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Q15811

- ITSN1_HUMAN

UniProt

Q15811 - ITSN1_HUMAN

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Protein

Intersectin-1

Gene

ITSN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase By similarity. Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi66 – 77121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi267 – 278122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. guanyl-nucleotide exchange factor activity Source: UniProtKB
  3. kinase activator activity Source: Ensembl
  4. proline-rich region binding Source: UniProtKB
  5. protein complex scaffold Source: UniProtKB
  6. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. apoptotic signaling pathway Source: Reactome
  2. negative regulation of neuron apoptotic process Source: Ensembl
  3. neurotrophin TRK receptor signaling pathway Source: Reactome
  4. positive regulation of apoptotic process Source: Reactome
  5. positive regulation of GTPase activity Source: GOC
  6. positive regulation of protein kinase B signaling Source: Ensembl
  7. regulation of small GTPase mediated signal transduction Source: Reactome
  8. small GTPase mediated signal transduction Source: Reactome
  9. synaptic vesicle endocytosis Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
SignaLinkiQ15811.

Names & Taxonomyi

Protein namesi
Recommended name:
Intersectin-1
Alternative name(s):
SH3 domain-containing protein 1A
SH3P17
Gene namesi
Name:ITSN1
Synonyms:ITSN, SH3D1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:6183. ITSN1.

Subcellular locationi

Endomembrane system By similarity. Cell junctionsynapsesynaptosome By similarity. Cell projectionlamellipodium. Membraneclathrin-coated pit
Note: Colocalizes with SGIP1 at the plasma membrane in structures corresponding most problably to clathrin-coated pits.Curated

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. coated pit Source: UniProtKB
  3. cytosol Source: Reactome
  4. endocytic vesicle Source: Ensembl
  5. lamellipodium Source: Ensembl
  6. neuron projection Source: UniProtKB-KW
  7. plasma membrane Source: UniProtKB
  8. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Coated pit, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1369 – 13691M → L: Decreases specificity for CDC42; when associated with I-1376. 1 Publication
Mutagenesisi1376 – 13761L → I: Decreases specificity for CDC42; when associated with L-1369. 1 Publication

Organism-specific databases

PharmGKBiPA29981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17211721Intersectin-1PRO_0000080957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei203 – 2031PhosphoserineBy similarity
Modified residuei902 – 9021Phosphoserine1 Publication
Modified residuei904 – 9041Phosphoserine1 Publication
Modified residuei1137 – 11371PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15811.
PaxDbiQ15811.
PRIDEiQ15811.

PTM databases

PhosphoSiteiQ15811.

Expressioni

Tissue specificityi

Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord.

Gene expression databases

BgeeiQ15811.
CleanExiHS_ITSN1.
ExpressionAtlasiQ15811. baseline and differential.
GenevestigatoriQ15811.

Organism-specific databases

HPAiHPA018007.

Interactioni

Subunit structurei

Interacts with dynamin, CDC42, SNAP25 and SNAP23. Clusters several dynamin in a manner that is regulated by alternative splicing. Interacts with clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2, STON2, FCHO1, FCHO2 and DAB2. Interacts (via SH3 domains) with REPS1 and SGIP1. Interacts with ARHGAP31. Interacts with ADAM15.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CBLP2268112EBI-602041,EBI-518228
CDC42P60953-12EBI-602041,EBI-3625591
DISC1Q9NRI53EBI-602041,EBI-529989
DNM2P505702EBI-602041,EBI-346547
Fcho2Q3UQN23EBI-602041,EBI-6094986From a different organism.
INPPL1O153579EBI-8052395,EBI-1384248
Sh3kbp1Q925Q94EBI-8052395,EBI-8020091From a different organism.

Protein-protein interaction databases

BioGridi112351. 124 interactions.
DIPiDIP-33609N.
IntActiQ15811. 44 interactions.
MINTiMINT-130199.
STRINGi9606.ENSP00000370719.

Structurei

Secondary structure

1
1721
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni12 – 143
Helixi19 – 3113
Beta strandi35 – 373
Beta strandi38 – 403
Helixi41 – 488
Helixi49 – 513
Helixi55 – 6511
Beta strandi70 – 734
Helixi75 – 8915
Helixi100 – 1023
Beta strandi215 – 2173
Helixi219 – 23012
Beta strandi239 – 2413
Helixi242 – 2509
Helixi256 – 26611
Beta strandi272 – 2754
Helixi276 – 29015
Helixi301 – 3033
Turni306 – 3094
Beta strandi916 – 9227
Beta strandi939 – 9457
Beta strandi947 – 9548
Beta strandi957 – 9626
Helixi963 – 9653
Beta strandi966 – 9694
Helixi1233 – 126230
Helixi1264 – 12696
Beta strandi1271 – 12733
Helixi1275 – 12828
Helixi1285 – 130622
Beta strandi1308 – 13103
Helixi1316 – 13227
Helixi1323 – 13275
Helixi1328 – 134922
Helixi1351 – 136111
Helixi1364 – 13663
Helixi1371 – 13744
Helixi1377 – 139317
Helixi1403 – 143735
Beta strandi1451 – 14544
Beta strandi1456 – 14605
Beta strandi1463 – 14664
Beta strandi1472 – 14743
Beta strandi1479 – 149315
Beta strandi1511 – 15133
Helixi1522 – 15243
Beta strandi1525 – 15284
Beta strandi1531 – 15333
Beta strandi1541 – 15444
Beta strandi1547 – 15504
Helixi1556 – 157722

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KI1X-ray2.30B/D1229-1581[»]
2KGRNMR-A210-312[»]
2KHNNMR-A1-111[»]
3FIAX-ray1.45A1-111[»]
3QBVX-ray2.65B/D1229-1579[»]
4IIMX-ray1.80A/B916-970[»]
ProteinModelPortaliQ15811.
SMRiQ15811. Positions 1-111, 210-312, 745-835, 916-1581, 1595-1718.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15811.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10989EH 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini221 – 31090EH 2PROSITE-ProRule annotationAdd
BLAST
Domaini254 – 28936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini740 – 80667SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini913 – 97159SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini1002 – 106059SH3 3PROSITE-ProRule annotationAdd
BLAST
Domaini1074 – 113865SH3 4PROSITE-ProRule annotationAdd
BLAST
Domaini1155 – 121460SH3 5PROSITE-ProRule annotationAdd
BLAST
Domaini1237 – 1423187DHPROSITE-ProRule annotationAdd
BLAST
Domaini1462 – 1571110PHPROSITE-ProRule annotationAdd
BLAST
Domaini1583 – 167997C2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni326 – 702377KLERQAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili351 – 705355Sequence AnalysisAdd
BLAST

Domaini

SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin By similarity. SH3-1 and SH3-4 bind to ARHGAP31.By similarity
The KLERQ domain binds to SNAP-25 and SNAP-23.By similarity
In an autoinhibited form the SH3 domain 5 may bind intramolecularly to the DH domain, thus blocking the CDC42-binding site.By similarity

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 EH domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 5 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5422.
GeneTreeiENSGT00760000118985.
HOVERGENiHBG052159.
InParanoidiQ15811.
OMAiVMVKGEW.
PhylomeDBiQ15811.
TreeFamiTF324293.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 5 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

This entry describes 13 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist. Alternative splicing affects domains involved in protein recognition and thus may play a role in selecting specific interactions.2 Publications

Isoform 1 (identifier: Q15811-1) [UniParc]FASTAAdd to Basket

Also known as: Long, ITSN-l

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ
60 70 80 90 100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP
110 120 130 140 150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV
160 170 180 190 200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK
210 220 230 240 250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM
260 270 280 290 300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP
310 320 330 340 350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF
360 370 380 390 400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE
410 420 430 440 450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE
460 470 480 490 500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR
510 520 530 540 550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND
560 570 580 590 600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI
610 620 630 640 650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ
660 670 680 690 700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE
710 720 730 740 750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP
760 770 780 790 800
FESRSHDEIT IQPGDIVMVK GEWVDESQTG EPGWLGGELK GKTGWFPANY
810 820 830 840 850
AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS SEPSTTPNNW
860 870 880 890 900
ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG
910 920 930 940 950
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW
960 970 980 990 1000
FGEVQGQKGW FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP
1010 1020 1030 1040 1050
VVSGEEFIAM YTYESSEQGD LTFQQGDVIL VTKKDGDWWT GTVGDKAGVF
1060 1070 1080 1090 1100
PSNYVRLKDS EGSGTAGKTG SLGKKPEIAQ VIASYTATGP EQLTLAPGQL
1110 1120 1130 1140 1150
ILIRKKNPGG WWEGELQARG KKRQIGWFPA NYVKLLSPGT SKITPTEPPK
1160 1170 1180 1190 1200
STALAAVCQV IGMYDYTAQN DDELAFNKGQ IINVLNKEDP DWWKGEVNGQ
1210 1220 1230 1240 1250
VGLFPSNYVK LTTDMDPSQQ WCSDLHLLDM LTPTERKRQG YIHELIVTEE
1260 1270 1280 1290 1300
NYVNDLQLVT EIFQKPLMES ELLTEKEVAM IFVNWKELIM CNIKLLKALR
1310 1320 1330 1340 1350
VRKKMSGEKM PVKMIGDILS AQLPHMQPYI RFCSRQLNGA ALIQQKTDEA
1360 1370 1380 1390 1400
PDFKEFVKRL AMDPRCKGMP LSSFILKPMQ RVTRYPLIIK NILENTPENH
1410 1420 1430 1440 1450
PDHSHLKHAL EKAEELCSQV NEGVREKENS DRLEWIQAHV QCEGLSEQLV
1460 1470 1480 1490 1500
FNSVTNCLGP RKFLHSGKLY KAKSNKELYG FLFNDFLLLT QITKPLGSSG
1510 1520 1530 1540 1550
TDKVFSPKSN LQYKMYKTPI FLNEVLVKLP TDPSGDEPIF HISHIDRVYT
1560 1570 1580 1590 1600
LRAESINERT AWVQKIKAAS ELYIETEKKK REKAYLVRSQ RATGIGRLMV
1610 1620 1630 1640 1650
NVVEGIELKP CRSHGKSNPY CEVTMGSQCH ITKTIQDTLN PKWNSNCQFF
1660 1670 1680 1690 1700
IRDLEQEVLC ITVFERDQFS PDDFLGRTEI RVADIKKDQG SKGPVTKCLL
1710 1720
LHEVPTGEIV VRLDLQLFDE P
Length:1,721
Mass (Da):195,422
Last modified:October 17, 2006 - v3
Checksum:iFC4DE644D8BEA2BE
GO
Isoform 2 (identifier: Q15811-2) [UniParc]FASTAAdd to Basket

Also known as: Short, ITSN-s

The sequence of this isoform differs from the canonical sequence as follows:
     1221-1721: Missing.

Show »
Length:1,220
Mass (Da):137,649
Checksum:iB09FDBEF1C06F487
GO
Isoform 3 (identifier: Q15811-3) [UniParc]FASTAAdd to Basket

Also known as: Short 2, SH3P17

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1006-1076: Missing.
     1221-1721: Missing.

Show »
Length:1,144
Mass (Da):129,416
Checksum:i8EEE8BE230C2F8C7
GO
Isoform 4 (identifier: Q15811-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1006-1076: Missing.

Show »
Length:1,650
Mass (Da):187,788
Checksum:i584F3A7AD02E4434
GO
Isoform 5 (identifier: Q15811-5) [UniParc]FASTAAdd to Basket

Also known as: ITSN1-22a

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     910-1025: GEKVEGLQAQ...SEQGDLTFQQ → PDFLLHPSMR...CFYLCLPHYL
     1026-1721: Missing.

Show »
Length:1,020
Mass (Da):115,873
Checksum:i53D58238CDB49BB4
GO
Isoform 6 (identifier: Q15811-6) [UniParc]FASTAAdd to Basket

Also known as: Long form variant 4, Short form variant 11

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1006-1020: EFIAMYTYESSEQGD → GLWNCWENREFRKKT
     1021-1721: Missing.

Note: Contains a premature stop codon, potentially subjected to NMD.

Show »
Length:1,015
Mass (Da):115,477
Checksum:i7FAD870DF7E4D42E
GO
Isoform 7 (identifier: Q15811-7) [UniParc]FASTAAdd to Basket

Also known as: Short form variant 5

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1221-1721: Missing.

Show »
Length:1,215
Mass (Da):137,049
Checksum:i9610DEBFC4781CED
GO
Isoform 8 (identifier: Q15811-8) [UniParc]FASTAAdd to Basket

Also known as: Long form variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.

Show »
Length:1,716
Mass (Da):194,822
Checksum:iA129042F01C34A47
GO
Isoform 9 (identifier: Q15811-9) [UniParc]FASTAAdd to Basket

Also known as: Long form variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1392-1447: Missing.

Show »
Length:1,660
Mass (Da):188,382
Checksum:i715F81F741A346E4
GO
Isoform 10 (identifier: Q15811-10) [UniParc]FASTAAdd to Basket

Also known as: Short form variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     116-152: Missing.
     770-774: Missing.
     1221-1721: Missing.

Show »
Length:1,178
Mass (Da):133,560
Checksum:iA344C5964504BDB1
GO
Isoform 11 (identifier: Q15811-11) [UniParc]FASTAAdd to Basket

Also known as: Short form variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     116-152: Missing.
     1006-1076: Missing.
     1221-1721: Missing.

Show »
Length:1,112
Mass (Da):126,526
Checksum:iAB25F8723B3FD22A
GO
Isoform 12 (identifier: Q15811-12) [UniParc]FASTAAdd to Basket

Also known as: Short form variant 10

The sequence of this isoform differs from the canonical sequence as follows:
     116-152: Missing.
     770-774: Missing.
     1006-1076: Missing.
     1221-1721: Missing.

Show »
Length:1,107
Mass (Da):125,926
Checksum:i7724CCE4FA98098A
GO
Isoform 13 (identifier: Q15811-13) [UniParc]FASTAAdd to Basket

Also known as: Short form variant 14

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     910-919: GEKVEGLQAQ → HGFWFFRESC
     920-1721: Missing.

Note: Contains a premature stop codon, potentially subjected to NMD.

Show »
Length:914
Mass (Da):104,194
Checksum:i3788E745D07FE820
GO

Sequence cautioni

The sequence AAC50592.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141A → P in AAC78610. (PubMed:9799604)Curated
Sequence conflicti114 – 1141A → P in AAC78611. (PubMed:9799604)Curated
Sequence conflicti114 – 1141A → P in ABG74695. (PubMed:19777371)Curated
Sequence conflicti114 – 1141A → P in ABG74697. (PubMed:19777371)Curated
Sequence conflicti114 – 1141A → P in ABG74698. (PubMed:19777371)Curated
Sequence conflicti863 – 8631E → G in ABD72328. (PubMed:21712076)Curated
Sequence conflicti1088 – 10881T → A in AAD53183. 1 PublicationCurated
Sequence conflicti1109 – 11091G → R in AAD53183. 1 PublicationCurated
Sequence conflicti1361 – 13611A → E in AAC78611. (PubMed:9799604)Curated
Sequence conflicti1361 – 13611A → E in AAC50592. (PubMed:9630982)Curated
Sequence conflicti1367 – 13671K → R in AAI16187. (PubMed:15489334)Curated
Sequence conflicti1474 – 14741S → N in AAC78611. (PubMed:9799604)Curated
Sequence conflicti1474 – 14741S → N in AAC50592. (PubMed:9630982)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1137 – 11371S → N.2 Publications
Corresponds to variant rs187895245 [ dbSNP | Ensembl ].
VAR_070011

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei116 – 15237Missing in isoform 10, isoform 11 and isoform 12. 1 PublicationVSP_053317Add
BLAST
Alternative sequencei770 – 7745Missing in isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10, isoform 12 and isoform 13. 6 PublicationsVSP_004293
Alternative sequencei910 – 1025116GEKVE…LTFQQ → PDFLLHPSMRLGHMQPRIVL LFPDPLQCSTSRLLPMLRPR PGVPFLRSPSCQSPSHPSRP ISDAAPSVKFTLMPPGRIHP CFLFIPAVNSRNSFLVYFIL PGGTLGCFYLCLPHYL in isoform 5. 1 PublicationVSP_047460Add
BLAST
Alternative sequencei910 – 91910GEKVEGLQAQ → HGFWFFRESC in isoform 13. CuratedVSP_053318
Alternative sequencei920 – 1721802Missing in isoform 13. CuratedVSP_053319Add
BLAST
Alternative sequencei1006 – 107671Missing in isoform 3, isoform 4, isoform 11 and isoform 12. 4 PublicationsVSP_004294Add
BLAST
Alternative sequencei1006 – 102015EFIAM…SEQGD → GLWNCWENREFRKKT in isoform 6. 1 PublicationVSP_053320Add
BLAST
Alternative sequencei1021 – 1721701Missing in isoform 6. 1 PublicationVSP_053321Add
BLAST
Alternative sequencei1026 – 1721696Missing in isoform 5. 1 PublicationVSP_047461Add
BLAST
Alternative sequencei1221 – 1721501Missing in isoform 2, isoform 3, isoform 7, isoform 10, isoform 11 and isoform 12. 7 PublicationsVSP_004295Add
BLAST
Alternative sequencei1392 – 144756Missing in isoform 9. 1 PublicationVSP_053322Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064244 mRNA. Translation: AAC78611.1.
AF064247, AF064245, AF064246 Genomic DNA. Translation: AAC80437.1.
AF064243 mRNA. Translation: AAC78610.1.
AF114488 mRNA. Translation: AAD29953.1.
AF114487 mRNA. Translation: AAD29952.1.
DQ679754 mRNA. Translation: ABG74695.1.
DQ679756 mRNA. Translation: ABG74697.1.
DQ679757 mRNA. Translation: ABG74698.1.
EU117382 mRNA. Translation: ABV21755.1.
EU140799 mRNA. Translation: ABV58335.1.
EU140800 mRNA. Translation: ABV58336.1.
EU120733 mRNA. Translation: ABV24866.1.
EU120734 mRNA. Translation: ABV24867.1.
EU120735 mRNA. Translation: ABV24868.1.
EU152331 mRNA. Translation: ABV69555.1.
DQ386455 mRNA. Translation: ABD72328.1.
AK300274 mRNA. Translation: BAG62034.1.
AP000308 Genomic DNA. No translation available.
AP000309 Genomic DNA. No translation available.
AP000310 Genomic DNA. No translation available.
AP000311 Genomic DNA. No translation available.
AP000312 Genomic DNA. No translation available.
AP000313 Genomic DNA. No translation available.
BC117560 mRNA. Translation: AAI17561.1.
BC116186 mRNA. Translation: AAI16187.1.
U61166 mRNA. Translation: AAC50592.1. Different initiation.
AF180522 mRNA. Translation: AAD53183.1.
CCDSiCCDS33545.1. [Q15811-1]
CCDS33546.1. [Q15811-2]
RefSeqiNP_001001132.1. NM_001001132.1. [Q15811-2]
NP_003015.2. NM_003024.2. [Q15811-1]
XP_005261083.1. XM_005261026.1. [Q15811-8]
XP_005261084.1. XM_005261027.1. [Q15811-7]
XP_005261088.1. XM_005261031.1. [Q15811-3]
UniGeneiHs.160324.

Genome annotation databases

EnsembliENST00000381291; ENSP00000370691; ENSG00000205726. [Q15811-2]
ENST00000381318; ENSP00000370719; ENSG00000205726. [Q15811-1]
ENST00000399338; ENSP00000382275; ENSG00000205726. [Q15811-5]
ENST00000399349; ENSP00000382286; ENSG00000205726. [Q15811-3]
ENST00000399352; ENSP00000382289; ENSG00000205726. [Q15811-7]
ENST00000399353; ENSP00000382290; ENSG00000205726. [Q15811-10]
ENST00000399367; ENSP00000382301; ENSG00000205726. [Q15811-8]
GeneIDi6453.
KEGGihsa:6453.
UCSCiuc002ysw.3. human. [Q15811-1]
uc002ysz.3. human. [Q15811-3]

Polymorphism databases

DMDMi116242596.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064244 mRNA. Translation: AAC78611.1 .
AF064247 , AF064245 , AF064246 Genomic DNA. Translation: AAC80437.1 .
AF064243 mRNA. Translation: AAC78610.1 .
AF114488 mRNA. Translation: AAD29953.1 .
AF114487 mRNA. Translation: AAD29952.1 .
DQ679754 mRNA. Translation: ABG74695.1 .
DQ679756 mRNA. Translation: ABG74697.1 .
DQ679757 mRNA. Translation: ABG74698.1 .
EU117382 mRNA. Translation: ABV21755.1 .
EU140799 mRNA. Translation: ABV58335.1 .
EU140800 mRNA. Translation: ABV58336.1 .
EU120733 mRNA. Translation: ABV24866.1 .
EU120734 mRNA. Translation: ABV24867.1 .
EU120735 mRNA. Translation: ABV24868.1 .
EU152331 mRNA. Translation: ABV69555.1 .
DQ386455 mRNA. Translation: ABD72328.1 .
AK300274 mRNA. Translation: BAG62034.1 .
AP000308 Genomic DNA. No translation available.
AP000309 Genomic DNA. No translation available.
AP000310 Genomic DNA. No translation available.
AP000311 Genomic DNA. No translation available.
AP000312 Genomic DNA. No translation available.
AP000313 Genomic DNA. No translation available.
BC117560 mRNA. Translation: AAI17561.1 .
BC116186 mRNA. Translation: AAI16187.1 .
U61166 mRNA. Translation: AAC50592.1 . Different initiation.
AF180522 mRNA. Translation: AAD53183.1 .
CCDSi CCDS33545.1. [Q15811-1 ]
CCDS33546.1. [Q15811-2 ]
RefSeqi NP_001001132.1. NM_001001132.1. [Q15811-2 ]
NP_003015.2. NM_003024.2. [Q15811-1 ]
XP_005261083.1. XM_005261026.1. [Q15811-8 ]
XP_005261084.1. XM_005261027.1. [Q15811-7 ]
XP_005261088.1. XM_005261031.1. [Q15811-3 ]
UniGenei Hs.160324.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KI1 X-ray 2.30 B/D 1229-1581 [» ]
2KGR NMR - A 210-312 [» ]
2KHN NMR - A 1-111 [» ]
3FIA X-ray 1.45 A 1-111 [» ]
3QBV X-ray 2.65 B/D 1229-1579 [» ]
4IIM X-ray 1.80 A/B 916-970 [» ]
ProteinModelPortali Q15811.
SMRi Q15811. Positions 1-111, 210-312, 745-835, 916-1581, 1595-1718.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112351. 124 interactions.
DIPi DIP-33609N.
IntActi Q15811. 44 interactions.
MINTi MINT-130199.
STRINGi 9606.ENSP00000370719.

PTM databases

PhosphoSitei Q15811.

Polymorphism databases

DMDMi 116242596.

Proteomic databases

MaxQBi Q15811.
PaxDbi Q15811.
PRIDEi Q15811.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381291 ; ENSP00000370691 ; ENSG00000205726 . [Q15811-2 ]
ENST00000381318 ; ENSP00000370719 ; ENSG00000205726 . [Q15811-1 ]
ENST00000399338 ; ENSP00000382275 ; ENSG00000205726 . [Q15811-5 ]
ENST00000399349 ; ENSP00000382286 ; ENSG00000205726 . [Q15811-3 ]
ENST00000399352 ; ENSP00000382289 ; ENSG00000205726 . [Q15811-7 ]
ENST00000399353 ; ENSP00000382290 ; ENSG00000205726 . [Q15811-10 ]
ENST00000399367 ; ENSP00000382301 ; ENSG00000205726 . [Q15811-8 ]
GeneIDi 6453.
KEGGi hsa:6453.
UCSCi uc002ysw.3. human. [Q15811-1 ]
uc002ysz.3. human. [Q15811-3 ]

Organism-specific databases

CTDi 6453.
GeneCardsi GC21P035014.
HGNCi HGNC:6183. ITSN1.
HPAi HPA018007.
MIMi 602442. gene.
neXtProti NX_Q15811.
PharmGKBi PA29981.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5422.
GeneTreei ENSGT00760000118985.
HOVERGENi HBG052159.
InParanoidi Q15811.
OMAi VMVKGEW.
PhylomeDBi Q15811.
TreeFami TF324293.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
SignaLinki Q15811.

Miscellaneous databases

EvolutionaryTracei Q15811.
GeneWikii ITSN1.
GenomeRNAii 6453.
NextBioi 25083.
PROi Q15811.
SOURCEi Search...

Gene expression databases

Bgeei Q15811.
CleanExi HS_ITSN1.
ExpressionAtlasi Q15811. baseline and differential.
Genevestigatori Q15811.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 5 hits.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
PROSITEi PS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon."
    Guipponi M., Scott H.S., Chen H., Schebesta A., Rossier C., Antonarakis S.E.
    Genomics 53:369-376(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANT ASN-1137.
    Tissue: Fetal brain.
  2. "Alu-splice cloning of human intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome."
    Pucharcos C., Fuentes J.-J., Casas C., de la Luna S., Alcantara S., Arbones M.L., Soriano E., Estivill X., Pritchard M.
    Eur. J. Hum. Genet. 7:704-712(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Structural diversity and differential expression of novel human intersectin 1 isoforms."
    Kropyvko S., Gerasymchuk D., Skrypkina I., Dergai M., Dergai O., Nikolaienko O., Rynditch A., Tsyba L.
    Mol. Biol. Rep. 37:2789-2796(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8; 9; 10; 11 AND 12), VARIANT ASN-1137, ALTERNATIVE SPLICING.
    Tissue: Brain and Lung.
  4. "Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1."
    Dergai M., Skrypkina I., Dergai O., Tsyba L., Novokhatska O., Filonenko V., Drobot L., Rynditch A.
    Gene 485:120-129(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    Tissue: Kidney.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Placenta.
  6. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Embryonic stem cell.
  8. "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins."
    Sparks A.B., Hoffman N.G., McConnell S.J., Fowlkes D.M., Kay B.K.
    Nat. Biotechnol. 14:741-744(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 620-1721 (ISOFORM 3).
    Tissue: Bone marrow.
  9. "Mouse homologs of human chromosome 21 genes."
    Tsyba L.O., Kvasha S.M., Skripkina I.Y., Anoprienko O.V., Slavov D., Tassone F., Rynditch A.V., Gardiner K.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 963-1721 (ISOFORM 3).
    Tissue: Brain.
  10. "The human intersectin genes and their spliced variants are differentially expressed."
    Pucharcos C., Casas C., Nadal M., Estivill X., de la Luna S.
    Biochim. Biophys. Acta 1521:1-11(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
    Tissue: Brain and Fetal liver.
  11. "The SH3D1A gene maps to human chromosome 21q22.1-->q22.2."
    Chen H., Antonarakis S.E.
    Cytogenet. Cell Genet. 78:213-215(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE MAPPING.
  12. "The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin."
    Jenna S., Hussain N.K., Danek E.I., Triki I., Wasiak S., McPherson P.S., Lamarche-Vane N.
    J. Biol. Chem. 277:6366-6373(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARHGAP31, SUBCELLULAR LOCATION.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-904, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."
    Kleino I., Ortiz R.M., Yritys M., Huovila A.P., Saksela K.
    J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADAM15.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits."
    Dergai O., Novokhatska O., Dergai M., Skrypkina I., Tsyba L., Moreau J., Rynditch A.
    Biochem. Biophys. Res. Commun. 402:408-413(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH REPS1 AND SGIP1, SUBCELLULAR LOCATION.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. "FCHo proteins are nucleators of clathrin-mediated endocytosis."
    Henne W.M., Boucrot E., Meinecke M., Evergren E., Vallis Y., Mittal R., McMahon H.T.
    Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FCHO2.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis."
    Teckchandani A., Mulkearns E.E., Randolph T.W., Toida N., Cooper J.A.
    Mol. Biol. Cell 23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DAB2.
  22. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."
    Umasankar P.K., Sanker S., Thieman J.R., Chakraborty S., Wendland B., Tsang M., Traub L.M.
    Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FCHO1.
  23. "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors."
    Snyder J.T., Worthylake D.K., Rossman K.L., Betts L., Pruitt W.M., Siderovski D.P., Der C.J., Sondek J.
    Nat. Struct. Biol. 9:468-475(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1229-1581 IN COMPLEX WITH CDC42, MUTAGENESIS OF MET-1369 AND LEU-1376.

Entry informationi

Entry nameiITSN1_HUMAN
AccessioniPrimary (citable) accession number: Q15811
Secondary accession number(s): A7Y322
, A8CTX8, A8CTY3, A8CTY7, A8D7D0, A8DCP3, B4DTM2, E7ERJ1, E9PE44, E9PG01, E9PHV2, O95216, Q0PW94, Q0PW95, Q0PW97, Q14BD3, Q1ED40, Q20BK3, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3