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Protein

Ubiquitin-conjugating enzyme E2 variant 2

Gene

UBE2V2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BRENDAi2.3.2.B6. 2681.
ReactomeiR-HSA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-HSA-5693571. Nonhomologous End-Joining (NHEJ).
R-HSA-5693607. Processing of DNA double-strand break ends.
R-HSA-5696395. Formation of Incision Complex in GG-NER.
R-HSA-69473. G2/M DNA damage checkpoint.
R-HSA-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ15819.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 2
Alternative name(s):
DDVit 1
Enterocyte differentiation-associated factor 1
Short name:
EDAF-1
Enterocyte differentiation-promoting factor 1
Short name:
EDPF-1
MMS2 homolog
Vitamin D3-inducible protein
Gene namesi
Name:UBE2V2
Synonyms:MMS2, UEV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169139.11.
HGNCiHGNC:12495. UBE2V2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169139.
PharmGKBiPA37143.

Polymorphism and mutation databases

BioMutaiUBE2V2.
DMDMi51701935.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000826022 – 145Ubiquitin-conjugating enzyme E2 variant 2Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15819.
MaxQBiQ15819.
PaxDbiQ15819.
PeptideAtlasiQ15819.
PRIDEiQ15819.
TopDownProteomicsiQ15819.

PTM databases

iPTMnetiQ15819.
PhosphoSitePlusiQ15819.

Expressioni

Tissue specificityi

Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.2 Publications

Inductioni

Up-regulated in cultured fresh blood cells upon treatment with vitamin D3.1 Publication

Gene expression databases

BgeeiENSG00000169139.
CleanExiHS_UBE2V2.
ExpressionAtlasiQ15819. baseline and differential.
GenevisibleiQ15819. HS.

Organism-specific databases

HPAiHPA052535.
HPA053186.

Interactioni

Subunit structurei

Heterodimer with UBE2N. Binds CHFR.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113184. 57 interactors.
CORUMiQ15819.
DIPiDIP-29830N.
IntActiQ15819. 25 interactors.
MINTiMINT-1368221.
STRINGi9606.ENSP00000428209.

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 24Combined sources14
Beta strandi29 – 37Combined sources9
Beta strandi45 – 51Combined sources7
Beta strandi54 – 56Combined sources3
Turni57 – 60Combined sources4
Beta strandi62 – 68Combined sources7
Turni71 – 75Combined sources5
Beta strandi79 – 84Combined sources6
Turni93 – 95Combined sources3
Helixi100 – 102Combined sources3
Helixi104 – 107Combined sources4
Helixi115 – 126Combined sources12
Helixi129 – 132Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J74X-ray1.90A1-145[»]
1J7DX-ray1.85A1-145[»]
1ZGUNMR-A7-145[»]
3VONX-ray3.15B/D/F/I/K/M/P/R/T/W/Y/a/d/f/h/k/m/o6-143[»]
4NR3X-ray1.80A6-145[»]
4NRGX-ray1.95A1-145[»]
4NRIX-ray2.30A6-145[»]
4ONLX-ray1.35A1-145[»]
4ONMX-ray1.35A1-145[»]
4ONNX-ray1.50A1-145[»]
4ORHX-ray4.80A/E/I1-145[»]
5AITX-ray3.40D/G1-145[»]
ProteinModelPortaliQ15819.
SMRiQ15819.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15819.

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0896. Eukaryota.
ENOG4111MDW. LUCA.
GeneTreeiENSGT00740000115534.
HOVERGENiHBG054552.
InParanoidiQ15819.
KOiK10704.
OMAiGPARTNY.
OrthoDBiEOG091G0SMT.
PhylomeDBiQ15819.
TreeFamiTF316971.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI
60 70 80 90 100
IGPPRTNYEN RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA
110 120 130 140
RSIPVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QTYNN
Length:145
Mass (Da):16,363
Last modified:January 23, 2007 - v4
Checksum:i98D632A1AEC0AADE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05243136E → G. Corresponds to variant dbSNP:rs11557776Ensembl.1
Natural variantiVAR_05243378P → Q. Corresponds to variant dbSNP:rs11557786Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98091 mRNA. Translation: CAA66717.1.
AF049140 mRNA. Translation: AAC05381.1.
U62136 mRNA. Translation: AAB04758.2.
BT006744 mRNA. Translation: AAP35390.1.
CR407628 mRNA. Translation: CAG28556.1.
BC007051 mRNA. Translation: AAH07051.1.
BC016332 mRNA. Translation: AAH16332.1.
BC016710 mRNA. Translation: AAH16710.1.
BC028673 mRNA. Translation: AAH28673.1.
BC062418 mRNA. Translation: AAH62418.1.
CCDSiCCDS43738.1.
PIRiJC5525.
RefSeqiNP_003341.1. NM_003350.2.
UniGeneiHs.491695.
Hs.595400.

Genome annotation databases

EnsembliENST00000523111; ENSP00000428209; ENSG00000169139.
GeneIDi7336.
KEGGihsa:7336.
UCSCiuc003xqm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUB2V2_HUMAN
AccessioniPrimary (citable) accession number: Q15819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 163 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families