Metallophosphoesterase MPPED2 - Homo sapiens (Human)

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Q15777 (MPPD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 87. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Metallophosphoesterase MPPED2
EC=3.1.-.-

Alternative name(s):
Fetal brain protein 239
Short name=239FB
Metallophosphoesterase domain-containing protein 2

Gene names

Name:	MPPED2
Synonyms:	C11orf8, FAM1B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system By similarity.
Cofactor	Manganese or cobalt By similarity.
Subunit structure	Homodimer By similarity.
Tissue specificity	Expressed predominantly in fetal brain.
Sequence similarities	Belongs to the UPF0046 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Cobalt Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nervous system development Traceable author statement. Source: ProtInc
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 294

294

Metallophosphoesterase MPPED2

PRO_0000053405

Natural variations

Natural variant

H → R.
Corresponds to variant rs11556749 [ dbSNP | Ensembl ].

VAR_052487

Sequences

Sequence

Length

Mass (Da)

Tools

Q15777 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 43B2BC0DA1BFD1F0
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FASTA

294

33,360

        10         20         30         40         50         60 
MAHGIPSQGK VTITVDEYSS NPTQAFTHYN INQSRFQPPH VHMVDPIPYD TPKPAGHTRF 

        70         80         90        100        110        120 
VCISDTHSRT DGIQMPYGDI LLHTGDFTEL GLPSEVKKFN DWLGNLPYEY KIVIAGNHEL 

       130        140        150        160        170        180 
TFDKEFMADL VKQDYYRFPS VSKLKPEDFD NVQSLLTNSI YLQDSEVTVK GFRIYGAPWT 

       190        200        210        220        230        240 
PWFNGWGFNL PRGQSLLDKW NLIPEGIDIL MTHGPPLGFR DWVPKELQRV GCVELLNTVQ 

       250        260        270        280        290 
RRVRPKLHVF GGIHEGYGIM TDGYTTYINA STCTVSFQPT NPPIIFDLPN PQGS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A WAGR region gene between PAX-6 and FSHB expressed in fetal brain." Schwartz F., Neve R., Eisenman R., Gessler M., Bruns G. Hum. Genet. 94:658-664(1994) [PubMed: 7527372] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region." Schwartz F., Eisenman R., Knoll J., Gessler M., Bruns G. Genomics 29:526-532(1995) [PubMed: 8666403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Kidney and Stomach.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57911 mRNA. Translation: AAC50564.1. CH471064 Genomic DNA. Translation: EAW68256.1. CH471064 Genomic DNA. Translation: EAW68257.1. BC031582 mRNA. Translation: AAH31582.1.
IPI	IPI00019521.
RefSeq	NP_001575.1. NM_001584.2.
UniGene	Hs.289795.
3D structure databases
ProteinModelPortal	Q15777.
SMR	Q15777. Positions 11-291.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15777. 1 interaction.
STRING	Q15777.
Polymorphism databases
DMDM	3023214.
Proteomic databases
PRIDE	Q15777.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358117; ENSP00000350833; ENSG00000066382.
GeneID	744.
KEGG	hsa:744.
UCSC	uc001msr.1. human.
Organism-specific databases
CTD	744.
GeneCards	GC11M030389.
H-InvDB	HIX0009524.
HGNC	HGNC:1180. MPPED2.
HPA	HPA039265.
MIM	600911. gene.
neXtProt	NX_Q15777.
PharmGKB	PA25499.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08451.
GeneTree	ENSGT00390000007681.
HOGENOM	HBG385841.
HOVERGEN	HBG000008.
InParanoid	Q15777.
OMA	PYGDVLL.
OrthoDB	EOG42V8GM.
PhylomeDB	Q15777.
Gene expression databases
ArrayExpress	Q15777.
Bgee	Q15777.
CleanEx	HS_MPPED2.
Genevestigator	Q15777.
GermOnline	ENSG00000066382. Homo sapiens.
Family and domain databases
InterPro	IPR024201. Calcineurin-like_Pesterase. IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF035808. Pdiesterase_Brain_239. 1 hit.
ProtoNet	Search...
Other
NextBio	3012.
SOURCE	Search...

Entry information

Entry name

MPPD2_HUMAN

Accession

Primary (citable) accession number: Q15777
Secondary accession number(s): D3DQZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.