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Protein

Zinc finger protein with KRAB and SCAN domains 8

Gene

ZKSCAN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri322 – 344C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 8
Alternative name(s):
LD5-1
Zinc finger protein 192
Gene namesi
Name:ZKSCAN8
Synonyms:ZNF192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000198315.10
HGNCiHGNC:12983 ZKSCAN8
MIMi602240 gene
neXtProtiNX_Q15776

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7745
OpenTargetsiENSG00000198315
PharmGKBiPA37563

Polymorphism and mutation databases

DMDMi116242856

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474451 – 578Zinc finger protein with KRAB and SCAN domains 8Add BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei201PhosphoserineBy similarity1
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki272Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki288Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki376Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki502Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki572Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15776
MaxQBiQ15776
PaxDbiQ15776
PeptideAtlasiQ15776
PRIDEiQ15776
TopDownProteomicsiQ15776-1 [Q15776-1]

PTM databases

iPTMnetiQ15776
PhosphoSitePlusiQ15776

Expressioni

Gene expression databases

BgeeiENSG00000198315
CleanExiHS_ZNF192
ExpressionAtlasiQ15776 baseline and differential
GenevisibleiQ15776 HS

Organism-specific databases

HPAiHPA003483

Interactioni

Protein-protein interaction databases

BioGridi113529, 86 interactors
IntActiQ15776, 6 interactors
STRINGi9606.ENSP00000332750

Structurei

3D structure databases

ProteinModelPortaliQ15776
SMRiQ15776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 133SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini220 – 316KRABPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri322 – 344C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ15776
KOiK09229
OMAiSPGDQEM
OrthoDBiEOG091G02KC
PhylomeDBiQ15776
TreeFamiTF338146

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15776-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEESRKPSA PSPPDQTPEE DLVIVKVEED HGWDQESSLH ESNPLGQEVF
60 70 80 90 100
RLRFRQLRYQ ETLGPREALI QLRALCHQWL RPDLNTKEQI LELLVLEQFL
110 120 130 140 150
TILPEELQTL VKEHQLENGE EVVTLLEDLE RQIDILGRPV SARVHGHRVL
160 170 180 190 200
WEEVVHSASA PEPPNTQLQS EATQHKSPVP QESQERAMST SQSPTRSQKG
210 220 230 240 250
SSGDQEMTAT LLTAGFQTLE KIEDMAVSLI REEWLLDPSQ KDLCRDNRPE
260 270 280 290 300
NFRNMFSLGG ETRSENRELA SKQVISTGIQ PHGETAAKCN GDVIRGLEHE
310 320 330 340 350
EARDLLGRLE RQRGNPTQER RHKCDECGKS FAQSSGLVRH WRIHTGEKPY
360 370 380 390 400
QCNVCGKAFS YRSALLSHQD IHNKVKRYHC KECGKAFSQN TGLILHQRIH
410 420 430 440 450
TGEKPYQCNQ CGKAFSQSAG LILHQRIHSG ERPYECNECG KAFSHSSHLI
460 470 480 490 500
GHQRIHTGEK PYECDECGKT FRRSSHLIGH QRSHTGEKPY KCNECGRAFS
510 520 530 540 550
QKSGLIEHQR IHTGERPYKC KECGKAFNGN TGLIQHLRIH TGEKPYQCNE
560 570
CGKAFIQRSS LIRHQRIHSG EKSESISV
Length:578
Mass (Da):65,816
Last modified:October 17, 2006 - v2
Checksum:i0A4FCA610DFF31F2
GO
Isoform 2 (identifier: Q15776-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-158: ARVHGHRVLWEEVVHSA → RRRSQLAYMDIGYSGRR
     159-578: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,490
Checksum:iFAA536A9FE01EAFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34D → A in AAB02260 (PubMed:9244436).Curated1
Sequence conflicti34D → A in AAC51656 (PubMed:9244436).Curated1
Sequence conflicti113E → D in AAB02260 (PubMed:9244436).Curated1
Sequence conflicti113E → D in AAC51656 (PubMed:9244436).Curated1
Sequence conflicti152E → G in AAH96283 (PubMed:15489334).Curated1
Sequence conflicti407Q → R in AAH96284 (PubMed:15489334).Curated1
Sequence conflicti477L → F in AAH96283 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009877163P → L1 PublicationCorresponds to variant dbSNP:rs62620225Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056437142 – 158ARVHG…VVHSA → RRRSQLAYMDIGYSGRR in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_056438159 – 578Missing in isoform 2. 1 PublicationAdd BLAST420

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57796 mRNA Translation: AAB02260.1
U88080, U88079 Genomic DNA Translation: AAC51656.1
AK302402 mRNA Translation: BAG63713.1
AL358933 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03135.1
BC096282 mRNA Translation: AAH96282.1
BC096283 mRNA Translation: AAH96283.1
BC096284 mRNA Translation: AAH96284.1
BC113961 mRNA Translation: AAI13962.1
BC130032 mRNA Translation: AAI30033.1
BC152378 mRNA Translation: AAI52379.1
CCDSiCCDS4645.1 [Q15776-1]
RefSeqiNP_001265048.1, NM_001278119.1 [Q15776-1]
NP_001265050.1, NM_001278121.1
NP_006289.2, NM_006298.3 [Q15776-1]
XP_011513172.1, XM_011514870.2 [Q15776-1]
XP_016866755.1, XM_017011266.1 [Q15776-1]
UniGeneiHs.57679
Hs.633128
Hs.711890

Genome annotation databases

EnsembliENST00000330236; ENSP00000332750; ENSG00000198315 [Q15776-1]
ENST00000457389; ENSP00000402948; ENSG00000198315 [Q15776-1]
ENST00000536028; ENSP00000439117; ENSG00000198315 [Q15776-2]
ENST00000606198; ENSP00000475589; ENSG00000198315 [Q15776-2]
GeneIDi7745
KEGGihsa:7745
UCSCiuc003nkn.3 human [Q15776-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZKSC8_HUMAN
AccessioniPrimary (citable) accession number: Q15776
Secondary accession number(s): A1L3D4
, B4DYF1, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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