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Protein

Mitochondrial import receptor subunit TOM34

Gene

TOMM34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.3 Publications

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

GO - Biological processi

  • protein targeting to mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000025772-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM34
Short name:
hTom34
Alternative name(s):
Translocase of outer membrane 34 kDa subunit
Gene namesi
Name:TOMM34
Synonyms:URCC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15746. TOMM34.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • integral component of membrane Source: ProtInc
  • membrane Source: UniProtKB
  • mitochondrial outer membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10953.
OpenTargetsiENSG00000025772.
PharmGKBiPA38032.

Polymorphism and mutation databases

BioMutaiTOMM34.
DMDMi24212065.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063341 – 309Mitochondrial import receptor subunit TOM34Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei186PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15785.
MaxQBiQ15785.
PaxDbiQ15785.
PeptideAtlasiQ15785.
PRIDEiQ15785.

PTM databases

iPTMnetiQ15785.
PhosphoSitePlusiQ15785.
SwissPalmiQ15785.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000025772.
CleanExiHS_TOMM34.
GenevisibleiQ15785. HS.

Organism-specific databases

HPAiHPA018845.
HPA056875.

Interactioni

Subunit structurei

Interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, and DMAP1 through its TPR repeat.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-1054499,EBI-717399

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116153. 42 interactors.
IntActiQ15785. 11 interactors.
MINTiMINT-5001321.
STRINGi9606.ENSP00000361900.

Structurei

3D structure databases

ProteinModelPortaliQ15785.
SMRiQ15785.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 42TPR 1Add BLAST34
Repeati51 – 84TPR 2Add BLAST34
Repeati86 – 118TPR 3Add BLAST33
Repeati193 – 226TPR 4Add BLAST34
Repeati227 – 260TPR 5Add BLAST34
Repeati262 – 294TPR 6Add BLAST33

Sequence similaritiesi

Belongs to the Tom34 family.Curated
Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00840000129761.
HOGENOMiHOG000070537.
HOVERGENiHBG105545.
InParanoidiQ15785.
KOiK17766.
OMAiNCNECIK.
OrthoDBiEOG091G0FFR.
PhylomeDBiQ15785.
TreeFamiTF106202.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKFPDSVE ELRAAGNESF RNGQYAEASA LYGRALRVLQ AQGSSDPEEE
60 70 80 90 100
SVLYSNRAAC HLKDGNCRDC IKDCTSALAL VPFSIKPLLR RASAYEALEK
110 120 130 140 150
YPMAYVDYKT VLQIDDNVTS AVEGINRMTR ALMDSLGPEW RLKLPSIPLV
160 170 180 190 200
PVSAQKRWNS LPSENHKEMA KSKSKETTAT KNRVPSAGDV EKARVLKEEG
210 220 230 240 250
NELVKKGNHK KAIEKYSESL LCSNLESATY SNRALCYLVL KQYTEAVKDC
260 270 280 290 300
TEALKLDGKN VKAFYRRAQA HKALKDYKSS FADISNLLQI EPRNGPAQKL

RQEVKQNLH
Length:309
Mass (Da):34,559
Last modified:October 19, 2002 - v2
Checksum:iA39D7987CC4A57E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62 – 64LKD → WKN in AAC64484 (PubMed:9324309).Curated3
Sequence conflicti126N → S in BAD96672 (Ref. 5) Curated1
Sequence conflicti147I → F in AAC64484 (PubMed:9324309).Curated1
Sequence conflicti160S → F in AAC64484 (PubMed:9324309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059860293R → K.Corresponds to variant rs6094061dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58970 mRNA. Translation: AAC64484.1.
AB085681 mRNA. Translation: BAF32949.1.
BT020008 mRNA. Translation: AAV38811.1.
BT020009 mRNA. Translation: AAV38812.1.
CR456765 mRNA. Translation: CAG33046.1.
AK222952 mRNA. Translation: BAD96672.1.
AL109839 Genomic DNA. Translation: CAB89422.1.
CH471077 Genomic DNA. Translation: EAW75886.1.
BC007423 mRNA. Translation: AAH07423.1.
BC001763 mRNA. Translation: AAH01763.1.
BC014907 mRNA. Translation: AAH14907.1.
CCDSiCCDS13340.1.
RefSeqiNP_006800.2. NM_006809.4.
UniGeneiHs.517066.

Genome annotation databases

EnsembliENST00000372813; ENSP00000361900; ENSG00000025772.
GeneIDi10953.
KEGGihsa:10953.
UCSCiuc002xmy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58970 mRNA. Translation: AAC64484.1.
AB085681 mRNA. Translation: BAF32949.1.
BT020008 mRNA. Translation: AAV38811.1.
BT020009 mRNA. Translation: AAV38812.1.
CR456765 mRNA. Translation: CAG33046.1.
AK222952 mRNA. Translation: BAD96672.1.
AL109839 Genomic DNA. Translation: CAB89422.1.
CH471077 Genomic DNA. Translation: EAW75886.1.
BC007423 mRNA. Translation: AAH07423.1.
BC001763 mRNA. Translation: AAH01763.1.
BC014907 mRNA. Translation: AAH14907.1.
CCDSiCCDS13340.1.
RefSeqiNP_006800.2. NM_006809.4.
UniGeneiHs.517066.

3D structure databases

ProteinModelPortaliQ15785.
SMRiQ15785.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116153. 42 interactors.
IntActiQ15785. 11 interactors.
MINTiMINT-5001321.
STRINGi9606.ENSP00000361900.

PTM databases

iPTMnetiQ15785.
PhosphoSitePlusiQ15785.
SwissPalmiQ15785.

Polymorphism and mutation databases

BioMutaiTOMM34.
DMDMi24212065.

Proteomic databases

EPDiQ15785.
MaxQBiQ15785.
PaxDbiQ15785.
PeptideAtlasiQ15785.
PRIDEiQ15785.

Protocols and materials databases

DNASUi10953.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372813; ENSP00000361900; ENSG00000025772.
GeneIDi10953.
KEGGihsa:10953.
UCSCiuc002xmy.4. human.

Organism-specific databases

CTDi10953.
DisGeNETi10953.
GeneCardsiTOMM34.
HGNCiHGNC:15746. TOMM34.
HPAiHPA018845.
HPA056875.
MIMi616049. gene.
neXtProtiNX_Q15785.
OpenTargetsiENSG00000025772.
PharmGKBiPA38032.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00840000129761.
HOGENOMiHOG000070537.
HOVERGENiHBG105545.
InParanoidiQ15785.
KOiK17766.
OMAiNCNECIK.
OrthoDBiEOG091G0FFR.
PhylomeDBiQ15785.
TreeFamiTF106202.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000025772-MONOMER.

Miscellaneous databases

GeneWikiiTOMM34.
GenomeRNAii10953.
PROiQ15785.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000025772.
CleanExiHS_TOMM34.
GenevisibleiQ15785. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM34_HUMAN
AccessioniPrimary (citable) accession number: Q15785
Secondary accession number(s): Q53GH9, Q6IBN7, Q9NTZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 2, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.