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Q15818

- NPTX1_HUMAN

UniProt

Q15818 - NPTX1_HUMAN

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Protein

Neuronal pentraxin-1

Gene

NPTX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi280 – 2801Calcium 1By similarity
Metal bindingi358 – 3581Calcium 1By similarity
Metal bindingi358 – 3581Calcium 2By similarity
Metal bindingi359 – 3591Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi360 – 3601Calcium 1By similarity
Metal bindingi360 – 3601Calcium 2By similarity
Metal bindingi370 – 3701Calcium 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. axonogenesis involved in innervation Source: Ensembl
  2. cellular response to glucose stimulus Source: Ensembl
  3. cellular response to potassium ion Source: Ensembl
  4. central nervous system development Source: ProtInc
  5. mitochondrial fragmentation involved in apoptotic process Source: Ensembl
  6. mitochondrial transport Source: Ensembl
  7. synaptic transmission Source: ProtInc
  8. transport Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-1
Short name:
NP1
Alternative name(s):
Neuronal pentraxin I
Short name:
NP-I
Gene namesi
Name:NPTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7952. NPTX1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. mitochondrion Source: Ensembl
  3. neuron projection Source: Ensembl
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 432410Neuronal pentraxin-1PRO_0000023547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi256 ↔ 316By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ15818.
PaxDbiQ15818.
PRIDEiQ15818.

PTM databases

PhosphoSiteiQ15818.

Expressioni

Gene expression databases

BgeeiQ15818.
CleanExiHS_NPTX1.
GenevestigatoriQ15818.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

BioGridi110944. 16 interactions.
STRINGi9606.ENSP00000307549.

Structurei

3D structure databases

ProteinModelPortaliQ15818.
SMRiQ15818. Positions 229-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini230 – 432203PentaxinAdd
BLAST

Sequence similaritiesi

Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47030.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiQ15818.
OMAiGASKWTF.
OrthoDBiEOG74XS6F.
PhylomeDBiQ15818.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15818-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSSVLQ LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG
110 120 130 140 150
EARAGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DELERQVLSR VNTLEEGKGG PRNDTEERVK
210 220 230 240 250
IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK
410 420 430
ALSGNVIAWA ESHIEIYGGA TKWTFEACRQ IN
Length:432
Mass (Da):47,122
Last modified:October 11, 2005 - v2
Checksum:iB881AC19F7C8F74A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71Missing in AAC50727. (PubMed:8884281)Curated
Sequence conflicti20 – 223AGA → P in AAC50727. (PubMed:8884281)Curated
Sequence conflicti57 – 571S → SN in AAC50727. (PubMed:8884281)Curated
Sequence conflicti192 – 1921R → K in AAC50727. (PubMed:8884281)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61849 mRNA. Translation: AAC50727.1.
AK127335 mRNA. Translation: BAG54485.1.
BC089441 mRNA. Translation: AAH89441.1.
CCDSiCCDS32762.1.
RefSeqiNP_002513.2. NM_002522.3.
UniGeneiHs.514556.
Hs.715784.

Genome annotation databases

EnsembliENST00000306773; ENSP00000307549; ENSG00000171246.
GeneIDi4884.
KEGGihsa:4884.
UCSCiuc002jyp.1. human.

Polymorphism databases

DMDMi77416871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61849 mRNA. Translation: AAC50727.1 .
AK127335 mRNA. Translation: BAG54485.1 .
BC089441 mRNA. Translation: AAH89441.1 .
CCDSi CCDS32762.1.
RefSeqi NP_002513.2. NM_002522.3.
UniGenei Hs.514556.
Hs.715784.

3D structure databases

ProteinModelPortali Q15818.
SMRi Q15818. Positions 229-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110944. 16 interactions.
STRINGi 9606.ENSP00000307549.

PTM databases

PhosphoSitei Q15818.

Polymorphism databases

DMDMi 77416871.

Proteomic databases

MaxQBi Q15818.
PaxDbi Q15818.
PRIDEi Q15818.

Protocols and materials databases

DNASUi 4884.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306773 ; ENSP00000307549 ; ENSG00000171246 .
GeneIDi 4884.
KEGGi hsa:4884.
UCSCi uc002jyp.1. human.

Organism-specific databases

CTDi 4884.
GeneCardsi GC17M078440.
HGNCi HGNC:7952. NPTX1.
MIMi 602367. gene.
neXtProti NX_Q15818.
PharmGKBi PA31738.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47030.
GeneTreei ENSGT00760000119128.
HOGENOMi HOG000231267.
HOVERGENi HBG003608.
InParanoidi Q15818.
OMAi GASKWTF.
OrthoDBi EOG74XS6F.
PhylomeDBi Q15818.
TreeFami TF330208.

Miscellaneous databases

ChiTaRSi NPTX1. human.
GeneWikii NPTX1.
GenomeRNAii 4884.
NextBioi 18800.
PROi Q15818.
SOURCEi Search...

Gene expression databases

Bgeei Q15818.
CleanExi HS_NPTX1.
Genevestigatori Q15818.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00289. PENTAXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization."
    Omeis I.A., Hsu Y.-C., Perin M.S.
    Genomics 36:543-545(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Chondrosarcoma.

Entry informationi

Entry nameiNPTX1_HUMAN
AccessioniPrimary (citable) accession number: Q15818
Secondary accession number(s): B3KXH3, Q5FWE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3