UniProtKB - Q15828 (CYTM_HUMAN)
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Protein
Cystatin-M
Gene
CST6
Organism
Homo sapiens (Human)
Status
Functioni
Shows moderate inhibition of cathepsin B but is not active against cathepsin C.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 36 | Reactive site | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity Source: GO_Central
- protease binding Source: GO_Central
GO - Biological processi
- anatomical structure morphogenesis Source: ProtInc
- epidermis development Source: Ensembl
- negative regulation of cysteine-type endopeptidase activity Source: GO_Central
Keywordsi
Molecular function | Protease inhibitor, Thiol protease inhibitor |
Protein family/group databases
MEROPSi | I25.006. |
Names & Taxonomyi
Protein namesi | Recommended name: Cystatin-MAlternative name(s): Cystatin-6 Cystatin-E |
Gene namesi | Name:CST6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175315.2. |
HGNCi | HGNC:2478. CST6. |
MIMi | 601891. gene. |
neXtProti | NX_Q15828. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1474. |
OpenTargetsi | ENSG00000175315. |
PharmGKBi | PA26979. |
Polymorphism and mutation databases
BioMutai | CST6. |
DMDMi | 2494024. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | CuratedAdd BLAST | 28 | |
ChainiPRO_0000006648 | 29 – 149 | Cystatin-MAdd BLAST | 121 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 98 ↔ 113 | By similarity | ||
Disulfide bondi | 126 ↔ 146 | By similarity | ||
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor.
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q15828. |
PaxDbi | Q15828. |
PeptideAtlasi | Q15828. |
PRIDEi | Q15828. |
PTM databases
iPTMneti | Q15828. |
PhosphoSitePlusi | Q15828. |
Expressioni
Tissue specificityi
Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.1 Publication
Gene expression databases
Bgeei | ENSG00000175315. |
CleanExi | HS_CST6. |
Genevisiblei | Q15828. HS. |
Organism-specific databases
HPAi | CAB019316. HPA044963. |
Interactioni
GO - Molecular functioni
- protease binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 107856. 42 interactors. |
IntActi | Q15828. 8 interactors. |
MINTi | Q15828. |
STRINGi | 9606.ENSP00000311313. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 38 – 41 | Combined sources | 4 | |
Helixi | 46 – 62 | Combined sources | 17 | |
Beta strandi | 65 – 99 | Combined sources | 35 | |
Turni | 102 – 106 | Combined sources | 5 | |
Helixi | 110 – 112 | Combined sources | 3 | |
Helixi | 118 – 120 | Combined sources | 3 | |
Beta strandi | 123 – 133 | Combined sources | 11 | |
Helixi | 134 – 136 | Combined sources | 3 | |
Beta strandi | 138 – 148 | Combined sources | 11 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4N6L | X-ray | 1.95 | A | 29-149 | [»] | |
4N6M | X-ray | 2.90 | A/B | 29-149 | [»] | |
4N6N | X-ray | 1.87 | B | 29-149 | [»] | |
4N6O | X-ray | 1.80 | B | 29-149 | [»] | |
ProteinModelPortali | Q15828. | |||||
SMRi | Q15828. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 80 – 84 | Secondary area of contact | 5 |
Sequence similaritiesi
Belongs to the cystatin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410J4P1. Eukaryota. ENOG410Y20I. LUCA. |
GeneTreei | ENSGT00900000140934. |
HOGENOMi | HOG000231754. |
HOVERGENi | HBG009556. |
InParanoidi | Q15828. |
KOi | K13902. |
OMAi | SLYYFRD. |
OrthoDBi | EOG091G0TP1. |
PhylomeDBi | Q15828. |
Family and domain databases
CDDi | cd00042. CY. 1 hit. |
InterProi | View protein in InterPro IPR027214. Cystatin. IPR000010. Cystatin_dom. IPR018073. Prot_inh_cystat_CS. |
PANTHERi | PTHR11413. PTHR11413. 1 hit. |
Pfami | View protein in Pfam PF00031. Cystatin. 1 hit. |
SMARTi | View protein in SMART SM00043. CY. 1 hit. |
PROSITEi | View protein in PROSITE PS00287. CYSTATIN. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q15828-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARSNLPLAL GLALVAFCLL ALPRDARARP QERMVGELRD LSPDDPQVQK
60 70 80 90 100
AAQAAVASYN MGSNSIYYFR DTHIIKAQSQ LVAGIKYFLT MEMGSTDCRK
110 120 130 140
TRVTGDHVDL TTCPLAAGAQ QEKLRCDFEV LVVPWQNSSQ LLKHNCVQM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62800 mRNA. Translation: AAB06566.1. U81233 mRNA. Translation: AAB61305.1. AY145051 Genomic DNA. Translation: AAN52757.1. BC031334 mRNA. Translation: AAH31334.1. |
CCDSi | CCDS8126.1. |
RefSeqi | NP_001314.1. NM_001323.3. |
UniGenei | Hs.139389. |
Genome annotation databases
Ensembli | ENST00000312134; ENSP00000311313; ENSG00000175315. |
GeneIDi | 1474. |
KEGGi | hsa:1474. |
UCSCi | uc001ogr.4. human. |
Similar proteinsi
Entry informationi
Entry namei | CYTM_HUMAN | |
Accessioni | Q15828Primary (citable) accession number: Q15828 Secondary accession number(s): Q540N7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |