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Q15818 (NPTX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuronal pentraxin-1

Short name=NP1
Alternative name(s):
Neuronal pentraxin I
Short name=NP-I
Gene names
Name:NPTX1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses By similarity.

Cofactor

Binds 2 calcium ions per subunit By similarity.

Subunit structure

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR) By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesicle Potential.

Sequence similarities

Contains 1 pentaxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 432410Neuronal pentraxin-1
PRO_0000023547

Regions

Domain230 – 432203Pentaxin

Sites

Metal binding2801Calcium 1 By similarity
Metal binding3581Calcium 1 By similarity
Metal binding3581Calcium 2 By similarity
Metal binding3591Calcium 1; via carbonyl oxygen By similarity
Metal binding3601Calcium 1 By similarity
Metal binding3601Calcium 2 By similarity
Metal binding3701Calcium 2 By similarity

Amino acid modifications

Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential
Disulfide bond256 ↔ 316 By similarity

Experimental info

Sequence conflict71Missing in AAC50727. Ref.1
Sequence conflict20 – 223AGA → P in AAC50727. Ref.1
Sequence conflict571S → SN in AAC50727. Ref.1
Sequence conflict1921R → K in AAC50727. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q15818 [UniParc].

Last modified October 11, 2005. Version 2.
Checksum: B881AC19F7C8F74A

FASTA43247,122
        10         20         30         40         50         60 
MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG AEELRSSVLQ 

        70         80         90        100        110        120 
LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG EARAGGGRKQ PGSGKNTMGD 

       130        140        150        160        170        180 
LSRTPAAETL SQLGQTLQSL KTRLENLEQY SRLNSSSQTN SLKDLLQSKI DELERQVLSR 

       190        200        210        220        230        240 
VNTLEEGKGG PRNDTEERVK IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY 

       250        260        270        280        290        300 
AKVKKSLPEM YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV 

       310        320        330        340        350        360 
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ GVLVLGQEQD 

       370        380        390        400        410        420 
TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK ALSGNVIAWA ESHIEIYGGA 

       430 
TKWTFEACRQ IN 

« Hide

References

« Hide 'large scale' references
[1]"Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization."
Omeis I.A., Hsu Y.-C., Perin M.S.
Genomics 36:543-545(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Chondrosarcoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U61849 mRNA. Translation: AAC50727.1.
AK127335 mRNA. Translation: BAG54485.1.
BC089441 mRNA. Translation: AAH89441.1.
CCDSCCDS32762.1.
RefSeqNP_002513.2. NM_002522.3.
UniGeneHs.514556.
Hs.715784.

3D structure databases

ProteinModelPortalQ15818.
SMRQ15818. Positions 229-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110944. 8 interactions.
STRING9606.ENSP00000307549.

PTM databases

PhosphoSiteQ15818.

Polymorphism databases

DMDM77416871.

Proteomic databases

MaxQBQ15818.
PaxDbQ15818.
PRIDEQ15818.

Protocols and materials databases

DNASU4884.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306773; ENSP00000307549; ENSG00000171246.
GeneID4884.
KEGGhsa:4884.
UCSCuc002jyp.1. human.

Organism-specific databases

CTD4884.
GeneCardsGC17M078440.
HGNCHGNC:7952. NPTX1.
MIM602367. gene.
neXtProtNX_Q15818.
PharmGKBPA31738.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47030.
HOGENOMHOG000231267.
HOVERGENHBG003608.
InParanoidQ15818.
OMAGASKWTF.
OrthoDBEOG74XS6F.
PhylomeDBQ15818.
TreeFamTF330208.

Gene expression databases

BgeeQ15818.
CleanExHS_NPTX1.
GenevestigatorQ15818.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNPTX1.
GenomeRNAi4884.
NextBio18800.
PROQ15818.
SOURCESearch...

Entry information

Entry nameNPTX1_HUMAN
AccessionPrimary (citable) accession number: Q15818
Secondary accession number(s): B3KXH3, Q5FWE6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM