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Protein

Zinc finger protein with KRAB and SCAN domains 8

Gene

ZKSCAN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri322 – 34423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri518 – 54023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri546 – 56823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 8
Alternative name(s):
LD5-1
Zinc finger protein 192
Gene namesi
Name:ZKSCAN8
Synonyms:ZNF192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12983. ZKSCAN8.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37563.

Polymorphism and mutation databases

DMDMi116242856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Zinc finger protein with KRAB and SCAN domains 8PRO_0000047445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineCombined sources
Cross-linki572 – 572Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15776.
MaxQBiQ15776.
PaxDbiQ15776.
PRIDEiQ15776.
TopDownProteomicsiQ15776-1. [Q15776-1]

PTM databases

iPTMnetiQ15776.
PhosphoSiteiQ15776.

Expressioni

Gene expression databases

BgeeiQ15776.
CleanExiHS_ZNF192.
ExpressionAtlasiQ15776. baseline and differential.
GenevisibleiQ15776. HS.

Organism-specific databases

HPAiHPA003483.

Interactioni

Protein-protein interaction databases

BioGridi113529. 25 interactions.
IntActiQ15776. 4 interactions.
STRINGi9606.ENSP00000332750.

Structurei

3D structure databases

ProteinModelPortaliQ15776.
SMRiQ15776. Positions 48-134, 260-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 13383SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini220 – 31697KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri322 – 34423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri518 – 54023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri546 – 56823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ15776.
KOiK09229.
OMAiSPGDQEM.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ15776.
TreeFamiTF338146.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15776-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEESRKPSA PSPPDQTPEE DLVIVKVEED HGWDQESSLH ESNPLGQEVF
60 70 80 90 100
RLRFRQLRYQ ETLGPREALI QLRALCHQWL RPDLNTKEQI LELLVLEQFL
110 120 130 140 150
TILPEELQTL VKEHQLENGE EVVTLLEDLE RQIDILGRPV SARVHGHRVL
160 170 180 190 200
WEEVVHSASA PEPPNTQLQS EATQHKSPVP QESQERAMST SQSPTRSQKG
210 220 230 240 250
SSGDQEMTAT LLTAGFQTLE KIEDMAVSLI REEWLLDPSQ KDLCRDNRPE
260 270 280 290 300
NFRNMFSLGG ETRSENRELA SKQVISTGIQ PHGETAAKCN GDVIRGLEHE
310 320 330 340 350
EARDLLGRLE RQRGNPTQER RHKCDECGKS FAQSSGLVRH WRIHTGEKPY
360 370 380 390 400
QCNVCGKAFS YRSALLSHQD IHNKVKRYHC KECGKAFSQN TGLILHQRIH
410 420 430 440 450
TGEKPYQCNQ CGKAFSQSAG LILHQRIHSG ERPYECNECG KAFSHSSHLI
460 470 480 490 500
GHQRIHTGEK PYECDECGKT FRRSSHLIGH QRSHTGEKPY KCNECGRAFS
510 520 530 540 550
QKSGLIEHQR IHTGERPYKC KECGKAFNGN TGLIQHLRIH TGEKPYQCNE
560 570
CGKAFIQRSS LIRHQRIHSG EKSESISV
Length:578
Mass (Da):65,816
Last modified:October 17, 2006 - v2
Checksum:i0A4FCA610DFF31F2
GO
Isoform 2 (identifier: Q15776-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-158: ARVHGHRVLWEEVVHSA → RRRSQLAYMDIGYSGRR
     159-578: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,490
Checksum:iFAA536A9FE01EAFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341D → A in AAB02260 (PubMed:9244436).Curated
Sequence conflicti34 – 341D → A in AAC51656 (PubMed:9244436).Curated
Sequence conflicti113 – 1131E → D in AAB02260 (PubMed:9244436).Curated
Sequence conflicti113 – 1131E → D in AAC51656 (PubMed:9244436).Curated
Sequence conflicti152 – 1521E → G in AAH96283 (PubMed:15489334).Curated
Sequence conflicti407 – 4071Q → R in AAH96284 (PubMed:15489334).Curated
Sequence conflicti477 – 4771L → F in AAH96283 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631P → L.1 Publication
Corresponds to variant rs62620225 [ dbSNP | Ensembl ].
VAR_009877

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 15817ARVHG…VVHSA → RRRSQLAYMDIGYSGRR in isoform 2. 1 PublicationVSP_056437Add
BLAST
Alternative sequencei159 – 578420Missing in isoform 2. 1 PublicationVSP_056438Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57796 mRNA. Translation: AAB02260.1.
U88080, U88079 Genomic DNA. Translation: AAC51656.1.
AK302402 mRNA. Translation: BAG63713.1.
AL358933 Genomic DNA. Translation: CAC15901.1.
CH471081 Genomic DNA. Translation: EAX03135.1.
BC096282 mRNA. Translation: AAH96282.1.
BC096283 mRNA. Translation: AAH96283.1.
BC096284 mRNA. Translation: AAH96284.1.
BC113961 mRNA. Translation: AAI13962.1.
BC130032 mRNA. Translation: AAI30033.1.
BC152378 mRNA. Translation: AAI52379.1.
CCDSiCCDS4645.1. [Q15776-1]
RefSeqiNP_001265048.1. NM_001278119.1. [Q15776-1]
NP_001265050.1. NM_001278121.1.
NP_006289.2. NM_006298.3. [Q15776-1]
XP_011513172.1. XM_011514870.1. [Q15776-1]
XP_011513173.1. XM_011514871.1. [Q15776-1]
XP_011513174.1. XM_011514872.1. [Q15776-1]
UniGeneiHs.57679.
Hs.633128.
Hs.711890.

Genome annotation databases

EnsembliENST00000330236; ENSP00000332750; ENSG00000198315. [Q15776-1]
ENST00000457389; ENSP00000402948; ENSG00000198315. [Q15776-1]
ENST00000536028; ENSP00000439117; ENSG00000198315. [Q15776-2]
ENST00000606198; ENSP00000475589; ENSG00000198315. [Q15776-2]
GeneIDi7745.
KEGGihsa:7745.
UCSCiuc003nkn.3. human. [Q15776-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57796 mRNA. Translation: AAB02260.1.
U88080, U88079 Genomic DNA. Translation: AAC51656.1.
AK302402 mRNA. Translation: BAG63713.1.
AL358933 Genomic DNA. Translation: CAC15901.1.
CH471081 Genomic DNA. Translation: EAX03135.1.
BC096282 mRNA. Translation: AAH96282.1.
BC096283 mRNA. Translation: AAH96283.1.
BC096284 mRNA. Translation: AAH96284.1.
BC113961 mRNA. Translation: AAI13962.1.
BC130032 mRNA. Translation: AAI30033.1.
BC152378 mRNA. Translation: AAI52379.1.
CCDSiCCDS4645.1. [Q15776-1]
RefSeqiNP_001265048.1. NM_001278119.1. [Q15776-1]
NP_001265050.1. NM_001278121.1.
NP_006289.2. NM_006298.3. [Q15776-1]
XP_011513172.1. XM_011514870.1. [Q15776-1]
XP_011513173.1. XM_011514871.1. [Q15776-1]
XP_011513174.1. XM_011514872.1. [Q15776-1]
UniGeneiHs.57679.
Hs.633128.
Hs.711890.

3D structure databases

ProteinModelPortaliQ15776.
SMRiQ15776. Positions 48-134, 260-572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113529. 25 interactions.
IntActiQ15776. 4 interactions.
STRINGi9606.ENSP00000332750.

PTM databases

iPTMnetiQ15776.
PhosphoSiteiQ15776.

Polymorphism and mutation databases

DMDMi116242856.

Proteomic databases

EPDiQ15776.
MaxQBiQ15776.
PaxDbiQ15776.
PRIDEiQ15776.
TopDownProteomicsiQ15776-1. [Q15776-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330236; ENSP00000332750; ENSG00000198315. [Q15776-1]
ENST00000457389; ENSP00000402948; ENSG00000198315. [Q15776-1]
ENST00000536028; ENSP00000439117; ENSG00000198315. [Q15776-2]
ENST00000606198; ENSP00000475589; ENSG00000198315. [Q15776-2]
GeneIDi7745.
KEGGihsa:7745.
UCSCiuc003nkn.3. human. [Q15776-1]

Organism-specific databases

CTDi7745.
GeneCardsiZKSCAN8.
HGNCiHGNC:12983. ZKSCAN8.
HPAiHPA003483.
MIMi602240. gene.
neXtProtiNX_Q15776.
PharmGKBiPA37563.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ15776.
KOiK09229.
OMAiSPGDQEM.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ15776.
TreeFamiTF338146.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7745.
PROiQ15776.
SOURCEiSearch...

Gene expression databases

BgeeiQ15776.
CleanExiHS_ZNF192.
ExpressionAtlasiQ15776. baseline and differential.
GenevisibleiQ15776. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain."
    Lee P.L., Gelbart T., West C., Adams M., Blackstone R., Beutler E.
    Genomics 43:191-201(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT LEU-163.
    Tissue: Ovary.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "A strategy for cloning the hereditary hemochromatosis gene."
    Beutler E., Gelbart T., West C., Kuhl W., Lee P.
    Blood Cells Mol. Dis. 21:207-216(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-572, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."
    Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., Vertegaal A.C.
    Cell Rep. 10:1778-1791(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-572, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZKSC8_HUMAN
AccessioniPrimary (citable) accession number: Q15776
Secondary accession number(s): A1L3D4
, B4DYF1, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 17, 2006
Last modified: June 8, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.