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Protein

Neuronal pentraxin-1

Gene

NPTX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi280Calcium 1By similarity1
Metal bindingi358Calcium 1By similarity1
Metal bindingi358Calcium 2By similarity1
Metal bindingi359Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi360Calcium 1By similarity1
Metal bindingi360Calcium 2By similarity1
Metal bindingi370Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • axonogenesis involved in innervation Source: Ensembl
  • central nervous system development Source: ProtInc
  • chemical synaptic transmission Source: ProtInc
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-1
Short name:
NP1
Alternative name(s):
Neuronal pentraxin I
Short name:
NP-I
Gene namesi
Name:NPTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7952. NPTX1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi4884.
OpenTargetsiENSG00000171246.
PharmGKBiPA31738.

Polymorphism and mutation databases

BioMutaiNPTX1.
DMDMi77416871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002354723 – 432Neuronal pentraxin-1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi256 ↔ 316By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15818.
MaxQBiQ15818.
PaxDbiQ15818.
PeptideAtlasiQ15818.
PRIDEiQ15818.

PTM databases

iPTMnetiQ15818.
PhosphoSitePlusiQ15818.

Expressioni

Gene expression databases

BgeeiENSG00000171246.
CleanExiHS_NPTX1.
GenevisibleiQ15818. HS.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

BioGridi110944. 39 interactors.
IntActiQ15818. 4 interactors.
STRINGi9606.ENSP00000307549.

Structurei

3D structure databases

ProteinModelPortaliQ15818.
SMRiQ15818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 432PentaxinAdd BLAST203

Sequence similaritiesi

Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiQ15818.
OMAiGASKWTF.
OrthoDBiEOG091G0AHP.
PhylomeDBiQ15818.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSSVLQ LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG
110 120 130 140 150
EARAGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DELERQVLSR VNTLEEGKGG PRNDTEERVK
210 220 230 240 250
IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK
410 420 430
ALSGNVIAWA ESHIEIYGGA TKWTFEACRQ IN
Length:432
Mass (Da):47,122
Last modified:October 11, 2005 - v2
Checksum:iB881AC19F7C8F74A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7Missing in AAC50727 (PubMed:8884281).Curated1
Sequence conflicti20 – 22AGA → P in AAC50727 (PubMed:8884281).Curated3
Sequence conflicti57S → SN in AAC50727 (PubMed:8884281).Curated1
Sequence conflicti192R → K in AAC50727 (PubMed:8884281).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61849 mRNA. Translation: AAC50727.1.
AK127335 mRNA. Translation: BAG54485.1.
BC089441 mRNA. Translation: AAH89441.1.
CCDSiCCDS32762.1.
RefSeqiNP_002513.2. NM_002522.3.
UniGeneiHs.514556.
Hs.715784.

Genome annotation databases

EnsembliENST00000306773; ENSP00000307549; ENSG00000171246.
GeneIDi4884.
KEGGihsa:4884.
UCSCiuc002jyp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61849 mRNA. Translation: AAC50727.1.
AK127335 mRNA. Translation: BAG54485.1.
BC089441 mRNA. Translation: AAH89441.1.
CCDSiCCDS32762.1.
RefSeqiNP_002513.2. NM_002522.3.
UniGeneiHs.514556.
Hs.715784.

3D structure databases

ProteinModelPortaliQ15818.
SMRiQ15818.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110944. 39 interactors.
IntActiQ15818. 4 interactors.
STRINGi9606.ENSP00000307549.

PTM databases

iPTMnetiQ15818.
PhosphoSitePlusiQ15818.

Polymorphism and mutation databases

BioMutaiNPTX1.
DMDMi77416871.

Proteomic databases

EPDiQ15818.
MaxQBiQ15818.
PaxDbiQ15818.
PeptideAtlasiQ15818.
PRIDEiQ15818.

Protocols and materials databases

DNASUi4884.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306773; ENSP00000307549; ENSG00000171246.
GeneIDi4884.
KEGGihsa:4884.
UCSCiuc002jyp.2. human.

Organism-specific databases

CTDi4884.
DisGeNETi4884.
GeneCardsiNPTX1.
HGNCiHGNC:7952. NPTX1.
MIMi602367. gene.
neXtProtiNX_Q15818.
OpenTargetsiENSG00000171246.
PharmGKBiPA31738.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiQ15818.
OMAiGASKWTF.
OrthoDBiEOG091G0AHP.
PhylomeDBiQ15818.
TreeFamiTF330208.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171246-MONOMER.

Miscellaneous databases

ChiTaRSiNPTX1. human.
GeneWikiiNPTX1.
GenomeRNAii4884.
PROiQ15818.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171246.
CleanExiHS_NPTX1.
GenevisibleiQ15818. HS.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPTX1_HUMAN
AccessioniPrimary (citable) accession number: Q15818
Secondary accession number(s): B3KXH3, Q5FWE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.