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Q15784

- NDF2_HUMAN

UniProt

Q15784 - NDF2_HUMAN

Protein

Neurogenic differentiation factor 2

Gene

NEUROD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter By similarity.By similarity

    GO - Molecular functioni

    1. E-box binding Source: UniProtKB
    2. protein heterodimerization activity Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc
    4. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. associative learning Source: Ensembl
    2. behavioral fear response Source: Ensembl
    3. cellular response to calcium ion Source: UniProtKB
    4. cellular response to electrical stimulus Source: UniProtKB
    5. cerebellar cortex development Source: UniProtKB
    6. negative regulation of synapse maturation Source: UniProtKB
    7. nervous system development Source: ProtInc
    8. neuron development Source: Ensembl
    9. positive regulation of calcium-mediated signaling Source: UniProtKB
    10. positive regulation of neuron differentiation Source: UniProtKB
    11. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    12. positive regulation of synapse maturation Source: UniProtKB
    13. positive regulation of synaptic plasticity Source: UniProtKB
    14. protein ubiquitination Source: UniProtKB
    15. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    16. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurogenic differentiation factor 2
    Short name:
    NeuroD2
    Alternative name(s):
    Class A basic helix-loop-helix protein 1
    Short name:
    bHLHa1
    NeuroD-related factor
    Short name:
    NDRF
    Gene namesi
    Name:NEUROD2
    Synonyms:BHLHA1, NDRF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7763. NEUROD2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31565.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Neurogenic differentiation factor 2PRO_0000127387Add
    BLAST

    Proteomic databases

    PaxDbiQ15784.
    PRIDEiQ15784.

    PTM databases

    PhosphoSiteiQ15784.

    Expressioni

    Gene expression databases

    BgeeiQ15784.
    CleanExiHS_NEUROD2.
    GenevestigatoriQ15784.

    Organism-specific databases

    HPAiHPA060457.

    Interactioni

    Subunit structurei

    Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription activation require dimerization with another bHLH protein By similarity.By similarity

    Protein-protein interaction databases

    BioGridi110834. 2 interactions.
    IntActiQ15784. 1 interaction.
    MINTiMINT-6774369.
    STRINGi9606.ENSP00000306754.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15784.
    SMRiQ15784. Positions 122-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini121 – 17353bHLHPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi107 – 1137Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi37 – 4610Poly-Pro
    Compositional biasi82 – 9110Poly-Glu
    Compositional biasi282 – 2854Poly-Gly

    Domaini

    The C-terminal region is necessary for depolarization-induced and calcium-dependent transcription activation.By similarity

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG268401.
    HOGENOMiHOG000049256.
    HOVERGENiHBG000250.
    InParanoidiQ15784.
    KOiK09078.
    OMAiLMEPRET.
    OrthoDBiEOG722J8S.
    PhylomeDBiQ15784.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR022575. Neurogenic_DUF.
    IPR016637. TF_bHLH_NeuroD.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF12533. Neuro_bHLH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15784-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTRLFSEPG LLSDVPKFAS WGDGEDDEPR SDKGDAPPPP PPAPGPGAPG    50
    PARAAKPVPL RGEEGTEATL AEVKEEGELG GEEEEEEEEE EGLDEAEGER 100
    PKKRGPKKRK MTKARLERSK LRRQKANARE RNRMHDLNAA LDNLRKVVPC 150
    YSKTQKLSKI ETLRLAKNYI WALSEILRSG KRPDLVSYVQ TLCKGLSQPT 200
    TNLVAGCLQL NSRNFLTEQG ADGAGRFHGS GGPFAMHPYP YPCSRLAGAQ 250
    CQAAGGLGGG AAHALRTHGY CAAYETLYAA AGGGGASPDY NSSEYEGPLS 300
    PPLCLNGNFS LKQDSSPDHE KSYHYSMHYS ALPGSRPTGH GLVFGSSAVR 350
    GGVHSENLLS YDMHLHHDRG PMYEELNAFF HN 382
    Length:382
    Mass (Da):41,361
    Last modified:May 30, 2000 - v2
    Checksum:iE33AA5C0BE371B47
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041R → G in AAH22481. (PubMed:15489334)Curated
    Sequence conflicti337 – 3382PT → H in BAA77569. (PubMed:10209266)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58681 Genomic DNA. Translation: AAC26058.1.
    AB021742 mRNA. Translation: BAA77569.1.
    BC022481 mRNA. Translation: AAH22481.1.
    CCDSiCCDS11338.1.
    PIRiG02668.
    RefSeqiNP_006151.3. NM_006160.3.
    UniGeneiHs.322431.

    Genome annotation databases

    EnsembliENST00000302584; ENSP00000306754; ENSG00000171532.
    GeneIDi4761.
    KEGGihsa:4761.
    UCSCiuc002hry.3. human.

    Polymorphism databases

    DMDMi6226655.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58681 Genomic DNA. Translation: AAC26058.1 .
    AB021742 mRNA. Translation: BAA77569.1 .
    BC022481 mRNA. Translation: AAH22481.1 .
    CCDSi CCDS11338.1.
    PIRi G02668.
    RefSeqi NP_006151.3. NM_006160.3.
    UniGenei Hs.322431.

    3D structure databases

    ProteinModelPortali Q15784.
    SMRi Q15784. Positions 122-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110834. 2 interactions.
    IntActi Q15784. 1 interaction.
    MINTi MINT-6774369.
    STRINGi 9606.ENSP00000306754.

    PTM databases

    PhosphoSitei Q15784.

    Polymorphism databases

    DMDMi 6226655.

    Proteomic databases

    PaxDbi Q15784.
    PRIDEi Q15784.

    Protocols and materials databases

    DNASUi 4761.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302584 ; ENSP00000306754 ; ENSG00000171532 .
    GeneIDi 4761.
    KEGGi hsa:4761.
    UCSCi uc002hry.3. human.

    Organism-specific databases

    CTDi 4761.
    GeneCardsi GC17M037760.
    HGNCi HGNC:7763. NEUROD2.
    HPAi HPA060457.
    MIMi 601725. gene.
    neXtProti NX_Q15784.
    PharmGKBi PA31565.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268401.
    HOGENOMi HOG000049256.
    HOVERGENi HBG000250.
    InParanoidi Q15784.
    KOi K09078.
    OMAi LMEPRET.
    OrthoDBi EOG722J8S.
    PhylomeDBi Q15784.
    TreeFami TF315153.

    Miscellaneous databases

    GeneWikii NEUROD2.
    GenomeRNAii 4761.
    NextBioi 18340.
    PROi Q15784.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15784.
    CleanExi HS_NEUROD2.
    Genevestigatori Q15784.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR022575. Neurogenic_DUF.
    IPR016637. TF_bHLH_NeuroD.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF12533. Neuro_bHLH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015618. bHLH_NeuroD. 1 hit.
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family."
      McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J.
      Mol. Cell. Biol. 16:5792-5800(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Tapscott S.J., Tamimi R.T., McCormick B.M.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 336-338.
    3. "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)."
      Kitamura T., Miyachi T., Nakamura S., Kawakami H.
      Biochim. Biophys. Acta 1445:142-147(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNDF2_HUMAN
    AccessioniPrimary (citable) accession number: Q15784
    Secondary accession number(s): Q8TBI7, Q9UQC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3