP00000311695.

PTM databases

iPTMnetiQ15834.
PhosphoSitePlusiQ15834.

Polymorphism and mutation databases

BioMutaiCCDC85B.
DMDMi92090801.

Proteomic databases

EPDiQ15834.
MaxQBiQ15834.
PaxDbiQ15834.
PeptideAtlasiQ15834.
PRIDEiQ15834.

Protocols and materials databases

DNASUi11007.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312579; ENSP00000311695; ENSG00000175602.
GeneIDi11007.
KEGGihsa:11007.
UCSCiuc001ogf.4. human.

Organism-specific databases

CTDi11007.
DisGeNETi11007.
GeneCardsiCCDC85B.
HGNCiHGNC:24926. CCDC85B.
HPAiHPA054415.
MIMi605360. gene.
neXtProtiNX_Q15834.
OpenTargetsiENSG00000175602.
PharmGKBiPA144596453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3819. Eukaryota.
ENOG410YXPD. LUCA.
GeneTreeiENSGT00390000003531.
HOGENOMiHOG000234335.
HOVERGENiHBG107255.
InParanoidiQ15834.
KOiK16758.
OMAiGHHAAKV.
OrthoDBiEOG091G0MA4.
PhylomeDBiQ15834.
TreeFamiTF320243.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175602-MONOMER.

Miscellaneous databases

GeneWikiiCCDC85B.
GenomeRNAii11007.
PROiQ15834.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175602.
CleanExiHS_CCDC85B.
GenevisibleiQ15834. HS.

Family and domain databases

InterProiIPR019359. CCDC85.
[Graphical view]
PfamiPF10226. CCDC85. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCC85B_HUMAN
AccessioniPrimary (citable) accession number: Q15834
Secondary accession number(s): B2R598, Q96HA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a complex with DIPA.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.