Reviewed-Annotation score: <p>Annotation score: 4 out of 5</p>
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.</p><p><a href='../manual/annotation_score' target='_top'>More...</a></p>Annotation score: 4 out of 5-Experimental evidence at protein leveli
<p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.</p><p><a href='../manual/protein_existence' target='_top'>More...</a></p> Select a section on the left to see content.
<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni
Shows moderate inhibition of cathepsin B but is not active against cathepsin C.
Sites
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|
| <p>Describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.</p><p><a href='../manual/site' target='_top'>More...</a></p>Sitei | 36 – 36 | 1 | Reactive site |   | | |
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity
<p>Traceable Author Statement</p>
<p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementi
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi
- anatomical structure morphogenesis
<p>Traceable Author Statement</p>
<p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementi
- epidermis development
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Molecular functioni
Protease inhibitor, Thiol protease inhibitorProtein family/group databases
|
MEROPS protease database<br/><a href='/database/59'>More..</a>MEROPSi | I25.006.
|
<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
| <p>Provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.</p><p><a href='../manual/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Cystatin-MAlternative name(s): |
| <p>Indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.</p><p><a href='../manual/gene_name' target='_top'>More...</a></p>Gene namesi | |
| <p>Provides information on the name(s) of the organism that is the source of the protein sequence.</p><p><a href='../manual/organism-name' target='_top'>More...</a></p>Organismi | Homo sapiens (Human) |
| <p>Shows the unique identifier assigned by the <span class="caps">NCBI</span> to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.</p><p><a href='../manual/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 9606 [NCBI] |
| <p>Contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.</p><p><a href='../manual/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo |
| <p>Is present for entries that are part of a <a href="/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.</p><p><a href='../manual/proteomes_manual' target='_top'>More...</a></p>Proteomesi | - UP000005640
<p>A UniProt <a href="/manual/proteomes_manual">proteome</a> can consist of several components. <br />The component name refers to the genomic component encoding a set of proteins. <br />These range from a single component such as Viral genomes to several components as in the case of eukaryotic chromosomes. They may also represent different stages in a genome project and include components such as contigs, scaffolds or Whole Genome Shotgun (WGS) master records.</p><p><a href='../manual/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11
|
Organism-specific databases
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Human Gene Nomenclature Database<br/><a href='/database/42'>More..</a>HGNCi | HGNC:2478. CST6.
|
<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti
- cornified envelope
- extracellular exosome
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti
Secreted<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
Organism-specific databases
|
The Pharmacogenetics and Pharmacogenomics Knowledge Base<br/><a href='/database/74'>More..</a>PharmGKBi | PA26979.
|
Polymorphism and mutation databases
|
BioMuta curated single-nucleotide variation and disease association database<br/><a href='/database/192'>More..</a>BioMutai | CST6.
|
|
Domain mapping of disease mutations (DMDM)<br/><a href='/database/166'>More..</a>DMDMi | 2494024.
|
<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni
<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br />Examples: <a href="/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="/uniprot/O14734#expression"><span class="caps">O14734</span></a></p><p><a href='../manual/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi
Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
Gene expression databases
|
Bgee dataBase for Gene Expression Evolution<br/><a href='/database/133'>More..</a>Bgeei | ENSG00000175315.
|
|
CleanEx database of gene expression profiles<br/><a href='/database/8'>More..</a>CleanExi | HS_CST6.
|
|
Genevisible search portal to normalized and curated expression data from Genevestigator<br/><a href='/database/194'>More..</a>Genevisiblei | Q15828. HS.
|
Organism-specific databases
<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni
Protein-protein interaction databases
|
The Biological General Repository for Interaction Datasets (BioGrid)<br/><a href='/database/184'>More..</a>BioGridi | 107856. 37 interactions.
|
|
Protein interaction database and analysis system<br/><a href='/database/51'>More..</a>IntActi | Q15828. 6 interactions.
|
|
Molecular INTeraction database<br/><a href='/database/158'>More..</a>MINTi | MINT-8247486.
|
<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei
Secondary structure
Legend: HelixTurnBeta strand
Show more detailsHide details3D structure databases
<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Motif
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|
| <p>Describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.</p><p><a href='../manual/motif' target='_top'>More...</a></p>Motifi | 80 – 84 | 5 | Secondary area of contact | | | |
<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini
SignalPhylogenomic databases
|
evolutionary genealogy of genes: Non-supervised Orthologous Groups<br/><a href='/database/152'>More..</a>eggNOGi | ENOG410J4P1. Eukaryota.
ENOG410Y20I. LUCA.
|
|
Ensembl GeneTree<br/><a href='/database/162'>More..</a>GeneTreei | ENSGT00840000129890.
|
|
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms<br/><a href='/database/44'>More..</a>HOGENOMi | HOG000231754.
|
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The HOVERGEN Database of Homologous Vertebrate Genes<br/><a href='/database/45'>More..</a>HOVERGENi | HBG009556.
|
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InParanoid: Eukaryotic Ortholog Groups<br/><a href='/database/146'>More..</a>InParanoidi | Q15828.
|
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KEGG Orthology (KO)<br/><a href='/database/164'>More..</a>KOi | K13902.
|
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Identification of Orthologs from Complete Genome Data<br/><a href='/database/137'>More..</a>OMAi | SLYYFRD.
|
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Database of Orthologous Groups<br/><a href='/database/143'>More..</a>OrthoDBi | EOG091G0TP1.
|
|
Database for complete collections of gene phylogenies<br/><a href='/database/144'>More..</a>PhylomeDBi | Q15828.
|
Family and domain databases
|
Integrated resource of protein families, domains and functional sites<br/><a href='/database/52'>More..</a>InterProi | IPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view] |
|
The PANTHER Classification System<br/><a href='/database/69'>More..</a>PANTHERi | PTHR11413. PTHR11413. 1 hit.
|
|
Pfam protein domain database<br/><a href='/database/73'>More..</a>Pfami | PF00031. Cystatin. 1 hit.
[Graphical view] |
|
Simple Modular Architecture Research Tool; a protein domain database<br/><a href='/database/97'>More..</a>SMARTi | SM00043. CY. 1 hit.
[Graphical view] |
|
PROSITE; a protein domain and family database<br/><a href='/database/84'>More..</a>PROSITEi | PS00287. CYSTATIN. 1 hit.
[Graphical view] |
<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei
<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.</p><p><a href='../manual/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.
Sequence databases
Genome annotation databases
|
Ensembl eukaryotic genome annotation project<br/><a href='/database/23'>More..</a>Ensembli | ENST00000312134; ENSP00000311313; ENSG00000175315.
|
|
Database of genes from NCBI RefSeq genomes<br/><a href='/database/118'>More..</a>GeneIDi | 1474.
|
|
KEGG: Kyoto Encyclopedia of Genes and Genomes<br/><a href='/database/53'>More..</a>KEGGi | hsa:1474.
|
|
UCSC genome browser<br/><a href='/database/139'>More..</a>UCSCi | uc001ogr.4. human.
|
<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
<p>Provides links to various web resources that are relevant for a specific protein.</p><p><a href='../manual/web_resource' target='_top'>More...</a></p>Web resourcesi
Sequence databases
3D structure databases
Protein-protein interaction databases
|
The Biological General Repository for Interaction Datasets (BioGrid)<br/><a href='/database/184'>More..</a>BioGridi | 107856. 37 interactions.
|
|
Protein interaction database and analysis system<br/><a href='/database/51'>More..</a>IntActi | Q15828. 6 interactions.
|
|
Molecular INTeraction database<br/><a href='/database/158'>More..</a>MINTi | MINT-8247486.
|
Protein family/group databases
|
MEROPS protease database<br/><a href='/database/59'>More..</a>MEROPSi | I25.006.
|
PTM databases
|
iPTMnet integrated resource for PTMs in systems biology context<br/><a href='/database/200'>More..</a>iPTMneti | Q15828.
|
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Comprehensive resource for the study of human and mouse PTMs<br/><a href='/database/123'>More..</a>PhosphoSitei | Q15828.
|
Polymorphism and mutation databases
|
BioMuta curated single-nucleotide variation and disease association database<br/><a href='/database/192'>More..</a>BioMutai | CST6.
|
|
Domain mapping of disease mutations (DMDM)<br/><a href='/database/166'>More..</a>DMDMi | 2494024.
|
Proteomic databases
|
MaxQB - The MaxQuant DataBase<br/><a href='/database/186'>More..</a>MaxQBi | Q15828.
|
|
PaxDb, a database of protein abundance averages across all three domains of life<br/><a href='/database/173'>More..</a>PaxDbi | Q15828.
|
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PeptideAtlas<br/><a href='/database/71'>More..</a>PeptideAtlasi | Q15828.
|
|
PRoteomics IDEntifications database<br/><a href='/database/130'>More..</a>PRIDEi | Q15828.
|
Protocols and materials databases
|
The DNASU plasmid repository<br/><a href='/database/167'>More..</a>DNASUi | 1474.
|
|
Structural Biology Knowledgebase | Search...
|
Genome annotation databases
|
Ensembl eukaryotic genome annotation project<br/><a href='/database/23'>More..</a>Ensembli | ENST00000312134; ENSP00000311313; ENSG00000175315.
|
|
Database of genes from NCBI RefSeq genomes<br/><a href='/database/118'>More..</a>GeneIDi | 1474.
|
|
KEGG: Kyoto Encyclopedia of Genes and Genomes<br/><a href='/database/53'>More..</a>KEGGi | hsa:1474.
|
|
UCSC genome browser<br/><a href='/database/139'>More..</a>UCSCi | uc001ogr.4. human.
|
Organism-specific databases
|
Comparative Toxicogenomics Database<br/><a href='/database/140'>More..</a>CTDi | 1474.
|
|
GeneCards: human genes, protein and diseases<br/><a href='/database/30'>More..</a>GeneCardsi | CST6.
|
|
Human Gene Nomenclature Database<br/><a href='/database/42'>More..</a>HGNCi | HGNC:2478. CST6.
|
|
Human Protein Atlas<br/><a href='/database/46'>More..</a>HPAi | CAB019316.
HPA044963.
|
|
Online Mendelian Inheritance in Man (OMIM)<br/><a href='/database/62'>More..</a>MIMi | 601891. gene.
|
|
neXtProt; the human protein knowledge platform<br/><a href='/database/161'>More..</a>neXtProti | NX_Q15828.
|
|
The Pharmacogenetics and Pharmacogenomics Knowledge Base<br/><a href='/database/74'>More..</a>PharmGKBi | PA26979.
|
|
GenAtlas: human gene database<br/><a href='/database/27'>More..</a>GenAtlasi | Search...
|
Phylogenomic databases
|
evolutionary genealogy of genes: Non-supervised Orthologous Groups<br/><a href='/database/152'>More..</a>eggNOGi | ENOG410J4P1. Eukaryota.
ENOG410Y20I. LUCA.
|
|
Ensembl GeneTree<br/><a href='/database/162'>More..</a>GeneTreei | ENSGT00840000129890.
|
|
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms<br/><a href='/database/44'>More..</a>HOGENOMi | HOG000231754.
|
|
The HOVERGEN Database of Homologous Vertebrate Genes<br/><a href='/database/45'>More..</a>HOVERGENi | HBG009556.
|
|
InParanoid: Eukaryotic Ortholog Groups<br/><a href='/database/146'>More..</a>InParanoidi | Q15828.
|
|
KEGG Orthology (KO)<br/><a href='/database/164'>More..</a>KOi | K13902.
|
|
Identification of Orthologs from Complete Genome Data<br/><a href='/database/137'>More..</a>OMAi | SLYYFRD.
|
|
Database of Orthologous Groups<br/><a href='/database/143'>More..</a>OrthoDBi | EOG091G0TP1.
|
|
Database for complete collections of gene phylogenies<br/><a href='/database/144'>More..</a>PhylomeDBi | Q15828.
|
Miscellaneous databases
|
The Gene Wiki collection of pages on human genes and proteins<br/><a href='/database/180'>More..</a>GeneWikii | CST6_(gene).
|
|
Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens<br/><a href='/database/169'>More..</a>GenomeRNAii | 1474.
|
|
Protein Ontology<br/><a href='/database/181'>More..</a>PROi | Q15828.
|
|
The Stanford Online Universal Resource for Clones and ESTs<br/><a href='/database/99'>More..</a>SOURCEi | Search...
|
Gene expression databases
|
Bgee dataBase for Gene Expression Evolution<br/><a href='/database/133'>More..</a>Bgeei | ENSG00000175315.
|
|
CleanEx database of gene expression profiles<br/><a href='/database/8'>More..</a>CleanExi | HS_CST6.
|
|
Genevisible search portal to normalized and curated expression data from Genevestigator<br/><a href='/database/194'>More..</a>Genevisiblei | Q15828. HS.
|
Family and domain databases
|
Integrated resource of protein families, domains and functional sites<br/><a href='/database/52'>More..</a>InterProi | IPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view] |
|
The PANTHER Classification System<br/><a href='/database/69'>More..</a>PANTHERi | PTHR11413. PTHR11413. 1 hit.
|
|
Pfam protein domain database<br/><a href='/database/73'>More..</a>Pfami | PF00031. Cystatin. 1 hit.
[Graphical view] |
|
Simple Modular Architecture Research Tool; a protein domain database<br/><a href='/database/97'>More..</a>SMARTi | SM00043. CY. 1 hit.
[Graphical view] |
|
PROSITE; a protein domain and family database<br/><a href='/database/84'>More..</a>PROSITEi | PS00287. CYSTATIN. 1 hit.
[Graphical view] |
|
ProtoNet; Automatic hierarchical classification of proteins<br/><a href='/database/85'>More..</a>ProtoNeti | Search...
|
<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi
| <p>Provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.</p><p><a href='../manual/entry_name' target='_top'>More...</a></p>Entry namei | CYTM_HUMAN |
| <p>Provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.</p><p><a href='../manual/accession_numbers' target='_top'>More...</a></p>Accessioni | Q15828Primary (citable) accession number: Q15828
Secondary accession number(s): Q540N7 |
| <p>Shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="help/canonical_and_isoforms">canonical sequence</a> are also displayed.</p><p><a href='../manual/entry_history' target='_top'>More...</a></p>Entry historyi | | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 | | Last sequence update: | November 1, 1997 | | Last modified: | September 7, 2016 | | This is version 138 of the entry and version 1 of the sequence. [Complete history] |
|
| <p>Indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).</p><p><a href='../manual/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
| Annotation program | Chordata Protein Annotation Program |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references
- SIMILARITY comments
Index of protein domains and families
<p>Provides links to the UniProt Reference Clusters (<a href="/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.</p><p><a href='../manual/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
