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Protein

Neuronal pentraxin-1

Gene

NPTX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi280Calcium 1By similarity1
Metal bindingi358Calcium 1By similarity1
Metal bindingi358Calcium 2PROSITE-ProRule annotation1
Metal bindingi359Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi360Calcium 1By similarity1
Metal bindingi360Calcium 2PROSITE-ProRule annotation1
Metal bindingi370Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • axonogenesis involved in innervation Source: Ensembl
  • central nervous system development Source: ProtInc
  • chemical synaptic transmission Source: ProtInc
  • transport Source: ProtInc

Keywordsi

LigandCalcium, Metal-binding

Protein family/group databases

TCDBi1.C.92.1.3. the pentraxin (pentraxin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-1
Short name:
NP1
Alternative name(s):
Neuronal pentraxin I
Short name:
NP-I
Gene namesi
Name:NPTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000171246.5.
HGNCiHGNC:7952. NPTX1.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi4884.
OpenTargetsiENSG00000171246.
PharmGKBiPA31738.

Polymorphism and mutation databases

BioMutaiNPTX1.
DMDMi77416871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002354723 – 432Neuronal pentraxin-1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi256 ↔ 316PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15818.
MaxQBiQ15818.
PaxDbiQ15818.
PeptideAtlasiQ15818.
PRIDEiQ15818.

PTM databases

iPTMnetiQ15818.
PhosphoSitePlusiQ15818.

Expressioni

Gene expression databases

BgeeiENSG00000171246.
CleanExiHS_NPTX1.
GenevisibleiQ15818. HS.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

BioGridi110944. 46 interactors.
IntActiQ15818. 4 interactors.
STRINGi9606.ENSP00000307549.

Structurei

3D structure databases

ProteinModelPortaliQ15818.
SMRiQ15818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 428Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiQ15818.
OMAiTKLGRCE.
OrthoDBiEOG091G0AHP.
PhylomeDBiQ15818.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSSVLQ LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG
110 120 130 140 150
EARAGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DELERQVLSR VNTLEEGKGG PRNDTEERVK
210 220 230 240 250
IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK
410 420 430
ALSGNVIAWA ESHIEIYGGA TKWTFEACRQ IN
Length:432
Mass (Da):47,122
Last modified:October 11, 2005 - v2
Checksum:iB881AC19F7C8F74A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7Missing in AAC50727 (PubMed:8884281).Curated1
Sequence conflicti20 – 22AGA → P in AAC50727 (PubMed:8884281).Curated3
Sequence conflicti57S → SN in AAC50727 (PubMed:8884281).Curated1
Sequence conflicti192R → K in AAC50727 (PubMed:8884281).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61849 mRNA. Translation: AAC50727.1.
AK127335 mRNA. Translation: BAG54485.1.
BC089441 mRNA. Translation: AAH89441.1.
CCDSiCCDS32762.1.
RefSeqiNP_002513.2. NM_002522.3.
UniGeneiHs.514556.
Hs.715784.

Genome annotation databases

EnsembliENST00000306773; ENSP00000307549; ENSG00000171246.
GeneIDi4884.
KEGGihsa:4884.
UCSCiuc002jyp.2. human.

Similar proteinsi

Entry informationi

Entry nameiNPTX1_HUMAN
AccessioniPrimary (citable) accession number: Q15818
Secondary accession number(s): B3KXH3, Q5FWE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot