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Q15818

- NPTX1_HUMAN

UniProt

Q15818 - NPTX1_HUMAN

Protein

Neuronal pentraxin-1

Gene

NPTX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi280 – 2801Calcium 1By similarity
    Metal bindingi358 – 3581Calcium 1By similarity
    Metal bindingi358 – 3581Calcium 2By similarity
    Metal bindingi359 – 3591Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi360 – 3601Calcium 1By similarity
    Metal bindingi360 – 3601Calcium 2By similarity
    Metal bindingi370 – 3701Calcium 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. axonogenesis involved in innervation Source: Ensembl
    2. cellular response to glucose stimulus Source: Ensembl
    3. cellular response to potassium ion Source: Ensembl
    4. central nervous system development Source: ProtInc
    5. mitochondrial fragmentation involved in apoptotic process Source: Ensembl
    6. mitochondrial transport Source: Ensembl
    7. synaptic transmission Source: ProtInc
    8. transport Source: ProtInc

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal pentraxin-1
    Short name:
    NP1
    Alternative name(s):
    Neuronal pentraxin I
    Short name:
    NP-I
    Gene namesi
    Name:NPTX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7952. NPTX1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. neuron projection Source: Ensembl
    3. plasma membrane Source: Ensembl
    4. transport vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31738.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 432410Neuronal pentraxin-1PRO_0000023547Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi256 ↔ 316By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ15818.
    PaxDbiQ15818.
    PRIDEiQ15818.

    PTM databases

    PhosphoSiteiQ15818.

    Expressioni

    Gene expression databases

    BgeeiQ15818.
    CleanExiHS_NPTX1.
    GenevestigatoriQ15818.

    Interactioni

    Subunit structurei

    Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

    Protein-protein interaction databases

    BioGridi110944. 8 interactions.
    STRINGi9606.ENSP00000307549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15818.
    SMRiQ15818. Positions 229-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini230 – 432203PentaxinAdd
    BLAST

    Sequence similaritiesi

    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47030.
    HOGENOMiHOG000231267.
    HOVERGENiHBG003608.
    InParanoidiQ15818.
    OMAiGASKWTF.
    OrthoDBiEOG74XS6F.
    PhylomeDBiQ15818.
    TreeFamiTF330208.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q15818-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG    50
    AEELRSSVLQ LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG 100
    EARAGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY 150
    SRLNSSSQTN SLKDLLQSKI DELERQVLSR VNTLEEGKGG PRNDTEERVK 200
    IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM 250
    YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV 300
    AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ 350
    GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK 400
    ALSGNVIAWA ESHIEIYGGA TKWTFEACRQ IN 432
    Length:432
    Mass (Da):47,122
    Last modified:October 11, 2005 - v2
    Checksum:iB881AC19F7C8F74A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71Missing in AAC50727. (PubMed:8884281)Curated
    Sequence conflicti20 – 223AGA → P in AAC50727. (PubMed:8884281)Curated
    Sequence conflicti57 – 571S → SN in AAC50727. (PubMed:8884281)Curated
    Sequence conflicti192 – 1921R → K in AAC50727. (PubMed:8884281)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61849 mRNA. Translation: AAC50727.1.
    AK127335 mRNA. Translation: BAG54485.1.
    BC089441 mRNA. Translation: AAH89441.1.
    CCDSiCCDS32762.1.
    RefSeqiNP_002513.2. NM_002522.3.
    UniGeneiHs.514556.
    Hs.715784.

    Genome annotation databases

    EnsembliENST00000306773; ENSP00000307549; ENSG00000171246.
    GeneIDi4884.
    KEGGihsa:4884.
    UCSCiuc002jyp.1. human.

    Polymorphism databases

    DMDMi77416871.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61849 mRNA. Translation: AAC50727.1 .
    AK127335 mRNA. Translation: BAG54485.1 .
    BC089441 mRNA. Translation: AAH89441.1 .
    CCDSi CCDS32762.1.
    RefSeqi NP_002513.2. NM_002522.3.
    UniGenei Hs.514556.
    Hs.715784.

    3D structure databases

    ProteinModelPortali Q15818.
    SMRi Q15818. Positions 229-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110944. 8 interactions.
    STRINGi 9606.ENSP00000307549.

    PTM databases

    PhosphoSitei Q15818.

    Polymorphism databases

    DMDMi 77416871.

    Proteomic databases

    MaxQBi Q15818.
    PaxDbi Q15818.
    PRIDEi Q15818.

    Protocols and materials databases

    DNASUi 4884.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306773 ; ENSP00000307549 ; ENSG00000171246 .
    GeneIDi 4884.
    KEGGi hsa:4884.
    UCSCi uc002jyp.1. human.

    Organism-specific databases

    CTDi 4884.
    GeneCardsi GC17M078440.
    HGNCi HGNC:7952. NPTX1.
    MIMi 602367. gene.
    neXtProti NX_Q15818.
    PharmGKBi PA31738.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47030.
    HOGENOMi HOG000231267.
    HOVERGENi HBG003608.
    InParanoidi Q15818.
    OMAi GASKWTF.
    OrthoDBi EOG74XS6F.
    PhylomeDBi Q15818.
    TreeFami TF330208.

    Miscellaneous databases

    GeneWikii NPTX1.
    GenomeRNAii 4884.
    NextBioi 18800.
    PROi Q15818.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15818.
    CleanExi HS_NPTX1.
    Genevestigatori Q15818.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization."
      Omeis I.A., Hsu Y.-C., Perin M.S.
      Genomics 36:543-545(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Chondrosarcoma.

    Entry informationi

    Entry nameiNPTX1_HUMAN
    AccessioniPrimary (citable) accession number: Q15818
    Secondary accession number(s): B3KXH3, Q5FWE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3