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Q15811

- ITSN1_HUMAN

UniProt

Q15811 - ITSN1_HUMAN

Protein

Intersectin-1

Gene

ITSN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase By similarity. Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi66 – 77121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi267 – 278122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. guanyl-nucleotide exchange factor activity Source: UniProtKB
    3. kinase activator activity Source: Ensembl
    4. proline-rich region binding Source: UniProtKB
    5. protein binding Source: IntAct
    6. protein complex scaffold Source: UniProtKB
    7. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. apoptotic signaling pathway Source: Reactome
    2. negative regulation of neuron apoptotic process Source: Ensembl
    3. neurotrophin TRK receptor signaling pathway Source: Reactome
    4. positive regulation of apoptotic process Source: Reactome
    5. positive regulation of GTPase activity Source: GOC
    6. positive regulation of protein kinase B signaling Source: Ensembl
    7. regulation of small GTPase mediated signal transduction Source: Reactome
    8. small GTPase mediated signal transduction Source: Reactome
    9. synaptic vesicle endocytosis Source: ProtInc

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.
    SignaLinkiQ15811.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intersectin-1
    Alternative name(s):
    SH3 domain-containing protein 1A
    SH3P17
    Gene namesi
    Name:ITSN1
    Synonyms:ITSN, SH3D1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:6183. ITSN1.

    Subcellular locationi

    Endomembrane system By similarity. Cell junctionsynapsesynaptosome By similarity. Cell projectionlamellipodium. Membraneclathrin-coated pit
    Note: Colocalizes with SGIP1 at the plasma membrane in structures corresponding most problably to clathrin-coated pits.Curated

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. coated pit Source: UniProtKB
    3. cytosol Source: Reactome
    4. endocytic vesicle Source: Ensembl
    5. lamellipodium Source: UniProtKB-SubCell
    6. neuron projection Source: UniProtKB-SubCell
    7. plasma membrane Source: UniProtKB
    8. synapse Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell projection, Coated pit, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1369 – 13691M → L: Decreases specificity for CDC42; when associated with I-1376. 1 Publication
    Mutagenesisi1376 – 13761L → I: Decreases specificity for CDC42; when associated with L-1369. 1 Publication

    Organism-specific databases

    PharmGKBiPA29981.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17211721Intersectin-1PRO_0000080957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei203 – 2031PhosphoserineBy similarity
    Modified residuei902 – 9021Phosphoserine1 Publication
    Modified residuei904 – 9041Phosphoserine1 Publication
    Modified residuei1137 – 11371PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15811.
    PaxDbiQ15811.
    PRIDEiQ15811.

    PTM databases

    PhosphoSiteiQ15811.

    Expressioni

    Tissue specificityi

    Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord.

    Gene expression databases

    ArrayExpressiQ15811.
    BgeeiQ15811.
    CleanExiHS_ITSN1.
    GenevestigatoriQ15811.

    Organism-specific databases

    HPAiHPA018007.

    Interactioni

    Subunit structurei

    Interacts with dynamin, CDC42, SNAP25 and SNAP23. Clusters several dynamin in a manner that is regulated by alternative splicing. Interacts with clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2, STON2, FCHO1, FCHO2 and DAB2. Interacts (via SH3 domains) with REPS1 and SGIP1. Interacts with ARHGAP31. Interacts with ADAM15.7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CBLP2268112EBI-602041,EBI-518228
    CDC42P60953-12EBI-602041,EBI-3625591
    DISC1Q9NRI53EBI-602041,EBI-529989
    DNM2P505702EBI-602041,EBI-346547
    Fcho2Q3UQN23EBI-602041,EBI-6094986From a different organism.
    INPPL1O153579EBI-8052395,EBI-1384248
    Sh3kbp1Q925Q94EBI-8052395,EBI-8020091From a different organism.

    Protein-protein interaction databases

    BioGridi112351. 120 interactions.
    DIPiDIP-33609N.
    IntActiQ15811. 44 interactions.
    MINTiMINT-130199.
    STRINGi9606.ENSP00000370719.

    Structurei

    Secondary structure

    1
    1721
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni12 – 143
    Helixi19 – 3113
    Beta strandi35 – 373
    Beta strandi38 – 403
    Helixi41 – 488
    Helixi49 – 513
    Helixi55 – 6511
    Beta strandi70 – 734
    Helixi75 – 8915
    Helixi100 – 1023
    Beta strandi215 – 2173
    Helixi219 – 23012
    Beta strandi239 – 2413
    Helixi242 – 2509
    Helixi256 – 26611
    Beta strandi272 – 2754
    Helixi276 – 29015
    Helixi301 – 3033
    Turni306 – 3094
    Beta strandi916 – 9227
    Beta strandi939 – 9457
    Beta strandi947 – 9548
    Beta strandi957 – 9626
    Helixi963 – 9653
    Beta strandi966 – 9694
    Helixi1233 – 126230
    Helixi1264 – 12696
    Beta strandi1271 – 12733
    Helixi1275 – 12828
    Helixi1285 – 130622
    Beta strandi1308 – 13103
    Helixi1316 – 13227
    Helixi1323 – 13275
    Helixi1328 – 134922
    Helixi1351 – 136111
    Helixi1364 – 13663
    Helixi1371 – 13744
    Helixi1377 – 139317
    Helixi1403 – 143735
    Beta strandi1451 – 14544
    Beta strandi1456 – 14605
    Beta strandi1463 – 14664
    Beta strandi1472 – 14743
    Beta strandi1479 – 149315
    Beta strandi1511 – 15133
    Helixi1522 – 15243
    Beta strandi1525 – 15284
    Beta strandi1531 – 15333
    Beta strandi1541 – 15444
    Beta strandi1547 – 15504
    Helixi1556 – 157722

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KI1X-ray2.30B/D1229-1581[»]
    2KGRNMR-A210-312[»]
    2KHNNMR-A1-111[»]
    3FIAX-ray1.45A1-111[»]
    3QBVX-ray2.65B/D1229-1579[»]
    4IIMX-ray1.80A/B916-970[»]
    ProteinModelPortaliQ15811.
    SMRiQ15811. Positions 1-111, 210-312, 745-835, 916-1581, 1595-1718.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15811.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 10989EH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini53 – 8836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini221 – 31090EH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini254 – 28936EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini740 – 80667SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini913 – 97159SH3 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1002 – 106059SH3 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1074 – 113865SH3 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1155 – 121460SH3 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1237 – 1423187DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini1462 – 1571110PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini1583 – 167997C2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni326 – 702377KLERQAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili351 – 705355Sequence AnalysisAdd
    BLAST

    Domaini

    SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin By similarity. SH3-1 and SH3-4 bind to ARHGAP31.By similarity
    The KLERQ domain binds to SNAP-25 and SNAP-23.By similarity
    In an autoinhibited form the SH3 domain 5 may bind intramolecularly to the DH domain, thus blocking the CDC42-binding site.By similarity

    Sequence similaritiesi

    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 2 EH domains.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 5 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG5422.
    HOVERGENiHBG052159.
    InParanoidiQ15811.
    OMAiVMVKGEW.
    PhylomeDBiQ15811.
    TreeFamiTF324293.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR000219. DH-domain.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000261. EPS15_homology.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF14604. SH3_9. 5 hits.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00239. C2. 1 hit.
    SM00054. EFh. 2 hits.
    SM00027. EH. 2 hits.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 5 hits.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF50044. SSF50044. 5 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50031. EH. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 5 hits.
    [Graphical view]

    Sequences (13)i

    Sequence statusi: Complete.

    This entry describes 13 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist. Alternative splicing affects domains involved in protein recognition and thus may play a role in selecting specific interactions.2 Publications

    Isoform 1 (identifier: Q15811-1) [UniParc]FASTAAdd to Basket

    Also known as: Long, ITSN-l

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ     50
    SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 100
    VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 150
    PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 200
    AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 250
    QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 300
    PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 350
    EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 400
    QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 450
    RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 500
    CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 550
    QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 600
    DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 650
    RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 700
    AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 750
    FESRSHDEIT IQPGDIVMVK GEWVDESQTG EPGWLGGELK GKTGWFPANY 800
    AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS SEPSTTPNNW 850
    ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG 900
    SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW 950
    FGEVQGQKGW FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP 1000
    VVSGEEFIAM YTYESSEQGD LTFQQGDVIL VTKKDGDWWT GTVGDKAGVF 1050
    PSNYVRLKDS EGSGTAGKTG SLGKKPEIAQ VIASYTATGP EQLTLAPGQL 1100
    ILIRKKNPGG WWEGELQARG KKRQIGWFPA NYVKLLSPGT SKITPTEPPK 1150
    STALAAVCQV IGMYDYTAQN DDELAFNKGQ IINVLNKEDP DWWKGEVNGQ 1200
    VGLFPSNYVK LTTDMDPSQQ WCSDLHLLDM LTPTERKRQG YIHELIVTEE 1250
    NYVNDLQLVT EIFQKPLMES ELLTEKEVAM IFVNWKELIM CNIKLLKALR 1300
    VRKKMSGEKM PVKMIGDILS AQLPHMQPYI RFCSRQLNGA ALIQQKTDEA 1350
    PDFKEFVKRL AMDPRCKGMP LSSFILKPMQ RVTRYPLIIK NILENTPENH 1400
    PDHSHLKHAL EKAEELCSQV NEGVREKENS DRLEWIQAHV QCEGLSEQLV 1450
    FNSVTNCLGP RKFLHSGKLY KAKSNKELYG FLFNDFLLLT QITKPLGSSG 1500
    TDKVFSPKSN LQYKMYKTPI FLNEVLVKLP TDPSGDEPIF HISHIDRVYT 1550
    LRAESINERT AWVQKIKAAS ELYIETEKKK REKAYLVRSQ RATGIGRLMV 1600
    NVVEGIELKP CRSHGKSNPY CEVTMGSQCH ITKTIQDTLN PKWNSNCQFF 1650
    IRDLEQEVLC ITVFERDQFS PDDFLGRTEI RVADIKKDQG SKGPVTKCLL 1700
    LHEVPTGEIV VRLDLQLFDE P 1721
    Length:1,721
    Mass (Da):195,422
    Last modified:October 17, 2006 - v3
    Checksum:iFC4DE644D8BEA2BE
    GO
    Isoform 2 (identifier: Q15811-2) [UniParc]FASTAAdd to Basket

    Also known as: Short, ITSN-s

    The sequence of this isoform differs from the canonical sequence as follows:
         1221-1721: Missing.

    Show »
    Length:1,220
    Mass (Da):137,649
    Checksum:iB09FDBEF1C06F487
    GO
    Isoform 3 (identifier: Q15811-3) [UniParc]FASTAAdd to Basket

    Also known as: Short 2, SH3P17

    The sequence of this isoform differs from the canonical sequence as follows:
         770-774: Missing.
         1006-1076: Missing.
         1221-1721: Missing.

    Show »
    Length:1,144
    Mass (Da):129,416
    Checksum:i8EEE8BE230C2F8C7
    GO
    Isoform 4 (identifier: Q15811-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1006-1076: Missing.

    Show »
    Length:1,650
    Mass (Da):187,788
    Checksum:i584F3A7AD02E4434
    GO
    Isoform 5 (identifier: Q15811-5) [UniParc]FASTAAdd to Basket

    Also known as: ITSN1-22a

    The sequence of this isoform differs from the canonical sequence as follows:
         770-774: Missing.
         910-1025: GEKVEGLQAQ...SEQGDLTFQQ → PDFLLHPSMR...CFYLCLPHYL
         1026-1721: Missing.

    Show »
    Length:1,020
    Mass (Da):115,873
    Checksum:i53D58238CDB49BB4
    GO
    Isoform 6 (identifier: Q15811-6) [UniParc]FASTAAdd to Basket

    Also known as: Long form variant 4, Short form variant 11

    The sequence of this isoform differs from the canonical sequence as follows:
         770-774: Missing.
         1006-1020: EFIAMYTYESSEQGD → GLWNCWENREFRKKT
         1021-1721: Missing.

    Note: Contains a premature stop codon, potentially subjected to NMD.

    Show »
    Length:1,015
    Mass (Da):115,477
    Checksum:i7FAD870DF7E4D42E
    GO
    Isoform 7 (identifier: Q15811-7) [UniParc]FASTAAdd to Basket

    Also known as: Short form variant 5

    The sequence of this isoform differs from the canonical sequence as follows:
         770-774: Missing.
         1221-1721: Missing.

    Show »
    Length:1,215
    Mass (Da):137,049
    Checksum:i9610DEBFC4781CED
    GO
    Isoform 8 (identifier: Q15811-8) [UniParc]FASTAAdd to Basket

    Also known as: Long form variant 2

    The sequence of this isoform differs from the canonical sequence as follows:
         770-774: Missing.

    Show »
    Length:1,716
    Mass (Da):194,822
    Checksum:iA129042F01C34A47
    GO
    Isoform 9 (identifier: Q15811-9) [UniParc]FASTAAdd to Basket

    Also known as: Long form variant 3

    The sequence of this isoform differs from the canonical sequence as follows:
         770-774: Missing.
         1392-1447: Missing.

    Show »
    Length:1,660
    Mass (Da):188,382
    Checksum:i715F81F741A346E4
    GO
    Isoform 10 (identifier: Q15811-10) [UniParc]FASTAAdd to Basket

    Also known as: Short form variant 2

    The sequence of this isoform differs from the canonical sequence as follows:
         116-152: Missing.
         770-774: Missing.
         1221-1721: Missing.

    Show »
    Length:1,178
    Mass (Da):133,560
    Checksum:iA344C5964504BDB1
    GO
    Isoform 11 (identifier: Q15811-11) [UniParc]FASTAAdd to Basket

    Also known as: Short form variant 3

    The sequence of this isoform differs from the canonical sequence as follows:
         116-152: Missing.
         1006-1076: Missing.
         1221-1721: Missing.

    Show »
    Length:1,112
    Mass (Da):126,526
    Checksum:iAB25F8723B3FD22A
    GO
    Isoform 12 (identifier: Q15811-12) [UniParc]FASTAAdd to Basket

    Also known as: Short form variant 10

    The sequence of this isoform differs from the canonical sequence as follows:
         116-152: Missing.
         770-774: Missing.
         1006-1076: Missing.
         1221-1721: Missing.

    Show »
    Length:1,107
    Mass (Da):125,926
    Checksum:i7724CCE4FA98098A
    GO
    Isoform 13 (identifier: Q15811-13) [UniParc]FASTAAdd to Basket

    Also known as: Short form variant 14

    The sequence of this isoform differs from the canonical sequence as follows:
         770-774: Missing.
         910-919: GEKVEGLQAQ → HGFWFFRESC
         920-1721: Missing.

    Note: Contains a premature stop codon, potentially subjected to NMD.

    Show »
    Length:914
    Mass (Da):104,194
    Checksum:i3788E745D07FE820
    GO

    Sequence cautioni

    The sequence AAC50592.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141A → P in AAC78610. (PubMed:9799604)Curated
    Sequence conflicti114 – 1141A → P in AAC78611. (PubMed:9799604)Curated
    Sequence conflicti114 – 1141A → P in ABG74695. (PubMed:19777371)Curated
    Sequence conflicti114 – 1141A → P in ABG74697. (PubMed:19777371)Curated
    Sequence conflicti114 – 1141A → P in ABG74698. (PubMed:19777371)Curated
    Sequence conflicti863 – 8631E → G in ABD72328. (PubMed:21712076)Curated
    Sequence conflicti1088 – 10881T → A in AAD53183. 1 PublicationCurated
    Sequence conflicti1109 – 11091G → R in AAD53183. 1 PublicationCurated
    Sequence conflicti1361 – 13611A → E in AAC78611. (PubMed:9799604)Curated
    Sequence conflicti1361 – 13611A → E in AAC50592. (PubMed:9630982)Curated
    Sequence conflicti1367 – 13671K → R in AAI16187. (PubMed:15489334)Curated
    Sequence conflicti1474 – 14741S → N in AAC78611. (PubMed:9799604)Curated
    Sequence conflicti1474 – 14741S → N in AAC50592. (PubMed:9630982)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1137 – 11371S → N.2 Publications
    Corresponds to variant rs187895245 [ dbSNP | Ensembl ].
    VAR_070011

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei116 – 15237Missing in isoform 10, isoform 11 and isoform 12. 1 PublicationVSP_053317Add
    BLAST
    Alternative sequencei770 – 7745Missing in isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10, isoform 12 and isoform 13. 6 PublicationsVSP_004293
    Alternative sequencei910 – 1025116GEKVE…LTFQQ → PDFLLHPSMRLGHMQPRIVL LFPDPLQCSTSRLLPMLRPR PGVPFLRSPSCQSPSHPSRP ISDAAPSVKFTLMPPGRIHP CFLFIPAVNSRNSFLVYFIL PGGTLGCFYLCLPHYL in isoform 5. 1 PublicationVSP_047460Add
    BLAST
    Alternative sequencei910 – 91910GEKVEGLQAQ → HGFWFFRESC in isoform 13. CuratedVSP_053318
    Alternative sequencei920 – 1721802Missing in isoform 13. CuratedVSP_053319Add
    BLAST
    Alternative sequencei1006 – 107671Missing in isoform 3, isoform 4, isoform 11 and isoform 12. 4 PublicationsVSP_004294Add
    BLAST
    Alternative sequencei1006 – 102015EFIAM…SEQGD → GLWNCWENREFRKKT in isoform 6. 1 PublicationVSP_053320Add
    BLAST
    Alternative sequencei1021 – 1721701Missing in isoform 6. 1 PublicationVSP_053321Add
    BLAST
    Alternative sequencei1026 – 1721696Missing in isoform 5. 1 PublicationVSP_047461Add
    BLAST
    Alternative sequencei1221 – 1721501Missing in isoform 2, isoform 3, isoform 7, isoform 10, isoform 11 and isoform 12. 7 PublicationsVSP_004295Add
    BLAST
    Alternative sequencei1392 – 144756Missing in isoform 9. 1 PublicationVSP_053322Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064244 mRNA. Translation: AAC78611.1.
    AF064247, AF064245, AF064246 Genomic DNA. Translation: AAC80437.1.
    AF064243 mRNA. Translation: AAC78610.1.
    AF114488 mRNA. Translation: AAD29953.1.
    AF114487 mRNA. Translation: AAD29952.1.
    DQ679754 mRNA. Translation: ABG74695.1.
    DQ679756 mRNA. Translation: ABG74697.1.
    DQ679757 mRNA. Translation: ABG74698.1.
    EU117382 mRNA. Translation: ABV21755.1.
    EU140799 mRNA. Translation: ABV58335.1.
    EU140800 mRNA. Translation: ABV58336.1.
    EU120733 mRNA. Translation: ABV24866.1.
    EU120734 mRNA. Translation: ABV24867.1.
    EU120735 mRNA. Translation: ABV24868.1.
    EU152331 mRNA. Translation: ABV69555.1.
    DQ386455 mRNA. Translation: ABD72328.1.
    AK300274 mRNA. Translation: BAG62034.1.
    AP000308 Genomic DNA. No translation available.
    AP000309 Genomic DNA. No translation available.
    AP000310 Genomic DNA. No translation available.
    AP000311 Genomic DNA. No translation available.
    AP000312 Genomic DNA. No translation available.
    AP000313 Genomic DNA. No translation available.
    BC117560 mRNA. Translation: AAI17561.1.
    BC116186 mRNA. Translation: AAI16187.1.
    U61166 mRNA. Translation: AAC50592.1. Different initiation.
    AF180522 mRNA. Translation: AAD53183.1.
    CCDSiCCDS33545.1. [Q15811-1]
    CCDS33546.1. [Q15811-2]
    RefSeqiNP_001001132.1. NM_001001132.1. [Q15811-2]
    NP_003015.2. NM_003024.2. [Q15811-1]
    XP_005261083.1. XM_005261026.1. [Q15811-8]
    XP_005261084.1. XM_005261027.1. [Q15811-7]
    XP_005261088.1. XM_005261031.1. [Q15811-3]
    UniGeneiHs.160324.

    Genome annotation databases

    EnsembliENST00000379960; ENSP00000369294; ENSG00000205726. [Q15811-13]
    ENST00000381291; ENSP00000370691; ENSG00000205726. [Q15811-2]
    ENST00000381318; ENSP00000370719; ENSG00000205726. [Q15811-1]
    ENST00000399338; ENSP00000382275; ENSG00000205726. [Q15811-5]
    ENST00000399349; ENSP00000382286; ENSG00000205726. [Q15811-3]
    ENST00000399352; ENSP00000382289; ENSG00000205726. [Q15811-7]
    ENST00000399353; ENSP00000382290; ENSG00000205726. [Q15811-10]
    ENST00000399367; ENSP00000382301; ENSG00000205726. [Q15811-8]
    ENST00000437442; ENSP00000387377; ENSG00000205726. [Q15811-9]
    GeneIDi6453.
    KEGGihsa:6453.
    UCSCiuc002ysw.3. human. [Q15811-1]
    uc002ysz.3. human. [Q15811-3]

    Polymorphism databases

    DMDMi116242596.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064244 mRNA. Translation: AAC78611.1 .
    AF064247 , AF064245 , AF064246 Genomic DNA. Translation: AAC80437.1 .
    AF064243 mRNA. Translation: AAC78610.1 .
    AF114488 mRNA. Translation: AAD29953.1 .
    AF114487 mRNA. Translation: AAD29952.1 .
    DQ679754 mRNA. Translation: ABG74695.1 .
    DQ679756 mRNA. Translation: ABG74697.1 .
    DQ679757 mRNA. Translation: ABG74698.1 .
    EU117382 mRNA. Translation: ABV21755.1 .
    EU140799 mRNA. Translation: ABV58335.1 .
    EU140800 mRNA. Translation: ABV58336.1 .
    EU120733 mRNA. Translation: ABV24866.1 .
    EU120734 mRNA. Translation: ABV24867.1 .
    EU120735 mRNA. Translation: ABV24868.1 .
    EU152331 mRNA. Translation: ABV69555.1 .
    DQ386455 mRNA. Translation: ABD72328.1 .
    AK300274 mRNA. Translation: BAG62034.1 .
    AP000308 Genomic DNA. No translation available.
    AP000309 Genomic DNA. No translation available.
    AP000310 Genomic DNA. No translation available.
    AP000311 Genomic DNA. No translation available.
    AP000312 Genomic DNA. No translation available.
    AP000313 Genomic DNA. No translation available.
    BC117560 mRNA. Translation: AAI17561.1 .
    BC116186 mRNA. Translation: AAI16187.1 .
    U61166 mRNA. Translation: AAC50592.1 . Different initiation.
    AF180522 mRNA. Translation: AAD53183.1 .
    CCDSi CCDS33545.1. [Q15811-1 ]
    CCDS33546.1. [Q15811-2 ]
    RefSeqi NP_001001132.1. NM_001001132.1. [Q15811-2 ]
    NP_003015.2. NM_003024.2. [Q15811-1 ]
    XP_005261083.1. XM_005261026.1. [Q15811-8 ]
    XP_005261084.1. XM_005261027.1. [Q15811-7 ]
    XP_005261088.1. XM_005261031.1. [Q15811-3 ]
    UniGenei Hs.160324.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KI1 X-ray 2.30 B/D 1229-1581 [» ]
    2KGR NMR - A 210-312 [» ]
    2KHN NMR - A 1-111 [» ]
    3FIA X-ray 1.45 A 1-111 [» ]
    3QBV X-ray 2.65 B/D 1229-1579 [» ]
    4IIM X-ray 1.80 A/B 916-970 [» ]
    ProteinModelPortali Q15811.
    SMRi Q15811. Positions 1-111, 210-312, 745-835, 916-1581, 1595-1718.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112351. 120 interactions.
    DIPi DIP-33609N.
    IntActi Q15811. 44 interactions.
    MINTi MINT-130199.
    STRINGi 9606.ENSP00000370719.

    PTM databases

    PhosphoSitei Q15811.

    Polymorphism databases

    DMDMi 116242596.

    Proteomic databases

    MaxQBi Q15811.
    PaxDbi Q15811.
    PRIDEi Q15811.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379960 ; ENSP00000369294 ; ENSG00000205726 . [Q15811-13 ]
    ENST00000381291 ; ENSP00000370691 ; ENSG00000205726 . [Q15811-2 ]
    ENST00000381318 ; ENSP00000370719 ; ENSG00000205726 . [Q15811-1 ]
    ENST00000399338 ; ENSP00000382275 ; ENSG00000205726 . [Q15811-5 ]
    ENST00000399349 ; ENSP00000382286 ; ENSG00000205726 . [Q15811-3 ]
    ENST00000399352 ; ENSP00000382289 ; ENSG00000205726 . [Q15811-7 ]
    ENST00000399353 ; ENSP00000382290 ; ENSG00000205726 . [Q15811-10 ]
    ENST00000399367 ; ENSP00000382301 ; ENSG00000205726 . [Q15811-8 ]
    ENST00000437442 ; ENSP00000387377 ; ENSG00000205726 . [Q15811-9 ]
    GeneIDi 6453.
    KEGGi hsa:6453.
    UCSCi uc002ysw.3. human. [Q15811-1 ]
    uc002ysz.3. human. [Q15811-3 ]

    Organism-specific databases

    CTDi 6453.
    GeneCardsi GC21P035014.
    HGNCi HGNC:6183. ITSN1.
    HPAi HPA018007.
    MIMi 602442. gene.
    neXtProti NX_Q15811.
    PharmGKBi PA29981.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5422.
    HOVERGENi HBG052159.
    InParanoidi Q15811.
    OMAi VMVKGEW.
    PhylomeDBi Q15811.
    TreeFami TF324293.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.
    SignaLinki Q15811.

    Miscellaneous databases

    EvolutionaryTracei Q15811.
    GeneWikii ITSN1.
    GenomeRNAii 6453.
    NextBioi 25083.
    PROi Q15811.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15811.
    Bgeei Q15811.
    CleanExi HS_ITSN1.
    Genevestigatori Q15811.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR000219. DH-domain.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000261. EPS15_homology.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF14604. SH3_9. 5 hits.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00239. C2. 1 hit.
    SM00054. EFh. 2 hits.
    SM00027. EH. 2 hits.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF50044. SSF50044. 5 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50031. EH. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon."
      Guipponi M., Scott H.S., Chen H., Schebesta A., Rossier C., Antonarakis S.E.
      Genomics 53:369-376(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANT ASN-1137.
      Tissue: Fetal brain.
    2. "Alu-splice cloning of human intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome."
      Pucharcos C., Fuentes J.-J., Casas C., de la Luna S., Alcantara S., Arbones M.L., Soriano E., Estivill X., Pritchard M.
      Eur. J. Hum. Genet. 7:704-712(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "Structural diversity and differential expression of novel human intersectin 1 isoforms."
      Kropyvko S., Gerasymchuk D., Skrypkina I., Dergai M., Dergai O., Nikolaienko O., Rynditch A., Tsyba L.
      Mol. Biol. Rep. 37:2789-2796(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8; 9; 10; 11 AND 12), VARIANT ASN-1137, ALTERNATIVE SPLICING.
      Tissue: Brain and Lung.
    4. "Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1."
      Dergai M., Skrypkina I., Dergai O., Tsyba L., Novokhatska O., Filonenko V., Drobot L., Rynditch A.
      Gene 485:120-129(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
      Tissue: Kidney.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Placenta.
    6. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Embryonic stem cell.
    8. "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins."
      Sparks A.B., Hoffman N.G., McConnell S.J., Fowlkes D.M., Kay B.K.
      Nat. Biotechnol. 14:741-744(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 620-1721 (ISOFORM 3).
      Tissue: Bone marrow.
    9. "Mouse homologs of human chromosome 21 genes."
      Tsyba L.O., Kvasha S.M., Skripkina I.Y., Anoprienko O.V., Slavov D., Tassone F., Rynditch A.V., Gardiner K.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 963-1721 (ISOFORM 3).
      Tissue: Brain.
    10. "The human intersectin genes and their spliced variants are differentially expressed."
      Pucharcos C., Casas C., Nadal M., Estivill X., de la Luna S.
      Biochim. Biophys. Acta 1521:1-11(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
      Tissue: Brain and Fetal liver.
    11. "The SH3D1A gene maps to human chromosome 21q22.1-->q22.2."
      Chen H., Antonarakis S.E.
      Cytogenet. Cell Genet. 78:213-215(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE MAPPING.
    12. "The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin."
      Jenna S., Hussain N.K., Danek E.I., Triki I., Wasiak S., McPherson P.S., Lamarche-Vane N.
      J. Biol. Chem. 277:6366-6373(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ARHGAP31, SUBCELLULAR LOCATION.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-904, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."
      Kleino I., Ortiz R.M., Yritys M., Huovila A.P., Saksela K.
      J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ADAM15.
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits."
      Dergai O., Novokhatska O., Dergai M., Skrypkina I., Tsyba L., Moreau J., Rynditch A.
      Biochem. Biophys. Res. Commun. 402:408-413(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH REPS1 AND SGIP1, SUBCELLULAR LOCATION.
    18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. "FCHo proteins are nucleators of clathrin-mediated endocytosis."
      Henne W.M., Boucrot E., Meinecke M., Evergren E., Vallis Y., Mittal R., McMahon H.T.
      Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FCHO2.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis."
      Teckchandani A., Mulkearns E.E., Randolph T.W., Toida N., Cooper J.A.
      Mol. Biol. Cell 23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DAB2.
    22. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."
      Umasankar P.K., Sanker S., Thieman J.R., Chakraborty S., Wendland B., Tsang M., Traub L.M.
      Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FCHO1.
    23. "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors."
      Snyder J.T., Worthylake D.K., Rossman K.L., Betts L., Pruitt W.M., Siderovski D.P., Der C.J., Sondek J.
      Nat. Struct. Biol. 9:468-475(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1229-1581 IN COMPLEX WITH CDC42, MUTAGENESIS OF MET-1369 AND LEU-1376.

    Entry informationi

    Entry nameiITSN1_HUMAN
    AccessioniPrimary (citable) accession number: Q15811
    Secondary accession number(s): A7Y322
    , A8CTX8, A8CTY3, A8CTY7, A8D7D0, A8DCP3, B4DTM2, E7ERJ1, E9PE44, E9PG01, E9PHV2, O95216, Q0PW94, Q0PW95, Q0PW97, Q14BD3, Q1ED40, Q20BK3, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 157 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3