CST6

Protein namesⁱ	Recommended name: Cystatin-M Alternative name(s): Cystatin-6 Cystatin-E
Gene namesⁱ	Name:CST6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2478. CST6.

HGNCⁱ

HGNC:2478. CST6.

Subcellular locationⁱ

Secreted

GO - Cellular componentⁱ

cornified envelope Source: Ensembl
extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
- 23376485
- 23533145
extracellular space Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1474.
Open Targets More...OpenTargetsⁱ	ENSG00000175315.
PharmGKBⁱ	PA26979.

Polymorphism and mutation databases

BioMutaⁱ	CST6.
DMDMⁱ	2494024.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	CuratedAdd BLAST		28
ChainⁱPRO_0000006648	29 – 149	Cystatin-MAdd BLAST		121

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	98 ↔ 113	By similarity
Disulfide bondⁱ	126 ↔ 146	By similarity
Glycosylationⁱ	137	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15828.
PaxDbⁱ	Q15828.
PeptideAtlas More...PeptideAtlasⁱ	Q15828.
PRIDEⁱ	Q15828.

PTM databases

iPTMnetⁱ	Q15828.
PhosphoSitePlusⁱ	Q15828.

Expressionⁱ

Tissue specificityⁱ

Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175315.
CleanExⁱ	HS_CST6.
Genevisibleⁱ	Q15828. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB019316. HPA044963.

HPAⁱ

CAB019316.
HPA044963.

Interactionⁱ

GO - Molecular functionⁱ

protease binding Source: GO_Central

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	107856. 37 interactors.
IntActⁱ	Q15828. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8247486.
STRINGⁱ	9606.ENSP00000311313.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	38 – 41	Combined sources	4
Helixⁱ	46 – 62	Combined sources	17
Beta strandⁱ	65 – 99	Combined sources	35
Turnⁱ	102 – 106	Combined sources	5
Helixⁱ	110 – 112	Combined sources	3
Helixⁱ	118 – 120	Combined sources	3
Beta strandⁱ	123 – 133	Combined sources	11
Helixⁱ	134 – 136	Combined sources	3
Beta strandⁱ	138 – 148	Combined sources	11

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4N6L	X-ray	1.95	A	29-149	[»]
	4N6M	X-ray	2.90	A/B	29-149	[»]
	4N6N	X-ray	1.87	B	29-149	[»]
	4N6O	X-ray	1.80	B	29-149	[»]
ProteinModelPortalⁱ	Q15828.
SMRⁱ	Q15828.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	80 – 84	Secondary area of contact		5

Sequence similaritiesⁱ

Belongs to the cystatin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J4P1. Eukaryota. ENOG410Y20I. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137924.
HOGENOMⁱ	HOG000231754.
HOVERGENⁱ	HBG009556.
InParanoidⁱ	Q15828.
KEGG Orthology (KO) More...KOⁱ	K13902.
OMAⁱ	SLYYFRD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TP1.
PhylomeDBⁱ	Q15828.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00042. CY. 1 hit.
InterProⁱ	View protein in InterPro IPR027214. Cystatin. IPR000010. Cystatin_dom. IPR018073. Prot_inh_cystat_CS.
PANTHERⁱ	PTHR11413. PTHR11413. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00031. Cystatin. 1 hit.
SMARTⁱ	View protein in SMART SM00043. CY. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00287. CYSTATIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q15828-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARSNLPLAL GLALVAFCLL ALPRDARARP QERMVGELRD LSPDDPQVQK 
        60         70         80         90        100
AAQAAVASYN MGSNSIYYFR DTHIIKAQSQ LVAGIKYFLT MEMGSTDCRK 
       110        120        130        140 
TRVTGDHVDL TTCPLAAGAQ QEKLRCDFEV LVVPWQNSSQ LLKHNCVQM

Length:149

Mass (Da):16,511

Last modified:November 1, 1997 - v1

Checksum:ⁱ2076A78BFC9FAC8C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U62800 mRNA. Translation: AAB06566.1. U81233 mRNA. Translation: AAB61305.1. AY145051 Genomic DNA. Translation: AAN52757.1. BC031334 mRNA. Translation: AAH31334.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8126.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001314.1. NM_001323.3.
UniGeneⁱ	Hs.139389.

Genome annotation databases

Ensemblⁱ	ENST00000312134; ENSP00000311313; ENSG00000175315.
GeneIDⁱ	1474.
KEGGⁱ	hsa:1474.
UCSC genome browser More...UCSCⁱ	uc001ogr.4. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U62800 mRNA. Translation: AAB06566.1. U81233 mRNA. Translation: AAB61305.1. AY145051 Genomic DNA. Translation: AAN52757.1. BC031334 mRNA. Translation: AAH31334.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8126.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001314.1. NM_001323.3.
UniGeneⁱ	Hs.139389.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4N6L	X-ray	1.95	A	29-149	[»]
	4N6M	X-ray	2.90	A/B	29-149	[»]
	4N6N	X-ray	1.87	B	29-149	[»]
	4N6O	X-ray	1.80	B	29-149	[»]
ProteinModelPortalⁱ	Q15828.
SMRⁱ	Q15828.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107856. 37 interactors.
IntActⁱ	Q15828. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8247486.
STRINGⁱ	9606.ENSP00000311313.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I25.006.

MEROPSⁱ

I25.006.

PTM databases

iPTMnetⁱ	Q15828.
PhosphoSitePlusⁱ	Q15828.

Polymorphism and mutation databases

BioMutaⁱ	CST6.
DMDMⁱ	2494024.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15828.
PaxDbⁱ	Q15828.
PeptideAtlas More...PeptideAtlasⁱ	Q15828.
PRIDEⁱ	Q15828.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1474.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000312134; ENSP00000311313; ENSG00000175315.
GeneIDⁱ	1474.
KEGGⁱ	hsa:1474.
UCSC genome browser More...UCSCⁱ	uc001ogr.4. human.

Organism-specific databases

CTDⁱ	1474.
DisGeNET More...DisGeNETⁱ	1474.
GeneCardsⁱ	CST6.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2478. CST6.
Human Protein Atlas More...HPAⁱ	CAB019316. HPA044963.
MIMⁱ	601891. gene.
neXtProtⁱ	NX_Q15828.
Open Targets More...OpenTargetsⁱ	ENSG00000175315.
PharmGKBⁱ	PA26979.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4P1. Eukaryota. ENOG410Y20I. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137924.
HOGENOMⁱ	HOG000231754.
HOVERGENⁱ	HBG009556.
InParanoidⁱ	Q15828.
KEGG Orthology (KO) More...KOⁱ	K13902.
OMAⁱ	SLYYFRD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TP1.
PhylomeDBⁱ	Q15828.

Miscellaneous databases

GeneWikiⁱ	CST6_(gene).
GenomeRNAiⁱ	1474.
Protein Ontology More...PROⁱ	PR:Q15828.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175315.
CleanExⁱ	HS_CST6.
Genevisibleⁱ	Q15828. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00042. CY. 1 hit.
InterProⁱ	View protein in InterPro IPR027214. Cystatin. IPR000010. Cystatin_dom. IPR018073. Prot_inh_cystat_CS.
PANTHERⁱ	PTHR11413. PTHR11413. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00031. Cystatin. 1 hit.
SMARTⁱ	View protein in SMART SM00043. CY. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00287. CYSTATIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CYTM_HUMAN
Accessionⁱ	Q15828Primary (citable) accession number: Q15828 Secondary accession number(s): Q540N7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	July 5, 2017
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15828 (CYTM_HUMAN)

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Cystatin-M

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ