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Protein

CREB-regulated transcription coactivator 1

Gene

Crtc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei571 – 5711Required for ubiquitination and degradationBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB-regulated transcription coactivator 1
Alternative name(s):
Mucoepidermoid carcinoma translocated protein 1 homolog
Transducer of regulated cAMP response element-binding protein 1
Short name:
TORC-1
Short name:
Transducer of CREB protein 1
Gene namesi
Name:Crtc1
Synonyms:Mect1, Torc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1589158. Crtc1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • neuronal cell body Source: RGD
  • nucleoplasm Source: Ensembl
  • nucleus Source: UniProtKB
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630CREB-regulated transcription coactivator 1PRO_0000413636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine; by SIK1 and SIK21 Publication
Modified residuei161 – 1611PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ157S1.

PTM databases

iPTMnetiQ157S1.
PhosphoSiteiQ157S1.

Expressioni

Tissue specificityi

Highly expressed in developing cortical neurons, peaking during dendrite development.1 Publication

Interactioni

Subunit structurei

Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ157S1. 1 interaction.
STRINGi10116.ENSRNOP00000030925.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi242 – 25817Nuclear export signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi295 – 36571Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the TORC family.Curated

Phylogenomic databases

eggNOGiENOG410IGNT. Eukaryota.
ENOG410XPDQ. LUCA.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000203638.
HOVERGENiHBG058314.
InParanoidiQ157S1.
KOiK15309.
OMAiIPQSPPG.
OrthoDBiEOG7MKW5P.
PhylomeDBiQ157S1.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q157S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY
60 70 80 90 100
LQLGPSRGQY YGGSLPNVNQ IGSSSMDLSF QTPFQSSGLD TSRTTRHHGL
110 120 130 140 150
VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTVYLSP PADTSWRRTN
160 170 180 190 200
SDSALHQSTM TPTQAESFTG GPQDAHQKRV LLLTVPGMEE TGSETDKTLS
210 220 230 240 250
KQSWDSKKAG SRPKSCEVPG INIFPSADQE NTAALIPATH NTGGSLPDLS
260 270 280 290 300
TIHFPSPLPT PLDPEEPPFP ALTSSGSTGS LAHLGVGGTG QGMNTPSSSP
310 320 330 340 350
QRRPAVVSPL SLSTEARRQQ AQQVPPTLSP LSPITQAVAM DALSLEQQLP
360 370 380 390 400
YAFFTQAGSQ QPPPQPQPPP PPPPVSQQQP PPPQVSVGLP QGGPLLPSAS
410 420 430 440 450
LTRGPQLPPL AVTVPSTLPQ SPTESPGQPP MGIDVTSAPA LQYRTGAGSP
460 470 480 490 500
ATQSPTSPVS NQGFSPGSSP QHTSTLGSVF GDAYYEQQMT ARQANALSRQ
510 520 530 540 550
LEQFNMMENA ISSSSLYNPG STLNYSQAAM MGLSGSHGGL QDPQQLGYAG
560 570 580 590 600
HGGIPNIILT VTGESPPSLS KELSSTLAGV SDVSFDSDHQ FPLDELKIDP
610 620 630
LTLDGLHMLN DPDMVLADPA TEDTFRMDRL
Length:630
Mass (Da):66,924
Last modified:July 25, 2006 - v1
Checksum:i2ABD42BE1F0D1095
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ538521 mRNA. Translation: ABG23027.1.
RefSeqiNP_001040580.1. NM_001047115.1.
UniGeneiRn.208248.

Genome annotation databases

EnsembliENSRNOT00000038057; ENSRNOP00000030925; ENSRNOG00000022421.
GeneIDi684527.
KEGGirno:684527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ538521 mRNA. Translation: ABG23027.1.
RefSeqiNP_001040580.1. NM_001047115.1.
UniGeneiRn.208248.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ157S1. 1 interaction.
STRINGi10116.ENSRNOP00000030925.

PTM databases

iPTMnetiQ157S1.
PhosphoSiteiQ157S1.

Proteomic databases

PaxDbiQ157S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038057; ENSRNOP00000030925; ENSRNOG00000022421.
GeneIDi684527.
KEGGirno:684527.

Organism-specific databases

CTDi23373.
RGDi1589158. Crtc1.

Phylogenomic databases

eggNOGiENOG410IGNT. Eukaryota.
ENOG410XPDQ. LUCA.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000203638.
HOVERGENiHBG058314.
InParanoidiQ157S1.
KOiK15309.
OMAiIPQSPPG.
OrthoDBiEOG7MKW5P.
PhylomeDBiQ157S1.

Miscellaneous databases

NextBioi727612.
PROiQ157S1.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "TORC1 in the central nervous system."
    Hao W., Hong S., Zhiqi X.
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons."
    Li S., Zhang C., Takemori H., Zhou Y., Xiong Z.Q.
    J. Neurosci. 29:2334-2343(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-151.

Entry informationi

Entry nameiCRTC1_RAT
AccessioniPrimary (citable) accession number: Q157S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 25, 2006
Last modified: May 11, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.