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Protein

Neurogenic differentiation factor 2

Gene

NEUROD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).By similarity

GO - Molecular functioni

  1. E-box binding Source: UniProtKB
  2. protein heterodimerization activity Source: UniProtKB
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: ProtInc
  6. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. associative learning Source: Ensembl
  2. behavioral fear response Source: Ensembl
  3. cellular response to calcium ion Source: UniProtKB
  4. cellular response to electrical stimulus Source: UniProtKB
  5. cerebellar cortex development Source: UniProtKB
  6. negative regulation of nucleic acid-templated transcription Source: GOC
  7. negative regulation of synapse maturation Source: UniProtKB
  8. nervous system development Source: ProtInc
  9. neuron development Source: Ensembl
  10. positive regulation of calcium-mediated signaling Source: UniProtKB
  11. positive regulation of neuron differentiation Source: UniProtKB
  12. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  13. positive regulation of synapse maturation Source: UniProtKB
  14. positive regulation of synaptic plasticity Source: UniProtKB
  15. protein ubiquitination Source: UniProtKB
  16. regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 2
Short name:
NeuroD2
Alternative name(s):
Class A basic helix-loop-helix protein 1
Short name:
bHLHa1
NeuroD-related factor
Short name:
NDRF
Gene namesi
Name:NEUROD2
Synonyms:BHLHA1, NDRF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7763. NEUROD2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31565.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Neurogenic differentiation factor 2PRO_0000127387Add
BLAST

Proteomic databases

PaxDbiQ15784.
PRIDEiQ15784.

PTM databases

PhosphoSiteiQ15784.

Expressioni

Gene expression databases

BgeeiQ15784.
CleanExiHS_NEUROD2.
GenevestigatoriQ15784.

Organism-specific databases

HPAiHPA060457.

Interactioni

Subunit structurei

Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription activation require dimerization with another bHLH protein (By similarity).By similarity

Protein-protein interaction databases

BioGridi110834. 2 interactions.
IntActiQ15784. 1 interaction.
MINTiMINT-6774369.
STRINGi9606.ENSP00000306754.

Structurei

3D structure databases

ProteinModelPortaliQ15784.
SMRiQ15784. Positions 122-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 17353bHLHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi107 – 1137Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 4610Poly-Pro
Compositional biasi82 – 9110Poly-Glu
Compositional biasi282 – 2854Poly-Gly

Domaini

The C-terminal region is necessary for depolarization-induced and calcium-dependent transcription activation.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG268401.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000049256.
HOVERGENiHBG000250.
InParanoidiQ15784.
KOiK09078.
OMAiCINGNFS.
OrthoDBiEOG722J8S.
PhylomeDBiQ15784.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15784-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTRLFSEPG LLSDVPKFAS WGDGEDDEPR SDKGDAPPPP PPAPGPGAPG
60 70 80 90 100
PARAAKPVPL RGEEGTEATL AEVKEEGELG GEEEEEEEEE EGLDEAEGER
110 120 130 140 150
PKKRGPKKRK MTKARLERSK LRRQKANARE RNRMHDLNAA LDNLRKVVPC
160 170 180 190 200
YSKTQKLSKI ETLRLAKNYI WALSEILRSG KRPDLVSYVQ TLCKGLSQPT
210 220 230 240 250
TNLVAGCLQL NSRNFLTEQG ADGAGRFHGS GGPFAMHPYP YPCSRLAGAQ
260 270 280 290 300
CQAAGGLGGG AAHALRTHGY CAAYETLYAA AGGGGASPDY NSSEYEGPLS
310 320 330 340 350
PPLCLNGNFS LKQDSSPDHE KSYHYSMHYS ALPGSRPTGH GLVFGSSAVR
360 370 380
GGVHSENLLS YDMHLHHDRG PMYEELNAFF HN
Length:382
Mass (Da):41,361
Last modified:May 30, 2000 - v2
Checksum:iE33AA5C0BE371B47
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041R → G in AAH22481. (PubMed:15489334)Curated
Sequence conflicti337 – 3382PT → H in BAA77569. (PubMed:10209266)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58681 Genomic DNA. Translation: AAC26058.1.
AB021742 mRNA. Translation: BAA77569.1.
BC022481 mRNA. Translation: AAH22481.1.
CCDSiCCDS11338.1.
PIRiG02668.
RefSeqiNP_006151.3. NM_006160.3.
UniGeneiHs.322431.

Genome annotation databases

EnsembliENST00000302584; ENSP00000306754; ENSG00000171532.
GeneIDi4761.
KEGGihsa:4761.
UCSCiuc002hry.3. human.

Polymorphism databases

DMDMi6226655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58681 Genomic DNA. Translation: AAC26058.1.
AB021742 mRNA. Translation: BAA77569.1.
BC022481 mRNA. Translation: AAH22481.1.
CCDSiCCDS11338.1.
PIRiG02668.
RefSeqiNP_006151.3. NM_006160.3.
UniGeneiHs.322431.

3D structure databases

ProteinModelPortaliQ15784.
SMRiQ15784. Positions 122-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110834. 2 interactions.
IntActiQ15784. 1 interaction.
MINTiMINT-6774369.
STRINGi9606.ENSP00000306754.

PTM databases

PhosphoSiteiQ15784.

Polymorphism databases

DMDMi6226655.

Proteomic databases

PaxDbiQ15784.
PRIDEiQ15784.

Protocols and materials databases

DNASUi4761.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302584; ENSP00000306754; ENSG00000171532.
GeneIDi4761.
KEGGihsa:4761.
UCSCiuc002hry.3. human.

Organism-specific databases

CTDi4761.
GeneCardsiGC17M037760.
HGNCiHGNC:7763. NEUROD2.
HPAiHPA060457.
MIMi601725. gene.
neXtProtiNX_Q15784.
PharmGKBiPA31565.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG268401.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000049256.
HOVERGENiHBG000250.
InParanoidiQ15784.
KOiK09078.
OMAiCINGNFS.
OrthoDBiEOG722J8S.
PhylomeDBiQ15784.
TreeFamiTF315153.

Miscellaneous databases

ChiTaRSiNEUROD2. human.
GeneWikiiNEUROD2.
GenomeRNAii4761.
NextBioi18340.
PROiQ15784.
SOURCEiSearch...

Gene expression databases

BgeeiQ15784.
CleanExiHS_NEUROD2.
GenevestigatoriQ15784.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family."
    McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J.
    Mol. Cell. Biol. 16:5792-5800(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Tapscott S.J., Tamimi R.T., McCormick B.M.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 336-338.
  3. "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)."
    Kitamura T., Miyachi T., Nakamura S., Kawakami H.
    Biochim. Biophys. Acta 1445:142-147(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNDF2_HUMAN
AccessioniPrimary (citable) accession number: Q15784
Secondary accession number(s): Q8TBI7, Q9UQC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: January 7, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.