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Q15784

- NDF2_HUMAN

UniProt

Q15784 - NDF2_HUMAN

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Protein

Neurogenic differentiation factor 2

Gene

NEUROD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter By similarity.By similarity

GO - Molecular functioni

  1. E-box binding Source: UniProtKB
  2. protein heterodimerization activity Source: UniProtKB
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: ProtInc
  6. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. associative learning Source: Ensembl
  2. behavioral fear response Source: Ensembl
  3. cellular response to calcium ion Source: UniProtKB
  4. cellular response to electrical stimulus Source: UniProtKB
  5. cerebellar cortex development Source: UniProtKB
  6. negative regulation of synapse maturation Source: UniProtKB
  7. nervous system development Source: ProtInc
  8. neuron development Source: Ensembl
  9. positive regulation of calcium-mediated signaling Source: UniProtKB
  10. positive regulation of neuron differentiation Source: UniProtKB
  11. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  12. positive regulation of synapse maturation Source: UniProtKB
  13. positive regulation of synaptic plasticity Source: UniProtKB
  14. protein ubiquitination Source: UniProtKB
  15. regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 2
Short name:
NeuroD2
Alternative name(s):
Class A basic helix-loop-helix protein 1
Short name:
bHLHa1
NeuroD-related factor
Short name:
NDRF
Gene namesi
Name:NEUROD2
Synonyms:BHLHA1, NDRF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7763. NEUROD2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31565.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Neurogenic differentiation factor 2PRO_0000127387Add
BLAST

Proteomic databases

PaxDbiQ15784.
PRIDEiQ15784.

PTM databases

PhosphoSiteiQ15784.

Expressioni

Gene expression databases

BgeeiQ15784.
CleanExiHS_NEUROD2.
GenevestigatoriQ15784.

Organism-specific databases

HPAiHPA060457.

Interactioni

Subunit structurei

Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription activation require dimerization with another bHLH protein By similarity.By similarity

Protein-protein interaction databases

BioGridi110834. 2 interactions.
IntActiQ15784. 1 interaction.
MINTiMINT-6774369.
STRINGi9606.ENSP00000306754.

Structurei

3D structure databases

ProteinModelPortaliQ15784.
SMRiQ15784. Positions 122-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 17353bHLHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi107 – 1137Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 4610Poly-Pro
Compositional biasi82 – 9110Poly-Glu
Compositional biasi282 – 2854Poly-Gly

Domaini

The C-terminal region is necessary for depolarization-induced and calcium-dependent transcription activation.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG268401.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000049256.
HOVERGENiHBG000250.
InParanoidiQ15784.
KOiK09078.
OMAiLMEPRET.
OrthoDBiEOG722J8S.
PhylomeDBiQ15784.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15784-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTRLFSEPG LLSDVPKFAS WGDGEDDEPR SDKGDAPPPP PPAPGPGAPG
60 70 80 90 100
PARAAKPVPL RGEEGTEATL AEVKEEGELG GEEEEEEEEE EGLDEAEGER
110 120 130 140 150
PKKRGPKKRK MTKARLERSK LRRQKANARE RNRMHDLNAA LDNLRKVVPC
160 170 180 190 200
YSKTQKLSKI ETLRLAKNYI WALSEILRSG KRPDLVSYVQ TLCKGLSQPT
210 220 230 240 250
TNLVAGCLQL NSRNFLTEQG ADGAGRFHGS GGPFAMHPYP YPCSRLAGAQ
260 270 280 290 300
CQAAGGLGGG AAHALRTHGY CAAYETLYAA AGGGGASPDY NSSEYEGPLS
310 320 330 340 350
PPLCLNGNFS LKQDSSPDHE KSYHYSMHYS ALPGSRPTGH GLVFGSSAVR
360 370 380
GGVHSENLLS YDMHLHHDRG PMYEELNAFF HN
Length:382
Mass (Da):41,361
Last modified:May 30, 2000 - v2
Checksum:iE33AA5C0BE371B47
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041R → G in AAH22481. (PubMed:15489334)Curated
Sequence conflicti337 – 3382PT → H in BAA77569. (PubMed:10209266)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58681 Genomic DNA. Translation: AAC26058.1.
AB021742 mRNA. Translation: BAA77569.1.
BC022481 mRNA. Translation: AAH22481.1.
CCDSiCCDS11338.1.
PIRiG02668.
RefSeqiNP_006151.3. NM_006160.3.
UniGeneiHs.322431.

Genome annotation databases

EnsembliENST00000302584; ENSP00000306754; ENSG00000171532.
GeneIDi4761.
KEGGihsa:4761.
UCSCiuc002hry.3. human.

Polymorphism databases

DMDMi6226655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58681 Genomic DNA. Translation: AAC26058.1 .
AB021742 mRNA. Translation: BAA77569.1 .
BC022481 mRNA. Translation: AAH22481.1 .
CCDSi CCDS11338.1.
PIRi G02668.
RefSeqi NP_006151.3. NM_006160.3.
UniGenei Hs.322431.

3D structure databases

ProteinModelPortali Q15784.
SMRi Q15784. Positions 122-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110834. 2 interactions.
IntActi Q15784. 1 interaction.
MINTi MINT-6774369.
STRINGi 9606.ENSP00000306754.

PTM databases

PhosphoSitei Q15784.

Polymorphism databases

DMDMi 6226655.

Proteomic databases

PaxDbi Q15784.
PRIDEi Q15784.

Protocols and materials databases

DNASUi 4761.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302584 ; ENSP00000306754 ; ENSG00000171532 .
GeneIDi 4761.
KEGGi hsa:4761.
UCSCi uc002hry.3. human.

Organism-specific databases

CTDi 4761.
GeneCardsi GC17M037760.
HGNCi HGNC:7763. NEUROD2.
HPAi HPA060457.
MIMi 601725. gene.
neXtProti NX_Q15784.
PharmGKBi PA31565.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG268401.
GeneTreei ENSGT00680000099860.
HOGENOMi HOG000049256.
HOVERGENi HBG000250.
InParanoidi Q15784.
KOi K09078.
OMAi LMEPRET.
OrthoDBi EOG722J8S.
PhylomeDBi Q15784.
TreeFami TF315153.

Miscellaneous databases

GeneWikii NEUROD2.
GenomeRNAii 4761.
NextBioi 18340.
PROi Q15784.
SOURCEi Search...

Gene expression databases

Bgeei Q15784.
CleanExi HS_NEUROD2.
Genevestigatori Q15784.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view ]
PIRSFi PIRSF015618. bHLH_NeuroD. 1 hit.
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family."
    McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J.
    Mol. Cell. Biol. 16:5792-5800(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Tapscott S.J., Tamimi R.T., McCormick B.M.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 336-338.
  3. "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)."
    Kitamura T., Miyachi T., Nakamura S., Kawakami H.
    Biochim. Biophys. Acta 1445:142-147(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNDF2_HUMAN
AccessioniPrimary (citable) accession number: Q15784
Secondary accession number(s): Q8TBI7, Q9UQC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3