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Protein

Neurogenic differentiation factor 2

Gene

NEUROD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171532-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 2
Short name:
NeuroD2
Alternative name(s):
Class A basic helix-loop-helix protein 1
Short name:
bHLHa1
NeuroD-related factor
Short name:
NDRF
Gene namesi
Name:NEUROD2
Synonyms:BHLHA1, NDRF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7763. NEUROD2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4761.
OpenTargetsiENSG00000171532.
PharmGKBiPA31565.

Polymorphism and mutation databases

BioMutaiNEUROD2.
DMDMi6226655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273871 – 382Neurogenic differentiation factor 2Add BLAST382

Proteomic databases

PaxDbiQ15784.
PeptideAtlasiQ15784.
PRIDEiQ15784.

PTM databases

iPTMnetiQ15784.
PhosphoSitePlusiQ15784.

Expressioni

Gene expression databases

BgeeiENSG00000171532.
CleanExiHS_NEUROD2.
GenevisibleiQ15784. HS.

Organism-specific databases

HPAiCAB033120.

Interactioni

Subunit structurei

Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription activation require dimerization with another bHLH protein (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110834. 2 interactors.
IntActiQ15784. 1 interactor.
MINTiMINT-6774369.
STRINGi9606.ENSP00000306754.

Structurei

3D structure databases

ProteinModelPortaliQ15784.
SMRiQ15784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 173bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi107 – 113Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 46Poly-Pro10
Compositional biasi82 – 91Poly-Glu10
Compositional biasi282 – 285Poly-Gly4

Domaini

The C-terminal region is necessary for depolarization-induced and calcium-dependent transcription activation.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000049256.
HOVERGENiHBG000250.
InParanoidiQ15784.
KOiK09078.
OMAiCINGNFS.
OrthoDBiEOG091G15AI.
PhylomeDBiQ15784.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032649. Neurod2.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PANTHERiPTHR19290:SF83. PTHR19290:SF83. 2 hits.
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTRLFSEPG LLSDVPKFAS WGDGEDDEPR SDKGDAPPPP PPAPGPGAPG
60 70 80 90 100
PARAAKPVPL RGEEGTEATL AEVKEEGELG GEEEEEEEEE EGLDEAEGER
110 120 130 140 150
PKKRGPKKRK MTKARLERSK LRRQKANARE RNRMHDLNAA LDNLRKVVPC
160 170 180 190 200
YSKTQKLSKI ETLRLAKNYI WALSEILRSG KRPDLVSYVQ TLCKGLSQPT
210 220 230 240 250
TNLVAGCLQL NSRNFLTEQG ADGAGRFHGS GGPFAMHPYP YPCSRLAGAQ
260 270 280 290 300
CQAAGGLGGG AAHALRTHGY CAAYETLYAA AGGGGASPDY NSSEYEGPLS
310 320 330 340 350
PPLCLNGNFS LKQDSSPDHE KSYHYSMHYS ALPGSRPTGH GLVFGSSAVR
360 370 380
GGVHSENLLS YDMHLHHDRG PMYEELNAFF HN
Length:382
Mass (Da):41,361
Last modified:May 30, 2000 - v2
Checksum:iE33AA5C0BE371B47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104R → G in AAH22481 (PubMed:15489334).Curated1
Sequence conflicti337 – 338PT → H in BAA77569 (PubMed:10209266).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58681 Genomic DNA. Translation: AAC26058.1.
AB021742 mRNA. Translation: BAA77569.1.
BC022481 mRNA. Translation: AAH22481.1.
CCDSiCCDS11338.1.
PIRiG02668.
RefSeqiNP_006151.3. NM_006160.3.
UniGeneiHs.322431.

Genome annotation databases

EnsembliENST00000302584; ENSP00000306754; ENSG00000171532.
GeneIDi4761.
KEGGihsa:4761.
UCSCiuc002hry.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58681 Genomic DNA. Translation: AAC26058.1.
AB021742 mRNA. Translation: BAA77569.1.
BC022481 mRNA. Translation: AAH22481.1.
CCDSiCCDS11338.1.
PIRiG02668.
RefSeqiNP_006151.3. NM_006160.3.
UniGeneiHs.322431.

3D structure databases

ProteinModelPortaliQ15784.
SMRiQ15784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110834. 2 interactors.
IntActiQ15784. 1 interactor.
MINTiMINT-6774369.
STRINGi9606.ENSP00000306754.

PTM databases

iPTMnetiQ15784.
PhosphoSitePlusiQ15784.

Polymorphism and mutation databases

BioMutaiNEUROD2.
DMDMi6226655.

Proteomic databases

PaxDbiQ15784.
PeptideAtlasiQ15784.
PRIDEiQ15784.

Protocols and materials databases

DNASUi4761.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302584; ENSP00000306754; ENSG00000171532.
GeneIDi4761.
KEGGihsa:4761.
UCSCiuc002hry.4. human.

Organism-specific databases

CTDi4761.
DisGeNETi4761.
GeneCardsiNEUROD2.
HGNCiHGNC:7763. NEUROD2.
HPAiCAB033120.
MIMi601725. gene.
neXtProtiNX_Q15784.
OpenTargetsiENSG00000171532.
PharmGKBiPA31565.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000049256.
HOVERGENiHBG000250.
InParanoidiQ15784.
KOiK09078.
OMAiCINGNFS.
OrthoDBiEOG091G15AI.
PhylomeDBiQ15784.
TreeFamiTF315153.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171532-MONOMER.

Miscellaneous databases

ChiTaRSiNEUROD2. human.
GeneWikiiNEUROD2.
GenomeRNAii4761.
PROiQ15784.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171532.
CleanExiHS_NEUROD2.
GenevisibleiQ15784. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032649. Neurod2.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PANTHERiPTHR19290:SF83. PTHR19290:SF83. 2 hits.
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDF2_HUMAN
AccessioniPrimary (citable) accession number: Q15784
Secondary accession number(s): Q8TBI7, Q9UQC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.