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Protein

Neuronal acetylcholine receptor subunit alpha-6

Gene

CHRNA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine-activated cation-selective channel activity Source: ProtInc
  • acetylcholine receptor activity Source: ProtInc
  • ligand-gated ion channel activity Source: Reactome

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • membrane depolarization Source: Ensembl
  • neuromuscular synaptic transmission Source: GO_Central
  • regulation of dopamine secretion Source: Ensembl
  • response to nicotine Source: GO_Central
  • signal transduction Source: ProtInc
  • synaptic transmission, cholinergic Source: GO_Central
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147434-MONOMER.
ReactomeiR-HSA-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-HSA-629597. Highly calcium permeable nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-6
Gene namesi
Name:CHRNA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:15963. CHRNA6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 239ExtracellularAdd BLAST214
Transmembranei240 – 264HelicalSequence analysisAdd BLAST25
Transmembranei272 – 290HelicalSequence analysisAdd BLAST19
Transmembranei306 – 327HelicalSequence analysisAdd BLAST22
Topological domaini328 – 465CytoplasmicAdd BLAST138
Transmembranei466 – 484HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: ProtInc
  • cell junction Source: UniProtKB-KW
  • plasma membrane Source: Reactome
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi8973.
OpenTargetsiENSG00000147434.
PharmGKBiPA26492.

Chemistry databases

ChEMBLiCHEMBL2109233.
DrugBankiDB09028. Cytisine.
DB00898. Ethanol.
DB00674. Galantamine.
DB00184. Nicotine.
DB01273. Varenicline.
GuidetoPHARMACOLOGYi467.

Polymorphism and mutation databases

BioMutaiCHRNA6.
DMDMi2492620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000036026 – 494Neuronal acetylcholine receptor subunit alpha-6Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi158 ↔ 172By similarity
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi222 ↔ 223Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15825.
PRIDEiQ15825.

PTM databases

iPTMnetiQ15825.
PhosphoSitePlusiQ15825.

Expressioni

Gene expression databases

BgeeiENSG00000147434.
CleanExiHS_CHRNA6.
ExpressionAtlasiQ15825. baseline and differential.
GenevisibleiQ15825. HS.

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta).

Protein-protein interaction databases

IntActiQ15825. 1 interactor.
STRINGi9606.ENSP00000276410.

Chemistry databases

BindingDBiQ15825.

Structurei

3D structure databases

ProteinModelPortaliQ15825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ15825.
KOiK04808.
OMAiCVFTPFF.
OrthoDBiEOG091G0R20.
PhylomeDBiQ15825.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15825-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTSKGQGFL HGGLCLWLCV FTPFFKGCVG CATEERLFHK LFSHYNQFIR
60 70 80 90 100
PVENVSDPVT VHFEVAITQL ANVDEVNQIM ETNLWLRHIW NDYKLRWDPM
110 120 130 140 150
EYDGIETLRV PADKIWKPDI VLYNNAVGDF QVEGKTKALL KYNGMITWTP
160 170 180 190 200
PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT YDKAEIDLLI IGSKVDMNDF
210 220 230 240 250
WENSEWEIID ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP MFYTINLIIP
260 270 280 290 300
CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVV
310 320 330 340 350
PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPTTHTMPRW VKTVFLKLLP
360 370 380 390 400
QVLLMRWPLD KTRGTGSDAV PRGLARRPAK GKLASHGEPR HLKECFHCHK
410 420 430 440 450
SNELATSKRR LSHQPLQWVV ENSEHSPEVE DVINSVQFIA ENMKSHNETK
460 470 480 490
EVEDDWKYVA MVVDRVFLWV FIIVCVFGTA GLFLQPLLGN TGKS
Length:494
Mass (Da):56,898
Last modified:November 1, 1997 - v1
Checksum:i1A437E6DEE02ABFE
GO
Isoform 2 (identifier: Q15825-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Note: No experimental confirmation available.
Show »
Length:479
Mass (Da):55,018
Checksum:i87749CBC64674D70
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048171447N → S.Corresponds to variant rs16891583dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04271374 – 88Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62435 mRNA. Translation: AAB40113.1.
Y16282 mRNA. Translation: CAA76155.1.
AB079251 Genomic DNA. Translation: BAC06855.1.
AK298798 mRNA. Translation: BAG60933.1.
AK313521 mRNA. Translation: BAG36301.1.
AC087533 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63207.1.
BC014456 mRNA. Translation: AAH14456.1.
CCDSiCCDS56536.1. [Q15825-2]
CCDS6135.1. [Q15825-1]
RefSeqiNP_001186208.1. NM_001199279.1. [Q15825-2]
NP_004189.1. NM_004198.3. [Q15825-1]
UniGeneiHs.103128.

Genome annotation databases

EnsembliENST00000276410; ENSP00000276410; ENSG00000147434. [Q15825-1]
ENST00000534622; ENSP00000433871; ENSG00000147434. [Q15825-2]
GeneIDi8973.
KEGGihsa:8973.
UCSCiuc003xpj.5. human. [Q15825-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62435 mRNA. Translation: AAB40113.1.
Y16282 mRNA. Translation: CAA76155.1.
AB079251 Genomic DNA. Translation: BAC06855.1.
AK298798 mRNA. Translation: BAG60933.1.
AK313521 mRNA. Translation: BAG36301.1.
AC087533 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63207.1.
BC014456 mRNA. Translation: AAH14456.1.
CCDSiCCDS56536.1. [Q15825-2]
CCDS6135.1. [Q15825-1]
RefSeqiNP_001186208.1. NM_001199279.1. [Q15825-2]
NP_004189.1. NM_004198.3. [Q15825-1]
UniGeneiHs.103128.

3D structure databases

ProteinModelPortaliQ15825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ15825. 1 interactor.
STRINGi9606.ENSP00000276410.

Chemistry databases

BindingDBiQ15825.
ChEMBLiCHEMBL2109233.
DrugBankiDB09028. Cytisine.
DB00898. Ethanol.
DB00674. Galantamine.
DB00184. Nicotine.
DB01273. Varenicline.
GuidetoPHARMACOLOGYi467.

PTM databases

iPTMnetiQ15825.
PhosphoSitePlusiQ15825.

Polymorphism and mutation databases

BioMutaiCHRNA6.
DMDMi2492620.

Proteomic databases

PaxDbiQ15825.
PRIDEiQ15825.

Protocols and materials databases

DNASUi8973.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276410; ENSP00000276410; ENSG00000147434. [Q15825-1]
ENST00000534622; ENSP00000433871; ENSG00000147434. [Q15825-2]
GeneIDi8973.
KEGGihsa:8973.
UCSCiuc003xpj.5. human. [Q15825-1]

Organism-specific databases

CTDi8973.
DisGeNETi8973.
GeneCardsiCHRNA6.
HGNCiHGNC:15963. CHRNA6.
MIMi606888. gene.
neXtProtiNX_Q15825.
OpenTargetsiENSG00000147434.
PharmGKBiPA26492.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ15825.
KOiK04808.
OMAiCVFTPFF.
OrthoDBiEOG091G0R20.
PhylomeDBiQ15825.
TreeFamiTF315605.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147434-MONOMER.
ReactomeiR-HSA-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-HSA-629597. Highly calcium permeable nicotinic acetylcholine receptors.

Miscellaneous databases

GeneWikiiCHRNA6.
GenomeRNAii8973.
PROiQ15825.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147434.
CleanExiHS_CHRNA6.
ExpressionAtlasiQ15825. baseline and differential.
GenevisibleiQ15825. HS.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA6_HUMAN
AccessioniPrimary (citable) accession number: Q15825
Secondary accession number(s): B2R8V4, B4DQH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.